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The Kdm-Family Inhibitor Jib-04 Sensitizes Aml Cells To Venetoclax By Inducing A Ferroptosis-Like Phenotype, Katharina Wohlan, Dandan Fan, Anna G Guzman, Alexis Quezada, Hyunji Park, Elmira Khabusheva, Farzane Sivandzade, Matthew Wither, Amber Alcorn, Tamara Thevarajah, Steven M Kornblau, Courtney D Dinardo, Jianzhong Su, Margaret A Goodell, Rachel E Rau Aug 2026

The Kdm-Family Inhibitor Jib-04 Sensitizes Aml Cells To Venetoclax By Inducing A Ferroptosis-Like Phenotype, Katharina Wohlan, Dandan Fan, Anna G Guzman, Alexis Quezada, Hyunji Park, Elmira Khabusheva, Farzane Sivandzade, Matthew Wither, Amber Alcorn, Tamara Thevarajah, Steven M Kornblau, Courtney D Dinardo, Jianzhong Su, Margaret A Goodell, Rachel E Rau

Faculty, Staff and Students Publications

Acute myeloid leukemia (AML) is an aggressive hematological malignancy with various molecular and cytogenetic subtypes. Treatment options for older adult patients are limited due to high toxicity of conventional chemotherapy. The B-cell leukemia/lymphoma 2 inhibitor venetoclax is effective in combination with hypomethylating agents or low-dose cytarabine, but ∼30% of patients do not respond to the initial combination treatment. Thus, alternative combinations are needed to sensitize AML cells to venetoclax and overcome resistance mechanisms. Here, we report that targeting histone lysine-specific demethylases induces a ferroptosis-like phenotype driven by oxidative stress in various AML subtypes. In both patient samples and cell lines, …


Indications, Techniques, And Safety Of Cryotherapy And Cryobiopsy Via Flexible Bronchoscopy In Pediatric Patients, Alex J Katz, Haley Haskett, Kubra M Bozkanat, Aoife Corcoran, Lauren M C Grant, Antoinette Wannes Daou, Sin Tran, Esra Caylan, Alfin Vicencio, Dan T Benscoter, Cherie A Torres-Silva, Sara M Zak, Gregory Burg, Lisa R Young, Pelton Phinizy, Shailendra Das, Richard Paul Boesch, Erik B Hysinger, Joseph Piccione Aug 2026

Indications, Techniques, And Safety Of Cryotherapy And Cryobiopsy Via Flexible Bronchoscopy In Pediatric Patients, Alex J Katz, Haley Haskett, Kubra M Bozkanat, Aoife Corcoran, Lauren M C Grant, Antoinette Wannes Daou, Sin Tran, Esra Caylan, Alfin Vicencio, Dan T Benscoter, Cherie A Torres-Silva, Sara M Zak, Gregory Burg, Lisa R Young, Pelton Phinizy, Shailendra Das, Richard Paul Boesch, Erik B Hysinger, Joseph Piccione

Faculty, Staff and Students Publications

Rationale: Cryotherapy and its diagnostic analogue, cryobiopsy, are emerging techniques via bronchoscopy with a wide range of clinical applications. While the use of cryotherapy and cryobiopsy has been established in adult pulmonary medicine, pediatric data describing the indications, procedural specifics, outcomes, and complications are limited.

Objective: To describe the indications, procedural specifics, outcomes, and complications of cryotherapy and cryobiopsy use in pediatric bronchoscopy.

Methods: A multicenter retrospective observational study was conducted at 5 pediatric hospitals in the United States. Patients aged 0 to 21 years who underwent cryotherapy or cryobiopsy via bronchoscopy between January 2017 and January 2025 were included. …


Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh Aug 2026

Proteomic Signatures Of 3-Year Progression From Impaired Fasting Glucose To Diabetes: The Atherosclerosis Risk In Communities (Aric) Study, Mary R Rooney, Justin B Echouffo Tcheugui, Jingsha Chen, Keenan A Walker, Christie M Ballantyne, Eric Boerwinkle, Tanika N Kelly, Chiadi E Ndumele, James S Pankow, Morgan E Grams, Wendy S Post, Peter J Ganz, Alexis C Wood, Jerome I Rotter, Elizabeth Selvin, Josef Coresh

Faculty, Staff and Students Publications

Objective: To identify proteomic signatures underlying 3-year progression from impaired fasting glucose (IFG) to diabetes.

Research design and methods: We examined IFG progression in the Atherosclerosis Risk in Communities (ARIC) study from visit 2 (1990-1992) to visit 3 (1993-1995). We tested associations of 4,955 plasma proteins (SomaScan version 4.0) with ∼3-year progression from IFG (FG 100-125 mg/dL without diabetes) to diabetes (diagnosis, medication, or FG ≥126 mg/dL) using logistic regression models adjusted for demographics, cardiometabolic risk factors, and baseline glucose with Bonferroni correction (P < 10-5). We explored biological pathways enriched among the top proteins and calculated improvements in prediction (ΔAUC and net reclassification using 3-year risk thresholds of 6% and 15% in 80% training and 20% internal validation subsamples). We validated results in the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.

Results: There were 3,786 ARIC participants with IFG (mean [SD] age 57 [6] years, 52% female, …


Obsessive-Compulsive Training Experiences In United States (Us) Medical School Education Programs, Carlos Valenzuela-Flores, Leanne Maduka, Dale Shepherd, Megan C Alam, Juliana E Avery, Hannah C Moore, Gian Depamphilis, Megan M Dailey, Caitlin M Pinciotti, Andrew D Wiese, Wayne K Goodman, Eric A Storch Aug 2026

Obsessive-Compulsive Training Experiences In United States (Us) Medical School Education Programs, Carlos Valenzuela-Flores, Leanne Maduka, Dale Shepherd, Megan C Alam, Juliana E Avery, Hannah C Moore, Gian Depamphilis, Megan M Dailey, Caitlin M Pinciotti, Andrew D Wiese, Wayne K Goodman, Eric A Storch

Faculty, Staff and Students Publications

Objective: To evaluate the content and structure of OCD-specific training within United States osteopathic (D.O.) and allopathic (M.D.) medical schools. Although many physicians encounter patients with obsessive-compulsive disorder (OCD) in clinical practice, limited familiarity with the full range of OCD presentations, including typical and atypical forms, may contribute to misdiagnosis and delays in accurate diagnosis and treatment.

Methods: Respondents from 35 of the 154 (22.73%) medical schools within the United States (28 (80%) allopathic, 7 (20%) osteopathic schools) completed a survey assessing demographics, school information, and OCD-focused training within medical school curriculums. Descriptives were gathered to characterize the level of …


Achilles Tendon Injuries In Major League Soccer: A 10-Year Analysis Of Injury Rate, Return To Play, And Performance Metrics, Brian Forsythe, Catherine Hand, Francis Hand, Henry Eilen, Matthew Varano, Jared Sasaki, Camden Bohn, Anne Timmermann, Lauren Fertig, Eric Giza, Robert H Brophy, Bert Mandelbaum, Kirk Mccullough Aug 2026

Achilles Tendon Injuries In Major League Soccer: A 10-Year Analysis Of Injury Rate, Return To Play, And Performance Metrics, Brian Forsythe, Catherine Hand, Francis Hand, Henry Eilen, Matthew Varano, Jared Sasaki, Camden Bohn, Anne Timmermann, Lauren Fertig, Eric Giza, Robert H Brophy, Bert Mandelbaum, Kirk Mccullough

2020-Current year OA Pubs

BACKGROUND: Injuries to the Achilles tendon, such as tears or ruptures, are commonly observed among elite athletes. These injuries can be debilitating for professional soccer players, leading to prolonged recovery and potential performance declines.

PURPOSE: To investigate the annual incidence, return-to-play (RTP) duration, and postinjury performance outcomes of Major League Soccer (MLS) players who sustained Achilles tendon injuries from 2010 to 2021.

STUDY DESIGN: Cohort study; Level of evidence, 3.

METHODS: This retrospective matched-cohort study evaluated MLS players with Achilles tendon injuries from 2010 to 2021, identified through the MLS Injury Surveillance database, and compared outcomes, including RTP duration, between …


Dupilumab Versus Placebo In Adults And Adolescents With Eosinophilic Gastritis (Degas): A Double-Blind, Placebo-Controlled, Phase 2, Multicentre, Randomised Controlled Trial, Nirmala P Gonsalves, Evan S Dellon, Kara L Kliewer, Tetsuo Shoda, Regina Yearout, Seema S Aceves, Nicoleta C Arva, John A Besse, Julie M Caldwell, Mirna Chehade, Amaziah Coleman, Margaret H Collins, Sara Anvari, Gary W Falk, Sandeep K Gupta, Girish Hiremath, David A Katzka, Paneez Khoury, John Leung, Calies Menard-Katcher, Paul Menard-Katcher, Kathryn A Peterson, Maria A Pletneva, Amanda K Rudman Spergel, Jonathan M Spergel, Tatyana Vaysman, Joshua B Wechsler, Benjamin L Wright, Guang-Yu Yang, Xue Zhang, Meijian Zhou, Ashish Bansal, Bram P Raphael, Amr Radwan, Jennifer Maloney, Antonio Martin, Yamo Deniz, Glenn T Furuta, Lisa J Martin, Marc E Rothenberg Aug 2026

Dupilumab Versus Placebo In Adults And Adolescents With Eosinophilic Gastritis (Degas): A Double-Blind, Placebo-Controlled, Phase 2, Multicentre, Randomised Controlled Trial, Nirmala P Gonsalves, Evan S Dellon, Kara L Kliewer, Tetsuo Shoda, Regina Yearout, Seema S Aceves, Nicoleta C Arva, John A Besse, Julie M Caldwell, Mirna Chehade, Amaziah Coleman, Margaret H Collins, Sara Anvari, Gary W Falk, Sandeep K Gupta, Girish Hiremath, David A Katzka, Paneez Khoury, John Leung, Calies Menard-Katcher, Paul Menard-Katcher, Kathryn A Peterson, Maria A Pletneva, Amanda K Rudman Spergel, Jonathan M Spergel, Tatyana Vaysman, Joshua B Wechsler, Benjamin L Wright, Guang-Yu Yang, Xue Zhang, Meijian Zhou, Ashish Bansal, Bram P Raphael, Amr Radwan, Jennifer Maloney, Antonio Martin, Yamo Deniz, Glenn T Furuta, Lisa J Martin, Marc E Rothenberg

Faculty, Staff and Students Publications

Background: Eosinophilic gastritis currently has no approved treatments and is postulated to be driven by type 2 inflammation. Dupilumab blocks type 2 cytokines IL-4 and IL-13 and has efficacy in multiple diseases characterised by type 2 inflammation, including eosinophilic oesophagitis. We aimed to assess the efficacy and safety of dupilumab in patients with eosinophilic gastritis.

Methods: DEGAS was a proof-of-concept, phase 2, multicentre, randomised controlled trial consisting of a 12-week, double-blind, placebo-controlled period, followed by a 24-week open-label extension period. Patients aged 12-70 years from 11 hospitals in the USA with histologically active eosinophilic gastritis (≥30 eosinophils per high-power field …


610 Paul Ross Tract #221 & 256 File, Land Acquisition Of The Ross Property In The Rocky Mountain National Park, Box 106, Paul Ross, Gertrude R. Ross, Howard W. Baker, David H. Canfield Jul 2026

610 Paul Ross Tract #221 & 256 File, Land Acquisition Of The Ross Property In The Rocky Mountain National Park, Box 106, Paul Ross, Gertrude R. Ross, Howard W. Baker, David H. Canfield

Rocky Mountain National Park

Documents contain information about the acquisition of the Ross property in the Rocky Mountain National Park. This document includes many memoranda and letters about this acquisition. There is a letter from Mr. Ross expressing concern for the Park Service discouraging development in the area on private land while waiting for more Federal funds to purchase the land. Paul Ross; Gertrude R. Ross; A. E. Demaray; Howard W. Baker; David H. Canfiled; Baldwin Ditch; H. U. Taylor;


610 Smith Tract 316a File, Box 106, Oscar Chapman, Mosses E. Smith Jul 2026

610 Smith Tract 316a File, Box 106, Oscar Chapman, Mosses E. Smith

Rocky Mountain National Park

Document containing various letters and memoranda dealing with selling land within the Rocky Mountain National Park area. David H. Canfield; Oscar L. Chapman; Moses E. Smith; Grand Lake; North Fork River; Colorado River;


620 Orin Frantz Snyder Tract #159 File Box 106, George F. Ingalls, Harry K. Sanders Jul 2026

620 Orin Frantz Snyder Tract #159 File Box 106, George F. Ingalls, Harry K. Sanders

Rocky Mountain National Park

Document contains information about the acquisition of the Snyder and Harbison Ranch lands in the Rocky Mountain National Park. George F. Ingalls; Harry K. Sanders; Snyder Ranch; Harbison Ranch; Harbison Pipeline; Sunny Slope Pipeline; Pieter Hondius; Fall River; Anna Frantz Snyder; Riley Harshbarger; Fall River Pipeline; Big Horn Creek; Organ Pipe Cactus National Monument; Cedar Breaks; Bryce Canyon; Death Valley; Saratoga Springs; Harbison Meadows;


660.05 4 Reservoirs (Dams) File, Inspection Of Lawn Lake Dam, Box 113, Howard W. Baker, David H. Canfield, Richard T. Montgomery Jul 2026

660.05 4 Reservoirs (Dams) File, Inspection Of Lawn Lake Dam, Box 113, Howard W. Baker, David H. Canfield, Richard T. Montgomery

Rocky Mountain National Park

Document contains field surveys of the Lawn Lake Dam along with maps and schematics of the Lawn Lake Dam. Arno B. Cammerer; Howard W. Baker; David H. Cranfield; Richard T. Montgomery; Lawn Lake Dam; A. D. Soderberg; South Platte River District; Richard Degenhardt; Lawn Lake Dam and Spillway; Lily Lake; Fish Creek; South St. Vrain Highway; Big Thompson Project; Olympus Dam; Lake Estes; J. H. Knights;


660.05, Pipeline Job Position And Job Description In The Rocky Mountain National Park, Vol 1 Of 2 File #2 Box 113, John E. Doen, Caroll H. Wegemann, Pual V. Brown, Eleanor E. Hondius, Joseph E. Taylor, John S. Mclaughlin, David H. Canfield Jul 2026

660.05, Pipeline Job Position And Job Description In The Rocky Mountain National Park, Vol 1 Of 2 File #2 Box 113, John E. Doen, Caroll H. Wegemann, Pual V. Brown, Eleanor E. Hondius, Joseph E. Taylor, John S. Mclaughlin, David H. Canfield

Rocky Mountain National Park

Document contains information from legal correspondence to memorandums surrounding the work crew and project outlines for the Honduis - Beaver Pipeline area. John E. Doen; Caroll H. Wegemann; Pual V. Brown; Eleanor E. Hondius; Joseph E. Taylor; John S. McLaughlin; David H. Canfield; A. van V. Dunn; CCC Job 2067-143; Lower Honduis - Beaver Pipeline; Hupp Spring; Beaver Meadows; Mill Creek; W. E. Dixon; Pieter Hondius; Emch Cottage; Moore Cottage; Timber Creek Campground; Inspector Dunham; G. A. Moskey; Sunny Slope Pipeline; Beaver Creek Ditch; A. Griffith; Worth Allen ; J. W. Kelley; Fleshuts Ditch; Timber Creek; Colorado- Big Thompson Project; …


660.05 Water Vol 1 Of 2, File #1,Rocky Mountain National Park, Colorado, Water Rights, Box 113, David H. Canfield, Stanley C. Joseph, Hillary A. Solson, Howard W. Baker, Chas. J. Smith, A. W. Burney, A. Van V. Dunn, Paul V. Brown, George W. Fry, Thos. J. Allen Jul 2026

660.05 Water Vol 1 Of 2, File #1,Rocky Mountain National Park, Colorado, Water Rights, Box 113, David H. Canfield, Stanley C. Joseph, Hillary A. Solson, Howard W. Baker, Chas. J. Smith, A. W. Burney, A. Van V. Dunn, Paul V. Brown, George W. Fry, Thos. J. Allen

Rocky Mountain National Park

Document contains information about the construction project for water service in the Rocky Mountain National Park. David H. Canfield; Stanley C. Joseph; Hillary A. Solson; Howard W. Baker; Chas. J. Smith; A. W. Burney; A. van V. Dunn; Paul V. Brown; George W. Fry; Thos. J. Allen; Sprague's Lodge; Mountainside Lodge; Bear Lake Lodge; Rocky Mountain Motor Company; Hugh M. Miller; Grand Lake Lodge; C. T. Wright; Roe Emery; Brinwood Hotel; McGreggor Meadow; Black Canyon Water System; Hondius - Beaver Pipeline;  James M. Siller; Minni March; Horseshoe Pipeline; Glacier Creek; Glacier Basin Campground; Hupps Ditches; Beaver Ditches; Bear Lake; Nymph …


660.05 Water Vol 2, 2 Of 2 File, Acquisition Of The Water Rights Of The Long Peak Campground, Box 113, John S. Mclaughlin, A. Van V. Dunn, Joseph E. Taylor, Oscar L. Chapman, Harry Slattery Jul 2026

660.05 Water Vol 2, 2 Of 2 File, Acquisition Of The Water Rights Of The Long Peak Campground, Box 113, John S. Mclaughlin, A. Van V. Dunn, Joseph E. Taylor, Oscar L. Chapman, Harry Slattery

Rocky Mountain National Park

Document contains information about the acquisition of water rights within the Rocky Mountain National Park. There are many correspondences to and from attorney Taylor. This document does give some information about property owners. John S. McLaughlin; A. van V. Dunn; Joseph E. Taylor; Oscar L. Chapman; Harry Slattery; Long Peaks Campground; Sunny Slope Pipeline; Sprague Pipeline; Sprague Ditch; Hondius Water System; W. R. Willard; F. F. Briggs; J. S. Fitzgerald; Wayne Hackett; Glacier Creek; Worth Allen; Winter vs United States; Harbison Estate; Roy Adams; Charle H. Woods; John Tomothy Stone; Camp Woods; J. M. Denning; Owl Pipeline; Hollowell Park Pipeline; …


660.05 Water Vol 3, 2 Of 2 File, Plans And Specifications For Beaver Brook Pipeline, Box 113, William E. Robertson, David H. Canfield, Howard W. Baker, Mastin G. White, George W. Miller, C. T. Carnahan, C. C. Mullady Jul 2026

660.05 Water Vol 3, 2 Of 2 File, Plans And Specifications For Beaver Brook Pipeline, Box 113, William E. Robertson, David H. Canfield, Howard W. Baker, Mastin G. White, George W. Miller, C. T. Carnahan, C. C. Mullady

Rocky Mountain National Park

Document contains information about new water supply lines and other correspondence. William E. Robertson; David H. Canfield; Howard W. Baker; Mastin G. White; George W. Miller; C. T. Carnahan; C. C. Mullady; Beaver Brook Pipeline; Morain Park; Moraine  Reservoir; Hondius Beaver Pipeline; Moraine Museum; Beaver Creek; Va Marmaduke; Paul R. Heeney; William Veeder; Colorado- Big Thompson Project; Timber Creek Water System; Tonahutu Creek; Mill Creek Camp; Beaver Meadows; Birtch Creek Springs; Empire Water and Power Company v. Cascade Town Company;


660.05 Rmnp Water Vol File, Water Right Filings, Box 113, John S. Mclaughlin, A Van V. Dunn, D. E. Lee, Arno B. Cammerer, Joseph E. Taylor, Howard W. Baker, Ross L. Heater, S. W. Berney, H. B. Hammon, David H. Canfield, Thos, J. Allen, Earl A. Trager, Noble P. Hollister Jul 2026

660.05 Rmnp Water Vol File, Water Right Filings, Box 113, John S. Mclaughlin, A Van V. Dunn, D. E. Lee, Arno B. Cammerer, Joseph E. Taylor, Howard W. Baker, Ross L. Heater, S. W. Berney, H. B. Hammon, David H. Canfield, Thos, J. Allen, Earl A. Trager, Noble P. Hollister

Rocky Mountain National Park

Document contains many kinds of water source documents for lakes, reservoirs, and other sources. John S. McLaughlin; A. van V. Dunn; D. E. Lee; Arno B. Cammerer; Joseph E. Taylor; Howard W. Baker; Ross L. Heater; S. W. Berney; H. B. Hommon; David H. Canfield; Thos. J. Allen Jr.; Earl A. Trager; Noble P. Hollister; Brinwood Pipeline; Brinwood Ditches; Bear Lake; Longs Peak Campground Water System; Alpine Brook; John N. Griffith; Virginia Griffith; Hollowell Park Water System; Ganby Reservoir; Shadow Mountain Reservoir; Aspenglen Water Line; Worth Allen; Fall river Drainage; C. G. Taylor; Beaver Creek; Colorado- Big Thompson Diversion Tunnel; …


Solid State Forms Of 2-Amino-N-{[Methyl({[6-(Trifluoromethoxy)-1,3-Benzothiazol-2- Yl]Carbamoyl}Methyl)Carbamoyl]Methyl}Acetamide Hydrochloride And Process For Preparation Thereof, Msn Laboratories Private Limited, R&D Center; Hyderabad, India; Srinivasan Thirumalai Rajan; Sagyam Rajeshwar Reddy; Kommera Rajasekhar; Batchanaboina Venkata Subbaiah; Kondeti Raju; Garai Abhijit Jul 2026

Solid State Forms Of 2-Amino-N-{[Methyl({[6-(Trifluoromethoxy)-1,3-Benzothiazol-2- Yl]Carbamoyl}Methyl)Carbamoyl]Methyl}Acetamide Hydrochloride And Process For Preparation Thereof, Msn Laboratories Private Limited, R&D Center; Hyderabad, India; Srinivasan Thirumalai Rajan; Sagyam Rajeshwar Reddy; Kommera Rajasekhar; Batchanaboina Venkata Subbaiah; Kondeti Raju; Garai Abhijit

Defensive Publications Series

The present invention relates to a solid state forms of 2-Amino-N- {[methyl({[6-(trifluoromethoxy)-1,3-benzothiazol-2-yl]carbamoyl} methyl) carbamoyl] methyl}acetamide hydrochloride represented by the following structural formula-1 and process for preparation thereof. Formula-1


Improved Process For The Preparation Of 4-Chloro-1,1-Diethoxybutane, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, D Shyla Prasad, Y Bhaskar Reddy, Kamatham Raja Reddy Jul 2026

Improved Process For The Preparation Of 4-Chloro-1,1-Diethoxybutane, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, D Shyla Prasad, Y Bhaskar Reddy, Kamatham Raja Reddy

Defensive Publications Series

The present invention provides improved process for 1,1-diethoxybutane represented by the following structural formula-1.

Formula-1


The Representation Of Suicide In Spanish Teen Fiction Tv Series: Narrative Trends And Media Literacy Implications, Patricia Palomares-Sánchez, Victoria Soto-Sanz Jul 2026

The Representation Of Suicide In Spanish Teen Fiction Tv Series: Narrative Trends And Media Literacy Implications, Patricia Palomares-Sánchez, Victoria Soto-Sanz

Journal of Media Literacy Education Pre-Prints

The present study analyses the narrative treatment of suicide in Spanish youth fiction television series produced between 2015 and 2024, aiming to identify representation trends in relation to the recommendations for responsible media coverage and their implications for media literacy. The methodology underpinning this study encompasses eight fiction TV series and combines quantitative research, derived from data collection and analysis, with a qualitative component, focusing on the interpretation and analysis of the results. Findings indicate that the representation lacks due caution in depicting the method and location of suicide, which increases the risk of imitation. Although the narratives present alternatives …


Comparative Effectiveness Of Antiseptic And Antibiotic Irrigation Versus Normal Saline In Infected Total Ankle Arthroplasty: A Systematic Review, Madelaine Adkins, Yahan Wei, Amanda Killeen Jul 2026

Comparative Effectiveness Of Antiseptic And Antibiotic Irrigation Versus Normal Saline In Infected Total Ankle Arthroplasty: A Systematic Review, Madelaine Adkins, Yahan Wei, Amanda Killeen

School of Podiatric Medicine - Student Research

Introduction: Periprosthetic joint infection (PJI) is a rare but devastating complication following total ankle arthroplasty (TAA). Acute infections are commonly managed with debridement, antibiotics, and implant retention (DAIR), in which irrigation plays a critical role in reducing bacterial burden. Although irrigation protocols have been investigated in total hip and total knee arthroplasty, evidence specific to infected TAA remains unclear. This systematic review evaluated the available literature regarding irrigation practices in the surgical management of infected TAA.

Methods: A systematic review was conducted in accordance with PRISMA guidelines. PubMed and Scopus were search for English-language studies published between December 2005 and …


Same Interdependent Risk, Different Valuation: How Risk Representation Shapes Ecosystem Investment Decisions, Shiyao Bao, Jiamin Zhao, En Yang, Llewellyn D. W. Thomas, Hansjörg Neth, Jan K. Woike, Sebastian Hafenbrädl Jul 2026

Same Interdependent Risk, Different Valuation: How Risk Representation Shapes Ecosystem Investment Decisions, Shiyao Bao, Jiamin Zhao, En Yang, Llewellyn D. W. Thomas, Hansjörg Neth, Jan K. Woike, Sebastian Hafenbrädl

School of Psychology

Why do decision makers value the same risky opportunity differently when the underlying probability of success is unchanged? We study this question in ecosystem investment decisions, where success requires that none of the critical components fail, causing component risks to compound. We conducted a high-powered preregistered replication and extension of Adner and Feiler's key study (N = 3,600). Participants valued a $100,000 opportunity that required six independent components to succeed, each with a 75% chance of success, yielding an overall success probability of ≈18%. Replicating prior work, participants reported higher confidence and assigned higher valuations when they first saw the …


1770 Dean Inc V. Paul-Sommerville Jul 2026

1770 Dean Inc V. Paul-Sommerville

All Decisions

In this unregulated nonpayment proceeding, the court granted the tenant's motion for summary judgment and dismissed the petition for lack of a lease agreement. The court distinguished a prior Appellate Term holding, finding that the regulatory status of the unit made the prior decision inapplicable. The court also rejected the landlord's argument that RPL § 226-c's language about 'continuance of existing terms' creates an automatic lease renewal after expiration, holding that such an interpretation conflicts with RPL § 232-c and that payment of rent after a lease expires does not create an involuntary leasehold by statute.


Ole Miss Mortar Board Chapter Honored For Service, Overall Excellence, Mitchell Diggs Jul 2026

Ole Miss Mortar Board Chapter Honored For Service, Overall Excellence, Mitchell Diggs

University of Mississippi News

OXFORD, Miss. – The University of Mississippi chapter of Mortar Board national honor society has earned its fifth consecutive Gold Torch Award, along with several other honors, for its continuing work to promote leadership and make a difference in the community.


Gregory Hartmann V. Brian Chudzik Jul 2026

Gregory Hartmann V. Brian Chudzik

2026 Decisions

USDC for the Eastern District of Pennsylvania


Select Plasma Oxylipins As Potential Biomarkers Of Effective Indomethacin Treatment Response In Preterm Infants With Patent Ductus Arteriosus., Khanh C K Nguyen, Cindy H T Yeung, Allison Scott, Thomas J. Velenosi, Tamorah Lewis Jul 2026

Select Plasma Oxylipins As Potential Biomarkers Of Effective Indomethacin Treatment Response In Preterm Infants With Patent Ductus Arteriosus., Khanh C K Nguyen, Cindy H T Yeung, Allison Scott, Thomas J. Velenosi, Tamorah Lewis

Manuscripts, Articles, Book Chapters and Other Papers

OBJECTIVES: Patent ductus arteriosus (PDA) is one of the most common heart conditions in preterm infants, and indomethacin treatment is used for PDA closure. However, its efficacy varies among patients. This pilot study aimed to identify novel metabolic biomarkers to predict effective indomethacin response in infants with PDA.

METHODS: Preterm infants with PDA <  34 weeks gestational age were recruited and treated with indomethacin. Plasma and urine samples were collected before and 2-7 days after initial treatment. Longitudinal targeted oxylipin and untargeted metabolomics analysis were performed on plasma and urine samples.

RESULTS: Among 17 infants, 12 were responders and 5 non-responders to indomethacin treatment. Before the treatment, four plasma oxylipins: 12,13-DiHOME, 9,10-DiHOME, 15,16-DiHODE, and 9,10-DiHODE were significantly higher in responders compared to non-responders (P <  0.05). Following treatment, these oxylipins decreased in responders but remained stable in non-responders. Urinary 12,13-DiHOME showed an opposite trend, with lower baseline concentrations in the responders.

CONCLUSIONS: Pre-treatment plasma levels of four oxylipins were associated with effective PDA response to …


Oral History With John Barry, Dan Royles Jul 2026

Oral History With John Barry, Dan Royles

History Faculty Scholarship

Oral history interview with John Barry, who has served as Executive Director of the Southern Tier AIDS Program (STAP) since 2008. He was born in Endicott, New York in 1966, grew up in Vestal, and attended high school at Seton Catholic Central in Binghamton before serving in Germany with the United States Army during the early 1980s. When he returned to Broome County in 1987, some of his friends had been affected by HIV/AIDS and, while earning a degree at SUNY Binghamton, Barry became involved in mutual aid efforts to help people affected by the disease. He went to work …


Final Unreclaimed Sites Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc. Jul 2026

Final Unreclaimed Sites Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Machine Learning Integrated Designing And Screening Of 8-Hydroxyquinoline Based Metallo-Beta-Lactamase Inhibitors, Anthony M. Baudino, Kari Stone Jul 2026

Machine Learning Integrated Designing And Screening Of 8-Hydroxyquinoline Based Metallo-Beta-Lactamase Inhibitors, Anthony M. Baudino, Kari Stone

Chemistry Department Faculty Articles

The rapid emergence of metallo-b-lactamase-mediated antibiotic resistance has created an urgent need for new inhibitor discovery strategies. In this work, a machine-learning-guided workflow was developed to generate and prioritize potential inhibitors targeting NDM-1. A SMILES-based variational autoencoder was first pretrained on a broad molecular dataset to learn general chemical syntax and latent molecular representations. The model was then fine-tuned on an 8-hydroxyquinoline-enriched dataset to bias molecular generation toward zinc-binding chemical space relevant to metallo-β-lactamase inhibition. Generated compounds were processed through structural filtering and docking-based evaluation to create training data for downstream predictive modeling. Molecular fingerprints and physicochemical descriptors were then …


Codesign And Implementation Of A Tai Chi Intervention For Managing The Fatigue, Sleep Disturbance And Depression Symptom Cluster In Breast Cancer Survivors In Regional Australia: A Feasibility Study Protocol, Suellen Skinner, Wai Hang Kwok, Jing Yu Benjamin Tan, Tao Wang, Daniel Bressington, Liqun Yao, Brona Nic Giolla Easpaig Jul 2026

Codesign And Implementation Of A Tai Chi Intervention For Managing The Fatigue, Sleep Disturbance And Depression Symptom Cluster In Breast Cancer Survivors In Regional Australia: A Feasibility Study Protocol, Suellen Skinner, Wai Hang Kwok, Jing Yu Benjamin Tan, Tao Wang, Daniel Bressington, Liqun Yao, Brona Nic Giolla Easpaig

Research outputs 2022 to 2026

Introduction: Breast cancer survivors (BCS) often experience side effects such as the fatigue, sleep disturbance and depression symptom cluster (FSDSC). Previous studies have demonstrated the potential efficacy of Tai Chi (TC) for improving FSDSC in BCS in a hospital setting in China. This study will explore the feasibility, acceptability and preliminary effects of the Easy 8 Form TC protocol as an adjuvant therapy in BC survivorship care, adapted to a regional Australian community setting.

Methods and analysis: The purpose of the present study is to provide a codesigned TC protocol. This multimethod study comprises a codesign study, followed by a …


Psychological Needs And Ai Delegation Across Four Social Domains - A Cross-Cultural Analysis Of 35 Nations, Magnus Liebherr, Ala Yankouskaya, Mohamed Basel Almourad, Justin Thomas, Guandong Xu, Raian Ali Jul 2026

Psychological Needs And Ai Delegation Across Four Social Domains - A Cross-Cultural Analysis Of 35 Nations, Magnus Liebherr, Ala Yankouskaya, Mohamed Basel Almourad, Justin Thomas, Guandong Xu, Raian Ali

All Works

As artificial intelligence (AI) systems increasingly assume roles with social, educational, and emotional significance, understanding the psychological drivers behind individuals' readiness to delegate such roles to AI is crucial. Drawing on Self-Determination Theory (SDT), this study examines how the satisfaction of basic psychological needs (autonomy, competence, and relatedness) predicts individuals' readiness to delegate socially significant roles to AI across four domains (education, healthcare, mental health, and companionship) and 35 nations. Using data from over 35,000 participants in the 2023 Global Digital Wellbeing Survey, we applied Bayesian multilevel multivariate modelling to assess both global and culture-specific motivational associations. Results revealed that …


The Temporary Exhibitions Of Cristóbal Balenciaga (2015-2022), Julio González-Liendo, Trilce Navarrete Hernández Jul 2026

The Temporary Exhibitions Of Cristóbal Balenciaga (2015-2022), Julio González-Liendo, Trilce Navarrete Hernández

Artículos científicos

Este estudio realiza un análisis comparativo y retrospectivo de las estrategias de comunicación utilizadas para promocionar las exposiciones temporales de Cristóbal Balenciaga entre 2015 y 2022. Los elementos utilizados en sus planes de comunicación se identificaron mediante entrevistas semiestructuradas con los directores de comunicación de 16 espacios expositivos internacionales y con el director de comunicación del Cristóbal Balenciaga Museoa. El análisis reveló que los museos no emplean estrategias transmedia, lo que se traduce en una política de comunicación unilateral que limita la participación en redes sociales y el compromiso con la narrativa de las exposiciones. La falta de una estrategia …