Digital Commons Network^™

Design Of A Gait Acquisition And Analysis System For Assessing The Recovery Of Mice Post-Spinal Cord Injury, Casey Harr

University of Kentucky Master's Theses

Current methods of determining spinal cord recovery in mice, post-directed injury, are qualitative measures. This is due to the small size and quickness of mice. This thesis presents a design for a gait acquisition and analysis system able to capture the footfalls of a mouse, extract position and timing data, and report quantitative gait metrics to the operator. These metrics can then be used to evaluate the recovery of the mouse. This work presents the design evolution of the system, from initial sensor design concepts through prototyping and testing to the final implementation. The system utilizes a machine vision camera, …

The Accelerating Degradation Of American Criminal Codes, Michael T. Cahill, Paul H. Robinson

Faculty Scholarship

No abstract provided.

Bone Engineering Of The Ulna Of Rabbit, Amanda Peter Hart

University of Kentucky Master's Theses

Repair of bone defects is a major challenge in orthopaedic surgery. Current bone graft treatments, including autografts, allografts and xenografts, have many limitations making it necessary to develop a biomaterial to be a bone graft substitute. One such biomaterial is bioactive resorbable silica-calcium phosphate nanocomposite (SCPC). SCPC was processed using a 3D rapid prototyping technique and sintered at different temperatures to create porous scaffolds. SEM analyses and mercury intrusion porosimetry showed SCPC to be highly porous with micro- and nanopores. BET analysis indicated that SCPC had high surface area. Mechanical testing demonstrated that SCPC had a compressive strength similar to …

The Impact Of Current Policy And Regulation On Future Stem Cell Human Health Applications, Michael J. Malinowski

Journal Articles

No abstract provided.

President's Report, 2005, University Of Montana (Missoula, Mont.). Office Of The President

University of Montana President’s Report, 1993-2016

The President’s Report of the University of Montana, produced by University Relations on behalf of the President’s Office.

The International Law Of Environmental Warfare: Active And Passive Damage During Armed Conflict, Eric T. Jensen

Vanderbilt Journal of Transnational Law

One of the constant elements of warfare is its degrading effects on the environment. Many writers blame this destruction of the environment on inadequate standards in the international law of environmental warfare. To remedy this shortfall, the international law of environmental warfare should be categorized as either passive or active environmental warfare. Active environmental warfare requires the intentional "use" of the environment as a weapon of waging armed conflict. Passive environmental warfare includes acts not specifically designed to "use" the environment for a particular military purpose but that have a degrading effect on the environment. Passive environmental warfare violates international …

Strafford County 2004 Annual Report Of The Commissioners, Treasurer, Other County Officers And The Strafford County Delegation Strafford County, New Hampshire For The Year Ending December 31, 2004., Stafford County Representatives

Strafford County, NH Annual Reports

This is an annual report containing vital statistics for a county in the state of New Hampshire.

Right To Know: A Diet Of The Future Presently Upon Us, Jamie E. Jorg Spence

Valparaiso University Law Review

No abstract provided.

Long-Term Consequences Of West Nile Virus In Virginia., Diana Cruz Ocampo

Theses and Dissertations

Objective: The purpose of this investigation was to describe the long-term effects and functional outcomes of patients in Virginia who were reported to the Virginia Department of Health with West Nile virus (WNV) non-neuroinvasive and neuroinvasive disease. The study identified the duration of symptoms after initial illness, the number of persons who fully recovered versus the number who continue to be symptomatic and how patients' quality of life differed after illness.Methods: The study population was drawn from 60 human cases that met the surveillance case definition for non-neuroinvasive and neuroinvasive WNV illness in Virginia between 2002-2004. Information was collected during …

Using Howard Gardner's Entry-Point Framework To Analyze A Multiple Intelligence Collaborative Unit Including A Multigenre Research Paper And Altered Books, Julia Richardson Radtke

Graduate Student Theses, Dissertations, & Professional Papers

No abstract provided.

Expressed Sequence Tags From Diabrotica Virgifera Virgifera Midgut Identify A Coleopteran Cadherin And A Diversity Of Cathepsins, Blair D. Siegfried, N. Waterfield, R. H. Ffrench-Constant

Department of Entomology: Faculty Publications

The Western corn rootworm is the major pest of corn in the USA and has recently become the target for insect-resistant transgenic crops. Transgenic crops have switched the focus for identifying insecticide targets from the insect nervous system to the midgut. Here we describe a collection of 691 sequences from the Western corn rootworm midgut, 27% of which predict proteins with no matches in current databases. Of the remaining sequences, most predict proteins with either catalytic (62%) or binding (19%) functions, as expected for proteins expressed in the insect midgut. The utility of this approach for the identification of targets …

Susceptibility Of Biological Stages Of The Horn Fly, Haematobia Irritans, To Entomopathogenic Fungi (Hyphomycetes), C. A. Angel-Sahagún, R. Lezama-Gutiérrez, J. Molina-Ochoa, E. Galindo-Velasco, M. López-Edwards, O. Rebolledo-Domínguez, C. Cruz-Vázquez, W. P. Reyes-Velázquez, S. R. Skoda, John E. Foster

Department of Entomology: Faculty Publications

The susceptibility of the egg, pupa, and adult of Haematobia irritans (L.) (Diptera: Muscidae) to isolates of the fungi Metarhizium anisopliae (Metsch.) Sor., Beauveria bassiana (Bals.) Vuill., and Paecilomyces fumosoroseus (Wize) Brown and Smith, was evaluated under laboratory conditions. Groups of 20 eggs than 4 h old, pupae less than 48h old and adults were sprayed with a conidial suspension of each isolate. Eggs, pupae and adults of horn fly were susceptible to these entomopathogenic fungi. For treated eggs, the isolates Ma3, Ma 15, Ma25, Pfr1, and Pfr8 reduced adult emergence to 3.8% to 6.3% in comparison with the control …

A Novel Role For Gadd45Β As A Mediator Of Mmp-13 Gene Expression During Chondrocyte Terminal Differentiation, Kosei Ijiri, Luiz F. Zerbini, Haibing Peng, Ricardo G. Correa, Binfeng Lu, Nicole Walsh, Yani Zhao, Noboru Taniguchi, Xu-Ling Huang, Hasan H. Otu, Hong Wang, Jian Fei Wang, Setsuro Komiya, Patricia Ducy, Mahboob U. Rahman, Richard A. Flavell, Ellen M. Gravallese, Peter Oettgen, Towia A. Libermann, Mary B. Goldring

Department of Electrical and Computer Engineering: Faculty Publications

The growth arrest and DNA damage-inducible 45β (GADD45β) gene product has been implicated in the stress response, cell cycle arrest, and apoptosis. Here we demonstrated the unexpected expression of GADD45β in the embryonic growth plate and uncovered its novel role as an essential mediator of matrix metalloproteinase-13 (MMP-13) expression during terminal chondrocyte differentiation. We identified GADD45β as a prominent early response gene induced by bone morphogenetic protein-2 (BMP-2) through a Smad1/Runx2-dependent pathway. Because this pathway is involved in skeletal development, we examined mouse embryonic growth plates, and we observed expression of Gadd45β mRNA coincident with Runx2 protein …

Reginald Pecock On The Authority Of Reason, Scripture And Tradition, Stephen E. Lahey

Department of Classics and Religious Studies: Faculty Publications

Bishop Reginald Pecock (c. 1390–1461) is remembered for vernacular works formulated to combat Lollardy using reason, not the force of ecclesiastical authority. He argued that Scripture’s teachings are true not because they are in Scripture, but because they are evident to unassisted reason. While scholars have explored his arguments in ecclesiastical and historical context, little analysis exists of the scholastic background to Pecock’s conception of the relation of reason to faith. This article suggests that Pecock’s arguments are grounded in the thought of Aquinas and Scotus, and illustrates how his understanding of reason’s capabilities directs his conception of the authority …

Gendered Interpretations: Two Fourth-Century B.C.E. Performances Of Sophocles' Electra, Anne Duncan

Department of Classics and Religious Studies: Faculty Publications

While the evidence for theatrical practice in the ancient world is admittedly spotty, we are fortunate to have anecdotal evidence concerning two different performances of Sophocles' Electra, both from the fourth century B.C.E., by two of the most famous tragic actors in ancient Greece, Theodorus and Polus, who apparently played Electra. The evidence suggests that their performances may have differed widely; it is even conceivable that the role was something of a yardstick for measuring great actors of the day (a la Hamlet). I will argue that these two "star" actors gave radically different interpretations of the character of Electra, …

Ctla-4 Signaling Regulates The Intensity Of Hypersensitivity Responses To Food Antigens, But Is Not Decisive In The Induction Of Sensitization, Femke Van Wijk, Sanne Hoeks, Stefan Nierkens, Stef J. Koppelman, Peter Van Kooten, Louis Boon, Leon M.J. Knippels, Raymond Pieters

Department of Food Science and Technology: Faculty Publications

Although food allergy has emerged as a major health problem, the mechanisms that are decisive in the development of sensitization to dietary Ag remain largely unknown. CTLA-4 signaling negatively regulates immune activation, and may play a crucial role in preventing induction and/or progression of sensitization to food Ag. To elucidate the role of CTLA-4 signaling in responses to food allergens, a murine model of peanut allergy was used. During oral exposure to peanut protein extract (PPE) together with the mucosal adjuvant cholera toxin (CT), which induces peanut allergy, CTLA-4 ligation was prevented using a CTLA-4 mAb. Additionally, the effect of …

A Model For Predicting The Evolution Of Damage In Viscoelastic Particle-Reinforced Composites, G. D. Seidel, D. H. Allen, K. L. E. Helms, S. E. Groves

Department of Engineering Mechanics: Faculty Publications

A viscoelastic cohesive zone model is employed within the framework of a finite element code to analyze a two-phase viscoelastic particle-reinforced composite material consisting of a relatively stiff aggregate embedded in a copolymer binder. The composite of interest, LX17, is noted to have a very large aggregate volume fraction and as such, aggregate grain boundaries were generated within finite element meshes along which viscoelastic cohesive zones have been embedded to model the binder. It has been observed experimentally that the majority of damage in LX17 occurs within the binder, and thus, a damage evolution law has been applied to the …

Variability In Vegetation Effects On Density And Nesting Success Of Grassland Birds, Maiken Winter, Douglas H. Johnson, Jill A. Shaffer

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

The structure of vegetation in grassland systems, unlike that in forest systems, varies dramatically among years on the same sites, and among regions with similar vegetation. The role of this variation in vegetation structure on bird density and nesting success of grassland birds is poorly understood, primarily because few studies have included sufficiently large temporal and spatial scales to capture the variation in vegetation structure, bird density, or nesting success. To date, no large-scale study on grassland birds has been conducted to investigate whether grassland bird density and nesting success respond similarly to changes in vegetation structure. However, reliable management …

Decline And Recovery Of A High Arctic Wolf-Prey System, L. David Mech

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

A long-existing system of wolves (Canis lupus), muskoxen (Ovibos moschatus), and arctic hares (Lepus arcticus) in a 2600 km² area of Canada’s High Arctic (80° N latitude) began collapsing in 1997 because of unusual adverse summer weather but recovered to a level at which all three species were reproducing by 2004. Recovery of wolf presence and reproduction appeared to be more dependent on muskox increase than on hare increase.

Un vieux système biologique composé de loups (Canis lupus), de boeufs musqués (Ovibos moschatus) et de lièvres arctiques (Lepus …

Bears Remain Top Summer Predators, Shannon M. Barber, L. David Mech, P. J. White

United States Geological Survey, Northern Prairie Wildlife Research Center: Publications

In the ten years since wolves (Canis lupus) were restored to Yellowstone National Park (YNP), elk (Cervus elaphus) numbers have substantially decreased. The northern range elk herd is the largest elk herd in Yellowstone, and constitutes the majority of the park’s elk population. During 1994–2005, early winter counts of northern Yellowstone elk decreased from 19,045 to 9,545. Also, during winters 2000–2004, calf:cow ratios declined from 29:100 to 12:100, and were among the lowest recorded during the past several decades. Though many factors (e.g., predation, hunting, and drought) likely contributed to this decreasing abundance and low recruitment, …

Seasonal Migration And Home Ranges Of Female Elk In The Black Hills Of South Dakota And Wyoming, Lakhdar Benkobi, Mark A. Rumble, Cynthia H. Stubblefield, R. Scott Gamo, Joshua J. Millspaugh

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Understanding the movement and dispersion patterns of elk (Cervus elaphus) on public lands and the underlying factors that affect each will facilitate elk management and help resolve conflicts between management that benefit elk and other uses of land resources. Consequently, there is a need to identify and examine the movement and dispersion patterns of elk in the Black Hills of South Dakota and Wyoming. Our study quantified seasonal movements, determined home ranges of female elk in two areas of the Black Hills, and examined underlying factors associated with each. Elk in the northern area did not demonstrate seasonal …

Science Priorities For Reducing The Threat Of Invasive Species To Sustainable Forestry, Elizabeth A. Chornesky, Ann M. Bartuska, Gregory H. Aplet, Kerry O. Britton, Jane Cummings-Carlson, Frank W. Davis, Jessica Eskow, Doria R. Gordon, Kurt W. Gottschalk, Robert A. Haack, Andrew J. Hansen, Richard N. Mack, Frank J. Rahel, Margaret A. Shannon, Lisa A. Wainger, T. Bently Wigley

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Invasive species pose a major, yet poorly addressed, threat to sustainable forestry. Here we set forth an interdisciplinary science strategy of research, development, and applications to reduce this threat. To spur action by public and private entities that too often are slow, reluctant, or unable to act, we recommend (a) better integrating invasive species into sustainable forestry frameworks such as the Montréal Process and forest certification programs; (b) developing improved cost estimates to inform choices about international trade and pest suppression efforts; and (c) building distributed information systems that deliver information on risks, identification, and response strategies. To enhance the …

A Retrospective Analysis Of Known And Potential Risks Associated With Exotic Toadflax-Feeding Insects, Sharlene E. Sing, Robert K.D. Peterson, David K. Weaver, Richard W. Hansen, George P. Markin

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

To date, eight exotic toadflax-feeding insect species have been accidentally or intentionally introduced to North America. Reports on their establishment and impact have been recorded for more than 60 years. Environmental risks linked to biological control of toadflax were identified in terms of host resources and undesirable impacts on the target species through the critical review of this record. Data gaps revealed during this retrospective analysis are addressed through suggestions for future research and associated experimental methodologies. Known and potential impacts of toadflax-feeding insects on both invasive toadflax and non-target species are examined. Recent programmatic demands for demonstrated agent efficacy …

Environmental Quality Incentives Program Contributions To Fish And Wildlife Conservation, Mark W. Berkland, Charles A. Rewa

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The Environmental Quality Incentives Program (EQIP) is a voluntary program whereby the U.S. Department of Agriculture provides technical and financial assistance to active farmers and ranchers to address natural resource concerns such as soil conservation, water quality and quantity, nutrient management, and fish and wildlife habitat. The Natural Resources Conservation Service (NRCS) is working with these landowners to maximize the environmental benefits gained for the expenditures made in the program. Funding has expanded significantly under the 2002 Farm Bill, with the amount of annual funding authorized reaching $1.3 billion by fiscal year 2007. The EQIP has been used to implement …

Fish And Wildlife Benefits Of The Wildlife Habitat Incentives Program, Randall L. Gray, Sally J. Benjamin, Charles A. Rewa

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

Th e Wildlife Habitat Incentives Program (WHIP) is a voluntary program that encourages the establishment and enhancement of a wide variety of fish and wildlife habitats of national, state, tribal, or local significance. Through voluntary agreements, the Natural Resources Conservation Service (NRCS) provides financial and technical assistance to participants who installed habitat restoration and management practices. Since 1998, nearly $150 million has been dedicated to the program and over 2.8 million acres involving over 18,000 contracts have been enrolled. A wide range of habitat-enhancement actions are cost-shared through the program, affecting hundreds of target and non-target species. While few quantitative …

Biology And Biological Control Of Knapweed, Linda M. Wilson, Carol Bell Randall

United States Department of Agriculture, Forest Service / University of Nebraska-Lincoln: Faculty Publications

The knapweeds comprise a diverse complex of species that predominantly infest rangelands in the western United States and Canada. This manual considers the biological control of six species of knapweeds: 1) spotted knapweed, 2) diffuse knapweed, 3) squarrose knapweed, 4) meadow knapweed, 5) black knapweed, and 6) brown knapweed. Spotted knapweed, Centaurea stoebe, is perhaps the most widespread species, followed in abundance by diffuse knapweed, C. diffusa. A third species, squarrose knapweed, C. virgata var. squarrosa, has a more limited distribution in the West. Three less widespread species, meadow (C. pratensis), brown (C. jacea …

Antigenicity And Immunogenicity Of A Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein, Feng Gao, Eric A. Weaver, Zhongjing Lu, Yingying Li, Hua-Xin Liao, Benjiang Ma, S. Munir Alam, Richard M. Scearce, Laura L. Sutherland, Jae-Sung Yu, Julie M. Decker, George M. Shaw, David C. Montefiori, Bette T. Korber, Beatrice H. Hahn, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between candidate immunogens and field virus strains, we have designed and synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary HIV-1 subtypes and recombinants. This novel envelope gene expresses a glycoprotein that binds soluble CD4, utilizes CCR5 but not CXCR4 as a coreceptor, and mediates HIV-1 entry. Key linear, conformational, and glycan-dependent monoclonal antibody epitopes are preserved in CON6, and the glycoprotein is recognized equally well by sera from individuals infected with different HIV-1 …

Antigenicity And Immunogenicity Of A Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein, Feng Gao, Eric A. Weaver, Zhongjing Lu, Yingying Li, Hua-Xin Liao, Benjiang Ma, S. Munir Alam, Richard M. Scearce, Laura L. Sutherland, Jae-Sung Yu, Julie M. Decker, George M. Shaw, David C. Montefiori, Bette T. Korber, Beatrice H. Hahn, Barton F. Haynes

Nebraska Center for Virology: Faculty Publications

Genetic variation of human immunodeficiency virus (HIV-1) represents a major obstacle for AIDS vaccine development. To decrease the genetic distances between candidate immunogens and field virus strains, we have designed and synthesized an artificial group M consensus env gene (CON6 gene) to be equidistant from contemporary HIV-1 subtypes and recombinants. This novel envelope gene expresses a glycoprotein that binds soluble CD4, utilizes CCR5 but not CXCR4 as a coreceptor, and mediates HIV-1 entry. Key linear, conformational, and glycan-dependent monoclonal antibody epitopes are preserved in CON6, and the glycoprotein is recognized equally well by sera from individuals infected with different HIV-1 …

Maternal Yolk Steroids: A Potential Compensatory Mechanism For Red-Winged Blackbirds (Agelaius Phoeniceus) In North Dakota, Rachel M. Bush, Mark E. Clark, Wendy L. Reed, George M. Linz

United States Department of Agriculture Wildlife Services: Staff Publications

Many of the suggested management techniques directed at reducing blackbird breeding populations fail to incorporate the underlying mechanisms regulating populations. Theoretically, removal of individuals from the breeding population should lower the breeding densities and presumably reduce recruitment. However, compensatory responses might occur with decreased breeding densities, but no empirical data are available to test this hypothesis. Much of the underlying compensatory theory is based on differential allocation of resources to reproduction vs. self maintenance at different breeding densities, mainly in the form of depensatory effects of resource limitation on growth and survival. However, as the breeding density in an area …

Wildlife Disease Research At The Aphis National Wildlife Research Center, R. G. Mclean, L. Clark, M. R. Dunbar, K. C. Vercauteren, T. A. Campbell

United States Department of Agriculture Wildlife Services: Staff Publications

Research on wildlife diseases at the newly formed Wildlife Disease Program (WDP) at the United States Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS), Wildlife Services (WS), National Wildlife Research Center (NWRC) concentrates on wildlife diseases of importance to domestic animal and human health. We are conducting studies on wildlife rabies, bovine tuberculosis (TB), chronic wasting disease (CWD), West Nile virus (WNV), pathogenic bacteria of birds, and pseudorabies (PR). The goal of the research is to develop innovative methods for surveillance, intervention, prevention, and control of these diseases.