Digital Commons Network^™

Heritable Transgenic Schistosomes As A Living Platform For Sars-Cov-2 Neutralizing Antibody Secretion, Wannaporn Ittiprasert, Bruce A Rosa, Sergej Djuranovic, Makedonka Mitreva, Et Al.

2020-Current year OA Pubs

We report the generation and propagation of not only the first heritable transgenic schistosome line but also a line that secretes a functional therapeutic protein in vivo. Using multiplexed CRISPR/Cas-mediated homology-directed knock-in targeted to a predicted genomic safe-harbor, we inserted a VHH-IgG1 Fc (termed C5-Fc) transgene into Schistosoma mansoni eggs. Single-miracidium infections of Biomphalaria glabrata yielded parental P0 lines; serial passage through snail and mouse hosts produced an F2 cohort in which all parasites carried the C5-Fc transgene and secreted C5-Fc into the murine venous circulation. Molecular assays confirmed chromosomal insertion, germline transmission and systemic secretion. Sera from mice harboring …

Altered Postnatal Chromatin Development In The Nucleus Accumbens Primes Enduring Stress Sensitivity, Rebekah L Rashford, Lisa Z Fang, Michael Deberardine, Hye Ji J Kim, Laura W Hirschfield, Ella Cervi, Mason R Barrett, Jeremy M Thompson, Meaghan C Creed, Catherine Jensen Peña

2020-Current year OA Pubs

Early life stress (ELS) sensitizes individuals to subsequent stressors to increase lifetime risk for psychiatric disorders. Within the nucleus accumbens (NAc)-a key limbic and reward-associated brain region-ELS sensitizes both cellular and transcriptional response to later stress, which are programmed by enduring epigenetic changes. Among the histone modifications persistently enriched by ELS in NAc is H3K4me1, which is associated with open chromatin and epigenetic priming of genomic enhancers. Here, we sought to determine whether H3K4me1 enrichment in NAc was sufficient to prime cellular and behavioral responses to adult stress. Viral-mediated overexpression of the histone H3 monomethyltransferase

Uc Resources Space And Budget Minutes 2026-08-26, Northern Illinois University

University Council Archives

No abstract provided.

Uc Resources Space And Budget Committee Agenda 2026-08-26, Northern Illinois University

University Council Archives

No abstract provided.

Fs Steering Committee Minutes 2026-08-26, Northern Illinois University

Faculty Senate Archives

No abstract provided.

Fs Steering Committee Agenda 2026-08-26, Northern Illinois University

Faculty Senate Archives

No abstract provided.

Lindenwood Digest, August 26, 2026, Lindenwood University

Lindenwood Digest

• Event & Date: The Lindenwood University Employee Digest was published on August 26, 2026, detailing campus schedules including the August 27, 2026 football home opener against Charleston Southern and the August 31, 2026 Library Services Documentary Night.

• Geographic Grounding: Activities and facilities referenced are situated at the Library and Academic Resources Center (LARC) and the Spellmann Campus Center, Lindenwood University, St. Charles, Missouri.

• Institutional Context: Academic Services transitioned its institutional title, forms, and primary administrative contacts to the Office of the Registrar effective for the Fall 2026 term.

Advancing Clean Mobility: Hydrogen Fuel Cell Electric Bus Workforce Development For Transit Agencies, Manideep Tummalapudi, Shantanu Kumar, Jaskaran Singh

Mineta Transportation Institute

Hydrogen fuel cell electric buses (FCEBs) are rapidly transforming public transportation in the United States. However, while transit agencies are investing heavily in new zero-emission vehicles and fueling infrastructure, far less attention has been paid to the workforce needed to operate and maintain them. As agencies accelerate toward ambitious climate and fleet transition goals, they are also confronting a critical challenge: preparing workers for an entirely new set of technologies, safety requirements, and operational demands. This study addresses that gap by systematically identifying the knowledge, skills, and abilities (KSAs) required for FCEB vehicle operators and maintenance technicians, assessing current training …

Allograft Tendon Pretensioning Technique Guide., Joseph R Brown, Robert W Mendicino

Surgery Articles

In foot and ankle surgery, allograft tendons are frequently used in both primary and revision cases to enhance stability and function. However, postoperative complications, such as creep, can compromise the intended correction and stability over time. This paper presents a practical guide on pretensioning techniques prior to implantation, aiming to reduce creep and improve long-term outcomes. Using two common allograft specimens, we demonstrate pretensioning methods with specific focus on tendon stitching, techniques for securing the allograft to the graft board, optimal tensioning and time parameters. We recommend pretensioning at 80 N for approximately 30 min to effectively decrease creep and …

Grounded Multi-Agent Ai System For Automated Publisher Analysis And Remediation, N/A

Defensive Publications Series

Digital publishers may face challenges in interpreting complex performance data to identify technical issues or monetization opportunities. The disclosed technology describes a system that can utilize a multi-agent artificial intelligence architecture to ingest and process varied data sources to detect anomalies. An orchestrator agent may delegate analysis to specialized sub-agents, which can use a retrieval-augmented generation engine grounded in a corpus of verifiable data to perform root cause analysis and formulate solutions. The system can present findings in a narrative format and may include an action engine to facilitate remediation, assisting users in converting performance data into actionable strategy and …

Late-Stage Semantic Disambiguation Of Multi-Hypothesis Automatic Speech Recognition In Digital Voice Platforms, Mubaraq Mishra

Defensive Publications Series

This publication describes a system and methodology for improving speech recognition accuracy in smart home devices by transitioning from early-stage transcription biasing to late-stage semantic disambiguation. Conventional automatic speech recognition architectures prematurely resolve phonetic ambiguities by selecting only the single highest-ranked transcript, which often fails when processing niche media requests, regional dialects, or voice commands in noisy environments. The described framework preserves a complete set of alternative transcript hypotheses, packages them with their respective confidence metrics into a contextual container, and forwards them to a downstream semantic processing engine. By analyzing the phonetic relationships among these hypotheses alongside contextual signals …

Plain-Language Guide To The Systemic Progress Regeneration Protocol (Sprp), Volodymyr Kotegov

Defensive Publications Series

This document serves as an operational commentary and plain-language implementation guide for the Systemic Progress Regeneration Protocol (SPRP). It translates the core theoretical constraints and validation criteria of the protocol into actionable workflows for independent developers. The guide focuses on the practical mechanics of maintaining tech lineage, executing isolation audits, and establishing onboarding steps within Phase 0 engineering domains.

In-Situ Eutectic Ultra-High-Temperature Ceramic Coatings With Dispersed Rhenium Intermetallics For Reusable Thermal Protection Systems, Volodymyr Kotegov

Defensive Publications Series

Reusable launch vehicles and hypersonic re-entry vehicles experience surface temperatures that routinely exceed 2000 °C on leading edges and nose tips. Conventional ultra-high-temperature ceramic (UHTC) coatings based on hafnium or zirconium diboride offer high melting points but remain vulnerable to thermal-shock cracking and delamination caused by coefficient-of-thermal-expansion mismatch with the underlying composite substrate.

This paper describes a coating architecture that forms its final microstructure in situ during the first high-temperature exposure. A precursor layer of HfB₂ or ZrB₂, SiC and finely dispersed rhenium-based intermetallic particles is applied to a carbon-carbon or ceramic-matrix-composite substrate. When the surface temperature reaches approximately 1800–1950 …

Junction-Stabilized Graphene Aerogels For Cryogenic Insulation And Lightweight Radiation Shielding, Volodymyr Kotegov

Defensive Publications Series

Long-duration deep-space missions and reusable cryogenic stages require insulation that remains dimensionally stable at liquid-hydrogen temperatures, adds very little mass, and provides at least modest attenuation of ionizing radiation. Conventional polymer foams become brittle and crack after repeated cryogenic cycling in vacuum. Multi-layer insulation is thermally efficient but offers almost no radiation protection and loses performance when compressed.

This paper describes a graphene aerogel whose open-cell network is locked at the sheet junctions by in-situ formed metallic nano-clusters. Two practical variants are defined: a lower-metal thermal-primary grade optimised for minimum conductivity and maximum recovery, and a higher-metal radiation-enhanced grade that …

Alternative Api Manufacturing Routes To Alimatravir (Mk-8527) - Version 1.0, Ryan Littich, Douglas Klumpp, Titas Deb, Li-Mei Jin

Defensive Publications Series

In this study, known chemical syntheses of MK-8527 (alimatravir) were examined and new synthetic routes proposed.

The baseline route to alimatravir was described in the 2015 Merck patent (WO2015148746A1). It involves a chemical synthesis of MK-8527 (no biocatalysis). Because of its similarities to islatravir (MK-8591), there has been a considerable amount of synthetic work related to this nucleoside structure. This synthetic chemistry is also briefly summarized.

Three synthetic routes are proposed with the aim of lowering the cost and improving the accessibility of MK-8527. In Proposed Route 1, the single enantiomer furanose intermediate (Cpd 31) is prepared from …

Multilingual Entity Mention Detection Using A Late-Fusion Transformer And Named-Entity-Recognition Architecture With Script-Aware Post-Filter Verification, Kaustav Saha, Shwetank Raghuvanshi, Batool Haider, Kliton Andrea, Chenhui Hu, Subramanian Srinivasan, Ashwin Kesireddy, Zscaler

Defensive Publications Series

A system and method for detecting entity mentions in multilingual text are disclosed. A shared multilingual transformer encoder produces a pooled representation from a tokenized representation of an item of text. A named-entity-recognition (NER) feature extraction module produces an NER feature vector from the item of text and a configured entity list, the NER feature vector including exact-match, fuzzy-similarity, entity-overlap, organization-entity, position-score, and mention-frequency components. A late-fusion concatenation module concatenates the pooled representation with the NER feature vector after and external to encoder layers of the shared multilingual transformer encoder to form a joint representation. A classification head produces an …

Multi-Signal Fusion Architecture For Semantic Leak Detection In Large Language Model Inputs, Kaustav Saha Saha, Shwetank Raghuvanshi, Batool Haider, Kliton Andrea, Chenhui Hu, Subramanian Srinivasan, Ashwin Kesireddy, Zscaler, Inc.

Defensive Publications Series

A system detects semantic leakage of contextual information in a prompt to a large language model (LLM) by extracting, in parallel from a reference context and a user input, a cosine similarity signal from multilingual sentence embeddings, an entity overlap signal from extracted named entities, and a number match signal from extracted numerical patterns. Fusion weights are selected from a plurality of language-tier weight profiles based on a detected language of the user input, and a fused score is computed as a weighted combination of the signals. The reference context and the user input are routed onto a fast trigger …

Sensor Fusion Method For In-Cabin Zonal Solar Load Estimation And Hvac Mode Control, Anonymous

Defensive Publications Series

Vehicle HVAC (Heating, Ventilation, and Air Conditioning) systems rely on solar load sensing to bias cabin cooling and maintain occupant thermal comfort. Conventional implementations use a single dash-mounted sunload sensor to estimate an aggregate solar heat load across the entire cabin, applying a uniform or, at best, a fixed left/right cooling bias. This approach does not account for the vehicle's actual heading relative to the sun, transient shading events, or differences in glass geometry and tint across occupant zones. This publication discloses a sensor fusion method that combines GPS-derived solar position geometry, vehicle heading, the existing single sunload sensor, and …

Timofey V V. Usa

2026 Decisions

USDC for the Eastern District of Pennsylvania

Jose Mejia-Henriquez V. Attorney General United States Of America

2026 Decisions

Agency

Bryan Shine V. County Of Montgomery

2026 Decisions

USDC for the Eastern District of Pennsylvania

Eric Harnett V. Cdc

2026 Decisions

USDC for the District of New Jersey

Optimizing Ball‐Milled Composites For Fast Energy Release Under Shock Compression, Siva Valluri, Edward Dreizin, Dana Dlott

Mechanical and Aerospace Engineering Faculty Research & Creative Works

Microparticle additives containing both Al fuel and oxidizer, fabricated by arrested reactive milling (ARM), could potentially increase the power of energetic materials such as HMX because they contain premixed fuel and oxidizer. Optimizing shock reactivity requires exploring a vast parametric space encompassing composition, milling parameters that govern microstructural features such as intraparticle voids and fuel-oxidizer mixing, and the resulting inhomogeneous shock reactivity of individual particles. To present our approach, we used a model composition 8Al⋅3CuO, previously optimized for combustion. We milled powders and prescreened different prepared batches using differential scanning calorimetry (DSC) to rule out batches with significant pre-reaction. Then …

Information Literacy Through Open Pedagogy: What’S The Role Of Ai Tools?, Virginia Clinton-Lisell

Education, Health & Behavior Studies Faculty Publications

Student engagement in developing open educational resources (OER; openly licensed materials without fees to access) may be critically important for sustainable higher education and for developing important skills. There has been substantial debate about the use of generative artificial intelligence (GenAI) for the sustainability of OER, but little empirical inquiry. In this quasi-experimental study in the United States, two sections of college students (N = 113) collaborated with their instructor to improve the sources cited in an OER textbook. In one section, students only used traditional library databases to find suitable sources (traditional; n = 55). In another section, students …

The Mundlak Estimator In A Panel Data Model With Serially Correlated Error Component Disturbances, Badi H. Baltagi, Long Liu

Center for Policy Research

This paper shows that the classic Mundlak (1978) result where the random effects estimator reduces to the fixed effects estimator when the regressors are all correlated with the individual effects, may not hold if the remainder disturbances have a general serial correlation variance-covariance matrix. This includes the popular AR(1), MA(1) and ARMA(p, q) processes for serial correlation. This is illustrated with an empirical example for the AR(1) case.

Information Revelation In Constant-Sum Games: Elections And Beyond, Navin Kartik, Francesco Squintani, Katrin Tinn

Cowles Foundation Discussion Papers

Do elections aggregate the private information of office-motivated candidates? Our answer stems from a general result for two-player constant-sum Bayesian games with type-independent payoffs. Under a “completeness” statistical condition, every “identifiable” equilibrium is an ex-post equilibrium. Applied to Downsian elections, the ex-post property implies a sharp bound on information aggregation: equilibrium voter welfare is at best equal to the efficient use of a single candidate’s information. In canonical specifications, politicians may “anti-pander” (overreact to their information), whereas some degree of pandering would be socially beneficial. We discuss other applications of the ex-post result.

Dataset For Effects Of Demineralization Protocols On Hydrogen And Oxygen Isotope Ratios In Fossil Bone Collagen, Linda M. Reynard

Geosciences Research Data

This dataset accompanies a peer-reviewed publication. The effect of three commonly used preparation protocols on bone collagen d2H and d18O values was investigated, using six generally well-preserved faunal bones (cattle, bison, horse) ranging in age from the Holocene to Late Pleistocene. The treatments tested were ethylene diamine tetraacetic acid demineralization without gelatinization and hydrochloric acid demineralization with and without gelatinization. There were small d2H changes noted by method; however, given the expected water isotopic variation among labs this should be an insignificant source of inter-lab variation.

Advancing Paternal Perinatal Mental Health: Integrating Qualitative Evidence, Theory, And Measurement Science, Rachael Elizabeth Schmitz

Nursing and Health Sciences

Aim: To advance understanding of paternal perinatal mental health through the integration of qualitative evidence, mid-range theory, and conceptual framework development.

Background: Existing scholarship largely emphasizes prevalence and symptom identification of paternal post partum depression, with limited integration of fathers lived experiences into theory development and assessment frameworks, and mental health nursing practice. Greater integration of qualitative evidence, theory, and measurement science may strengthen the recognition and assessment of paternal distress.

Methods & results: This integrative paper synthesizes findings from a phenomenological study of fathers with postpartum depression, the Reciprocal Adaptation in Postpartum Fathers mid-range nursing theory, and the P- …

Eece310w Oer Syllabus, Daisuke Akiba

Open Educational Resources

This course has been designated Zero Textbook Cost (ZTC) under the CUNY OER Initiative.

Pellissippi State Community College For The Year Ended June 30, 2024, Tennessee. Comptroller Of The Treasury.

Financial and Compliance Audit Reports

No abstract provided.