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Global Cns Gene Transfer For A Childhood Neurogenetic Enzyme Deficiency: Canavan Disease., Paola Leone, Christopher G Janson, Scott J Mcphee, Matthew J During

Department of Neurosurgery Faculty Papers

The neurogenetic prototypic disease on which we chose to test our gene therapy strategy is Canavan disease (CD). CD is an autosomal recessive leukodystrophy associated with spongiform degeneration of the brain. At present the disease is uniformly fatal in affected probands. CD is characterized by mutations in the aspartoacylase (ASPA) gene, resulting in loss of enzyme activity. In this review, recent evidence is summarized on the etiology and possible treatments for CD. In particular, we discuss two gene delivery systems representing recent advances in both viral and liposome technology: a novel cationic liposome-polymer-DNA (LPD) complex, DCChol/DOPE-protamine, as well as recombinant …

Effect Of Various Starch Sources On The Silicone Holdout Of Release Paper, Chandrasekaran Duraiswamy

Masters Theses

Siliconized papers are widely being used from food and packaging industry to pressure sensitive label industry and their use has increased considerably over the last decade. Surface and structural properties of the sheet influence the silicone hold out and release properties.

Surface sizing of the sheet is done prior to silicone coating. The objective of this research is to find their film forming capabilities, fluid hold out of various starches, and the effect of the various calendering process on the release properties was also studied.

No significant difference between the starch sources were observed, except for the modified com starch …

Systematics Of The Eucestoda: Advances Toward A New Phylogenetic Paradigm And Observations On The Early Diversification Of Tapeworms And Vertebrates, Eric P. Hoberg, Scott Lyell Gardner, Ronald A. Campbell

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Evolutionary relationships of the Eucestoda have received intense but sporadic attention over the past century. Since 1996, the landscape has dramatically changed with respect to our knowledge of the phylogenetic relationships among the tapeworms. The 2nd International Workshop for Tapeworm Systematics (IWTS) held in Lincoln, Nebraska in October of that year provided the catalyst for development of novel hypotheses for inter-and intra-ordinal phylogeny. The working-group structure of the 2nd IWTS and results of phylogenetic studies are briefly introduced in the present manuscript. Higher-level phylogenies derived from parsimony analysis of independent data bases representing comparative morphology or molecular sequences were largely …

Surveys Of Recent Developments In Third Circuit Law

Seton Hall Law Review

No abstract provided.

Evidence Supporting The Recent Origin And Species Status Of The Timberline Sparrow, John Klicka, Robert M. Zink, Jon C. Barlow, W. Bruce Mcgillivray, Terry J. Doyle

Ornithology Program (HRC)

The Timberline Sparrow (Spizella taverneri), although originally described as a species, is currently classified as a subspecies of the more widespread Brewer's Sparrow (S. breweri). We investigated the taxonomic status and recent evolutionary history of these species by comparison of both morphological and molecular characters. Morphometric comparisons using 6 external and 18 skeletal measurements show that S. taverneri specimens from two widely separated populations (Yukon and southwestern Alberta, Canada) are indistinguishable with respect to size yet are significantly larger (by 3%) than representatives of several breweri populations. Analysis of 1,413 base pairs of mitochondrial DNA (mtDNA) for 10 breweri and …

Agriculture Western Australia's Centre For Cropping Systems - Northam, Agriculture Western Australia

Grain and other field crops published reports

Agriculture Western Australia's Centre for Cropping Systems in York Road, Northam, was established as a centre of excellence for research, development and extension into cropping systems.

Its role is to stimulate the contribution of ideas from individuals, groups and organisations with an interest in research, development, and extension relating to innovative, profitable and sustainable crop-based farming systems.

The Centre for Cropping Systems is part of a regional network with strong links to Agriculture Western Australia's Crop Improvement Institute based at South Perth, the Dryland Research Institute at Merredin and the Avondale Research Fann at Beverley. It also links with universities …

Implementation Of An Activity-Based Costing System In An Air Force Laboratory Environment, Jayson M. Wrona, Martin Memminger

Theses and Dissertations

The purpose of this study was to examine the initial implementation of an Activity Based Costing (ABC) system within the United States Air Force's Research Laboratories (AFRL). We were attempting to ascertain what the initial purposes for implementing ABC within AFRL were, then determine whether or not those goals were being attained. We also attempted to evaluate the current system's appropriateness for achieving those initial purposes. Finally, we provide suggested changes to the model and areas for future research. We noted problems with AFRL's current ABC system. We were able to condense the problem into two main categories. First, when …

Skin: A Work Of Fiction, Kellie Wells

Dissertations

In Skin, a polyphonous novel, a community of characters similarly metaphysically vexed and similarly grappling with issues of selfhood and identity intersect and catalyze in one another moments of recognition. These brief self-reckonings suggest to the characters that though the quest to discern their place in the universe is a plagued one, it is not without value as it at least results in faint glimmers of enlightenment. Ultimately, how ever, these flickerings of understanding inch the characters no closer to the big certainties they seek, and they therefore must determine that the process itself, or, more to the point, …

Thanatos-Eros, Being-Non Being: Psychoanalytic - Existential Connection, Ryan D. Miller

Student Work

This Thesis examines and shows the relationship between Sigmund Freud's Death Instinct and Life Instinct Theories and their relation to the Existential concepts of Being and Non- Being. These intertheoretical concepts were interpreted in order for practitioners of Psychotherapy to be better acquainted with both concepts; so they may be better used in the mental health professions. A discussion of the two concepts as seen in Existential Psychotherapy and Freudian Psychoanalytic thought was presented and expanded upon and the relationship between the two was explained.

Trait Anxiety As A Moderator Of Problem Structuring Effects On Solution Generation, Judith A. Wightman

Student Work

This study investigated the effects of problem structuring and anxiety on the quantity and quality of solutions generated for ill-structured, complex problems. Trait anxiety, the tendency to feel anxious across a wide variety of situations, has been shown to impair problem solving performance in certain conditions. Trait anxiety was examined as a possible moderator of the relationship between problem structuring and solution generation. Participants were 184 undergraduate psychology students. Participants completed a trait anxiety measure (State-Trait Anxiety Inventory; Spielberger, 1983) and generated solutions to an ill-structured problem, with varying levels of structuring (no objectives, one-objective-at-a-time, conflicting objectives). The quantity and …

Signaling Mechanisms For Muscarinic Receptor-Mediated Coronary Vasoconstriction In Isolated Rat Hearts, Yi Zhang

Electronic Theses and Dissertations

The signaling mechanisms for muscarinic receptor-mediated vasoconstriction in coronary resistance arteries were studied in KCl-arrested isolated rat hearts perfused at a constant flow rate. The cholinergic agonists acetylcholine and bethanechol were given by bolus injection or constant infusion. The coronary vascular resistance was monitored by measuring the changes in perfusion pressure. The selective muscarinic agonist bethanechol caused a similar vasoconstrictor response as ACh, but with less potency and efficacy. Bolus injection of bethanechol evoked a phasic vasoconstriction in a dose-dependent manner, while infusion of bethanechol evoked a tonic vasoconstriction without producing tachyphylaxis. Coronary vascular responses to bethanechol were further examined …

The Children's Internet Protection Act Of 1999: Is Internet Filtering Software The Answer?, Elizabeth M. Shea

Seton Hall Journal of Legislation and Public Policy

No abstract provided.

‘Supernatural, Or At Least Romantic': The Ancient Mariner And Parody, Steven Jones

English: Faculty Publications and Other Works

This essay looks through the lens of parody at one of Coleridge's most characteristically "romantic" works, his famous ballad of the supernatural, The Rime of the Ancient Mariner. Along with the other so-called "Mystery Poems"—"Christabel" and "Kubla Khan"—this is among his most significant generic contributions to the developing idea of Romanticism, the kind of work that comes through a kind of synecdoche to stand for the whole movement as it was conceived.

Effect Of Allopurinol And Hemin On Some Biological Markers Of Aging In Broiler Chickens, Dinesh Singh Rathore

Graduate Theses, Dissertations, and Problem Reports (ETD)

Uric acid has been hypothesized as one of the most important antioxidants in limiting the accumulation of advanced glycolated endproducts in broiler breeder hens. This study was designed to quantitatively manipulate the plasma uric acid concentrations using hemin and allopurinol and determine its effect on skin pentosidine, shear force value of Pectoralis major muscle, plasma glucose, body and breast weight, and chemiluminescence induced oxidative stress in broiler chickens. Allopurinol decreased plasma uric acid, ranging from 26% to 74%, with the most pronounced effect at wk 22. Hemin increased plasma uric acid concentrations between 11 and 14%. Skin pentosidine levels increased …

Associations Of Egg Production With The Major Histocompatibility Complex In Broiler Breeder Hens, Becky Jean Tarleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study documents effects of the major histocompatibility complex (MHC) on reproductive traits in a flock of Cobb X Cobb broiler breeder hens. The objective was to determine if the MHC affects reproduction of non-congenic broiler breeder hens. Genomic DNA was isolated from 35 hens. Restriction fragment length polymorphism (RFLP) analysis was performed on each sample, using a chicken class II MHC probe (Xu et al. 1989). Restriction endonuclease digestion using PvuII resulted in polymorphisms in all birds. Five polymorphic bands were identified. The largest bands, 7.5 kb and 5.4 kb, were present in one and four hens respectively. The …

Influence Of Selection For Breast Muscle Mass On Ph And Metabolism Of Supracoracoideus Muscle From Male And Female Turkey, John Kenneth Yost

Graduate Theses, Dissertations, and Problem Reports (ETD)

The objective of this study was to determine if selection for increased breast muscle mass has affected the supracoracoideus muscle's ability to regulate pH during physical activity in turkeys. The lightweight male line (LM) had the greatest breast muscle mass as a percent of body weight (p < 0.0001), a lower average pH (6.68; p < 0.0001), and greater Lactate Dehydrogenase (293 mmol NADH min-1mug-1 ; p < 0.0001) and Glyceraldehyde Phosphate Dehydrogenase (0.4452 mmol NADH min-1mug-1; p < 0.05) activities than the HM and FL lines. The LM line had the highest ratio (2.33:1) (p < 0.05) of adult to neonatal myosin. Hens had greater breast muscle mass as a percent of body weight than males (p < 0.0001), and a lower average pH (6.62; p < 0.05). This study showed that genetic selection for breast muscle mass resulted in an increased ratio of adult to neonatal myosin and an increased anaerobic capacity, which may predispose birds to a lower ultimate pH during physical activity.

Effect Of Sward Height And Concentrate Supplementation On Forage Dry Matter Intake, Digestibility And Grazing Time Of Spring-Calving Beef Cows, Ondieki J. Gekara

Graduate Theses, Dissertations, and Problem Reports (ETD)

To establish the effect of sward height (SH) and concentrate supplementation on performance of grazing cattle, twenty-four cross bred Angus beef cow-calves were randomly assigned to two SH treatments (4--8 or 8--11 cm) with three supplement levels: 6.24, 3.12 or 0 kg/d. The study was conducted in three periods (P): May (P1), June/July (P2) and August (P3) in 1996. There was no SH x supplement level x period or SH x supplement level interaction (P > .10) on forage DMI, DMD or grazing time (GT). Cows on low SH had greater (P < .08) DMI and GT (P < .01) than cows on high SH. Forage DMI, DMD and GT decreased (P < .05) with supplementation. Grazing efficiency declined with supplementation and advancing grazing season (P < .01). Cows consumed more forage DM (P < .01) in P1 and P2 than P3. Forage DMI and grazing efficiency decreased with supplementation suggesting that supplemented cattle can optimally be grazed at SH < 8 cm.

Forecasting Electricity Demand Using Regression And Monte Carlo Simulation Under Conditions Of Insufficient Data, Kathleen Ann Cullen

Graduate Theses, Dissertations, and Problem Reports (ETD)

The problem studied is that of a summer peak residential energy demand model for Appalachian Power Company's service area in West Virginia. By restricting the forecast to a region smaller than the state, serious data problems result due to insufficient data to obtain reliable forecasts.;Regression analysis and Monte Carlo Simulation are the two methods used to forecast energy demand. Both methods incorporate risk into the analysis in different ways. Regression analysis yields a measure of the reliability of the coefficients of the variables and of the reliability of the forecast. The resulting forecast and confidence limits of the forecast values …

Occurrence, Etiology And Management Of Ringwomb In Ewes, Nancy Jean Kerr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Pedigrees of ewes with Ringwomb were studied to determine the etiology, incidence and treatment of Ringwomb. Purebred Suffolk and crossbred Hampshire and Shropshire ewes aged from one to seven years were observed over a period of five lambing seasons. The study was conducted on 24 clinical cases of ringwomb occurring in one flock. Ringwomb or incomplete cervical dilation accounted for an incidence of 20.5% (24/117) of all ewes lambing. The ewes affected were all daughters, granddaughters, or great-granddaughters of one particular sire used on the farm as a service sire. Because ringwomb does not typically affect ewes in two consecutive …

Perceptions Of Students And Teachers Regarding Agriculture In Leflore County, Mississippi, Ronald L. Howard

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to assess the perceptions of public high school teachers and students in Leflore County, Mississippi regarding agriculture and provide baseline data regarding the perception of high school students and teachers residing in an agriculturally dependent county with no agricultural education program. A population of 240 high school teachers and students was surveyed for their perceptions regarding agriculture. All three public high schools in Leflore County were represented in this study. Over 65% of the sample resided in the city, while only 3% live on a farm. The major finding of this study was that …

Social And Economic Impacts Of Wild Harvested Products, Brent Bailey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Wild harvested products (WHPs) are plants and animals, or parts of them, that are harvested from their native habitats for sale, trade, or personal consumption, by harvesters who are not employed by others to collect them. WHPs embody a range of economic, cultural, and social values held by residents of rural areas. However, the products' significance to harvesters and communities, and their conservation status, have until recently been little studied.;Assessments of social and economic impacts of WHPs on households and communities were conducted in West Virginia and West Africa. Interviews with harvesters, dealers, and resource managers revealed the range of …

Alcalá View 1999 15.11, University Of San Diego Publications And Human Resources Offices

Alcalá View (1985-2006)

Pedal Patrol is Revamped; Box Office Offerings; Fresh Air Parking Permits; Benefits Brief; Library's Very Own Treasure Hunter; The Picnic in Pictures; From Party Planner Davis, Calista; Picnic Prize Winners; Happy Birthday, USD! 1999 Employee Appreciation Picnic; Trivia Contest Answers; This Takes the Cake; MFCDC Earns National Ranking; Roulette, Riverboats and Retail Outlets Await You; Carpool Partners; Passages; Psst...Bits and Pieces from the Readers; New Hires and Promotions

Outcomes Of A Teaching Intervention On College Cigarette Smokers, Jeanne Benson

MSN Research Projects

Even though there has been a significant decrease in the number of adults who smoke in recent years, adolescents are initiating the habit at an alarming rate. Cigarette smoking is the number one preventable cause of death and illness in the United States. The purpose of this quasi­ experiment al pretest/posttest study was to explore the knowledge levels and attitudes of college students in Northeast Mississippi regarding cigarette smoking. The study was guided by two null hypotheses. The convenience sample consisted of 53 college students enrolled in a public community college in Northeast Mississippi. The Cigarette Smoking Questionnaire was utilized …

Comparison Of Self-Monitoring Blood Glucose Devices For Accuracy And Ease Of Use, Kelly Kitabchi Pfrommer

MSN Research Projects

The purpose of this comparative study was to evaluate several self-monitoring blood glucose devices with regard to accuracy and ease of use.

Avian Communities Of Large Reclaimed Mine Grasslands In Southwestern Indiana, Travis L. Devault

All-Inclusive List of Electronic Theses and Dissertations

Many bird species native to the tallgrnss prairie region oCthc central U.S. have declined drastically since European settlement due lo the destruction and alteration of grassland habitat. In this study, the breeding bird communities or 21 large reclaimed surface coal mine grasslands in a seven-county area or southwestern Indiana were examined with respect to species and guild composition, density, variation among sites, and grassland size. In addition, the vegetation characteristics of nine large mine grasslands were described and related to the presence and abundance or eight grasslund bird species common to the study areas. The immense size of mine grasslands …

Unconstrained Instantaneous Center Integration (Ici) Algorithms, Nathan Eggleton

Theses

This paper presents several unique "instantaneous center integration" (ICI) algorithms for use in studying unconstrained vehicle motion using computer simulations and animations. Specifically, these algorithms are most appropriate for the case when high angular rates are present, such as would occur during tight cornering and/or possibly during an accident. The three ICI algorithms presented are the "pseudo-exact", first order approximation and the second order approximation. These ICI algorithms are capable of producing valid, accurate, and efficient simulation results, which describe the behavior of a vehicle under these conditions. The "pseudo-exact" is the most accurate, yet the most computationally expensive. The …

Smart Decisions, Beatriz Gomez

Theses

It is very often that parents and educators find themselves running out of words when it comes to explaining a sensitive topic to a child. Such topics include but are not limited to sex, abortion, adoption, pregnancy, divorce, drugs, and disease. A computer based game has been designed to help parents and educators address such sensitive topics. This software package consists of a series of two dimensional animations. All of the animations belong to the same story, which as it progress, gives the player the opportunity to make diverse decisions. Each decision leads the player through a different path, hence …

Use Of Extractable Lipofuscin For Age Determination Of Blue Crab Callinectes Sapidus, Se-Jong Ju, David H. Secor, H. Rodger Harvey

OES Faculty Publications

The blue crab Callinectes sapidus is an economically and ecologically important species in many temperate estuaries, yet stock assessments have been limited to length-based methods for demographic analyses. We evaluated the potential of age pigments (lipofuscins) sequestered in neural tissue of eye-stalks and brains to estimate the age of blue crabs collected from Chesapeake Bay and Chincoteague Bay. The rate of lipofuscin accumulation was determined using crabs of known age reared in the laboratory. Age pigments were extracted from neural tissues (eye-stalk or brain), quantified, and normalized to protein content to allow comparisons across tissue types and crab sizes. Field-collected …

Echoes Of Scientific Truth In The Halls Of Justice: The Standards Of Review Applied By The United States Court Of Appeals For The Federal Circuit In Patent-Related Matters , Lawrence M. Sung

American University Law Review

No abstract provided.

The Relationship Between Homicidal Fantasies And Dangerousness, James C. Peterson

All-Inclusive List of Electronic Theses and Dissertations

Aggressive behavior is a serious problem in the United States and has been studied from a variety of perspectives. Psychologists in many different settings are frequently asked to assess the risk of future dangerous behavior by individuals. Due to their important role, research into the prediction of dangerousness has dramatically increased in the past ten years. However, to date, research has offered few reliable predictors that can be used in such assessments. This exploratory study was designed to examine whether homicidal fantasies can be used to reliably discriminate between violent and non-violent individuals. Undergraduate male students (N=l42) completed a questionnaire …