Digital Commons Network^™

Development Of Bioactive Peptidomimetics, Lei Wang

USF Tampa Graduate Theses and Dissertations

In the past two decades, a lot of different peptidomimetics, such as β-peptides, oligoureas, azapeptides, peptoids, aromatic oligoamides, and others, have been developed. These peptidomimetics with distinctive scaffolds have shown potential in protein surface recognition and mimicry, PPI regulation, catalysis, etc. Moreover, these bioactive peptidomimetics demonstrate much better bioavailability and biostability than the bioactive peptides. To expand the application of peptidomimetics, our group have developed a new sequence-specific peptidomimetics- γ-AApeptide, which is derived from chiral γ-PNA. It shows excellent advantages including highly resistant to various proteolytical degradations and has the potential to increase chemodiversity. γ-AApeptide also exhibits remarkable biomedical applications, …

Development Of Antiviral Peptidomimetics, Songyi Xue

USF Tampa Graduate Theses and Dissertations

Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases. As a result, modulation of PPIs has been recognized as one of the most promising strategies to develop the novel drugs. Peptide modulators always exhibit higher specificity and affinities with targets than small compounds or monoclonal antibodies, but their broad medicinal effectiveness is constrained by their poor bioavailability and biostability. Peptidomimetics, which have been developed to mimic the structure as well as function of bioactive peptides and proteins, have shown excellent potential in protein surface mimicry and …

Selective Framing And Narrative As Anthropocentric Agents In Yellowstone: America’S Eden, Breanna Lee Hansen

USF Tampa Graduate Theses and Dissertations

Yellowstone: America’s Eden is but one example of nature documentaries tackling the complexities of nature-culture relationships during the age of the Anthropocene. Yellowstone National Park, the first to be named, is a primary example of how our relationship to the natural world developed through conservation and commodification. Yellowstone: America’s Eden demonstrates how film techniques conceal nature as a human construct through selective framing and narrative. By analyzing editing techniques made in the representation of Yellowstone National Park, this thesis bridges anthropocentrism to nature documentaries. Drawing on interdisciplinary research from media studies, environmental humanities, and anthropology, this thesis analyzes the ways …

Role Of Short Interspersed Nuclear Elements (Sines) Of Maternally Imprinted Microrna Clusters In Hemochorial Placental Antiviral Immunity, Ishani Wickramage

USF Tampa Graduate Theses and Dissertations

The evolution of hemochorial placentas in which the fetal trophoblast is bathed in maternal blood has vastly improved fetal development and survival in primates and rodents, due to the enhanced efficiency of nutrient, gas and waste exchange between the mother and the fetus. However, the extensive contact between the fetal tissues and maternal blood in these placentas also poses an increased risk of vertical transmission of pathogens such as viruses from the mother to the fetus. In response to this selection pressure, hemochorial placentas have evolved robust defense mechanisms to protect the immunologically naive fetus. Unlike somatic cells that require …

Synthesis Of Small Molecule Modulators Of Non-Traditional Drug Targets, Jamie Nunziata

USF Tampa Graduate Theses and Dissertations

This work details the effort toward structure-activity-relationship (SAR) studies and synthesis of the small molecule modulators of two non-traditional drug targets. The first part of this manuscript (chapters 1–2) will discuss the collaborative work and synthesis of an inhibitor of Slingshot Homology 1 (SSH1) with the potential therapeutic application toward Alzheimer’s Disease (AD) treatment. The second part (chapters 3–6) will discuss the synthetic efforts toward modulation of a protein target known as STING, or stimulator of interferon genes, with the therapeutic application toward autoimmune disease or anti-tumor activity.

AD is a progressive and degenerative illness that holds the title of …

Synthesis Of Tools For The Investigation And Treatment Of Infectious Diseases, Grant Lawrence

USF Tampa Graduate Theses and Dissertations

Modern medicine’s ability to treat a wide array of diseases is due mainly to the development of small-molecule drug discovery. Thousands of years of traditional medicines have been dwarfed in less than a hundred years. In addition, drug discovery has becoming a more consistent process with the introduction of the clinical trials process as well.Plasmodium is a genus of tropical parasites that have the potential to wreak havoc on billions of people globally. Current methods of drug discovery aimed at defeating these parasites require expensive assays that use radioactive material. By using an alkyne-labeled agent instead of a tritium-labeled agent, …

Examining Treatment Differences In Anxiety Disorders And Body-Focused Repetitive And Related Disorders In A Pediatric Clinic Sample, Katrina Scarimbolo

USF Tampa Graduate Theses and Dissertations

Anxiety disorders are one of the most common mental health concerns that affect youth. It is estimated about 9.4% of youth have an anxiety disorder such as panic disorder, generalized anxiety disorder, social anxiety disorder, separation anxiety disorder or specific phobias (CDC, 2022). The present study includes obsessive compulsive disorder and post-traumatic stress disorder as a part of the definition of anxiety disorders. Anxiety disorders can be comorbid with many mental health conditions. The focus of this study was on the comorbidity between anxiety disorders and body-focused repetitive behaviors (BFRBs) and related disorders. BFRBs are behaviors that involve repeated picking, …

Exposure Characteristics Of Environmental Chemicals By Life Stages, Nisha Vijayakumar

USF Tampa Graduate Theses and Dissertations

Environmental chemicals are ubiquitous and can contribute to human exposure. These exposures can result in long-term health consequences if they occur in early life. However, exposures to environmental chemicals are not evenly distributed throughout childhood. As a result, there exists variation in the levels of chemical exposure depending on the developmental stages, pathways of exposure, and broader systemic factors. However, in early life, limited research exists on exposures to environmental chemicals, particularly phthalates, pesticides, and polycyclic aromatic hydrocarbons (PAHs). In addition, environmental exposures to phthalates, pesticides, and PAHs, considering life stages, have not been fully explored. Hence it is imperative …

From Counter-Strike To Counterterrorism: How The Cheater Reconfigures Our Understanding Of Asymmetric Warfare, Enya C. Silva

USF Tampa Graduate Theses and Dissertations

Around the turn of the century, as the United States increased its military presence in the Middle East in what was widely known as the War on Terror, computer games were also rising in popularity. Military inspired narratives and settings are very common in video games, especially in the genre known as the first person shooter – characterized by a single player, first person point of view. Alexander Galloway provides a vocabulary for understanding the video game, and the first person shooter in particular, derived from the framework of game studies. Scholarship around video games usually either seeks to affirm …

Machine Learning Approach For Static Ransomware Analysis, Aldin Vehabovic

USF Tampa Graduate Theses and Dissertations

Ransomware is a form of malware which uses encryption methods to make data inaccessible to legitimate users. This cyberthreat has emerged as one of the most serious security challenges today, and a wide range of ransomware families have been developed and deployed, causing immense damage to governments, corporations, and private users. As this malware type continues to expand, governments across the world are taking serious steps to limit its reach. In addition, researchers have proposed a range of ransomware detection and attribution schemes, most of which use advanced machine learning (ML) techniques to process and analyze real-world empirical data from …

Meta-Analysis Of United States Seabird Populations Based On Ocean Biodiversity Information System (Obis) Records (1965–2018), Savannah Hartman

USF Tampa Graduate Theses and Dissertations

Understanding the distribution of organisms is an important priority for society as we live through ecosystem transformations that threaten the well-being of all organisms. I have approached the dynamic and complex issue of studying biodiversity by using open-access seabird data collected along the Americas since the 1960s. I explained how these data have changed over time and space, how certain species populations could have shifted over time, and possible correlations between this potential geographic change and select environmental variables.

In Chapter 2 I evaluated the suitability of the open-access data archive Ocean Biodiversity Information System (OBIS) for supporting detailed inquiry …

Exploring The Impact Of Eddies On Southern Ocean Biogeochemical Structure Using Bgc-Argo Float Observations, Nicola J. Guisewhite

USF Tampa Graduate Theses and Dissertations

The Southern Ocean plays a crucial role in global ocean circulation, and global heat and nutrient transport. However, this region is both distant and dangerous and is therefore largely under-sampled and understudied. Methods to fill in biogeochemical data-gaps include using limited in-situ data in models to output biogeochemical property estimates, but a number of recent studies have raised concerns about how most Southern Ocean models do not resolve eddies. Eddies are known to impact biogeochemistry around the globe but little is known about their impact in the Southern Ocean. This study examines temperature, salinity, oxygen, nitrate, and dissolved inorganic carbon …

Exploration Of Shared Passenger Urban Air Mobility – Integrated Network Design, Operation Scheduling And System Configuration, Zhiqiang Wu

USF Tampa Graduate Theses and Dissertations

Urban air mobility (UAM) is an emerging concept proposed in recent years that uses electric vertical take-off and landing vehicles (eVTOLs). UAM is expected to offer an alternative way of transporting passengers and goods in urban areas with significantly improved mobility by making use of low-altitude airspace. Considering the high capital investment of eVTOLs and relative high fee of using UAM passenger service, a viable UAM format is shared passenger service. Such a service is usually station-based, i.e., with vertiport located in popular sites where potential passengers can access. To understand the viability of such use cases, the vertiport owners …

Optimizing The Membrane-Assisted Recovery Of Solids (Mars) Technology For Nutrient Removal And Recovery From Concentrated Waste Streams, Ben Yamin Hoque

USF Tampa Graduate Theses and Dissertations

The effective management of nutrients, such as nitrogen and phosphorus, in decentralizedwastewater treatment environments is a pressing challenge. These nutrients pose significant risks to the environment and public health when discharged into water bodies, while their recovery and reuse can help alleviate nutrient shortages in various industries, including agriculture. Conventional biological treatment methods used in centralized facilities are not suitable for decentralized systems due to operational complexities and space limitations. Chemical treatment mechanisms, such as adsorption, ion exchange, precipitation, and air-stripping, offer potential solutions but are accompanied by challenges like high costs and logistical issues. Therefore, finding a sustainable and …

Defining A Factor-Induced Signaling Signature For Endothelial Tubulogenesis, Sprouting, And Pericyte Recruitment, Prisca Kuanting Lin

USF Tampa Graduate Theses and Dissertations

Endothelial cells (ECs) form the inner lining of blood capillary walls. Our laboratory has developed a serum-free, defined Factor system that allows for human ECs to sprout, form lumens and tube networks, recruit pericytes, and induce capillary basement membrane deposition in 3D extracellular matrices. We have shown that the Factor system drives morphogenesis through the activation of multiple signaling pathways; however, we do not know if all factors in the Factor system are needed to induce maximal EC morphogenesis. If so, we have yet to identify why the Factors are critical to the model other than that they induce activation …

Enhancing And Securing Wireless Medical Technology For Diagnosis And Treatment Of Lower Urinary Tract Dysfunction, Farhath Zareen

USF Tampa Graduate Theses and Dissertations

Lower urinary tract dysfunction (LUTD) is a debilitating medical condition that affects millions of individuals worldwide. Urodynamics is the current gold standard for diagnosing LUTD but uses non-physiologically fast, retrograde cystometric filling to obtain a brief snapshot of bladder function. Current state-of-the-art research in bladder monitoring includes ambulatory urodynamics using wireless implantable devices to evaluate bladder function during natural filling for long-term monitoring. However, there are various challenges and limitations to this multi-sensor approach. This research focuses on developing frameworks for automated event detection, data analysis, and optimization of long-term bladder recordingsto improve the diagnosis and treatment of LUTD. In …

Evaluating The Accuracy Of Inertial Measurment Units In Detecting Gait Parameters For Lower Limb Prosthesis And Orthosis Users, Bryce Fuller

USF Tampa Graduate Theses and Dissertations

A Gait Extraction System (GES) was developed to investigate the accuracy of wearable sensors by producing gait parameters, to be compared against a gold standard motion capture system. Two inertial measurement units (IMUs) were placed in the lower limb region, specifically in the shank region of each leg. The GES uses algorithms to extract the gait cycle from raw acceleration data to produce gait parameters such as stride length, stride time, step length, step time, stance time, swing time and cadence. There were three main trials that consisted solely of a flat road, a road with small hills and a …

Optimization Techniques For Machine Learning Inference And Near Memory Image Processing In Hardware For Highly Constrained Iot Edge Nodes, Rajeev Joshi

USF Tampa Graduate Theses and Dissertations

The growing demand for fast and energy-efficient hardware for resource-constrained Internet of Things (IoT) edge devices has highlighted the limitations of conventional computing architectures. This research focuses on addressing the demand for fast, optimized, and energy-efficient machine learning inference engines as well as image processing in IoT edge applications. In this work, we address three challenging research problems and devise efficient solutions. Our investigation involved comprehensive exploration and analysis, leading to the proposal of effective approaches for overcoming these demanding issues. Through our work, we contribute novel solutions that offer improved efficiency and effectiveness in handling these research problems.

First, …

Vehicle-To-Vehicle (V2v) And Vehicle-To-Infrastructure (V2i) Based Intersection Movement Assist, Lane Change Assist, And Rear Traffic Jam Formation Safety Applications, Gustavo Olenscki

USF Tampa Graduate Theses and Dissertations

Vehicle-to-Vehicle (V2V) technology can be implemented in many different ways in terms of communication protocols. Utilizing Dedicated Short-Range Communication (DSRC) in the implementation of V2V, or even Vehicle-to-Everything (V2X), may prove to be extremely effective in solving issues related to transit safety as well as traffic flow. Forward Collision Warning (FCW), Slow Moving Vehicle (SMV), and Lane Keep Assist (LKA) are some examples of V2V safety applications whereas Platoonig may be considered to focus on improving traffic flow and fuel efficiency. Vehicles can be equipped with inexpensive embedded devices known as on-board units (OBUs) which offers the capability of data …

Multimodal Assessment Of Human Behavior With Applications In Analysis Of Autism Spectrum Disorder, Sk Rahatul Jannat

USF Tampa Graduate Theses and Dissertations

Human behavior analysis is an important application area of artificial intelligence. Usingdata collected from sensors (e.g., cameras), human behavior including, but not limited to, emotions, expressions, body movement, and eye gaze are analyzed. This analysis is useful in applications in diverse fields ranging from healthcare, defense, education, and marketing. Considering this, in this dissertation, we have proposed new approaches to emotion and expression recognition, subject identification, and classification of autism spectrum disorder. More specifically, this dissertation has the following contributions: 1) A new approach for multimodal ubiquitous emotion recognition is proposed; 2) Investigation into the impact of large expression variations …

Flow Generation And Propagation From Headwater Wetlands To Downstream Waters, Leanne Marie Stepchinski

USF Tampa Graduate Theses and Dissertations

Headwater wetlands are connected to one another and to downstream waters by dynamic hydrologic flowpaths, functioning as integrated hydrologic networks at the watershed scale. Headwater wetlands perform a variety of hydrologic lag, sink, and source functions, including flow generation and propagation, thereby contributing to the natural flow regimes of downgradient waters. The functions of individual wetlands and their contributions to hydrologic connectivity and subsequently to the natural flow regime have been widely studied and are well understood. Comparatively, the functions and hydrologic connectivity within wetland complexes as a whole and their collective subsequent contributions to the natural flow regime of …

Case Study And Fidelity Assessment Development For The Family Intervention Specialist (Fis) Program, Areana Cruz

USF Tampa Graduate Theses and Dissertations

This dissertation involved an in-depth analysis of the Family Intervention Specialist (FIS) program and the development of an FIS fidelity assessment. Three studies were conducted for this analysis. Study one analyzed FIS administrative data from one Managing Entity to determine the extent that the quality assurance measures align with the core program policies and procedures established by the Department of Children and Families. Study two included a content analysis of FIS policies and procedures manuals for alignment regarding implementation practices and qualitative interviews with FIS stakeholders regarding FIS implementation, strengths, challenges, and adherence to established policies and procedures. Study three …

Enhancing Smart Grid Security And Reliability Through Graph Signal Processing And Energy Data Analytics, Md Abul Hasnat

USF Tampa Graduate Theses and Dissertations

Situational awareness in a large, dynamic, and complex cyber-physical critical infrastructure, such as a smart grid, is vital for ensuring its smooth and uninterrupted operation. With the evolving realities of the modern-day smart grids, new challenges associated with the situational awareness of these systems are emerging that demand intelligent and efficient solutions. This dissertation intends to address several problems for enhancing situational awareness by studying the dynamic interaction among the components of the smart grids through energy data analytics using various data-driven, machine learning, and graph signal processing (GSP) techniques. The presented work provides valuable insight into the data-driven analysis …

Supervision Needs At 2 And 5 Years Post Traumatic Brain Injury: A Veterans Affairs Tbi Model Systems Study, Deveney M. K. Ching

USF Tampa Graduate Theses and Dissertations

The present study assessed the supervision needs, with the Supervision Rating Scale [SRS] (Boake, 1996) of Veterans and Service Members enrolled in the Veterans' Affairs (VA) Traumatic Brain Injury Model System (TBIMS) at 2- and 5-year follow-ups after moderate to severe traumatic brain injury (TBI). A cross sectional analysis was conducted at 2-year follow-up (N=428) where it was found that 35% of subjects still needed supervision. At 5-year follow-up (N=295) it was found that 32% of subjects needed supervision. Finally, a multilevel model of supervision (N=164) found that the relationship of supervision needs remains a constant linear line over the …

Detection Of Subsidence In West-Central Florida Using Persistent Scatterer Interferometry And Near-Surface Geophysics, Tonian R. Robinson

USF Tampa Graduate Theses and Dissertations

This dissertation consists of three studies that employ Persistent Scatterer Interferometry (PSI, also known as PSInSAR) to better understand how subsidence in west-central Florida relates to underlying geological processes. In the first study, near-surface geophysical methods (Ground Penetrating Radar (GPR) and Electrical Resistivity (ERT)), terrestrial remote sensing applications (Light Detection and Ranging (LiDAR) and Structure from Motion (SfM)), and PSI were used to monitor the spatial and temporal behaviors of a suspected growing sinkhole in the Sandhill Boyscout Reservation, Hernando County, Florida. The survey area was located within and around a topographic low assumed to be the surface of the …

Enhancing The Safety And Reliability Of Closed-Loop Medical Control Systems, Shakil Mahmud

USF Tampa Graduate Theses and Dissertations

The Internet of Medical Things (IoMT) is a rapidly advancing field that relies heavily on semi- or closed-loop Wearable and Implantable Medical Devices (WIMDs). In recent years, there has been renewed interest in clinical automation, with researchers looking for innovative solutions for Physiological Closed-Loop Control Systems (PCLCS). However, these devices can have various security issues, including vulnerabilities in software and firmware, physical attacks, weak encryption/authentication, and compromised system components. Government agencies, including the US Food and Drug Administration (FDA) and European Medicines Agency (EMA), emphasize the importance of ensuring the safety and reliability of PCLCS since malfunctioning medical devices can …

Vascular And Auditory Changes After Repetitive Traumatic Brain Injury, Courtney Lynn Penn

USF Tampa Graduate Theses and Dissertations

Traumatic brain injury (TBI) affects over 2.87 million people in the US each year. The large majority of these injuries can be classified as mild. However, evidence suggests that even mild TBIs can lead to long-lasting symptoms that greatly impact quality of life. This is particularly true when an individual sustains multiple TBIs (repetitive TBI, rTBI). Much of the damage caused by rTBI is due to secondary injury mechanisms that cause the initial injury site to spread and worsen over time. No therapies currently exist which can mitigate secondary injury, and monitoring this phase of rTBI is difficult. Development of …

A Novel Jazz Music Curriculum For Young Children: Results Of A Pilot Study, Jazmin D. Ghent

USF Tampa Graduate Theses and Dissertations

Jazz improvisation is known as the highest-known art form concerning improvisation due to its frequency and development of creative ideas (Feldman 1964). Research shows that the art of spontaneous creation can contribute to children’s ability to problem-solve, social and emotional well-being, and academic success into adulthood (Biasutti, 2017; Heble & Laver, 2016; Kiehn, 2003; Kuzmich, 1980; Solis, 2009). Improvisation is crucial for developmentally comprehensive music programs; however, improvisation is scarce in elementary music classrooms and curricula. For this pilot study, a group of 31 children aged 5-8 and considered at-risk participated in a study where they were randomly assigned to …

Reframing Resistance, Resilience, And Racial Equity In Maternal Health: A Mixed Methods Exploration Of Paternal Involvement And The Racial Disparity In Severe Maternal Morbidity, Marshara G. Fross

USF Tampa Graduate Theses and Dissertations

Background: The preventable, persistent racial inequity observed in maternal and infant death has lasting impacts on African American communities and families. Fathers, partners, and co-parents are important supports during the sensitive and vulnerable perinatal period. Emerging research has begun to demonstrate a concerted effort to move beyond the sphere of medicine and quality improvement, towards exploring and integrating social factors into targeted intervention strategies to address racial inequality in health outcomes. However, sparse literature concentrates on understanding the role of fathers and partners in peripartum care and maternal health outcomes. This study aimed to explore, understand, and describe the role …

Understanding How Cancer Adapts To Stress And Therapy Using Evolutionary Game Theory, Mariyah Pressley

USF Tampa Graduate Theses and Dissertations

Adaptive responses in cancer promote disease initiation, progression, and resistance to treatment. Understanding the underlying evolutionary dynamics behind these adaptive responses is crucial for developing effective therapeutic strategies. Evolutionary game theory (EGT) has proven a useful tool in analyzing how different cellular behaviors and evolutionary forces shape the dynamics of tumor growth, response to therapy, and the emergence of resistance. In this dissertation, we utilize EGT to understand the adaptive responses of cancer through the lens of ecology and evolution. By employing fitness-generating models and exploring various ecological contexts, we aimed to unveil critical factors influencing aggressive cell phenotypes, treatment …