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Filter System For Filtering Fluids And Filter Element Sep 2026

Filter System For Filtering Fluids And Filter Element

Defensive Publications Series

The invention relates to a filter system (100) for filtering fluids, in particular a liquid filter system, comprising a filter housing (110) with a first housing part (112) and a second housing part (114), having a raw fluid inlet (105), a central fluid outlet (104) and a component, in particular an eccentric fluid drainage opening (106), the fluid outlet (104) and component being arranged at the second housing part (114), a central standpipe (120) with a top portion (122) providing an inclined control surface (124), a filter element (10) comprising a center tube arrangement (90) being arranged in the interior …


Host‑To‑Fabric Context Switching Through Sideband Signaling And Wave‑Propagated Reconfiguration Of A Coarse‑Grained Reconfigurable Array, Jonathon Murphy Sep 2026

Host‑To‑Fabric Context Switching Through Sideband Signaling And Wave‑Propagated Reconfiguration Of A Coarse‑Grained Reconfigurable Array, Jonathon Murphy

Defensive Publications Series

Reconfiguring a hardware accelerator through an operating system (OS) commonly costs microseconds, because kernel drivers, thread scheduling, and register‑level writes sit between the requesting program and the hardware.  This disclosure describes a system in which a compiler backend embeds routing configurations in a metadata segment of an executable and an OS‑bypass bootstrapper maps those configurations and a doorbell into user space.  A sideband control plane then carries a switch trigger to a reconfigurable co‑processor without a system call or an interrupt.  Shadow configuration planes, resident at each routing node ahead of use, enable a context switch to travel across the …


Routing Congestion Mitigation Via Hotspot Root Cause Classification And Timing-Aware Engineering Change Orders In A Reinforcement Learning Loop, Kishore R Sep 2026

Routing Congestion Mitigation Via Hotspot Root Cause Classification And Timing-Aware Engineering Change Orders In A Reinforcement Learning Loop, Kishore R

Defensive Publications Series

Physical design flows for a system on a chip (SoC) commonly resolve routing congestion with uniform placement or routing blockages.  Such blockages can waste floorplan area and degrade timing on paths holding no spare slack.  This publication presents a congestion mitigation method that resolves each congestion hotspot into one of three physical root causes and generates an engineering change order (ECO) matched to the cause found.  A slack test protects timing, so a net with negative slack keeps a direct route while a clock latency adjustment borrows margin from a neighboring pipeline stage.  Generated directives compile into a variable file …


Tab-Level Access Control And Atomic Extraction Architecture For Multi-Tab Cloud Documents, Richa Gupta Sep 2026

Tab-Level Access Control And Atomic Extraction Architecture For Multi-Tab Cloud Documents, Richa Gupta

Defensive Publications Series

The present disclosure relates to access control and data extraction within multi-tab cloudbased document platforms. Existing platforms enforce file-level permissions in an all-or-nothing manner, granting collaborators access to every tab within a document. Extracting individual tabs requires manual copy-paste operations into separate documents. The disclosed architecture introduces tab-level virtual sandboxing that selectively renders authorized tabs while masking unauthorized tab nodes from a user's viewport and client-side document object model. A tab copyextraction feature parses and clones tab content into a new, editable cloud document while preserving the original tab. An atomic extract-and-purge operation transactionally clones a selected tab to a …


Automated Clock Sink Load Balancing Across Multi-Tap H-Tree Regions Via Adaptive Block Coordinate Descent, Kishore R Sep 2026

Automated Clock Sink Load Balancing Across Multi-Tap H-Tree Regions Via Adaptive Block Coordinate Descent, Kishore R

Defensive Publications Series

Clock tree synthesis for a system on a chip can distribute a clock signal through an H-tree that feeds several tap regions.  Balanced timing calls for each rectilinear clock region to carry a comparable share of a load product formed from total distance and sink capacitance.  Reaching that balance over a non-binary grid has historically consumed hours of manual trial and error, in part because live queries against a physical design database respond slowly.  To address these limitations disclosed is a method that caches sink coordinates and capacitance values in memory, anchors a two-by-two base grid, and injects supplemental boundary …


Filter System For Filtering Fluids And Filter Element Sep 2026

Filter System For Filtering Fluids And Filter Element

Defensive Publications Series

The invention relates to a filter system (100) for filtering fluids, in particular a liquid filter system, comprising a filter housing (110) with a first housing part (112) and a second housing part (114), having a raw fluid inlet (105), a central fluid outlet (104) and a component, in particular an eccentric fluid drainage opening (106), the fluid outlet (104) and the component being arranged at the second housing part (114), a central standpipe (120) with a top portion (122) arranged above the fluid outlet (104), the top portion (122) providing an inclined control surface (124), a filter element (10) …


Multi-Turn Evaluation Of Language Models Using Private Information Games, Jacob Eisenstein, Jonathan Berant, Adam Fisch, Mirella Lapata, Fantine Huot Sep 2026

Multi-Turn Evaluation Of Language Models Using Private Information Games, Jacob Eisenstein, Jonathan Berant, Adam Fisch, Mirella Lapata, Fantine Huot

Defensive Publications Series

Evaluating the capability of language models to conduct multi-turn interactions presents significant challenges. Current evaluation frameworks rely on arbitrary text sharding or user simulators, which introduce unwanted noise and require complex behavioral modeling. A methodology for evaluating multi-turn interactions through collaborative private information games is disclosed. Private information, such as images or structured data, is provided to participants. This information is essential for task completion but difficult to efficiently convert into text. A shared understanding must be collaboratively built by the participants through constrained linguistic communication. A fixed communication budget is allocated, and the number of permitted conversation turns is …


Battery Aging Budget Controller For Ai Meeting Features During Notebook Collaboration Sessions, Hp Inc Sep 2026

Battery Aging Budget Controller For Ai Meeting Features During Notebook Collaboration Sessions, Hp Inc

Defensive Publications Series

This disclosure describes a controller for AI-enabled notebook computers that reduces predicted battery aging during video collaboration sessions without relying solely on a coarse system-wide battery-saver policy. The controller detects an active collaboration session, identifies active AI meeting features, and maintains both a session-level battery aging budget and a feature-level battery aging ledger. Using battery, thermal, processor, feature, and meeting-state telemetry, the controller estimates the incremental aging contribution and current importance of each feature, then selectively maintains, reduces, defers, migrates, or disables individual features. Unlike conventional power-saving approaches, the controller dynamically reallocates an aging budget among AI meeting features to …


Filter System For Filtering Fluids And Filter Element Sep 2026

Filter System For Filtering Fluids And Filter Element

Defensive Publications Series

The invention relates to a filter system (100) for filtering fluids, in particular a liquid filter system, comprising a filter housing (110) with a first housing part (112) and a second housing part (114), having a raw fluid inlet (105), a central fluid outlet (104) and a component, in particular an eccentric fluid drainage opening (106), the fluid outlet (104) and the component being arranged at the second housing part (114), a central standpipe (120) with a top portion (122) arranged above the fluid outlet (104), the top portion (122) providing an inclined control surface (124), a filter element (10) …


Local Web Task Actuation And Background Execution Via An Integrated Web Browser Artificial Intelligence Agent, Hena Virginia Haines, Linda Yin Wang, Siddhartha Sivakumar, Wenyu Fu, Yi Xuan Wang, Ritika Gupta, Salvador Guerrero Ramos, Bhuvana Sree Betini, Xinyi Wu, Nayeon Kim, Bryant Eldon Chandler, Nasim Sedaghat, Lillian Ming Chen, Daniel Edwin Harrington, Calder Evan Kitagawa, David Andrew Trainor Sep 2026

Local Web Task Actuation And Background Execution Via An Integrated Web Browser Artificial Intelligence Agent, Hena Virginia Haines, Linda Yin Wang, Siddhartha Sivakumar, Wenyu Fu, Yi Xuan Wang, Ritika Gupta, Salvador Guerrero Ramos, Bhuvana Sree Betini, Xinyi Wu, Nayeon Kim, Bryant Eldon Chandler, Nasim Sedaghat, Lillian Ming Chen, Daniel Edwin Harrington, Calder Evan Kitagawa, David Andrew Trainor

Defensive Publications Series

Procedural delays are caused during multi-step web tasks on mobile devices due to constrained interfaces and restricted web browser state access. Failures are encountered by remote cloud automation when local credential or security barriers are presented. An artificial intelligence web agent is integrated directly into a mobile web browser architecture to perform local task execution. The web agent is bound to an active tab context to execute actions directly on a local document object model. Local credential stores, session cookies, and autofill entries are utilized to navigate authentication barriers. Workflows are executed within a background execution service when the browser …


A Knowledge Graph And Machine Learning Framework For Relationship-Aware Risk Intelligence In Enterprise Networks, Akash Dhure Sep 2026

A Knowledge Graph And Machine Learning Framework For Relationship-Aware Risk Intelligence In Enterprise Networks, Akash Dhure

Defensive Publications Series

A knowledge graph and graph neural network framework is proposed herein to replace flat, entity-by-entity infrastructure risk reports with a relationship-aware view of how risk emerges across configuration, software, hardware, topology, and other operational dimensions. The framework preserves relationship types during representation learning, so that risk arising through an entity's relationships is distinguished from risk recorded on the entity itself. The learned representations are composed into a prioritized remediation ordering, and a language model translates the resulting findings into clear, operator-readable narratives bounded to the supplied facts. The result is a repeatable, scalable, and explainable workflow that surfaces at-risk entity …


Dynamic Agentic Visualization To Aid The Conversations As Part Of Multi-Agentic Execution Trajectories, Robert Barton, Yathiraj B. Udupi, Maithri V M Sep 2026

Dynamic Agentic Visualization To Aid The Conversations As Part Of Multi-Agentic Execution Trajectories, Robert Barton, Yathiraj B. Udupi, Maithri V M

Defensive Publications Series

Techniques are proposed herein for using visualization in multi-agent enterprise artificial intelligence (AI) systems. The core approach treats visualization as a specialized agent that a supervisor can invoke at multiple points during a live execution trajectory. Rather than generating only a final static widget, the system can insert intermediate visual checkpoints that explain what an agent team has discovered, which hypotheses remain, which sub-agents contributed, and why a recommendation should be trusted. The techniques can support complex, cross-domain troubleshooting and remediation workflows in which a user supervises, understands, and approves a next step. By stitching prompt-and-response pairs, evidence widgets, executor-agent …


Method Of Blockchain Integration To Secure A Digital Twin, Hp Inc Sep 2026

Method Of Blockchain Integration To Secure A Digital Twin, Hp Inc

Defensive Publications Series

In a previous disclosure AI based twin assistants offered in poly rooms was patented. This disclosure builds upon the previous disclosure to protect the ability to tokenize a twin assistant in order to control access to assistants and even allow the exchange of crypto currencies for features of AI based digital twins. When assistants are tokenized they are able to be paid for to join meetings, and even enable companies to own digital assistants that are of a certain quality level. In this similar method, digital twins can be stored in wallets so even specialized workers with specific niche knowledge …


The Fool- Proofing Design For Paper Loading Enhances The User Experience, Hp Inc Sep 2026

The Fool- Proofing Design For Paper Loading Enhances The User Experience, Hp Inc

Defensive Publications Series

This invention introduces a mechanical fool-proofing system for printer paper loading that improves user experience and reduces paper feed failures caused by incorrect width guide positioning. The system integrates a blocking feature into the movable width adjuster and a corresponding guide slot within the input tray. When the width adjuster is correctly aligned with the selected media size, paper can be fully loaded and printing proceeds normally. When the adjuster is incorrectly positioned, the blocking feature interferes with the paper loading path, preventing full media insertion and providing immediate visual and mechanical feedback to the user. Unlike conventional solutions that …


Loci: A Heat-Decaying, Goal-Conditioned Memory Architecture For Long-Horizon Ai Agents — With Imagination Engine, Circuit Breaker For Recursive Rumination Prevention, And The First Documented Case Of Sustained Human-Ai Co-Invention Via Persistent Memory, Arko Sanyal, Independent Research Sep 2026

Loci: A Heat-Decaying, Goal-Conditioned Memory Architecture For Long-Horizon Ai Agents — With Imagination Engine, Circuit Breaker For Recursive Rumination Prevention, And The First Documented Case Of Sustained Human-Ai Co-Invention Via Persistent Memory, Arko Sanyal, Independent Research

Defensive Publications Series

AI agents fail over time for three reasons: their memory fills with stale history, they re-process the same goals in loops, and injected information corrupts what they know. LOCI solves all three. LOCI assigns every memory fact a heat score that decays over time by tier — critical facts survive 30 days, routine facts 3 days, nothing is ever deleted. Facts are placed across hardware tiers: the most important live in GPU memory during inference, the rest wait in RAM or on disk until needed. When an agent's goal changes, the decay rates shift — facts relevant to the current …


Acid Addition Salts Of N-[5-[[4-[4-[(Dimethylamino)Methyl]-3- Phenylpyrazol-1-Yl] Pyrimidin-2-Yl]Amino]-4-Methoxy-2-Morpholin -4-Ylphenyl]Acrylamide And Process For The Preparation Thereof, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Kommera Rajashekar, Garai Abhijit, Rajavel B Sep 2026

Acid Addition Salts Of N-[5-[[4-[4-[(Dimethylamino)Methyl]-3- Phenylpyrazol-1-Yl] Pyrimidin-2-Yl]Amino]-4-Methoxy-2-Morpholin -4-Ylphenyl]Acrylamide And Process For The Preparation Thereof, Msn Laboratories Private Limited, R&D Center, Hyderabad, India, Srinivasan Thirumalai Rajan, Sagyam Rajeshwar Reddy, Kommera Rajashekar, Garai Abhijit, Rajavel B

Defensive Publications Series

Field of the Disclosure:

The present disclosure relates to acid addition salts of N-[5-[[4-[4-[(dimethylamino) methyl]-3-phenylpyrazol-1-yl]pyrimidin-2-yl]amino]-4-methoxy-2-morpholin-4-ylphenyl] acrylamide of formula-1 referred to as Lazertinib which is represented by the following structural formula.


Broadening The Community Of Nudibranch Enthusiasts Through Multilingual Educational Programming To Increase Climate Advocacy Engagement, Richelle Li Tanner, Cintya Felix Mendivil, Ashley Lam, Lorena Muñoz, Micah Kim, Elena G. Morales Poot, Gabrielle Keeler-May Sep 2026

Broadening The Community Of Nudibranch Enthusiasts Through Multilingual Educational Programming To Increase Climate Advocacy Engagement, Richelle Li Tanner, Cintya Felix Mendivil, Ashley Lam, Lorena Muñoz, Micah Kim, Elena G. Morales Poot, Gabrielle Keeler-May

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Environmental literacy and advocacy for environmental protections are essential components of responsible stewardship. For coastal communities, stewardship requires knowledge of ocean processes and the biological communities living within these ecosystems. While many studies highlight difficulties in engaging American audiences in environmental concern and stewardship due to hyper-individualistic societal values, tidepooling is one recreational pathway to coastal community engagement that strengthens sense of place, and therefore, responsibility to protect natural resources. We sought to broaden the tidepooling community to include more diverse voices through a participatory science program with inland city-dwelling, multilingual, and non-English speaking adults. Using nudibranchs as an environmental …


Fall 2026 Environmental Sciences Seminar Series, Rebecca L. Hale, Rebecca L. Hale Sep 2026

Fall 2026 Environmental Sciences Seminar Series, Rebecca L. Hale, Rebecca L. Hale

NRESS Seminars

Dissolved organic matter (DOM) is a powerful lens for understanding watershed processes and ecosystem impacts, integrating upstream biogeochemistry, landscapes, and climate. In particular, DOM provides insights into how urbanization reshapes ecosystems and hydrology.

In this talk, Dr. Hale will share work on local to continental patterns of urban DOM and how DOM can be used as a predictive tool for water quality monitoring.


The George-Anne Daily, Georgia Southern University Sep 2026

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.


Midweek Memo, Georgia Southern University Sep 2026

Midweek Memo, Georgia Southern University

Midweek Memo

  • Applaud 
  • Remember 
  • Share 
  • Experience 
  • Around the Nest


Final Butte Priority Soils Operable Unit Unreclaimed Sites Field Sampling And Investigation Plan: Ur-51 –Area Near Bres No. 50 – Zelia And Mountain Con Mine, Mike Mcanulty Sep 2026

Final Butte Priority Soils Operable Unit Unreclaimed Sites Field Sampling And Investigation Plan: Ur-51 –Area Near Bres No. 50 – Zelia And Mountain Con Mine, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Butte Priority Soils Operable Unit Final Butte Priority Soils Operable Unit Unreclaimed Sites Field Sampling And Investigation Plan: Ur-41 – Montana Street And Interstate 90, Mike Mcanulty Sep 2026

Butte Priority Soils Operable Unit Final Butte Priority Soils Operable Unit Unreclaimed Sites Field Sampling And Investigation Plan: Ur-41 – Montana Street And Interstate 90, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Humboldt Wetland Restoration & Mitigation Map And Tables, Sylvia Van Royen Sep 2026

Humboldt Wetland Restoration & Mitigation Map And Tables, Sylvia Van Royen

Spatial Data

The Map

This large-format georeferenced PDF map displays the Project Boundaries, Reference Points, and Eelgrass Mitigation Sites layers of the Humboldt Wetland Restoration & Mitigation Geodatabase. This map was designed to show a high level of detail across a large area - the best way to use it is to zoom into an area of interest. Each Project Boundary is labelled with a number, which corresponds to the “ID #” column in the tables.

The Tables

Tables of data from the Restoration Project Boundaries and Restoration Reference Points feature classes in the Humboldt Wetland Restoration & Mitigation Geodatabase. The PDF …


The Little Book Of Gifts: Great Ideas For Teaching, Eugene Korsunskiy, Petra Bonfert-Taylor, Emme Burgin, Jentry Campbell, Solomon G. G. Diamond, Kendall R. Farnham, Mattias W. Fitzpatrick, Rebecca Gallivan, Katherine R. Hixon, Michael Kokko, Wesley Marrero, Vicki V. May, Erin N. Mayfield, Colin R. Meyer, Emily H. Monroe, Nina Montgomery, Kofi M. Odame, Laura E. Ray, Peter J. Robbie, Rafe H. Steinhauer, Douglas W. Van Citters, Vikrant S. Vaze Sep 2026

The Little Book Of Gifts: Great Ideas For Teaching, Eugene Korsunskiy, Petra Bonfert-Taylor, Emme Burgin, Jentry Campbell, Solomon G. G. Diamond, Kendall R. Farnham, Mattias W. Fitzpatrick, Rebecca Gallivan, Katherine R. Hixon, Michael Kokko, Wesley Marrero, Vicki V. May, Erin N. Mayfield, Colin R. Meyer, Emily H. Monroe, Nina Montgomery, Kofi M. Odame, Laura E. Ray, Peter J. Robbie, Rafe H. Steinhauer, Douglas W. Van Citters, Vikrant S. Vaze

Dartmouth Scholarship

We borrowed the “GIFTs” acronym from the American Society for Engineering Education (ASEE), whose annual conference includes sessions in which educators share quick, actionable ideas for new and exciting teaching practices that they’ve developed.

In this collection, we present over thirty Great Ideas For Teaching—collected from faculty and staff at the Thayer School of Engineering at Dartmouth College—that can be used in diverse labs and classrooms.

The specific theme of the GIFTs in this volume is: accessibility & inclusion. The ideas in this collection are all aimed at making our course content more understandable, our …


2026-2027 Dr. Kiran C. Patel College Of Allopathic Medicine Bylaws, Nova Southeastern University Sep 2026

2026-2027 Dr. Kiran C. Patel College Of Allopathic Medicine Bylaws, Nova Southeastern University

Dr. Kiran C. Patel College of Allopathic Medicine Bylaws

No abstract provided.


Monthly Progress Report Butte Priority Soils Operable Unit Consent Decree Partial Remedial Design/Remedial Action And Operation And Maintenance, Josh Bryson Sep 2026

Monthly Progress Report Butte Priority Soils Operable Unit Consent Decree Partial Remedial Design/Remedial Action And Operation And Maintenance, Josh Bryson

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Financial Pessimism Abounds In Connecticut Amid Widespread Opposition To Tariffs 9/9/2026, Unh Survey Center Sep 2026

Financial Pessimism Abounds In Connecticut Amid Widespread Opposition To Tariffs 9/9/2026, Unh Survey Center

All UNH Survey Center Polls

Half of Connecticut residents say they are worse off financially than a year ago, particularly those with lower incomes, and four in ten expect to be worse off a year from now. Most say their cost of living has increased in the past year, especially groceries, gasoline, and energy. State residents are downbeat about the short and long-term futures of the state and national economies, with majorities expecting a recession within the next year in both economies. A majority of Connecticut residents disapprove of President Trump's use of tariffs and believe they will have a negative effect on the U.S. …


Metastatic Proinsulin-Secreting Tumor: A Rare Cause Of Persistent Hypoglycemia, Robert J. Heins, John Yazji, Philip Eber, Stefanie Furlan Sep 2026

Metastatic Proinsulin-Secreting Tumor: A Rare Cause Of Persistent Hypoglycemia, Robert J. Heins, John Yazji, Philip Eber, Stefanie Furlan

Student Publications

Proinsulin-secreting neuroendocrine tumors (NETs) are a rare cause of severe hypoglycemia, characterized by normal or low insulin levels and disproportionate elevations of proinsulin. Clinical features and optimal management of unresectable cases remain poorly defined, in part due to such few cases described in the literature. We describe a 47-year-old female with metastatic large-cell neuroendocrine carcinoma who presented with obstructive jaundice and was incidentally found to have profound, asymptomatic fasting hypoglycemia. Initial insulin and C-peptide levels were within reference ranges, but proinsulin concentrations were markedly elevated. The patient developed recurrent, refractory hypoglycemia requiring high-dose corticosteroids, glucagon, diazoxide, octreotide, and ultimately central-line …


Separation Of Ferric Ions From Waste Aqueous Solution Using Solvent Extraction/Precipitation Process With Deep Eutectic Solvents And Resonant Accoustic Mixing, Frank Agyemang Sep 2026

Separation Of Ferric Ions From Waste Aqueous Solution Using Solvent Extraction/Precipitation Process With Deep Eutectic Solvents And Resonant Accoustic Mixing, Frank Agyemang

Honors Theses

The problem of ferric ions (Fe³⁺) in industrial wastewater is a critical issue for several sectors, such as mining, electronic plating, and metal finishing, due to both its environmental and economic impact. Traditional treatment methods using energy-intensive procedures and unsafe organic solvents are not in compliance with sustainability, but can succeed in achieving a valid metal recycling. By utilizing deep eutectic solvents (DES) and resonant vibratory mixing technology, an environmental friendly method is developed to selectively extract/precipitate ferric ions from waste aqueous solutions. Deep eutectic solvents (DES) have been developed to replace common organic solvents, representing environmental friendly alternatives with …


Arriving At A Diagnosis: Effective Strategies Used By The Undiagnosed Diseases Network, Somin Hwang, Rachel M Brown, Dustin Baldridge, Erin E Baldwin, Alan H Beggs, Jonathan A Bernstein, Elizabeth Blue, Nicholas A Borja, Lorenzo D Botto, Lauren C Briere, Thomas Cassini, Cecilia Esteves, Elizabeth L Fieg, Gail P Jarvik, Shilpa Nadimpalli Kobren, Mia P Levanto, Julian A Martínez-Agosto, Shruti Marwaha, Stanley F Nelson, Jill A Rosenfeld, Tim Schedl, Tina K Truong, Jennifer A Wambach, Matthew T Wheeler, Shinya Yamamoto, Undiagnosed Diseases Network, Vandana Shashi, Alexa T Mccray, David R Adams, Kimberly Leblanc Sep 2026

Arriving At A Diagnosis: Effective Strategies Used By The Undiagnosed Diseases Network, Somin Hwang, Rachel M Brown, Dustin Baldridge, Erin E Baldwin, Alan H Beggs, Jonathan A Bernstein, Elizabeth Blue, Nicholas A Borja, Lorenzo D Botto, Lauren C Briere, Thomas Cassini, Cecilia Esteves, Elizabeth L Fieg, Gail P Jarvik, Shilpa Nadimpalli Kobren, Mia P Levanto, Julian A Martínez-Agosto, Shruti Marwaha, Stanley F Nelson, Jill A Rosenfeld, Tim Schedl, Tina K Truong, Jennifer A Wambach, Matthew T Wheeler, Shinya Yamamoto, Undiagnosed Diseases Network, Vandana Shashi, Alexa T Mccray, David R Adams, Kimberly Leblanc

Duncan NRI Faculty and Staff Publications

Purpose: Despite the increasing use of exome sequencing (ES) and genome sequencing (GS) in clinical settings, many individuals remain undiagnosed. This study examined the Undiagnosed Diseases Network (UDN)'s approach to establishing diagnoses for participants.

Methods: As a continuation of the first UDN cohort (9/16/2015-5/23/2017), this study reviewed diagnostic strategies and outcomes in the second UDN cohort (5/24/2017-6/30/2023).

Results: Over the study period, the proportion of UDN participants with prior ES/GS increased from 40.2% to 75.0%. The diagnostic rate for the UDN was 22.1% (379/1,713). Reanalysis/reinterpretation of sequencing data (prior ES: 21.4%, prior GS: 2.6%, UDN ES: 4.8%, UDN GS: 17.3%) …