Digital Commons Network^™

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

The Formation Of Immunogenic Major Histocompatibility Complex Class Ii-Peptide Ligands In Lysosomal Compartments Of Dendritic Cells Is Regulated By Inflammatory Stimuli, Kayo Inaba, Shannon J. Turley, Tomonori Iyoda

Publications

During their final differentiation or maturation, dendritic cells (DCs) redistribute their major histocompatibility complex (MHC) class II products from intracellular compartments to the plasma membrane. Using cells arrested in the immature state, we now find that DCs also regulate the initial intracellular formation of immunogenic MHC class II-peptide complexes. Immature DCs internalize the protein antigen, hen egg lysozyme (HEL), into late endosomes and lysosomes rich in MHC class II molecules. There, despite extensive colocalization of HEL protein and MHC class II products, MHC class II-peptide complexes do not form unless the DCs are exposed to inflammatory mediators such as tumor …

Human Cd4+ T Lymphocytes Consistently Respond To The Latent Epstein- Barr Virus Nuclear Antigen Ebna1, Christian Münz, Kara L. Bickham, Marion S. Subklewe

Publications

The Epstein-Barr virus (EBV)-encoded nuclear antigen EBNA1 is critical for the persistence of the viral episome in replicating EBV-transformed human B cells. Therefore, all EBV-induced tumors express this foreign antigen. However, EBNA1 is invisible to CD8⁺ cytotoxic T lymphocytes because its Gly/Ala repeat domain prevents proteasome-dependent processing for presentation on major histocompatibility complex (MHC) class I. We now describe that CD4⁺ T cells from healthy adults are primed to EBNA1. In fact, among latent EBV antigens that stimulate CD4⁺ T cells, EBNA1 is preferentially recognized. We present evidence that the CD4⁺ response may provide a protective …

Canarypox Virus-Induced Maturation Of Dendritic Cells Is Mediated By Apoptotic Cell Death And Tumor Necrosis Factor Alpha Secretion, Ralf Ignatius, Mary A. Marovich, Erin Mahlhop

Publications

Recombinant avipox viruses are being widely evaluated as vaccines. To address how these viruses, which replicate poorly in mammalian cells, might be immunogenic, we studied how canarypox virus (ALVAC) interacts with primate antigen-presenting dendritic cells (DCs). When human and rhesus macaque monocyte-derived DCs were exposed to recombinant ALVAC, immature DCs were most susceptible to infection. However, many of the infected cells underwent apoptotic cell death, and dying infected cells were engulfed by uninfected DCs. Furthermore, a subset of DCs matured in the ALVAC-exposed DC cultures. DC maturation coincided with tumor necrosis factor alpha (TNF-α) secretion and was significantly blocked in …

The Ability Of Trail Making Test Parts A And B For Children And Adolescents To Discriminate Between Learning Disabled Students And Non-Learning Disabled Students, Glorene K. Evilsizor

Theses, Dissertations and Capstones

The Trail Making Test Parts A and B is a neuropsychological test that has long been thought to be a highly reliable and valid test that is able to discriminate cerebral dysfunction. In the present study, an investigation was completed in order to determine whether or not the Trail Making Test Parts A and B could differentiate learning disabled students from non-learning disabled students in four counties in West Virginia. Fifty-six students ranging from ages 9-16 (mean age 9.9) were involved in the study. The convenience sample consisted of 27 learning disabled students and 29 controls or non-learning disabled students. …

Sulfa Or Sulfone Prophylaxis And Geographic Region Predict Mutations In The Pneumocystis Carinii Dihydropteroate Synthase Gene, Laurence Huang, Charles B. Beard, Jennifer Creasman, Deborah A. Levy, Jeffrey S. Duchin, Sherline Lee, Norman Pieniazek, Jane L. Carter, Carlos Del Rio, David Rimland, Thomas R. Navin

Journal Articles: Epidemiology

To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase (DHPS) gene, a prospective study of human immunodeficiency virus (HIV)-infected patients with confirmed P. carinii pneumonia was conducted in Atlanta, Seattle, and San Francisco. Clinical information was obtained from patient interview and chart abstraction. DHPS genotype was determined from DNA sequencing. Overall, 76 (68.5%) of 111 patients had a mutant DHPS genotype, including 22 (81.5%) of 27 patients from San Francisco. In multivariate analysis, sulfa or sulfone prophylaxis and study site were independent predictors of a mutant genotype. Fourteen (53.8%) of 26 patients who were newly diagnosed with …

Protease Inhibitor Therapy In Hiv-Infected Children : Effects On Viral Load And Cd4+ T-Lymphocyte Counts, Naomi Lustman Katz

Yale Medicine Thesis Digital Library

No abstract provided.

The Sequential Schedule For Poliovirus Immunization: Factors Associated With Its Adoption By Primary Care Providers, Melissa Sharyn Ellis

Yale Medicine Thesis Digital Library

No abstract provided.

Virginia Commonwealth University Commencement Program [2000], Virginia Commonwealth University

VCU Commencement Programs

No abstract provided.

Evaluation And Treatment Of Severe Hyperacusis, Michael Valente, Joel Goebel, Diane Duddy, Belinda Sinks, Judy Peterin

Publications

No abstract provided.

Genetic Diversity And Transcriptional Analysis Of The Bys1 Gene From Blastomyces Dermatitidis, James L. Bono, Basam Jaber, Mark A. Fisher, Raed O. Abuodeh, Erin O’Leary-Jepson, Gene M. Scalarone, Laurens H. Smith Jr.

Roman L. Hruska U.S. Meat Animal Research Center: Reports

Blastomyces dermatitidis, a pathogenic fungal organism, is able to exist in two differentmorphologies, a multicellular mycelium or a unicellular yeast, according to temperature, 25˚C and 37˚C respectively. The switching between morphologies must be accompanied by a cascade of signaling events in which expression of genes responsible for the change of morphology is increased or decreased. bys1, a gene from B. dermatitidis isolate #58, is expressed at high levels in the unicellular yeast, but gradually diminishes as the temperature is lowered and the organism converts to the mycelial phase where there is no transcription of bys1. We explored …

Ada Code Of Ethics (January 2000), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.

Health Is A Human Right: Why The U.S. Immigration Law Response To Gender-Based Asylum Claims Requires More Attention To International Human Rights Norms, Caroline J. O'Neill

Journal of Contemporary Health Law & Policy (1985-2015)

No abstract provided.

Physician Assistant Program 2000, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Severe Anemia In Young Children After High And Low Malaria Transmission Seasons In The Kassena-Nankana District Of Northern Ghana, Kwadwo A. Koram, Francis K. Nkrumah, Seth Owusu-Agyei, Fred N. Binka, Greg Utz, Kevin J. Baird, Steven L. Hoffman

United States Navy: Publications

Malaria and anemia accounted for 41% and 18% respectively of hospital deaths in the Kassena-Nankana district of northern Ghana during 1996. We measured hemoglobin (Hb), malaria prevalence, and anthropometric indices of 6—24-month-old infants and young children randomly selected from this community at the end of the high (May–October, n = 347) and low (November–April, n = 286) malaria transmission seasons. High transmission season is characterized by rainfall (the equivalent of 800–900 mm/yr.), while the remaining months receive less than 50 mm/ yr. Severe anemia, defined as Hb < 6.0 g/dL, was 22.1% at the end of the high transmission season compared to 1.4% at the end of the low transmission season (Odds Ratio [OR] = 20.1; 95% CI: 7.1–55.3). Parasitemia was 71% and 54.3% at these time points (OR = 2.1; 95% CI: 1.5–2.9). Nutritional anemia appeared to have little impact upon this seasonal difference since anthropometric indices were comparable. Although the relative contributions of other causes of severe anemia were not assessed, repeated malaria infections may be a primary determinant of severe anemia among infants and young children during the high transmission season.

Banning Correctional Facility: Residential Substance Abuse Treatment Program Process Survey, Melinda Deann Hulvey

Theses Digitization Project

The purpose of this study is to examine more closely those program components which facilitate dissonance, disharmony, and ambiguity among the keygroups of a residential substance abuse treatment program.

The Global Decline Of Reptiles, Deja’ Vu Amphibians, J. Whitfield Gibbons, David E. Scott, Travis J. Ryan, Kurt A. Buhlmann, Tracey D. Tiuberville, Brian S. Metts, Judith L. Greene, Tony Mills, Yale Leiden, Sean Poppy, Christopher T. Winne

Scholarship and Professional Work - LAS

Reptile species are declining on a global scale. Six significant threats to reptile populations are habitat loss and degradation, introduced invasive species, environmental pollution, disease, unsustainable use, and global climate change.

Telemedicine: The Invisible Legal Barriers To The Health Care Of The Future, Heather A. Daley

Annals of Health Law and Life Sciences

Telemedicine has the potential to transform the world of health care just as the Internet transformed the world of commerce. Ms. Daly examines two legal obstacles to expanding the use of telemedicine: licensure and liability. She defines telemedicine and discusses its common applications and significant benefits. Licensure laws and liability rules result in formidable barriers to the expanded use of telemedicine, while also failing to provide sufficient protection for consumers. Ms. Daly argues that for the benefits of telemedicine to reach those most in need, mutual recognition of licensing laws coupled with a universal standard of care is necessary.

Regulation Of Contact With Offspring By Domestic Sows: Temporal Patterns And Individual Variation, E. A. Pajor, D. L. Kramer, D. Fraser

Rearing Behavior Collection

We used a sow-controlled housing system to examine temporal and individual variation in the tendency of sows to associate with young. During a 5-week lactation, 22 sows and litters were housed in a pen where the sow could freely leave and re-enter the piglets' area by stepping over a barrier that the piglets could not cross. Despite this option, the sows remained with the piglets almost constantly during the 1st day after birth. Nineteen sows ('leavers') changed to spending most of their time away from the litter at some point in the lactation. The change was rapid, often within a …

Information Systems In The San Diego Region, David Michael Ryfe

California Western Law Review

No abstract provided.

Mapping Of The Human Genome: Current Approaches To Sharing The Benefits With Developing Countries, Paige Gardner

Colorado Environmental Law Journal

No abstract provided.

Assessing The Risk Of Surface And Ground Water Contamination From Livestock Yards Management, Utah State University Extension

All Archived Publications

No abstract provided.

Prevalence Of Antibody To Hepatitis E Virus Among Rodents In The United States, Michael O. Favorov, Michael Y. Kosoy, Sergei A. Tsarev, James E. Childs, Harold S. Margolis

Zoonotics and Wildlife Disease: Publications

The recent identification of antibody to hepatitis E virus (HEV) in pigs, sheep, and cattle and characterization of an HEV isolated from domestic pigs suggest animal reservoirs for this virus. To investigate whether rodents might be a natural reservoir of HEV, the prevalence of anti-HEV was determined among a variety of species throughout the United States. Serum samples were obtained from 806 rodents of 26 species in 15 genera. Anti-HEV prevalence was assessed by 2 EIAs (mosaic protein- and 55-kDa protein-based), which gave concordant results. The highest prevalence of antibody was found in the genus Rattus (59.7%; 66/278). Overall, rodents …

Incidence Of Rocky Mountain Spotted Fever Among American Indians In Oklahoma, Jennifer H. Mcquiston, Robert C. Holman, Amy V. Groom, Stephen F. Kaufman, James E. Cheek, James E. Childs

Zoonotics and Wildlife Disease: Publications

Althought he state of Oklahoma has traditionally reported very high incidence rates of Rocky Mountain spotted fever (RMSF) cases, the incidence of RMSF among the American Indian population of the state has not been studied. The authors used data from several sources to estimate the incidence of RMSF among American Indians in Oklahoma.

The Impact Of Elevated Environmental Temperature On Cytokine Synthesis And Nitric Oxide Production During Experimental Chagas' Disease, L. Curtis Cary

Mahurin Honors College Capstone Experience/Thesis Projects

C3H mice that have been infected with a Brazil strain of Trypanosoma cruzi and maintained at an elevated environmental temperature of 36°C survive an otherwise lethal infection. These mice show increased longevity and a dramatic increase in parasitemia levels. In contrast, C3H mice maintained at room temperature typically experience high parasitemia levels and die within 40 days of infection. Previous studies in the laboratory suggest cell-mediated immune responses rather than antibody-mediated responses are responsible for the enhances protection. The goal of the present study was to analyze cytokine synthesis and nitric oxide production in spleen cells from mice infected with …

2000 Stethoscope, University Of Health Sciences College Of Osteopathic Medicine

Yearbooks (1927-2005)

Annual publication of the University of Health Sciences College of Osteopathic Medicine.

Print copy located in the Special Collections room in the D'Angelo Library.

Climate Change And Development, Luis Gómez-Echeverri

Yale School of the Environment Publications Series

A collaborative publication of the UNDP Regional Bureau for Latin America and the Caribbean and the Yale School of Forestry & Environmental Studies.

Health Professions Division Catalog Academic Year 2000-2001, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Childhood Pneumonia In Nuwakot District, Nepal: Perceptions, Management, And The Impact Of A Community Intervention, Amy B. Levin

Yale Medicine Thesis Digital Library

No abstract provided.

Severity Of Illness And Prognosis Of Liver Transplant Candidates At Yale, Arvind Venkat

Yale Medicine Thesis Digital Library

The increasing number of patients with end-stage liver disease (ESLD) listed for transplantation has forced physicians to examine the disparities in waiting times (WT) for this procedure across the US. The debate has centered upon whether physicians within regions with longer WT, such as that of Yale, are listing patients prematurely compared to regions with shorter WT . Using regional variations in WT, per this argument, to analyze access to organs is therefore misleading. To determine the appropriateness of listing practices at Yale, the authors applied stratification guidelines for liver transplant candidates adopted by the United Network for Organ Sharing …