Digital Commons Network^™

Care Down Syndrome: Responding To An Unmet Need, Brian Chicoine, Dana Sciullo, Laura Krohn, Amanda Zhang, Margot Rhondeau, Jessica Kuss

Advocate GME

No abstract provided.

Risk And Timing Of Age-Related And Other Conditions In Individuals With Down Syndrome, Hannah Tavalire, Akaninyene I. Noah, Veronica Fitzpatrick, Hannah Graham, Shelly Verma, Laura Krohn, Daniel Vockeroth, Brian Chicoine

Advocate GME

No abstract provided.

Is Originalism Orthodoxy?, Neel Sukhatme

Articles

What theory of constitutional interpretation has the Supreme Court followed? We search Supreme Court opinions for a wide range of sources that originalists identify as central to their methodology, over the entire universe of cases beginning in 1791. We find that for much of Supreme Court history, conventional indicators of originalist practice--citations to Founding-era sources--are largely absent, raising questions about originalism's past orthodoxy. Originalist citation practices are absent for much of the 19th century and grow sharply in the late 20th century. The Article elaborates the implications of these findings for debates in constitutional law.

Sammy Group Llc V. Collins

All Decisions

After trial on the tenant's counterclaims of breach of warranty of habitability, harassment, and rent overcharge, the court entered judgment for the tenant on all three. The subject apartment was found to be an unlawful combination of predecessor apartments whose legal rent was never registered with DHCR, requiring application of the default formula under RSC § 2522.6(b)(3) to calculate overcharge damages. The court awarded a rent abatement, civil penalties for harassment, and entered an order enjoining the landlord from further harassing the tenant.

Keeping Local Produce Safe: N.H. Farmers Get Assistance From Extension, Adam Drapcho

UNH Today Archive

No abstract provided.

Raymond Rodriguez V. Loyal Source Government Services

2026 Decisions

USDC for the Middle District of Pennsylvania

Dupilumab For Patients With Allergic Fungal Rhinosinusitis, Amber U Luong, Joshua M Levy, Sarah K Wise, Joseph K Han, Mamoru Yoshikawa, Luo Zhang, Rodney Schlosser, Prerna Ranganathan, Paula Dakin, Jennifer Maloney, George D Yancopoulos, Andrew P Fontenot, Neelam A Phadke, Lacey R Robinson

The Brown Foundation: Institute of Molecular Medicine

Background: Allergic fungal rhinosinusitis (AFRS) is a severe subtype of chronic rhinosinusitis characterized by fungal hypersensitivity and accentuated type 2 inflammation. Dupilumab-a fully human mAb blocking IL-4/13, approved for type 2 inflammatory diseases, including chronic rhinosinusitis with nasal polyps-may benefit patients with AFRS.

Objective: We sought to understand the effect of dupilumab in AFRS.

Methods: In this phase 3 trial, patients with AFRS age ≥6 years were randomized to dupilumab or matched placebo for 52 weeks. The primary end point was Lund-Mackay computed tomography score, quantifying sinus opacification, at 52 weeks. Secondary end points were multiplicity-controlled and hierarchically tested.

Results: …

Effects Of Non-Surgical Periodontal Therapy On Dental Plaque Microbiome, Qingguo Wang, Bing-Yan Wang, Derek Wilus, Hua Xie

Faculty, Staff and Student Publications

Periodontitis, a chronic inflammatory disease affecting approximately 40% of U.S. adults aged 30 years and older, is characterized by dysbiosis of the dental plaque microbiome. However, although scaling and root planing (SRP) is the cornerstone of periodontal treatment, its effects on the taxonomic composition and functional potential of the dental plaque microbiome remain incompletely understood. In this study, we used whole-metagenome shotgun sequencing to characterize taxonomic composition and functional potential in dental plaque microbiomes collected from 39 patients with Stage II or III generalized periodontitis before and 3–4 months after SRP. Consistent with clinical improvement, periodontal therapy significantly reduced probing …

La\'Keya Keo V. Wellspan York Hospital

2026 Decisions

USDC for the Middle District of Pennsylvania

Reseña Del Libro Introducción Al Estudio Del Discurso Digital En Español, De M. E. Placencia Y A. Parini (Eds.) (2024), New York: Routledge, David Sanchez-Jimenez

Publications and Research

Se trata de una reseña del libro Introducción al estudio del discurso digital en español, editado por  M. E. Placencia y A. Parini

Availability Of Cannabinoid-Infused Products In Corner Stores In Franklin Park, Allentown, Abigale Brosious, Joselyn Correa-Melendez Dhsc, Mph, Kimberly C. Brown Md

Research Scholars

No abstract provided.

Whole-Life Carbon–Cost–Circularity Optimization For Ai-Era Data Centers: A Robust Multi-Objective Framework Under Carbon Pricing Uncertainty, Arezou Shafaghat, Da Hu, Ali Keyvanfar

Faculty Articles

The explosive growth of artificial intelligence workloads has triggered unprecedented data center construction, yet environmental assessment remains focused on operational energy efficiency. This paper introduces DC-WLC3O, a framework that simultaneously optimizes three objectives across the full data center lifecycle: whole-life cost, whole-life carbon, and material circularity index. The framework integrates cradle-to-cradle lifecycle assessment with dynamic material flow analysis, employing a four-layer analytical stack: Monte Carlo simulation with Latin Hypercube Sampling and Iman–Conover rank correlation; NSGA-III tri-objective Pareto optimization; Sobol’ variance-based global sensitivity analysis; and Many-Objective Robust Decision Making (MORDM). The framework evaluates 192 design configurations for a 30 MW hyperscale …

Developing Three-Dimensional (3d) Skin Models To Study The Interaction Between The Skin Microbiome And Immune Cells In Chronic Wounds, Laith Basch, Asha Gopu, Hannah Welp, Mahnoor Mukarram, Precious Ochuwa Imokhai, Kim Huynh, Shantanu Amin, Randy Jacobs

Student Publications

Developing three-dimensional (3D) skin models provides a physiologically relevant platform to investigate the dynamic interactions between the skin microbiome and immune cells in chronic wounds, offering insights into delayed healing, persistent inflammation, and microbial dysbiosis. Traditional in vitro models fail to replicate the complex architecture of human skin and its immune-microbiome crosstalk, motivating the development of biomimetic systems that incorporate stratified epidermal layers, dermal fibroblasts, and innate immune components such as macrophages and neutrophils. Engineered 3D skin constructs inoculated with wound-associated microbiota, including Staphylococcus aureus, Pseudomonas aeruginosa, and Cutibacterium acnes, can reveal how biofilm formation, quorum sensing, …

Board Of Trustees Agenda, Jul. 24, 2026, Indiana State University Board Of Trustees

Board of Trustees

Indiana State University Board of Trustees meeting agenda

Board Of Trustees Minutes, Jul. 24, 2026, Indiana State University Board Of Trustees

Board of Trustees

Indiana State University Board of Trustees meeting minutes

Development And Psychometric Evaluation Of A Medical Device-Related Pressure Injury Risk Assessment Scale, Ayise Karadag, Aleyna Uçanbelen, Öznur Erbay Dalli

Individual Articles

Medical device–related pressure injuries are a significant and largely preventable patient safety problem, yet existing pressure injury risk scales do not adequately capture device-specific risk factors in adults. This methodological study developed and psychometrically evaluated a standardized risk assessment scale to identify medical device–related pressure injury risk in hospitalized adult patients. An initial item pool was generated from an extensive literature review and clinical expertise, and content validity was assessed by seven experts using the Davis technique (content validity index = 0.96). The scale was administered to160 adults receiving at least one medical device in medical, surgical and oncology wards …

Identity-Dependent Externalities Can Mitigate Overbidding In Tullock Contests: Theory And Evidence, Dan Kovenock, Jian Song, Francesco Trevisan

ESI Working Papers

We investigate how identity-dependent externalities infuence bidding behavior in Tullock lottery contests. While experimental studies of standard contests, in which losers are indiferent to the winner’s identity, consistently document overbidding, the role of identity-dependent preferences remains less explored. We address this gap by frst showing that the class of three-player Tullock lottery contests with identity-dependent externalities considered here can be mapped into a standard Tullock lottery contest with appropriately chosen prize valuations and endowments, yielding identical Nash equilibrium predictions. We then use this mapping to design a laboratory experiment that directly compares the two “equilibrium-equivalent” contest formats. In our three-player …

Loss Of Nemp1 Disrupts Female Meiosis And Activates A Conserved Atm-Chk2 Checkpoint, Bilal Ahmad Hakim, Yonit Tsatskis, Ling Zhang, Esther Choi, Ying Zhang, Didier Hodzic, Que Wu, Muyun Zhang, Maryam Pashaei, Kyungwon Ha, Jannette Rusch, Julie A Brill, Miguel Angel Brieño-Enríquez, Andrea Jurisicova, Helen Mcneill

2020-Current year OA Pubs

Female germ cells must preserve the integrity of their genome and generate genetic diversity via meiotic recombination. This challenging process is error prone. Highly conserved checkpoint pathways detect errors in recombination and DNA damage, inducing the death of defective oocytes. Nuclear Envelope Membrane Protein (NEMP) homologs are highly conserved proteins critical for fertility in flies, worms, fish and mice. They localize to the inner nuclear envelope where they provide mechanical support. However, why NEMP homologs are specifically required for fertility is still unclear. Using both Drosophila and mouse models, we establish that loss of NEMP homologs leads to activation of …

Entity Labels Are Not Entity Signals: A Framework For Observable Relevance In Document Re-Ranking, Utshab Kumar Ghosh, Shubham Chatterjee

Computer Science Faculty Research & Creative Works

Entity-aware document retrieval uses query-associated entities as ranking signals, assuming that semantically relevant entities are also useful retrieval signals. We show this assumption is insufficient - and explain why. Unlike terms, which are ground-truth observations, entity links are hypotheses produced by an imperfect linker: an entity can be topically central yet provide no discriminative signal if the linker fires indiscriminately across relevant and non-relevant documents. We formalize this as a distinction between Conceptual Entity Relevance (CER) - whether an entity is topically related to a query - and Observable Entity Relevance (OER) - whether its observed presence in a collection …

The Aga Khan University Charter

Charter of the University

No abstract provided.

Decision In Art. 78 Proceeding - Chrysler, Gregory (2026-06-30)

Decisions in Art. 78 Proceedings

No abstract provided.

Decision In Art. 78 Proceeding - Quinones, Jose (2026-07-22)

Decisions in Art. 78 Proceedings

No abstract provided.

600 Parks, Reservations And Antiquities Rocky Mountain National Park Lands- General, Part One, File 12-15, Box 402, Enos A. Mills, E. J. Ayers, Arno B. Canmerer

Rocky Mountain National Park

Document contains information on additional land that is suggested to be acquired into the National Park East of Estes Park. There is a telegram within this document as well as a news clipping informing us of the weather conditions in Estes Park are affecting the area's animal population. Stephen T. Mather; R. B. Marshell; Gem Lake; Estes Park Village; Deer Mountain; Horseshoe Park; Tahosa Land Track; Twin Peaks; Colorado National Forest; Enos A. Mills; C. R. Trowbridge; George S. Fuller; E. J. Ayers; Long's Peak; L. C. Way; Lily Lake; Glacier National Park; Glacier Park Motel Company;

600 Lands Peter Hondius 1929-1932, Solinksy Files, File #2, Box 402, Pieter Honduis, E. J. Ayers, Arno B. Canmerer

Rocky Mountain National Park

Document covers correspondence for the Houdius Pipeline within Rocky Mountain National Park. During the discussion, there is a mention of a telegraph at Palm Springs, California. Loma Linda, California; Beaver Valley; Palm Springs, California; Pieter Hondius; Ab H. Romans; F.J. Solinsky Jr.; Edmund B. Rodgers; The Title Guaranty Company; Hondius Water Supply System;

600 Parks, Reservations And Antiquities Rocky Mountain National Park Lands. File No. 12-15, Box 402, L. E. Way, Arno B. Cammerer, Abuen E. Sprague, Stephen T. Mather, Rodger W. Toll

Rocky Mountain National Park

Document is correspondence for the changing of private to public lands. Pieter Hondius; Horseshoe Park; L. E. Way; Arno B. Cammerer; O. W. Bechtel; Abner E. Sprague; Glacier Basin; Estes Park Bank; M. Alberta Sprague; Mabel Stopher; Sprague Lake; Stephen T. Mather; Rodger W. Toll;

600 Lands Patented #2, Fil No. 12-15, Box 402, Arno B. Cammerer, L. E. Way, Rodger W. Toll

Rocky Mountain National Park

Document contains the correspondence of individuals claiming property and homesteading within the Rocky Mountain National Park. Charles L. Duer; Robert Harbison; Julius Christiansen; Glenn Cogill; Gilcrest; Arno B. Cammerer; L. C. Way; A. N. House; Arizona District; Fort Collins; Grand Lake; A. D. Lewis; Abner E. Sprague; R. H. Malone; Glacier Basin; Longs Peak; Lake Mills; Loch Lake; Rodger W. Toll;

600 Rocky Mountain National Park- General 1930 To 1931, Box 402, Horace M. Albright, Francis O. Stanley, Arno B. Cammerer, Joseph S. Dixson, Pieter Hondius, Charles W. Eliot

Rocky Mountain National Park

Document contains information about the bodies of waters, waterways, boundary lines, roads and structures of the general plan for the Rocky Mountain National Park. Frank J. Solinsky Jr.; Willard H. Ashton; Edwin Jackson; Glacier Park; E. S. Allen; H. K. Allen; Emil O. Schubert; Wm. Sibley; Peter Hondius, James D. Stead Estate; Abner E. Sprague; F. O. Stanley; Charles (Jack) H. Woods; M. I. McPherson Estate; John Griffith; Fred Bunnell; Henery E. Bunnell; Harry E. Blinn; Chas. Chapman; E. L. Reed and sons; Minnie E. March; Esther B. Mills; Joe Mills; Y.M.C.A. Estes Park Conference; Y. M. C. A. Executive …

600 List Of Patented And Entered Lands Within Rocky Mounntain National Park, Box 401, Stephen T. Mather, Horace M. Albright, Alexander T. Vogelsang, L. C. Way, Clay Tallman, Dean Babcock, A E. Sprague

Rocky Mountain National Park

Document contains a map and supporting documents of Rocky Mountain National Park's boundary lines, homesteads, rivers, lakes, state school lands and ranger stations. Stephen T. Mather; James S. Jenks; John B. Copeland; David K. Daniels; William L. McGill; Greeley W. Whiteford; Frank G. Bartholf; Alexander Adams; Lizzie Disckerson; Louise J. Adams; Robert L. Sutherland; Annie C. Gregg; James Cairns; Rebecca E. Mclaren Smith; Andrew K. Harbison; Samuel Stone; James W. Mitchell; Annie Harbison; Kate Harbison; Benjamin J. Mitchell; Ezra H. Kauffman; John H. Hedrick; Isaac P. Maryield; Christian F. Young; Charles F. Hertel; Danial J. March; Almond N. House; Mark …

600 Lands Rocky Mountain National Park (General) 1932 Solinsky Part One, Box 402, Francis O. Stanley, William R. Kelley, F. J. Solinski Jr.

Rocky Mountain National Park

Document contains correspondents regarding the acquisition of the land and property around the borders of the Rocky Mountain National Park. It does include some information about the titling of the property during the accusation. F. J. Solinsky Jr.; Title Guaranty Company; William R. Kelly; Edmund Rodgers; Little Thompson River; Moraine Park; Y.M.C.A.; J. E. Smith; Exchange National Bank of Colorado Springs; Eugene Autrey; Charles H. Woods; John N. Griffith; Ernest C. Gooch; Alma M. Gooch; Harry E. Blinn; William White; Donald G. Kilton; John M. B. Petrikin; E. S. Allen; H. K. Allen; Thala M. Bunnell; Watkins National Bank; Charles …

600 Lands Rocky Mountain National Park (General) 1932 Solinsky Part Two, Box 402, F. J. Solinski Jr., A. W. Albright

Rocky Mountain National Park

Document that discusses the cancellation of the acquisition of the Hondius pipeline and other contracts dealing with his property in Rocky Mountain National Forest. Estes Park Municipal Water System; Division of Water Rights; The Title Guaranty Company; California Pacific Title and Trust Company; Pieter Hondius; Caushatapa Indians; Colonial National Monument, Virginia; Zion National Park; Glacier National Park; A. W. Albright; W. Rodgers; Beaver Valley; Beaver Creek; Nab Park; Horseshoe Park; Beaver Ranch; Fall River; C. A. Carlton; Hondius Pipeline;