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Articles 4411 - 4440 of 6937
Full-Text Articles in Entire DC Network
Material World - Future Investments
Material World - Future Investments
Syracuse University Magazine
No abstract provided.
Aspartate 19 And Glutamate 121 Are Critical For Transport Function Of The Myo-Inositol/H+ Symporter From Leishmania Donovani, Andreas Seyfang, Michael Kavanaugh, Scott M. Landfear
Aspartate 19 And Glutamate 121 Are Critical For Transport Function Of The Myo-Inositol/H+ Symporter From Leishmania Donovani, Andreas Seyfang, Michael Kavanaugh, Scott M. Landfear
Biomedical and Pharmaceutical Sciences Faculty Publications
The protozoan flagellate Leishmania donovani has an active myo-inositol/proton symporter (MIT), which is driven by a proton gradient across the parasite membrane. We have used site-directed mutagenesis in combination with functional expression of transporter mutants in Xenopusoocytes and overexpression in Leishmania transfectants to investigate the significance of acidic transmembrane residues for proton relay and inositol transport. MIT has only three charged amino acids within predicted transmembrane domains. Two of these residues, Asp19 (TM1) and Glu121 (TM4), appeared to be critical for transport function of MIT, with a reduction of inositol transport to about 2% of wild-type …
Tyrosine 140 Of The Γ-Aminobutyric Acid Transporter Gat-1 Plays A Critical Role In Neurotransmitter Recognition, Yona Bismuth, Michael Kavanaugh, Baruch I. Kanner
Tyrosine 140 Of The Γ-Aminobutyric Acid Transporter Gat-1 Plays A Critical Role In Neurotransmitter Recognition, Yona Bismuth, Michael Kavanaugh, Baruch I. Kanner
Biomedical and Pharmaceutical Sciences Faculty Publications
The γ-aminobutyric acid (GABA) transporter GAT-1 is located in nerve terminals and catalyzes the electrogenic reuptake of the neurotransmitter with two sodium ions and one chloride. We now identify a single tyrosine residue that is critical for GABA recognition and transport. It is completely conserved throughout the superfamily, and even substitution to the other aromatic amino acids, phenylalanine (Y140F) and tryptophan (Y140W), results in completely inactive transporters. Electrophysiological characterization reveals that both mutant transporters exhibit the sodium-dependent transient currents associated with sodium binding as well as the chloride-dependent lithium leak currents characteristic of GAT-1. On the other hand, in both …
Mutation Of An Amino Acid Residue Influencing Potassium Coupling In The Glutamate Transporter Glt-1 Induces Obligate Exchange, Michael Kavanaugh, Annie Bendahan, Noa Zerangue, Yumin Zhang, Baruch I. Kanner
Mutation Of An Amino Acid Residue Influencing Potassium Coupling In The Glutamate Transporter Glt-1 Induces Obligate Exchange, Michael Kavanaugh, Annie Bendahan, Noa Zerangue, Yumin Zhang, Baruch I. Kanner
Biomedical and Pharmaceutical Sciences Faculty Publications
Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux of other ions. After cotransport of glutamic acid with Na+, the cycle is completed by countertransport of K+. We have identified an amino acid residue (glutamate 404) influencing ion coupling in a domain of the transporter implicated previously in kainate binding. Mutation of this residue to aspartate (E404D) prevents both forward and reverse transport induced by K+. Sodium-dependent transmitter exchange and a transporter-mediated chloride conductance are unaffected by the mutation, indicating that this residue selectively influences potassium flux coupling. The results …
Student Handbook, 1997-1998, George Fox University Archives
Student Handbook, 1997-1998, George Fox University Archives
Student Handbooks
Student Handbook of George fox University.
1997 Media Guide, George Fox University Archives
1997 Media Guide, George Fox University Archives
Softball
1997 Women's Softball Media Guide, George Fox College.
Status Report On The International Criminal Court, David Stoelting
Status Report On The International Criminal Court, David Stoelting
Hofstra Law & Policy Symposium
No abstract provided.
Brochure- 1997, Admissions Staff
Brochure- 1997, Admissions Staff
Student Handbooks
Student handbook, general information
Student Viewbook- 1997-1998, Admissions Staff
Student Viewbook- 1997-1998, Admissions Staff
Student Handbooks
Student handbook, general information
Pre-Employment Screening And Investigation: Navigating Between A Rock And A Hard Place, Stephen F. Befort
Pre-Employment Screening And Investigation: Navigating Between A Rock And A Hard Place, Stephen F. Befort
Hofstra Labor & Employment Law Journal
No abstract provided.
Virginia Commonwealth University Commencement Program [1997], Virginia Commonwealth University
Virginia Commonwealth University Commencement Program [1997], Virginia Commonwealth University
VCU Commencement Programs
No abstract provided.
Old Growth Ponderosa Pine And Western Larch Stand Structures: Influences Of Pre-1900 Fires And Fire Exclusion, United States Department Of Agriculture, Forest Service
Old Growth Ponderosa Pine And Western Larch Stand Structures: Influences Of Pre-1900 Fires And Fire Exclusion, United States Department Of Agriculture, Forest Service
Forestry
Presents detailed age structure for two western larch stands that historically experienced frequent fires. Compares age structures of eleven ponderosa pine and western larch stands representing a broad range of sites that had frequent fires. Interprets causal factors possibly linked to variations in stand age structures.
1997 Acropolis, Whittier College
1997 Acropolis, Whittier College
Acropolis (Yearbook)
The 1997 Acropolis yearbook for Whittier College
Learning To Teach, Teaching To Learn, Kathryn M. Plank, Diane M. Enerson, Susannah Milner, R. Neill Johnson
Learning To Teach, Teaching To Learn, Kathryn M. Plank, Diane M. Enerson, Susannah Milner, R. Neill Johnson
Faculty Scholarship
No abstract provided.
Chrysalis Yearbook, 1997, Molloy University Archives And Special Collections
Chrysalis Yearbook, 1997, Molloy University Archives And Special Collections
Yearbooks
This is the yearbook for the 1997 graduating class of Molloy College. The yearbook documents the graduating senior class portraits, faculty and administrators, student organizations and clubs, and athletics.
Press Releases - January-March 1997, Northeastern Illinois University University Relations
Press Releases - January-March 1997, Northeastern Illinois University University Relations
Press Releases
No abstract provided.
Beloved Enemies: Our Need For Opponents, Dean Reschke
Beloved Enemies: Our Need For Opponents, Dean Reschke
Clinical Sociology Review
No abstract provided.
Lawyers Of The Future (1997-1998), University Of Tennessee College Of Law
Lawyers Of The Future (1997-1998), University Of Tennessee College Of Law
Lawyers of the Future (1979 - 2002)
No abstract provided.
1997 Morehead State University Eagle Softball, Morehead State University. Office Of Athletics.
1997 Morehead State University Eagle Softball, Morehead State University. Office Of Athletics.
Morehead State Sports Team Programs
The 1997 official media guide of the Morehead State University softball team.
1997 Morehead State Volleyball, Morehead State University. Office Of Athletics.
1997 Morehead State Volleyball, Morehead State University. Office Of Athletics.
Morehead State Sports Team Programs
The 1997 official media guide of the Morehead State University volleyball team.
Mutagenesis Of Raphanus Sativus Using Ionizing Radiation, Adam Lyko
Mutagenesis Of Raphanus Sativus Using Ionizing Radiation, Adam Lyko
Capstone Research Projects
Mutagenesis of Raphanus sativus was conducted using 10kR, 20kR, and 30kR radiation in an attempt to determine the dosage which produces most mutants without being lethal. Pelargonidin production and physical characteristics of the storage root of the radishes were used as measures of mutagenicity. Plants which received of radiation exhibited the poorest development in every measured aspect except germination which was high. The results of this study suggest that at least 30kR of radiation should be used in experiments involving mutagenesis of Raphanus plants.
Ephedrine: An Herbal Toxicological Hazard, Jeffrey Peeke
Ephedrine: An Herbal Toxicological Hazard, Jeffrey Peeke
Capstone Research Projects
Many individuals are currently using herbal products that are toxicologically unsafe due to inaccurate dosages and/or addition of harmful substances of which the consumer is unaware. This is primarily because the health supplement industry has failed to supply adequate research and regulation on its products. This paper makes a brief review of the general field of toxicology, but ultimately narrows its scope to an in-depth consideration of ephedrine, an ancient Chinese medicinal herb capable of concerted stimulation of the sympathetic nervous system. Ephedrine use has resulted in negative reactions in a number of cases.
Pcr Amplification Of Three Kilobase Segments Of Mitochondrial Dna Of Larval Drosophila Melanogaster, Doug Sammer
Pcr Amplification Of Three Kilobase Segments Of Mitochondrial Dna Of Larval Drosophila Melanogaster, Doug Sammer
Capstone Research Projects
No abstract provided.
Cysteine-To-Alanine Replacements In The Escherichia Coli Soxr Protein And The Role Of The [2fe-2s] Centers In Transcriptional Activation, Terence M. Bradley, Elena Hidalgo, Veronica Leautaud, Huangen Ding, Bruce Demple
Cysteine-To-Alanine Replacements In The Escherichia Coli Soxr Protein And The Role Of The [2fe-2s] Centers In Transcriptional Activation, Terence M. Bradley, Elena Hidalgo, Veronica Leautaud, Huangen Ding, Bruce Demple
Past Departments Faculty Publications (CELS)
10.1093/nar/25.8.1469Available a: doi: 10.1093/nar/25.8.1469https://doi.org/10.1093/nar/25.8.1469Bradley, T. M., Hidalgo, E., Leautaud, V., Ding, H. & Demple, B. (1997). Cysteine-to-alanine replacements in the Escherichia coli SoxR protein and the role of the [2Fe-2S] centers in transcriptional act. Nucleic Acids Research, 25(8), 1469-1475.The Escherichia coli soxRS regulon activates oxidative stress and antibiotic resistance genes in two transcriptional stages. SoxR protein becomes activated in cells exposed to excess superoxide or nitric oxide and then stimulates transcription of the soxS gene, whose product in turn activates ≥10 regulon promoters. Purified SoxR protein is a homodimer containing a pair of [2Fe-2S] centers essential for soxS transcription in …
1997 Rowan County High School Yearbook, Rowan County High School (Morehead, Ky.)
1997 Rowan County High School Yearbook, Rowan County High School (Morehead, Ky.)
Yearbooks of Rowan County High Schools
The 1997 Rowan County High School Yearbook from Morehead, Kentucky.