Digital Commons Network^™

Analysis Of Risk Factors For Fatal Rocky Mountain Spotted Fever: Evidence For Superiority Of Tetracyclines For Therapy, Robert C. Holman, Christopher D. Paddock, Aaron T. Curns, John W. Krebs, Jennifer H. Mcquiston, James E. Childs

Zoonotics and Wildlife Disease: Publications

Epidemiologic and clinical characteristics of fatal and nonfatal cases of Rocky Mountain spotted fever (RMSF) were compared to identify risk factors for death caused by this disease. Confirmed and probable RMSF cases reported through US national surveillance for 1981- 1998 were analyzed. Among 6388 RMSF patients, 213 died (annual case-fatality rate, 3M; range, 4.9 % in 1982 to 1.1 % in 1996). Use of tetracycline-class antibiotics for treatment of RMSF increased significantly in the 1990s, compared with use in the 1980s. Older patients, patients treated with chloramphenicol only, patients for whom tetracycline antibiotics were not the primary therapy, and patients …

Prp-C And Prp-Sc At The Fetal-Maternal Interface, Wenbin Tuo, Dongyue Zhuang, Donald P. Knowles, William P. Cheevers, Man-Sun Sy, Katherine I. O'Rourke

Zoonotics and Wildlife Disease: Publications

Scrapie is a naturally occurring prion (PrP) disease causing a fatal neurodegenerative disorder in sheep and goats. Previous studies suggest that scrapie is transmitted naturally through exposure to the scrapie agent in wasted placentas of infected ewes. This study determined the distribution and biochemical properties of PrP cellular (PrP-C) and the distribution of PrP scrapie (PrP-Sc) in reproductive, placental, and selected fetal tissues and fetal fluids in sheep. Glycosylated, N-terminally truncated, proteinase K-sensitive PrP-C with apparent molecular masses of 23–37 kDa was present in reproductive, placental, and fetal tissues and fetal fluids. PrP-C was low or undetectable in intercotyledonary chorioallantois, …

Immunohistochemical Detection Of Scrapie Prion Proteins In Clinically Normal Sheep In Pennsylvania, Hyun Kim, Katherine I. O'Rourke, Mark Walter, H. Graham Purchase, John Enck, Tae Kyun Shin

Zoonotics and Wildlife Disease: Publications

Following diagnosis of scrapie in a clinically suspect Suffolk sheep, 7 clinically normal flockmates were purchased by the Pennsylvania Department of Agriculture to determine their scrapie status using an immunohistochemical procedure. Two of the 7 euthanized healthy sheep had positive immunohistochemical staining of the prion protein of scrapie (PrP-Sc) in their brains, nictitating membranes, and tonsils. The PrP-Sc was localized in the areas of the brain where, histopathologically, there was neurodegeneration and astrocytosis. The PrP-Sc occurred within germinal centers of the affected nictitating membranes and tonsils and was located in the cytoplasm of the dendrite-like cells, lymphoid cells, and macrophages. …

Preliminary Findings On The Experimental Transmission Of Chronic Wasting Disease Agent Of Mule Deer To Cattle, Amir N. Hamir, Randall C. Cutlip, Janice M. Miller, Elizabeth S. Williams, Mick J. Stack, Michael W. Miller, Katherine I. O'Rourke, Melanie J. Chaplin

Zoonotics and Wildlife Disease: Publications

To determine the transmissibility of chronic wasting disease (CWD) to cattle and to provide information about clinical course, lesions, and suitability of currently used diagnostic procedures for detection of CWD in cattle, 13 calves were inoculated intracerebrally with brain suspension from mule deer naturally affected with CWD. Between 24 and 27 months postinoculation, 3 animals became recumbent and were euthanized. Gross necropsies revealed emaciation in 2 animals and a large pulmonary abscess in the third. Brains were examined for protease-resistant prion protein (PrP^res) by immunohistochemistry and Western blotting and for scrapie-associated fibrils (SAFs) by negative-stain electron microscopy. Microscopic …

The Brook Summer 2001, V. 3, N. 02, Stony Brook University Office Of Communications.

The Brook

v.: ill. ; 30 cm (original analog pub.),Brook

2001 Stethoscope, University Of Health Sciences College Of Osteopathic Medicine

Yearbooks (1927-2005)

Annual publication of the University of Health Sciences College of Osteopathic Medicine.

Print copy located in the Special Collections room in the D'Angelo Library.

Healing Logics, Erika Brady

All USU Press Publications

Scholars in folklore and anthropology are more directly involved in various aspects of medicine—such as medical education, clinical pastoral care, and negotiation of transcultural issues—than ever before. Old models of investigation that artificially isolated "folk medicine," "complementary and alternative medicine," and "biomedicine" as mutually exclusive have proven too limited in exploring the real-life complexities of health belief systems as they observably exist and are applied by contemporary Americans. Recent research strongly suggests that individuals construct their health belief systmes from diverse sources of authority, including community and ethnic tradition, education, spiritual beliefs, personal experience, the influence of popular media, and …

Carbon Sequestration Policy And Global Warming: A Legal Analysis, Norman W. Thorson, Harry A. Spencer

University of Nebraska Public Policy Center: Publications

Global warming seems destined to become one of the defining issues of the twenty-first century. Most scientists now agree that measurable increases in average global mean temperatures over the past decades cannot be explained by natural temporal variations in the earth’s climate. Instead, global warming appears to be a fact that can be attributed to human induced changes in the composition of greenhouse gasses in the earth’s atmosphere. Moreover, if the trend toward ever increasing temperatures continues, consequences for the earth’s environment will be dramatic, and perhaps irreversible. Growing concern over the potential for human activities to alter the earth’s …

Environmental Justice: A Review Of State Responses, Hillary Gross, Hannah Shafsky, Kara Brown

UC Law Environmental Journal

No abstract provided.

Same Planet - New World? A Chronicle Of The American Century, Don P. Diffine Ph.D.

Belden Center Monographs

No abstract provided.

Arbovirus Infection Increases With Group Size, Charles R. Brown, Nicholas Komar, Sunita B. Quick, Rajni A. Sethi, Nicholas A. Panella, Mary Bromberger Brown, Martin Pfeffer

Zoonotics and Wildlife Disease: Publications

Buggy Creek (BCR) virus is an arthropod-borne alphavirus that is naturally transmitted to its vertebrate host the cliff swallow (Petrochelidon pyrrhonota) by an invertebrate vector, namely the cimicid swallow bug (Oeciacus vicarius). We examined how the prevalence of the virus varied with the group size of both its vector and host. The study was conducted in southwestern Nebraska where cliff swallows breed in colonies ranging from one to 3700 nests and the bug populations at a site vary directly with the cliff swallow colony size. The percentage of cliff swallow nests containing bugs infected with BCR …

Confirmatory Factor Analysis Of The Coping Style Inventory In A College Sample, Christopher Garth Bellah

Doctoral Dissertations

The present study conducted a confirmatory factor analysis of the Coping Style Inventory (CSI). A comprehensive review of the history of stress and coping research was provided, along with a presentation of suggestions for future research that have indicated a need for a melding of both theory-driven and empirically-driven methodology in coping assessment. Pursuant to this need, a pilot study was conducted to explore the factor structure and psychometric properties of the CSI (N = 560). Results of pilot work using a principle components extraction and a parallel analysis criterion for factor retention indicated that six primary factors were …

Uab Magazine - Summer 2001, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

University Of South Florida Fact Book, 2001, University Of South Florida. Office Of Budget And Policy Analysis

USF Fact Book

A statistical fact book for the University of South Florida for 2001-2002. The book is broken into ten sections: Introduction: History and Historical Trends; Current University Characteristics; Student Profile; Enrollment; Courses and Degrees; Faculty and Staff; Awards and Honors; Fiscal Resources; Physical Resources; and Glossary. A table of contents lists all the tables within each section.

Department Of Veterinary And Biomedical Sciences: 2001 Annual Report, John A. Schmitz

School of Veterinary and Biomedical Sciences: Information and History

Twenty Departmental students completed their Bachelor of Science in Agricultural Science degrees in 2001, nineteen in the Veterinary Science Major and one in the Veterinary Technologist Major. Twenty-five Nebraska residents were admitted into the College of Veterinary Medicine at Kansas State University, twelve of them having completed all or part of their pre-veterinary studies at UNL. Seven students completed their Master of Science degree in Veterinary Science. Enrollment in the Distance Education MS in Veterinary Science Master of Science, Distance Education Program increased to seven students, with several applications still being processed or expected. Three new Distance Education courses were …

Evidence For Different Mechanisms Of Chloroquine Resistance In 2 Plasmodium Species That Cause Human Malaria, Takashi Nomura, Jane M-R Carlton, J. Kevin Baird, Hernando A. Del Portillo, David J. Fryauff, Dharmendar Rathore, David A. Fidock, Xin-Zhuan Su, William E. Collins, Thomas F. Mccutchan, John C. Wootton, Thomas E. Wellems

United States Public Health Resources

Chloroquine (CQ)–resistant Plasmodium vivax malaria was first reported 12 years ago, nearly 30 years after the recognition of CQ-resistant P. falciparum. Loss of CQ efficacy now poses a severe problem for the prevention and treatment of both diseases. Mutations in a digestive vacuole protein encoded by a 13-exon gene, pfcrt, were shown recently to have a central role in the CQ resistance (CQR) of P. falciparum. Whether mutations in pfcrt orthologues of other Plasmodium species are involved in CQR remains an open question. This report describes pfcrt homologues from P. vivax, P. knowlesi, P. berghei, and …

Incidence Of Symptomatic And Asymptomatic Plasmodium Falciparum Infection Following Curative Therapy In Adult Residents Of Northern Ghana, S. Owusu-Agyei, K. A. Koram, J. Kevin Baird, G. C. Utz, F. N. Binka, F. K. Nkrumah, D. J. Fryauff, S. L. Hoffman

United States Public Health Resources

Adult residents of holoendemic malaria regions in Africa have a naturally acquired immunity (NAI) to malaria that renders them more resistant to new infections, limits parasitemia, and reduces the frequency and severity of illness. Given such attributes, it is not clear how one might evaluate drug or vaccine efficacy in adults without serious confounding. To determine symptomatic and asymptomatic malaria attack rates in adults of northern Ghana, 197 men and women underwent curative therapy for any pre-existing malaria infections at the start of the high transmission (wet) season. They were monitored for first parasitemia and first clinical episode of infection …

Borrelia Lonestari Infection After A Bite By An Amblyomma Americanum Tick, Angela M. James, Dionysios Liveris, Gary P. Wormser, Ira Schwartz, Marisa A. Montecalvo, Barbara J. B. Johnson

United States Public Health Resources

Erythematous rashes that are suggestive of early Lyme disease have been associated with the bite of Amblyomma americanum ticks, particularly in the southern United States. However, Borrelia burgdorferi, the causative agent of Lyme disease, has not been cultured from skin biopsy specimens from these patients, and diagnostic serum antibodies usually have not been found. Borrelia lonestari sp nov, an uncultured spirochete, has been detected in A. americanum ticks by DNA amplification techniques, but its role in human illness is unknown. We observed erythema migrans in a patient with an attached A. americanum tick. DNA amplification of the flagellin gene …

Impact Of Livestock Animal Disease Outbreaks On International Trade: A Study Focusing On The Current Foot-And-Mouth Disease And Mad Cow Disease Crises, Carolyn A. Schwarz

ILSA Journal of International & Comparative Law

Ten years elapsed from the time the first case of Bovine Spongiform Encephalopathy (BSE), commonly referred to as "mad cow disease,"' was discovered in Great Britain, until researchers confirmed that BSE was responsible for many human deaths

International Institutions, Michael P. Scharf, Edward Beagan, Detra Michlle Chandler, Lawrence K. Demeo

The International Lawyer

No abstract provided.

Paradox On The High Seas: Evasive Standards Of Medical Care - Duty Without Standards Of Care; A Call For The International Regulation Of Maritime Healthcare Aboard Ships, 34 J. Marshall L. Rev. 751 (2001), Thomas A. Gionis

UIC Law Review

No abstract provided.

Interventions To Reduce Hiv/Aids Stigma: What Have We Learned?, Lisanne Brown, Lea Trujillo, Kate Macintyre

HIV and AIDS

Stigma is a common human reaction to disease. Throughout history many diseases have carried considerable stigma, including leprosy, tuberculosis, cancer, mental illness, and many sexually transmitted diseases. HIV/AIDS is only the latest disease to be stigmatized. This paper reviews 21 interventions that have explicitly attempted to decrease AIDS stigma both in the developed and developing countries and 9 studies that aim to decrease stigma related with other diseases. The studies selected met stringent evaluation criteria in order to draw common lessons for future development of interventions to combat stigma. This paper assesses published and reported studies through comparison of audiences, …

Concerning The Authority Of The State Agricultural Commission To Prevent The Spread Of Livestock Disease In Colorado., Colorado General Assembly

Session Laws 2001-Present

No abstract provided.

International Governance Through Trade Agreements: Patent Protection For Essential Medicines, Judy Rein

Northwestern Journal of International Law & Business

This paper examines the current conflicts surrounding the implementation of patent protection for pharmaceuticals. Part II outlines the specifics of trade agreements shaping the global intellectual property regime and the consequences for governments seeking to devise an essential drugs policy. Part III analyzes the process of obtaining consensus and compliance with patent protection rules through the negotiation and implementation of trade agreements, and the utilization of dispute settlement mechanisms. This section also examines the aggressive application of unilateral measures to induce adherence to levels of protection beyond those established at the multilateral and regional level. Part IV considers alternative approaches …

Lessons Taught By Miss Evers' Boys: The Inadequacy Of Benevolence And The Need For Legal Protection Of Human Subjects In Medical Research , Donald H.J. Hermann

Journal of Law and Health

The Tuskegee study is perhaps the most notorious example of abuse in medical research in the United States. It is significant that the project was not ended until twenty-five years after the adoption of the Nuremberg Code of 1948, the first article of which establishes its principle that human subjects should not be experimented on without their consent. Continuing concern about the ethics of medical and scientific research have been fueled by finding about other research abuse such as the radiation experiments in the 1940's and 1950's that involved subjects being injected with plutonium without their knowledge and feeding radioactive …

The Application Of Universal Human Rights Law To People With Mental Disabilities, Debra Benko, Brittany Benowitz

Human Rights Brief

No abstract provided.

America's Economic Partnership With Europe, Stuart E. Eizenstat

Journal of Diplomacy and International Relations

No abstract provided.

Crime, Punishment And Penal Policy, Ian O'Donnell

Irish Journal of Applied Social Studies

Academic interest in crime and punishment in Ireland has grown in recent years and a number of important books have appeared (Bacik and O'Connell 1998, Brewer et al 1997, McCullagh 1996, O'Mahony 1993, O'Malley 2000). However any attempt to create a detailed understanding of the criminal justice process is frustrated by a lack of data. Statistical information is often published years in arrears, is of poor quality and is uncritically accepted as accurate and meaningful. The purpose of this paper is to give a snapshot of current understanding of the criminal justice system and to highlight a small number of …

The Case For Microbicides: A Global Priority, Kathy Attawell

HIV and AIDS

The HIV/AIDS epidemic continues to spread, undermining development, reversing health gains, and exacerbating poverty. It will be some time before a vaccine is available and accessible, thus there is an urgent need to identify additional prevention options, in particular a method that women control, which could save millions of lives. This report from the Population Council and International Family Health presents the case for microbicides—products used vaginally to prevent infection from HIV and other STIs in women and their sexual partners—and discusses recent progress and developments, outstanding challenges, and the action required to ensure that products will be made available …

Gsbs News, Winter 2001-2002, Graduate School Of Biomedical Sciences, University Of Texas Health Science Center At Houston/M.D. Anderson Cancer Center

GSBS News

No abstract provided.