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2004

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Modeling The Effects Of Rainfall Intensity And Deep Chiseling On Infiltration And Runoff Within Drainmod For Alluvial Soils, Daniel Nyabiba Moriasi Jan 2004

Modeling The Effects Of Rainfall Intensity And Deep Chiseling On Infiltration And Runoff Within Drainmod For Alluvial Soils, Daniel Nyabiba Moriasi

LSU Doctoral Dissertations

Accurate hydrologic models are needed to aid engineers and researchers design, install and evaluate efficient and cost-effective agricultural water management systems to reduce risks associated with food production, and to reduce soil erosion and water pollution. One model used for the alluvial soils of Louisiana is DRAINMOD. This model does not accurately predict infiltration and runoff for the crusting-prone alluvial soils of Louisiana. The main goal of this study was to modify the current DRAINMOD model to incorporate the effects of rainfall intensity and deep chiseling to improve its estimation of infiltration and surface runoff. The second goal was to …

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Against Biopoetics: On The Use And Misuse Of The Concept Of Evolution In Contemporary Literary Theory, Bradley Bankston Jan 2004

Against Biopoetics: On The Use And Misuse Of The Concept Of Evolution In Contemporary Literary Theory, Bradley Bankston

LSU Doctoral Dissertations

This dissertation is a critical assessment of "biopoetics:" a new literary theory that attempts to import ideas from evolutionary science to the study of literature. Borrowing from the field of evolutionary psychology, the biopoeticists argue that some literary forms and themes are particularly valuable because they result from our innate and evolved cognitive structure; they also attempt to create a normative aesthetic from the idea that evolution is progressive. In its first half, this study examines the claims of evolutionary psychology and their application by the biopoeticists; in the second half, it examines the idea that evolution is progressive, and …

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Students' Construction Of The Body In Physical Education, Laura Azzarito Jan 2004

Students' Construction Of The Body In Physical Education, Laura Azzarito

LSU Doctoral Dissertations

Recently, physical education researchers have been concerned about the results of national studies reporting young people's low level of participation in physical activity and health problems associated with inactivity. In general girls are less active than boys, and youth from low socioeconomic classes are less active and are more likely be unhealthy than middle or upper class youth. Blacks have the highest risks of health problems and the highest levels of physical inactivity. Among a number of recommendations included in Healthy People 2010, physical education has been identified as a fundamental site for addressing today's challenges. According to physical education …

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Hemodynamic Responses Following Dynamic Resistance Exercise In Young And Older Adult Women, Rafael Antonio Reyes Jan 2004

Hemodynamic Responses Following Dynamic Resistance Exercise In Young And Older Adult Women, Rafael Antonio Reyes

LSU Doctoral Dissertations

This investigation examined the effects of age, exercise and test condition on hemodynamic variables, autonomic and vascular function in relation to resistance exercise (RE). The associations among these variables were also examined. METHODS: Sixteen young (21.4+1.4 yrs) and 16 older (69.7+3.9 yrs) women performed 5- and 15- repetition maximal (RM) of knee extension RE. Continuous blood pressure (BP) and electrocardiography (ECG) data were recorded. The dependent variables are reported at pre-exercise, peak exercise and recovery period. Heart rate variability data were derived from 5- and 10-min segments before and after exercise. Resting and after arterial occlusion forearm vascular function indices …

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Mothering Modes: Analyzing Mother Roles In Novels By Twentieth-Century United States Women Writers, Preselfannie Whitfield Mcdaniels Jan 2004

Mothering Modes: Analyzing Mother Roles In Novels By Twentieth-Century United States Women Writers, Preselfannie Whitfield Mcdaniels

LSU Doctoral Dissertations

For this dissertation, the following novels have been chosen as examples of the many issues that are involved in mothering in United States society: Chapter 1: Dorothy Allison’s Bastard Out of Carolina and Toni Morrison’s Beloved, Chapter 2: Toni Morrison’s Song of Solomon and Dorothy West’s The Wedding, Chapter 3: Amy Tan’s The Kitchen God’s Wife and Christina García’s Dreaming in Cuban, and Chapter 4: Betty Smith’s A Tree Grows in Brooklyn and Paule Marshall’s Brown Girl, Brownstones. For this study, the term “mothering” is specifically related to the rearing of children by the female parent. Rearing is defined as …

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Protein Aggregation Studies: Inhibiting And Encouraging Β-Amyloid Aggregation, Jed Paul Aucoin Jan 2004

Protein Aggregation Studies: Inhibiting And Encouraging Β-Amyloid Aggregation, Jed Paul Aucoin

LSU Doctoral Dissertations

This work demonstrates peptide-based aggregation mediation of fibril forming peptides, notably β-amyloid (1-40), Aβ1-40. To achieve the goals of this work, Aβ1-40 aggregation was governed by ionic strength, temperature, and pH. After controlling and reproducing Aβ1-40 aggregate formation (fibrils), each peptide-based aggregation mediator was evaluated for its ability to self-aggregate and to possess surface-active properties. The incorporation of these mediators in Aβ1-40 solutions changed the surface tension and produced aggregate complexes of mediator and Aβ1-40. Evidence that Aβ1-40 fibril formation may be mediated by disorder-to-order transitions has been observed by layer formation …

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Chemical Production Complex Optimization, Pollution Reduction And Sustainable Development, Aimin Xu Jan 2004

Chemical Production Complex Optimization, Pollution Reduction And Sustainable Development, Aimin Xu

LSU Doctoral Dissertations

The objective of this research is to propose, develop and demonstrate chemical production complex optimization to determine the optimal configuration of chemical plants in a superstructure of possible plants. The Chemical Complex Analysis System is a new methodology that has been developed to determine the best configuration of plants in a chemical production complex based on the AIChE Total Cost Assessment (TCA) for economic, energy, environmental and sustainable costs. All new, energy-efficient, and environmentally acceptable plants using greenhouse gases that can produce potentially commercial products designed with HYSYS were integrated into the chemical complex using the System. The optimum configuration …

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Integration Of Management Tactics For The Rice Water Weevil Lissorhoptrus Oryzophilus Kuschel With Particular Emphasis On Use Of Plant Resistance (Tolerance), Li Zou Jan 2004

Integration Of Management Tactics For The Rice Water Weevil Lissorhoptrus Oryzophilus Kuschel With Particular Emphasis On Use Of Plant Resistance (Tolerance), Li Zou

LSU Doctoral Dissertations

Studies were conducted to test the hypothesis, significant benefits can be achieved for the management of rice water weevil, Lissorhoptrus oryzophilus Kuschel, by the use of rice varieties with low levels of host plant resistance coupled with the judicious use of cultural practices and insecticides. Tolerant traits of a current commercial variety of rice, "Bengal", was manifested consistently over multiple years. Study on rice growth as effected by weevil injury showed that pruning of root systems by larvae of weevil resulted in a decrease in tiller number and shoot biomass of rice plants in the vegetative stage of growth. Yield …

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Development Of Outdoor Educational Landscapes In Forested Wetlands Of Louisiana's Atchafalaya Basin, Margaret Ann Mcclain Jan 2004

Development Of Outdoor Educational Landscapes In Forested Wetlands Of Louisiana's Atchafalaya Basin, Margaret Ann Mcclain

LSU Master's Theses

Natural landscapes, formed by eons of plant succession, are changing or disappearing as a result of rapid urban development and industrial growth. In addition, the human population explosion pressures are being applied to alter the urban/wildland interface in the United States and throughout the world. Many of Louisiana wetlands are subjected to these pressures and have caused change and loss in forested wetland areas. Most of the Mississippi River Delta consists of wetlands in a state of transition to either open water or degraded hardwood forest due to the effects of several key factors. Being a native of south Louisiana, …

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A Study Of The Anti-Inflammatory, Anti-Microbial And Immunomodulatory Properties Of Thalidomide In Leprosy, Azeb Tadesse Argaw Jan 2004

A Study Of The Anti-Inflammatory, Anti-Microbial And Immunomodulatory Properties Of Thalidomide In Leprosy, Azeb Tadesse Argaw

LSU Doctoral Dissertations

During the course of their disease, leprosy patients may experience two types of inflammatory reactions- erythema nodosum leprosum (ENL) or reversal reaction (RR). Thalidomide is effective treatment for ENL, but not for RR. Using concentrations of thalidomide similar to that achieved in the treatment of ENL, we investigated thalidomide’s effect on reactions, viability of M. leprae, and integrity of plasma membranes. Cells from patients with and without RR were stimulated with M. leprae (AFB), a cytosol fraction of M. leprae (MLSA) or DHAR (DHAR) antigen, and the effect of thalidomide on lymphocyte proliferation, expression of TNF-a mRNA and synthesis of …

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Deterrence Factors For Copyright Infringement Online, Nico Nergadze Jan 2004

Deterrence Factors For Copyright Infringement Online, Nico Nergadze

LSU Master's Theses

The purpose of this study was to investigate deterrence factors for online file-sharing by analyzing different conditions that affect compliance with the law through survey of the students in a large university in Southern U.S. The findings show that certainty of punishment, stigma of the label, knowledge of the laws and consensus with the rule negatively correlated with both actual and likely future file-sharing activities of the users

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The Performance Of The Baldcypress Leafroller (Archips Goyerana Kruse, Lepidoptera: Torticidae) In Response To Fertilization, Thinning, And Genetic Variation In Host Baldcypress (Taxodium Distichum L. Richard), Crawford Wood Johnson Jan 2004

The Performance Of The Baldcypress Leafroller (Archips Goyerana Kruse, Lepidoptera: Torticidae) In Response To Fertilization, Thinning, And Genetic Variation In Host Baldcypress (Taxodium Distichum L. Richard), Crawford Wood Johnson

LSU Master's Theses

Mississippi River diversions into coastal Louisiana wetlands aim to provide nutrient inputs and slow the impacts resulting from saltwater intrusion. Baldcypress (Taxodium distichum L. Richard) exhibits significant intraspecific tolerance to salinity and is being developed for restoration projects. Two studies were conducted using five half-sibling families of baldcypress planted at two locations in southeast Louisiana to investigate the effects of nutrient additions, thinning, and phenology on the growth of the baldcypress leafroller (Archips goyerana Kruse, BCLR). In the Jeanfreau study, families were subjected to a control, low, and high level of fertilization simulating two-four years’ effects, respectively, from a Mississippi …

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Behavioral And Electrophysiological Assessment Of Children With A Specific Temporal Processing Disorder, Annette Hurley Jan 2004

Behavioral And Electrophysiological Assessment Of Children With A Specific Temporal Processing Disorder, Annette Hurley

LSU Doctoral Dissertations

Auditory processing disorders (APDs) have received considerable attention over the past few decades. Much of the attention has focused on the controversy surrounding the operational definition of APD, the heterogeneous nature of APD, and an appropriate test battery for APD assessment. Temporal processing deficits are one characteristic of APD and are the focus of the present investigation. This investigation reports behavioral and early electrophysiological measures in a group of children with specific temporal processing difficulties and an age-matched control group. In an effort to better describe the subjects, two language tests and the SCAN-C were administered. Significant differences were found …

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Estimation Of The Effect Of Misclassifications On Diagnostic Test Performance In Two Persistent Bovine Viral Infections, Kimberly Orr Jan 2004

Estimation Of The Effect Of Misclassifications On Diagnostic Test Performance In Two Persistent Bovine Viral Infections, Kimberly Orr

LSU Doctoral Dissertations

Validation of diagnostic assay performance is hampered where no gold standard exists. Bayesian estimates of the sensitivity and specificity were applied to studies of two persistent bovine infections: bovine immunodeficiency virus (BIV), and bovine viral diarrhea virus (BVDV). BVDV pathogenesis is well described. Losses of $20 million in 1992 alone led the Danish government to mandate eradication. Two enzyme-linked immunosorbent assay (ELISA) tests were developed; one antibody-based to detect exposure, one antigen-based to detect persistent infection. Bayesian estimates of the sensitivity and specificity were 96.6% and 99.2%, and 98.2% and 99.8% for the antibody and antigen ELISA, respectively. Maximum Likelihood …

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The Significance Of Selected Piano Compositions By Pancho Vladigerov, Boriana Kojouharova Buckles Jan 2004

The Significance Of Selected Piano Compositions By Pancho Vladigerov, Boriana Kojouharova Buckles

LSU Doctoral Dissertations

This study examines selected compositions for piano by Pancho Vladigerov - the Three Pieces for Piano, Opus 15, Bulgarian Rhapsody, Opus 16, Shumen Miniatures, Opus 29, and Improvisation and Toccata, from Episodes, Opus 36. These pieces strongly represent the various periods and stylistic trends of the composer. They are also among Vladigerov's most popular and frequently performed piano compositions. The first chapter provides a brief biography of Pancho Vladigerov and an overview of his most important compositions. Chapter Two contains an overview of the solo piano works of Vladigerov. Chapter Three examines the selected piano compositions from a formal and …

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The Mitigation Of Asymmetric Information Through The Use Of Earnouts, David Robert Beard Jan 2004

The Mitigation Of Asymmetric Information Through The Use Of Earnouts, David Robert Beard

LSU Doctoral Dissertations

We examine the use of a contracting method in mergers and acquisitions known as an earnout. In this type of transaction, the bidder agrees to pay the target an initial amount for the acquisition plus future payments contingent on the achievement of performance milestones. Theory suggests that the contingent payment associated with earnouts should reduce adverse selection problems facing both parties in the merger. The purpose of this dissertation is to study the ability of earnouts to mitigate problems associated with asymmetric information and problem of agency. Specifically, we answer the following questions in analyzing these transactions. First, empirical evidence …

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Influence Of Venous Emptying On Reactive Hyperemic Blood Flow, Zeki Bahadir Jan 2004

Influence Of Venous Emptying On Reactive Hyperemic Blood Flow, Zeki Bahadir

LSU Master's Theses

Recent work by Tschakovsky & Hughson (Am J Physiol Heart Circ Physiol 279: H1007, 2000) indicates that venous emptying serves as a stimulus for vasodilation. This suggests the importance of recognizing the potential influence of venous volume on reactive hyperemic blood flow (RHBF) following occlusion. Purpose: To examine the influence of venous emptying on RHBF. Methods: Non-dominant forearm in-flow, venous capacitance and outflow were examined in 21 individuals [age=23±2.27y]. Forearm arterial inflow, venous capacitance, and outflow were obtained two times using strain gauge plethysmography. Forearm blood inflow was estimated at rest and following 5 min of upper arm occlusion. Forearm …

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Routes Of Freedom: Slave Resistance And The Politics Of Literary Geography, Judith Louise Kemerait Jan 2004

Routes Of Freedom: Slave Resistance And The Politics Of Literary Geography, Judith Louise Kemerait

LSU Doctoral Dissertations

This dissertation integrates rhetorical, historical, and spatial analysis in an effort to expand our understanding of the cultural work performed by antebellum narratives that take slavery in the United States as their subject matter. Specifically, it focuses on the complicated relationship between place and human praxis as revealed in five texts: The Confessions of Nat Turner, Harriet Beecher Stowe’s Dred, Martin R. Delany’s Blake, Frederick Douglass’s “The Heroic Slave,” and Herman Melville’s Benito Cereno. In my attention to literary geographies, I trace spatial patterns in which considerations of organized resistance and slave rebellion are repeatedly placed in “wild-spaces” such as …

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Synthesis, Characterization And Study Of Novel Reagents For The Detection Of Saccharides And Amino Acids, Nadia Nadette St. Luce Jan 2004

Synthesis, Characterization And Study Of Novel Reagents For The Detection Of Saccharides And Amino Acids, Nadia Nadette St. Luce

LSU Doctoral Dissertations

The design of synthetic receptors for the recognition and sensing of saccharides and amino acids is currently a major challenge. This is due to inherent structural similarity and a lack of chromophoric or fluorophoric properties of these compounds. The synthesis and study of novel detection agents for bioactive molecules as well as mechanistic studies are presented herein. The elucidation of the mechanism by which tetraarylboronic acid resorcinarene interact with sugar molecules and promote a solution color change is explored. This vast collaborative study, reveals that DMSO solutions of boronic acid functionalized resorcinarene macrocycles afford visual color changes upon heating or …

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Analysis Of Bacterial Diversity And Biogeography At The Central Arizona-Phoenix Long Term Ecological Research (Cap Lter) Site, Brian Anthony Rash Jan 2004

Analysis Of Bacterial Diversity And Biogeography At The Central Arizona-Phoenix Long Term Ecological Research (Cap Lter) Site, Brian Anthony Rash

LSU Doctoral Dissertations

The limiting factor involved in past assessments of soil bacterial diversity when using culture-independent techniques has often been the lack of sampling and replication. As a result, analyses of community structural shifts across soil environments have lacked statistical power. In this study, 23 16S rRNA gene clone libraries consisting of over 11,000 clones were constructed from soils at the Central Arizona Phoenix Long Term Ecological Research (CAP LTER) site. Subsequent ARDRA fingerprinting and partial 16S rRNA gene sequencing allowed for a more robust investigation of various components that may explain any observed variations in bacterial species composition. The designated land …

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Attachment Of Oligonucleotide Probes To Polymer Biochips And Its Application For The Detection Of Point Mutations, Yun Wang Jan 2004

Attachment Of Oligonucleotide Probes To Polymer Biochips And Its Application For The Detection Of Point Mutations, Yun Wang

LSU Doctoral Dissertations

This dissertation is on the fabrication of polymer-based microfluidic arrays for the detection of genetic mutations. Poly(methyl methacrylate) was chosen as one of the polymer substrate materials due to its low background noise, low adsorption of biomolecules, and low assembly temperature. The surface modification of polymer substrates for covalent attachment of oligonucleotide probes, the construction of fluidic channels/arrays, and hybridization kinetics will be covered. As an example of the application, point mutation detection using immobilized arrays constructed in microfluidic devices will be demonstrated. The PMMA surface was derivatized with N-lithioethylenediamine solution to introduce amine groups, which were utilized for the …

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"Never Could Read No Road Map": Geographic Perspectives On The Grateful Dead, Daniel R. Culli Jan 2004

"Never Could Read No Road Map": Geographic Perspectives On The Grateful Dead, Daniel R. Culli

LSU Master's Theses

The Grateful Dead hold a unique niche in the musical, social, and cultural history of the United States. However, while the volume of available academic literature concerning the band is increasing, the Grateful Dead remain to be nearly ignored by academia and, to this point apparently, completely ignored by cultural geographers. This paper introduces the Grateful Dead into the field of geography. I analyze the geography of certain aspects of the band, such as its context in San Francisco, the carnival atmosphere of the entire phenomenon, the over 2300 tour dates, as well as the huge catalog of lyrics sung …

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The Relation Between Knowledge Of Adhd And Treatment Acceptability In A Multi-Disciplinary Pediatric Clinic, Rebecca Owen Currier Jan 2004

The Relation Between Knowledge Of Adhd And Treatment Acceptability In A Multi-Disciplinary Pediatric Clinic, Rebecca Owen Currier

LSU Doctoral Dissertations

Behavior modification and medication have been proven to be the most effective interventions for children with ADHD. For these treatments to be effective, utilization of mental health care services as well as compliance with treatment recommendations is necessary. There has been shown lower care utilization among minorities for the treatment of behavioral disorders. In addition, lack of adherence among these populations to ADHD treatment is not explained by SES, parenting stress, or family coping. An alternative explanation may be parental knowledge of ADHD and opinions of commonly used treatments. The present investigation examined the effect of a brief knowledge intervention …

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A New Broad Spectrum Disinfectant Suitable For The Food Industry, Giovanna Aita Dequeiroz Jan 2004

A New Broad Spectrum Disinfectant Suitable For The Food Industry, Giovanna Aita Dequeiroz

LSU Doctoral Dissertations

A unique biocide composition (patent pending) that is formed from a hydrogen peroxide and sodium hypochlorite mixture was investigated. A biocidal "complex" is formed by adding the peroxide to the hypochlorite in an amount so that the weight ratio of the peroxide to the hypochlorite is no less than 1:10. The chemical structure of this biocidal "complex" is uncertain but we postulate that it is a semi-stable complex, whose stability is disrupted by heat, acid, U/V exposure and the presence of organic matter (i.e., microbes) The antimicrobial activity of the biocidal "complex" is most likely a combination effect between oxidation …

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The Effects Of Auditory Distraction On Attention Performance In Asymptomatic College Students With A History Of Mild Head Injury, John H.,Ii Denning Jan 2004

The Effects Of Auditory Distraction On Attention Performance In Asymptomatic College Students With A History Of Mild Head Injury, John H.,Ii Denning

LSU Doctoral Dissertations

Introduction: The majority of individuals experiencing a mild head injury (MHI) recover fully experiencing few residual symptoms. Some individuals who fully recover have shown evidence of residual, albeit subtle, brain functioning disturbances on tasks requiring high levels of cognitive effort. Also, memory complaints in MHI patients may be related to these subtle difficulties when cognitive resources are overwhelmed. This study assessed a group of asymptomatic college students with a history of MHI to determine if there were any residual attention difficulties as well as increased memory complaints. Method: One-hundred twelve college students with and without a history of MHI were …

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Assessing The Identity Of Black Indians In Louisiana: A Quantitative And Qualitative Analysis, Francis J. Powell Jan 2004

Assessing The Identity Of Black Indians In Louisiana: A Quantitative And Qualitative Analysis, Francis J. Powell

LSU Doctoral Dissertations

This study shows the existence of Black Indians in Louisiana and investigates whether differences exist between Black Indians who are members of officially recognized tribes and those who do not have any type of recognition. The study examined if a relationship exist between tribal recognition and ethnic identity, subjective well-being, and social support. A cross-sectional survey design was used. Semi-structured interviews were conducted to obtain qualitative data. The sample consisted of 60 participants. 30 were from recognized tribal groups and 30 were from non-recognized tribal communities. The study specifically examined variables related to the perceptions of Black Indians in Louisiana …

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Modulation Of Gabaergic Signaling In Retinal Amacrine Cells, Brian Kevin Hoffpauir Jan 2004

Modulation Of Gabaergic Signaling In Retinal Amacrine Cells, Brian Kevin Hoffpauir

LSU Doctoral Dissertations

The intricate circuitry formed by amacrine cells in the inner plexiform layer (IPL) of the retina suggests that these interneurons play a major role in shaping the visual message. The majority of amacrine cells in the vertebrate retina are GABAergic. Thus, elucidating how GABAergic signaling is modulated in the IPL is critical in order to understand how the visual message is processed in the retina. The results presented here suggest that GABAergic signaling between amacrine cells can be modulated by the activation of metabotropic glutamate receptor 5 (mGluR5) or by the production of the second messenger, nitric oxide (NO). A …

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Nature Is To Nurture: A Post Occupancy Evaluation Of The St. Michael Health Care Center, Texarkana, Tx, Leigh Lafargue Jan 2004

Nature Is To Nurture: A Post Occupancy Evaluation Of The St. Michael Health Care Center, Texarkana, Tx, Leigh Lafargue

LSU Master's Theses

This thesis explores therapeutic garden design and its role in landscape architecture. It also conducts a post occupancy evaluation (POE) for an existing therapeutic landscape. The St. Michael Health Care Center campus, Texarkana, Texas, is a Sisters of Charity institution and was designed and built in 1994 as a healing environment for patients, staff, and visitors. In this thesis, A POE was conducted to determine (1) user-perceptions and utilization of the campus, (2) whether the campus reduces stress and fosters restoration, and (3) any barriers or constraints to use of the campus. Results from visual analysis, behavioral observations, and survey …

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Microelectrophoresis System Utilizing Conductivity Detection Analyzing Biological Molecues, Michelle Galloway Jan 2004

Microelectrophoresis System Utilizing Conductivity Detection Analyzing Biological Molecues, Michelle Galloway

LSU Doctoral Dissertations

Microfabrication technology has proven to be a valuable tool for creating polymer-based devices utilized in chemical and biochemical assays. Although, reducing the size of the device allows for short analysis times and reduces the reagent demand to ultrasmall volumes (< 1 nanoliter), a resulting consequence is the constraint placed on the limits of detection associated with the detector hardware required for readout. To overcome such constraints, laser-induced fluorescence (LIF) is often employed as a detection method as it provides low detection limits, which approach the single molecule level. Unfortunately, most LIF systems do not offer the benefits of miniaturization, with the detector components (i.e. laser, optics, filters) often times requiring a much larger footprint compared to the device. Another readout strategy that has shown promise for these devices is conductivity detection. Detection can be accomplished using either conventional-size or microfabricated electrodes, which can be integrated on the device. Although conductivity has been commonly used to detect inorganic or small organic species, the potential for detection of biological species has received little attention. In this work, an integrated conductivity detector was developed for the analysis of amino acids, peptides, proteins, and oligonucleotides (double-stranded DNA). Using the detector, mass detection sensitivities in the range of 10-18 - 10-21 moles were achieved. To increase the throughput of the system a state-of-the-art, multichannel device with a conductivity array detector was devised. This device, which consists of a 16-channel fluidic network and a printed circuit board, is geared toward automating three-processing steps onto a single fluidic platform including purification, preconcentration and detection for downstream parallel processing.

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Effects Of Gp130 Cytokines On Adipocytes, Sanjin Zvonic Jan 2004

Effects Of Gp130 Cytokines On Adipocytes, Sanjin Zvonic

LSU Doctoral Dissertations

Members of the gp130 cytokine family are known for their pleiotropic roles in various cell types. Our work has focused on their actions in adipocytes. CNTF administration has been shown to ameliorate most complications associated with obesity and type 2 diabetes through an unknown mechanism. In this study CNTF is shown to activate JAK/STAT and MAPK signaling, both in vitro and in vivo. In 3T3-L1 adipocytes, chronic CNTF also regulates the expression of SREBP-1, FAS, IRS-1 and GLUT4. Acute CNTF administration enhances the activation of IRS-1 and Akt by insulin. Our data also demonstrate that the expression of CNTF-specific receptor, …

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