Digital Commons Network^™

State Of The University Address 2000, Shirley Strum Kenny

State of the University Address

No abstract provided.

Assessing The Risk Of Surface And Ground Water Contamination From Livestock Manure Storage & Utilization, Utah State University Extension

All Archived Publications

No abstract provided.

Development Of Vaccines For Prevention Of Botulism, Michael P. Byrne, Leonard A. Smith

United States Army: Publications

Botulism is a potentially lethal disease caused by one of seven homologous neurotoxic proteins usually produced by the bacterium, Clostridium botulinum. This neuromuscular disorder occurs through an exquisite series of molecular events, ultimately ending with the arrest of acetylcholine release and hence, flaccid paralysis. The development of vaccines that protect against botulism dates back to the 1940s. Currently, a pentavalent vaccine that protects against BoNT serotypes A-E and a separate monovalent vaccine that protects against BoNT serotype F are available as Investigational New Drugs. However, due to the numerous shortcomings associated with the toxoid vaccines, several groups have efforts …

Virginia Dental Journal (Vol. 77, No. 2, 2000)

Virginia Dental Journal

No abstract provided.

Response To Critique Of The Claim Of Cannibalism At Cowboy Wash, Patricia M. Lambert, Banks L. Leonard, Brian R. Billman, Richard A. Marlar, Margaret E. Newman, Karl J. Reinhard

Karl Reinhard Publications

The original authors of Billman et af. (2000) are joined by three other analysts from the Cowboy Wash research team to respond to the critique of this article by Dongoske et af. (2000). Dongoske and his coauthors state that Billman et af. (2000) failed to test alternative hypotheses or to consider alternative explanations for the findings at 5MTJOOJO and similar sites. The original authors point out that alternative hypotheses were examined and rejected, leaving a violent episode of cannibalism as the most plausible explanation for the remains found at 5MTJOOJO. Dongoske et af. also question many aspects of the osteological, …

Hepp News, Vol. 3 No. 1, Hiv Education Prison Project

Infectious Diseases in Corrections Report (IDCR)

No abstract provided.

Primary Isolation Of Ehrlichia Chaffeensis From Patients With Febrile Illnesses: Clinical And Molecular Characteristics, Steven M. Standaert, Tina Yu, Margie A. Scott, James E. Childs, Christopher D. Paddock, William L. Nicholson, Joseph Singleton Jr., Martin J. Blaser

Zoonotics and Wildlife Disease: Publications

Ehrlichia chaffeensis was sought among patients with a history of tick exposure and fever, and the accuracy of other diagnostic tests was compared with that of primary isolation. Among the 38 patients enrolled, E. chaffeensis was isolated from the blood of 7 (18%) and from cerebrospinal fluid specimens of 2 of these 7. All 7 patients also were positive by polymerase chain reaction (PCR) of blood, and 6 patients developed diagnostic titers of antibody to E. chaffeensis. The isolates were characterized by molecular analysis of the 16S rRNA gene, the 120-kDa protein gene, and the variable-length PCR target (VLPT) …

Clinical Evaluation Of A Vaccinia-Vectored Hantaan Virus Vaccine, David Mccain, Peter Summers, Stephen Harrison, Alan Schmaljohn, Connie Schmaljohn

United States Army: Publications

We evaluated a vaccinia-vectored vaccine for hemorrhagic fever with renal syndrome in clinical trials. A Phase I dose-escalation study in 16 volunteers divided into four groups demonstrated that subcutaneous inoculation of approximately 107 plaque-forming units of the recombinant virus was safe and immunogenic. Vaccination of a fifth group of 12 volunteers indicated that neutralizing antibody titers to both vaccinia virus and Hantaan virus were enhanced after a second inoculation. Comparing two routes of vaccination showed that scarification effectively induced neutralizing antibodies in vaccinia virus-naive volunteers but that subcutaneous inoculation was superior to scarification in vaccinia virus-immune individuals. A Phase II, …

Persistent Hantavirus Infections: Characteristics And Mechanisms, Barbara Meyer, Connie Schmaljohn

United States Army: Publications

Hantaviruses include serious human pathogens that are maintained in nature in persistently infected rodents and that can also persistently infect cultured mammalian cells, causing little or no cytopathology. The mechanisms of hantavirus persistence are only beginning to be explored. Recent data point to subtle changes in the viral genome that might result in the differential regulation of replication and lead to persistence.

Genetic Diversity Of Hantaviruses Associated With Hemorrhagic Fever With Renal Syndrome In The Far East Of Russia, Connie Schmaljohn, Lyudmila Yashina, Nikolai Patrushev, Leonid Ivanov, Raisa Slonova, Vasiliy Mishin, Galina Kompanez, Nina Zdanovskaya, Irina Kuzina, Pavel Safronov, Vladimir Chizhikov, Sergei Ketesov

United States Army: Publications

blood samples collected from HFRS patients in 1994–1998, were examined by reverse transcription–polymerase chain reaction. In addition, 36 sera were tested by an immunofluorescence assay for antibodies against Hantaan, Seoul, Puumala, and Khabarovsk viruses, and 54 samples were tested by plaque reduction neutralization test. With both serological assays, the highest antibody titers were to Hantaan and:or Seoul viruses. Of 110 blood samples 36 were found RT-PCR positive. Phylogenetic analysis the sequences of a 256-nucleotide (nt) fragment of the hantavirus M genome segment revealed at least 3 genetically distinct hantavirus lineages. Nucleotide sequence comparison showed that two of the lineages, designated …

Expression Of Biologically Active Human Butyrylcholinesterase In The Cabbage Looper (Trichoplusia Ni), Peter L. Platteborze, Clarence A. Broomfield

United States Army: Publications

This investigation examined the utility of three recombinant protein-expression systems (COS cells, insect cells and insect larvae) to cost-effectively produce biologically active human butyrylcholinesterase (BuChE). It was determined that baculovirus-infected insect cells (Sf9 and High 5) expressed 3.5- and 8.2-fold, respectively, more active enzyme than COS-7 cells. Baculovirus-infected cabbage looper (Trichoplusia ni) insect larvae produced over 26 times more than High 5 cells ; in fact, one baculovirus-infected insect larva provided more active protein than 100 ml of insect cell culture. Analysis of the larvally expressed proteins revealed that the vast majority of BuChE expressed was inactive due to …

The Good Of Agency, Lawrence C. Becker

Philosophy Faculty Scholarship

No abstract provided.

Mortality In Serologically Unconfirmed Mediterranean Spotted Fever [With Reply], Pablo Yagupsky, Christopher D. Paddock, James E. Childs, Sherif R. Zaki, Stephen A. Berger

Zoonotics and Wildlife Disease: Publications

I read with interest the article by Paddock et al. [1], who described the detection of occult mortality due to Rocky Mountain spotted fever (RMSF) by demonstrating Rickettsia rickettsii antigens or DNA in blood and tissues. In Mediterranean countries, including Israel, spotted fever is caused by members of the R. conorii complex, which are antigenically related to R. rickettsii. ...

To the Editor -- We appreciate the comments by Yagupsky, which underscore several of the salient features of spotted fever- group rickettsial infections that we emphasized in our report [2]. For patients, diagnosticians, and clinicians faced with the potentially tragic …

Asian Carp Management And Control Workshop

National Invasive Species Council

The U.S. Fish & Wildlife Service’s Columbia Fishery Resources Office and Region 6 Aquatic Nuisance Species Coordinator co-hosted an Asian Carp Workshop in St. Louis, Missouri on April 19-20, 2000 to initiate the process of gathering input for the development of a Mississippi River Basin Asian Carp Management and Control Plan. The goal of the workshop was to review status, distribution, biology; ecological and economic benefits and impacts of four Asian carp species and identify management and control alternatives to reduce or mitigate these impacts.

Fifty-eight participants from state and federal natural resources agencies, universities and research facilities along with …

2000 Annual Report, The Jackson Laboratory

Annual Reports

No abstract provided.

Department Of Veterinary And Biomedical Sciences: 2000 Annual Report

School of Veterinary and Biomedical Sciences: Information and History

Foreword, 2000 John A . Schmitz. Professor and Department Head
Veterinary and Biomedical Sciences Personnel
Faculty Profiles
Teaching program
Research program
Extension Program
Nebraska Veterinary and Diagnostic Laboratory Systems
Grants and Contracts Funded or Active in 2000
Patents by VBMS Faculty in 2000
Publications by VBMS Faculty in 2000
Presentations by VBMS Faculty in 2000
Articles Regarding the Department in 2000
Selected Committees, Editorial and Other Appointments of VBMS Faculty
Departmental Budget Summaries
Nebraska Agricultural Statistics 1999

Use Of Gis To Evaluate Livestock-Wildlife Interactions Relative To Tuberculosis Spread On Molokai Island, Hawaii, Stephanie Bany, Jerome Freier

Michigan Bovine Tuberculosis Bibliography and Database

Historically, bovine tuberculosis has occurred and been eradicated several times on the Hawaiian island of Molokai. After the most recent depopulation of cattle, TB was again identified in an adult cow in 1997, thus continuing the investigation into why bovine tuberculosis is reoccurring on the island. The Centers for Epidemiology and Animal Health (CEAH) have implemented spatial analysis using ArcView software that, along with epidemiological investigations, attempts to identify the environmental factors responsible for maintaining this disease in natural foci. To examine the ecological aspects of tuberculosis transmission from wildlife to livestock, and to identify the foci of infection, we …

Gaps In International Legal Literature What's Wrong With International Law Scholarship, Lyonette Louis-Jacques

Articles

No abstract provided.

Introduction, John F. Murphy

The International Lawyer

No abstract provided.

International Health Law, Michele Forzley, Hale Hawbecker, Mark E. Wojcik, Edmund G. Howe Iii

The International Lawyer

No abstract provided.

Pentoxifylline Modulation Of The Cytotoxic T-Cell Differentiation Pathway To Enhance Immunological Memory, Eric Goodspeed

Inquiry: The University of Arkansas Undergraduate Research Journal

Immunological memory, acquired either by previous infection or vaccination, affords vertebrates a large margin of survival. Subsequent exposure to a "remembered" pathogen signals memory cells to undergo a rapid, clonal proliferation into armed effector cells. This rapidly mobilized clone mediates the specific clearance of the trespassing pathogen. Typically, this secondary recall response effectively dispatches the particular pathogen prior to any manifest disease pathology. This is the age-old, enjoyed benefit of immunity. Though this appreciation for immunological memory has been in documentation for nearly 3 millennia, our ability to intentionally increase its normal level of formation is only now beginning. The …

Adolescent Autonomy: Clarifying An Ageless Conundrum, Rhonda Gay Hartman

UC Law Journal

The law governing adolescence is discordant at best, impoverished at worst. Regarded as an appendage to paternalistic policy for children, present legal rules based upon presumptive decisional incapacity produce anomalous results. Most striking, a 16-year-old may confront criminal conviction with punitive and retributive sanction, including the death penalty, but is deemed decisionally incapable to refuse debilitating life-sustaining treatment. Adolescence and its accoutrement of distinct issues has hitherto remained unexamined, until now. In this Article, Professor Hartman proposes a paradigmatic shift in thinking about adolescence that entails a legal framework predicated on decisional ability, rather than presumptive decisional incapacity. By comprehensively …

Comparing Genotypic And Phenotypic Methods For Differentiating Strains Of Escherichia Coli Isolated From The Environment, Lateef Y. Saffore

Theses, Dissertations and Capstones

Escherichia coli is a Gram-negative, oxidase-negative, lactose fermenting rod belonging to the family Enterohacleriaceae. The enteric bacteria are common inhabitants of animal and human guts, but are not considered to be native to the environment. The presence of E. coli and similar enteric bacteria (coliforms) in surface water or groundwater implies the presence of fecal contamination from human or animal sources. E. coli has been used as an indicator of sewage-contaminated water since the 1930's and some strains are also causative agents of food or waterborne disease (Francy et al., 1993). The severity of disease can vary markedly depending …

Cytotoxic Mab From Rheumatic Carditis Recognizes Heart Valves And Laminin, Jeffrey E. Galvin, Mark E. Hemric, Kent Ward, Madeleine W. Cunningham

Faculty Publications and Presentations

Anti-streptococcal antibodies cross-reactive with N-acetyl-bD-glucosamine (GlcNAc) and myosin are present in the sera of patients with rheumatic fever (RF). However, their role in tissue injury is not clear. In this study, we show that anti-GlcNAc/anti-myosin mAb 3.B6 from a rheumatic carditis patient was cytotoxic for human endothelial cell lines and reacted with human valvular endothelium and underlying basement membrane. Reactivity of mAb 3.B6 with the valve was inhibited by human cardiac myosin > laminin > GlcNAc. The mAb 3.B6 epitopes were localized in fragments of human cardiac myosin, including heavy meromyosin (HMM), the S1 subfragment, and two light meromyosin (LMM) peptides containing …

Biomedical And Behavioral Research On Juvenile Inmates: Uninformed Choices And Coerced Participation, Brian Paul Wyman

Journal of Law and Health

The question that will be addressed here is whether juvenile inmates can voluntarily give informed consent to participate in biomedical and behavioral research. Further, can juvenile inmates act voluntarily in the midst of coercion used by researchers to persuade the subjects to participate, and coercion that is inherent in the nature of being a juvenile inmate? Can consent be informed when a juvenile inmate's comprehension and understanding of what biomedical and behavioral research entails is limited by age and maturity level? Finally, even if juvenile inmates are deemed capable to give voluntary informed consent to biomedical and behavioral research, is …

2000 Philip C. Jessup, J. Michael Allen Iii, Elizabeth Bosquet, Kristi L. Deason, David R. Pruet

ILSA Journal of International & Comparative Law

The State of Kuraca and the Republic of Senhava have submitted their differences concerning the vaccine trials to the International Court of Justice for resolution through a Special Agreement, in accordance with Article 40(1) of the Statute of the International Court of Justice.

Organizing Federal Food Safety Regulation, Richard A. Merrill, Jeffrey K. Francer

Seton Hall Law Review

No abstract provided.

Genetic Variation In Pneumocystis Carinii Isolates From Different Geographic Regions: Implications For Transmission, Charles B. Beard, Jane L. Carter, Scott P. Keely, Laurence Huang, Norman J. Pieniazek, Iaci N. S. Moura, Jacquelin M. Roberts, Allen W. Hightower, Michelle S. Bens, Amanda R. Freeman, Sherline Lee, James R. Stringer, Jeffrey S. Duchin, Carlos Del Rio, David Rimland, Robert P. Baughman, Deborah A. Levy, Vance J. Dietz, Paul Simon, Thomas R. Navin

Journal Articles: Epidemiology

To study transmission patterns of Pneumocystis carinii pneumonia (PCP) in persons with AIDS, we evaluated P. carinii isolates from patients in five U.S. cities for variation at two independent genetic loci, the mitochondrial large subunit rRNA and dihydropteroate synthase. Fourteen unique multilocus genotypes were observed in 191 isolates that were examined at both loci. Mixed infections, accounting for 17.8% of cases, were associated with primary PCP. Genotype frequency distribution patterns varied by patients' place of diagnosis but not by place of birth. Genetic variation at the two loci suggests three probable characteristics of transmission: that most cases of PCP do …

A Guide To Permitting Confined Animal Feeding Operations In Wyoming, Rachel Jay Smith

Land & Water Law Review

No abstract provided.

Calcitonin Gene-Related Peptide Decreases Expression Of Hla-Dr And Cd86 By Human Dendritic Cells And Dampens Dendritic Cell-Driven T Cell- Proliferative Responses Via The Type I Calcitonin Gene-Related Peptide Receptor, John A. Carucci, Ralf Ignatius, Yang Wei

Publications

These studies were performed to establish whether functional receptors for calcitonin gene-related peptide (CGRP) are present on human dendritic cells (DCs) and to investigate potential immunomodulatory effects of CGRP on DCs other than Langerhans cells. Reverse transcriptase-PCR revealed expression of mRNA for a type 1 CGRP receptor by mature and immature blood- derived DCs. Sequence analysis confirmed the identity of the type 1 CGRP receptor (CGRP-R1). Addition of CGRP (10^-7 M) to mature and immature DCs resulted in mobilization of intracellular calcium. Treatment of immature DCs with CGRP (10^-7 M), before and after maturation in monocyte-conditioned medium, resulted …