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Demographic Characteristics Of Adoptees Presenting To The Yale International Adoption Clinic And The Utility Of Pre-Adoption Video Review, Jon L. Boone

Yale Medicine Thesis Digital Library

The major purpose of this study was to examine whether the assessment of pre-adoption video (pre-vid) by an experienced pediatrician accurately predicts the post-adoption developmental (post-dev) status of the adoptee on arrival and to examine any difference in the extent of developmental delay between those adoptees with and those without a pre-vid review. As a foundation for the study, an extensive database for all adoptees seen at the Yale International Adoption Clinic was created and their demographic characteristics were analyzed. The developmental status of 20 children from Russian and Eastern European orphanages was assessed by an experienced pediatrician using a …

Mustang Daily, January 9, 2003

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Schedule Of Classes, Spring 2003, University Of Alabama In Huntsville

Course Schedules

No abstract provided.

Cvm Annual Report 2003, College Of Veterinary Medicine, University Of The Philippines Los Baños

CVM Reports

No abstract provided.

Healthnet News V.18:No.4 Winter 2003, Judith S. Kronick, Alberta Richetelle

Articles - Patient Care

A newsletter for public librarians and others interested in consumer health information services.

Fact Book 2003-2004

Fact Books

No abstract provided.

Discussed In Federico Stella, Criminal Omissions, Causality, Probability, Counterfactuals: Medical-Surgical Activity, Richard W. Wright

All Faculty Scholarship

No abstract provided.

Greenhouse Gas Emissions Inventory 1990-2003 Full Report, Unh Sustainability Institute

The Sustainability Institute Publications

No abstract provided.

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

2003 Women Making History Booklet, Women's Center

Women Making History

No abstract provided.

Cloning Of A Salivary Gland Metalloprotease And Characterization Of Gelatinase And Fibrin(Ogen)Lytic Activities In The Saliva Of The Lyme Disease Tick Vector Ixodes Scapularis, Ivo M.B. Francischetti, Thomas N. Mather, José M.C. Ribeiro

Past Departments Faculty Publications (CELS)

The full-length sequence of tick salivary gland cDNA coding for a protein similar to metalloproteases (MP) of the reprolysin family is reported. The Ixodes scapularis MP is a 488 amino acid (aa) protein containing pre- and pro-enzyme domains, the zinc-binding motif HExxHxxGxxH common to metalloproteases, and a cysteine-rich region. In addition, the predicted amino-terminal sequences of I. scapularis MPs were found by Edman degradation of PVDF-transferred SDS/PAGE-separated tick saliva proteins, indicating that these putative enzymes are secreted. Furthermore, saliva has a metal-dependent proteolytic activity towards gelatin, fibrin(ogen), and fibronectin, but not collagen or laminin. Accordingly, I. scapularis saliva has a …

Adefovir Dipivoxil For The Treatment Of Hepatitis B E Antigen–Positive Chronic Hepatitis B, Patrick Marcellin , M.D., Ting-Tsung Chang , M.D., Seng Gee Lim , M.D., Myron J. Tong , Ph.D., M.D., William Seivert , M.D., Mitchell L. Shiffman , M.D., Lennox Jeffers , M.D., Zachary Goodman , M.D., Ph.D., Michael S. Wulfsohn , M.D., Ph.D., Shelly Xiong , Ph.D., John Fry , B.Sc., Carol L. Brosgart , M.D.

Internal Medicine Publications

BACKGROUND

In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains.

METHODS

We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to receive 10 mg of adefovir dipivoxil (172 patients), 30 mg of adefovir dipivoxil (173), or placebo (170) daily for 48 weeks. The primary end point was histologic improvement in the 10-mg group as compared with the placebo group.

RESULTS

After 48 weeks of treatment, significantly more patients who received 10 mg or 30 mg of adefovir dipivoxil per day than …

Macrophages Control The Retention And Trafficking Of B Lymphocytes In The Splenic Marginal Zone, Mikael Karlsson, Rodolphe Renè Guinamard, Silvia M. Bolland

Publications

The marginal zone of the spleen is a precisely ordered region that contains specialized subsets of B lymphocytes and macrophages. Disruption of the negative signaling inositol phosphatase, SH2-containing inositol-5-phosphatase 1 (SHIP), results in the loss of marginal zone B cells (MZBs) with reorganization of marginal zone macrophages (MZMOs) to the red pulp of the spleen. This primary macrophage defect, as revealed by selectively depleting SHIP in myeloid cells shows that MZMOs are specifically required for the retention of MZBs. The MZMO phenotype was reverted in SHIP/Bruton's tyrosine kinase (Btk) double knockout mice, thus identifying the Btk activating pathway as an …

Activation Of Natural Killer T Cells By Α-Galactosylceramide Rapidly Induces The Full Maturation Of Dendritic Cells In Vivo And Thereby Acts As An Adjuvant For Combined Cd4 And Cd8 T Cell Immunity To A Coadministered Protein, Shinichiro Fujii, Kanako Shimizu, Carol L. Smith

Publications

The maturation of dendritic cells (DCs) allows these antigen-presenting cells to initiate immunity. We pursued this concept in situ by studying the adjuvant action α-galactosylceramide (αGalCer) in mice. A single i.v. injection of glycolipid induced the full maturation of splenic DCs, beginning within 4 h. Maturation was manifest by marked increases in costimulator and major histocompatibility complex class II expression, interferon (IFN)-γ production, and stimulation of the mixed leukocyte reaction. These changes were not induced directly by αGalCer but required natural killer T (NKT) cells acting independently of the MyD88 adaptor protein. To establish that DC maturation was responsible for …

Tolerogenic Dendritic Cells, Ralph M. Steinman, Daniel Hawiger, Michel C. Nussenzweig

Publications

Dendritic cells (DCs) have several functions in innate and adaptive immunity. In addition, there is increasing evidence that DCs in situ induce antigen-specific unresponsiveness or tolerance in central lymphoid organs and in the periphery. In the thymus DCs generate tolerance by deleting self-reactive T cells. In peripheral lymphoid organs DCs also induce tolerance to antigens captured by receptors that mediate efficient uptake of proteins and dying cells. Uptake by these receptors leads to the constitutive presentation of antigens on major histocompatibility complex (MHC) class I and II products. In the steady state the targeting of DC antigen capture receptors with …

Dendritic Cells Initiate Immune Control Of Epstein-Barr Virus Transformation Of B Lymphocytes In Vitro, Kara L. Bickham, Kiera Goodman, Casper Paludan

Publications

The initiation of cell-mediated immunity to Epstein-Barr virus (EBV) has been analyzed with cells from EBV-seronegative blood donors in culture. The addition of dendritic cells (DCs) is essential to prime naive T cells that recognize EBV-latent antigens in enzyme-linked immunospot assays for interferon γ secretion and eradicate transformed B cells in regression assays. In contrast, DCs are not required to control the outgrowth of EBV-transformed B lymphocytes from seropositive donors. Enriched CD4⁺ and CD8 ⁺ T cells mediate regression of EBV-transformed cells in seronegative and seropositive donors, but the kinetics of T-dependent regression occurs with much greater speed with …

Association Of Knowledge, Attitudes, And Self-Efficacy With Sexual Risk Behaviors Among High School Students In Aguablanca District-Cali, Colombia, Zulma Hernandez

Theses, Dissertations and Capstones

The purpose of this study was to evaluate the level of knowledge, attitudes, and self-efficacy related to reproduction, contraception, STD/HIV and sexual risk behaviors among high school students. The study featured a cluster sampling involving eleventh grade students from two high schools in Aguablanca District - Cali, Colombia. A cohort of 313 students completed an anonymous questionnaire with a 20–item scale that measured level of knowledge in reproduction, contraception and STD/HIV; 5 item-scale that measured attitudes and self-efficacy related to practices of protective sexual behavior; and a 5-item scale that measured intentions toward their capabilities to perform specific actions that …

Design, Trading, And Innovation, David M. Driesen

College of Law - Faculty Scholarship

This article questions the conventional theory purporting to establish that environmental benefit trading encourages innovation better than comparable traditional regulation. It argues that the induced innovation hypothesis, that high costs encourage innovation, suggests that trading would lessen incentives for innovation by lowering the cost of complying with conventional approaches. The conventional theory relies upon the incentive emissions trading creates for polluters to make additional reductions in order to sell credits. But emissions trading also creates incentives for half of the pollution sources (the credit buyers) to make less reductions than they would under a traditional regulation. By focusing analysis only …

Not So Rare: Errors Of Metabolism During The Neonatal Period, Sandra Banta-Wright, Robert D. Steiner

Faculty Publications - College of Nursing

During the neonatal period, the diagnosis of an error of metabolism (EM) was once thought to portend a poor prognosis or lethality. Over the past two decades, the prognosis of many EMs has changed. The critical aspect of the metabolic evaluation in a sick newborn is to rapidly identify whether there may be a metabolic problem. If there is a metabolic problem, the goal is to minimize the sequelae of the specific disorder. This review will explore how to approach and evaluate a newborn suspected of having an EM. A discussion of clinical and laboratory findings that often accompany EM …

Alumni Briefs

JD Alumni Magazine

No abstract provided.

New Center Helps Safeguard Our Shores, Marlene England

JD Alumni Magazine

Headquartered at the School of Law, the University's new Center for Health and Homeland Security brings together and builds upon the six professional schools' counterterrorism and homeland security issues.

Use Of Ikonos And Landsat For Malaria Control In The Republic Of Korea, Penny M. Masuoka, David M. Claborn, Richard G. Andre, Joseph Nigro, Scott W. Gordon, Terry A. Klein, Hung-Chol Kim

United States Army: Publications

Malaria reemerged in the Republic of Korea (ROK) in 1993. While limited numbers of U.S. soldiers in high-risk areas use chloroquine/ primaquine chemoprophylaxis to prevent malaria, control of mosquito larvae through larviciding also can be used to reduce the risk of malaria transmission. In order to estimate the cost of larviciding, accurate estimates of the spatial extent of mosquito larval habitats are necessary. The purpose of this study was to determine whether an accurate estimate of the area covered by mosquito larval habitats can be obtained using Landsat 7 Enhanced Thematic Mapper+ (ETM+) and/or IKONOS data for the Korean test …

Generation Of An Hfrs Patient-Derived Neutralizing Recombinant Antibody To Hantaan Virus G1 Protein And Definition Of The Neutralizing Domain, Mifang Liang, Michael Mahler, Joachim Kock, Yan Ji, Dexin Li, Connie Schmaljohn, Ekkehard K.F. Bautz

United States Army: Publications

Hantaan virus (HTNV) in the Hantavirus genus, family Bunyaviridae, is the major cause of severe hemorrhagic fever with renal syndrome (HFRS). We prepared a combinatorial phage display library of human Fabs to HTNV from RNA extracted from the blood lymphocytes of a convalescent HFRS patient. We selected two G1 glycoproteinspecific clones and one nucleocapsid protein (N)-specific clone from the Fab library for further studies. The human Fab antibodies were converted to IgG form in baculovirus/insect cells system by using cassette vectors that we developed earlier. Characterization of the recombinant antibodies revealed that the two G1-specific IgGs, could bind to and …

Search, Sentence, And (Don't) Sell: Combating The Threat Of Biological Weapons Through Inspections, Criminalization, And Restrictions On Equipment, Timothy K. Gilman

Florida State University Journal of Transnational Law & Policy

No abstract provided.

College Of Osteopathic Medicine Student Handbook, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

College Of Osteopathic Medicine Program Overview, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Age-Dependent Impairment Of Igg Responses To Glycosylphosphatidylinositol With Equal Exposure To Plasmodium Falciparum Among Javanese Migrants To Papua, Indonesia, Sarah N. Hudson Keenihan, Sutanti Ratiwayanto, Saraswati Soebianto, Krisin, Harijani Marwoto, Gowdahalli Krishnegowda, D. Channe Gowda, Michael J. Bangs, David J. Frayauff, Thomas L. Richie, Sanjai Kumar, J. Kevin Baird

United States Navy: Publications

Immune responses directed at glycosylphosphatidylinositol (GPI) anchors of Plasmodium falciparum may offer protection against symptomatic malaria. To independently explore the effect of age on generation of the anti-GPI IgG response, we measured serum anti-GPI IgGs in a longitudinal cohort of migrant Javanese children (6–12 years old) and adults (≥ 20 years old) with equivalent numbers of exposures to P. falciparum in Papua, Indonesia. While the peak response in adults was achieved after a single infection, comparable responses in children required ≥ 3–4 infections. Significantly fewer children (16%) than adults (41%) showed a high (optical density > 0.44) anti-GPI IgG response (odds …

Very High Risk Of Therapeutic Failure With Chloroquine For Uncomplicated Plasmodium Falciparum And P. Vivax Malaria In Indonesian Papua, Iwa W. Sumawinata, Bernadeta, Budhi Leksana, Awalludin Sutamihardja, Purnomo, Budi Subianto, Sekartuti, David J. Fryauff, J. Kevin Baird

United States Navy: Publications

Chloroquine remains the first-line therapy for uncomplicated malaria in Indonesia. Among a series of trials of chloroquine for malaria on this archipelago conducted since 1990, we now report the highest risk of therapeutic failure yet observed. A clinical trial of standard chloroquine therapy for uncomplicated malaria at Arso PIR V in northeastern Indonesian Papua was conducted during 1995. We enrolled 104 non-immune subjects infected with Plasmodium falciparum (n=55), P. vivax (n=29), or P. falciparum plus P. vivax (n=20) and administered supervised standard chloroquine therapy (10 + 10 + 5 mg/kg at 24-hour intervals). The 28-day cumulative incidence of therapeutic failure …

Primaquine For Prevention Of Malaria In Travelers, J. Kevin Baird, David J. Fryauff, Stephen L. Hoffman

United States Navy: Publications

An expanding risk and range of endemic malaria threatens travelers. Primaquine is an old drug recently demonstrated to offer effective prophylaxis. Clinical trials conducted in Indonesia, Kenya, and Colombia showed that a primaquine base (30 mg per day) had protective efficacy against Plasmodium falciparum and Plasmodium vivax of 85%–93%. Among 339 children (age, >8 years) and adults taking this regimen for 12– 52 weeks, there was no greater risk of adverse symptomatic events among primaquine users than among recipients of placebo in double-blind studies. Among 151 subjects evaluated after 20 or 52 weeks of daily primaquine therapy, methemoglobinemia was found …

Flight Physician - January, 2003, Civil Aviation Medical Association

Browse all Civil Aviation Medical Association Newsletters

A twenty page newsletter of the Civil Aviation Medical Association. The newsletter provided news about civil aviation medicine and information related to the organization.