Digital Commons Network^™

Characterization Of The Airway Epithelial Bioelectric Mechanisms Associated With The Effects Of Epithelium-Derived Relaxing Factor In Guinea Pig-Isolated Trachea, Richard Alan Johnston

Graduate Theses, Dissertations, and Problem Reports (ETD)

In response to elevated serosal or mucosal tonicity, guinea-pig tracheal epithelium releases the non-nitric oxide, non-prostanoid, epithelium-derived relaxing factor (EpDRF), which subsequently diffuses to the underlying airway smooth muscle to initiate relaxation. Hypertonicity-induced smooth muscle relaxation via EpDRF involves epithelial Na+ and Cl- channels and is preceded by a depolarization of the transepithelial potential difference (Vms). By utilizing two different experimental systems, this study sought to characterize further the airway epithelial bioelectric mechanisms associated with the effects of EpDRF in guinea-pig isolated trachea.;First, this study attempted to elucidate which epithelial ion channels and/or transporters are involved in the depolarization of …

Finite Element Modeling Of Dowel -Jointed Plain Concrete Pavement Response To Thermal And Moving Traffic Loads, Michel Ramsis Fahmy

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study was to develop Three Dimensional Finite Element Models (3D-FEM) that can be used to investigate the separate or combined effect of moving axle loads and thermal gradient on the response of dowel Jointed Portland Cement Concrete Pavement (JPCCP) structures. The availability of a mechanistic tool that can be used for an accurate prediction of rigid pavement response to such loads would enable designing longer lasting pavements and understanding some of its modes of distress. In this respect, finite element modeling offers a powerful tool for the simulation of the structural behavior of pavements under the …

Vaccinia Virus-Mediated Glioma Gene Therapy Using P53, Il-2 And Il-12, Bing Chen

Loma Linda University Electronic Theses, Dissertations & Projects

Malignant brain tumors are generally lethal soon after their diagnosis, and the five-year survival rate for the patient is low in spite of neurosurgery, radiation therapy, and/or chemotherapy. Gene therapy has the potential to improve patient survival and quality of life by delivering specific combinations of therapeutic genes directly to the tumor for localized treatment.

We have based our cancer gene therapy for glioma on a highly attenuated variant of the Lister strain of vaccinia virus (VV) which has been proven to be a safe and effective vaccine vector. Other advantages include a wide host range, a strong promoter system, …

Chronic Hypoxia, Exercise Training, And Skeletal Muscle Capillarity: Angiogenic Regulation And Morphological Consequences, Ivan Mark Olfert

Loma Linda University Electronic Theses, Dissertations & Projects

Angiogenesis is important in health and disease. In particular, exercise training is known to increase skeletal muscle capillarity, providing there is sufficient training intensity. The stimulus for this may be intracellular hypoxia activating angiogenic growth factor gene expression. Acute hypoxia alone has been shown to increase the gene expression of several key angiogenic regulators, e.g. vascular endothelial growth factor (VEGF) and to a lesser degree transforming growth factor-β1 (TGF-β1), basic fibroblast growth factor (bFGF), and thrombospondin-1 (TSP-1), an endogenous negative angiogenic regulator. Paradoxically, however, chronic hypoxia is generally not found to increase mammalian skeletal muscle capillarity. Accordingly, we hypothesized that …

Studies On The Purification And Role Of Igfbp-5 Protease In Bone, H. Garrett Rush Thompson

Loma Linda University Electronic Theses, Dissertations & Projects

Osteoporosis is a disease characterized by low bone density and deterioration of mineralized bone leading to enhanced susceptibility to fracture. Several growth factors have been implicated in the coupling of formation to resorption during the bone remodeling process. The net bone forming activity of many growth factors has prompted numerous studies focused on the regulation of osteoblast cell proliferation, differentiation and activity. The current study focuses on the insulin-like growth factor (IGF) system, an important growth factor system involved in the regulation of bone formation and bone resorption.

IGF binding protein -5 (IGFBP-5), the most abundant IGF binding protein in …

Toward A Pragmatic Understanding Of Status-Consciousness: The Case Of Deregulated Education, Tomiko Brown-Nagin

Duke Law Journal

This Article discusses the relationship between federal equal protection doctrine and the states' experiment with deregulated education-in particular, charter schools whose student bodies are identifiable on the basis of status. I argue that the states' experiment with deregulated education and the Supreme Court's understanding of the limitations imposed by the federal Equal Protection Clause on status-conscious state action are substantially in conflict, though not inevitably so. Reconciling state policy and federal constitutional law requires, first, that state legislatures draft laws that are consistent with the Court's skepticism of explicitly status-conscious state action, and its ambivalence toward state action that addresses …

Rogue River Watershed Project / Rogue River Watershed Management Plan, Annis Water Resources Institute

Watershed Management Plans and Reports

The Rogue River is located in west central lower Michigan and is a major tributary of the Grand River. The Rogue River Watershed refers to all the land that is drained by the Rogue River. This area is 167,625 acres and includes portions of Kent, Montcalm, Muskegon, Newaygo, and Ottawa counties. The City of Rockford and Cedar Springs, and the villages of Sparta, Kent City, Sand Lake, and Casnovia are within the Rogue River Watershed boundaries. The Rogue River is fed by wetlands, county drains, lakes, and both warm and cool-cold water tributaries. The cool-cold water tributaries help to sustain …

Parallelization Of Ecg Template-Based Abnormality Detection, Sherry Lea Kratsas

Graduate Theses, Dissertations, and Problem Reports (ETD)

In order to develop techniques to predict cardiac arrest, long-term study of electrocardiogram (ECG) data needs to be done to detect changes in electrical activity of diseased hearts. In the past, limitations of computing power and storage space restricted the duration of long-term studies to several days. However, with today's technological advancement, data collection can be extended to months or years. The goal of this thesis research is to evaluate several alternatives for distributing the analysis of ECG data over multiple processors. Parallel algorithms utilizing Correlation Waveform Analysis (CWA) were implemented to compare individual heartbeats and form heartbeat templates. The …

West Virginians' Perceptions And Use Of Complementary Medicine, Joshua David Blevins

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to determine how West Virginian's perceive and use complementary medicine. The first objective was to determine the frequency of respondents who had used at least one complementary therapy in the last year. The second objective was to determine the most commonly used complementary therapies among respondents. The third objective was to examine the demographic characteristics of respondents who used complementary therapies. The fourth objective was to determine if certain types of medical problems led to complementary medicine use among respondents. The fifth objective was to show the percentage of users who informed their physician …

Evidence For A Systemic Embryotoxic Effect Of Early Luteal Regression In The Ewe, Beth Alyson Costine

Graduate Theses, Dissertations, and Problem Reports (ETD)

Experiments were performed to determine if a short-lived corpus luteum was embryotoxic in ewes given supplemental progesterone and the route of transfer of embryotoxic products. Mated ewes were lutectomized or sham lutectomized on day 4 after estrus. Following surgery, ewes received saline or PGF 2alpha through days 6 or 7. Pregnancy rate was reduced after treatment with PGF2alpha (P < 0.001) compared to controls and was increased in PGF2alpha-treated ewes by lutectomy (P < 0.05). Mated ewes with bilateral ovulations were unilaterally lutectomized, and each uterine horn was ligated to eliminate intercornual flow on day 4 after estrus. Treatment with PGF2alpha on day 5 through 8 reduced pregnancy rates (P < 0.01), but embryonic survival did not differ in the uterine horns ipsilateral or contralateral to the regressing CL. The regressing CL is embryotoxic in progesterone-supplemented ewes, and embryotoxic luteal products have been shown to act by non-local pathways.

Scotus On Morality And Nature, John E. Hare

University Faculty Publications and Creative Works

No abstract provided.

Montana Kaimin, December 1, 2000, Associated Students Of The University Of Montana

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

The Utilization Of Spirituality In Occupational Therapy: Beliefs, Practices, And Barriers, Jennifer S. Collins

Masters Theses

Spirituality has become an increasingly important topic in healthcare and specifically in occupational therapy. Previous studies of spirituality in occupational therapy indicated that while therapists believed spirituality was important to health and rehabilitation potential, few therapists reported incorporating spirituality into treatment (Engquist, Short-DeGraff, Gliner, & Oltjenbruns, 1997; Howe, 1996; Rose, 1999). This study utilized a survey design to examine occupational therapists' current beliefs and practices regarding spirituality, as well as asking therapists to identify barriers to the use of spirituality in treatment.

The results of this study indicate that beliefs and practices regarding spirituality in occupational therapy may be changing. …

Ostensible Abductions, Real Anthropology, Timothy F. Mccauley

Masters Theses

A gap has developed in the research agenda of contemporary anthropology with regard to a phenomenon which has received notable attention from research professionals in other fields, such as history and psychiatry. What has been called the "alien abduction phenomenon" has had considerable impact, not only on those who sincerely believe these events are an everyday part of human experience (called "abductees") but also on the changing tapestry of American culture. Alien abduction accounts are closely related to the Unidentified Flying Object (UFO) phenomenon, a theme which has shaped American culture since the tum of the century. This thesis represents …

Reconsidering The Auricular Surface As An Indicator Of Age At Death, Daniel Osborne

Masters Theses

Using standards established by Lovejoy et al. (1985) to score and estimate age at death from auricular surface morphology, the auricular surfaces of 266 individuals of documented age from two different skeletal collections (Terry and Bass Donated Collections) were examined. The age, sex and race of the individuals used in the study were unknown to the investigator during analysis. This study supports the claim proposed in the original study that auricular surface morphology is unaffected by an individual's sex or race. However, this study indicates that auricular surface morphology does not change as regularly with age as was originally proposed. …

Technology Evaluation: Pro-542, Progenics Pharmaceuticals Inc., Muhammad Mukhtar, Zahida Parveen, Roger J Pomerantz

Department of Medicine Faculty Papers

Progenics's rCD4-IgG2 (PRO-542) is a recombinant fusion protein, which has been developed using the company's Universal Antiviral Binding (UnAB) technology, and is in phase I/II clinical trials for the treatment of human immunodeficiency virus type I (HIV-1) infection [273391]. At the beginning of 1997, Progenics received a Phase II Small Business Innovation Research Program (SBIR) grant from the National Institute of Allergy and Infectious diseases (NIAID) to fund the development of PRO-542 [236048]. A further grant of $2.7 million was awarded in August 1998 for the clinical evaluation of PRO-542 and other anti-HIV therapies [294200]. Progenics is collaborating with the …

Eastern Progress - 30 Nov 2000, Eastern Kentucky University

Eastern Progress 2000-2001

No abstract provided.

Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for November 30, 2000

Lanthorn, Vol. 35, No. 15, November 30, 2000, Grand Valley State University

Volume 35, August 24, 2000 - June 14, 2001

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Exponent Vol. 32, No. 13, 2000-11-30, University Of Alabama In Huntsville

2000

No abstract provided.

Spartan Daily, November 30, 2000, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 115, Issue 61

Ua12/2/1 College Heights Herald, Vol. 76, No. 25, Wku Student Affairs

WKU Administration Documents

WKU campus newspaper reporting campus, athletic and Bowling Green, Kentucky news.

• Warren, Brandy. Diddle Arena to Get $28 Million Renovation
• Ragan, Jason. Students Camp Out for Chance to Live in McLean Hall
• Dawes, Jennifer. Western’s Computer Network Susceptible to Hacking
• Lynch, Caroline. Officer Alleges Incompetency – Anthony Purcell, WKU Police
• Act Now to Protect Campus Online Privacy
• Grady, Brian. Editorial Cartoon – Diddle Arena
• Frost, Jack. Students Don’t Want Sports
• Felton, Dennis. Thanks for Caring – Basketball
• McCabe, Jaclyn. Too Many to Love – Bowling Green Warren County Humane Society, Andy McDowell
• Corbin, Brett. WKU Telescope Undergoes Renovation – Bell …

Easterner, Volume 53, No. 10 November 30, 2000, Eastern Washington University. Associated Students

Student Newspapers

This issue of the Easterner contains articles about bed bugs in the campus family townhouses conflict, letter from President Stephen Jordan on racist literature, student rally against hate, and the basketball season.

Commonwealth Times 2000-11-30

Commonwealth Times, 1969-

No abstract provided.

R.I.T. News & Events - November 30 2000, University News Services, Rochester Institute Of Technology

University Publications

No abstract provided.

The Murray Ledger And Times, November 30, 2000, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The Pan American (2000-11-30), Ryan R. Henry

UTPA Archives - The Pan American Newspaper

49th Year, No. 24

The Alestle - Vol. 53 No. 27 - 11/30/2000, Southern Illinois University Edwardsville

The Alestle

Vol. 53 No. 27

The Grizzly, November 30, 2000, Lauren Cyrsky, Dan Reimold

Ursinus College Grizzly Newspaper, 1978 to Present

This is a parody edition of the Ursinus College Grizzly newspaper entitled "The Goofly."

Brief Amici Curiae Of Christian Legal Society And Union Of Orthodox Jewish Congregations Of America In Support Of Petitioners, Richard W. Garnett, Nathan J. Diament, Carl H. Esbeck

Court Briefs

No. 99-2036
The Good News Club v. Milford Central School

On Writ Of Certiorari To The United States Court Of Appeals For The Second Circuit

From the Summary of the Argument

The parties agree that Milford's Community Use Policy creates a limited public forum. See, e.g., Pet. A13 ("We think it clear that the Community Use Policy has created a limited public forum in the Milford school facilities."). And the parties agree that any content restrictions in such fora must be "viewpoint neutral" and constitutionally "reasonable." Pet. A14 & n.8 ("If the Club's use is not a 'religious use' but …