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Counting Every Death When Every Death Counts: A Mixed-Methods Study Of Hurricane Michael Excess Mortality, Blake L. Scott

USF Tampa Graduate Theses and Dissertations

Vulnerable populations have been shown to be disproportionately impacted by natural disasters, such as hurricanes. Hurricane Michael, a Category 5 storm, in October of 2018 hit the rural and socioeconomically vulnerable area of the Florida Panhandle, causing 50 fatalities in Florida, massive destruction to area including the healthcare infrastructure, and led a prolonged recovery period. The purpose of the research was to examine long-term impacts to health in Florida Panhandle after Hurricane Michael; changes to mortality trends, changes to health of survivors, and changes to their access to health care using a mixed-methods, sequential, explanatory study design.

The initial phase …

The Relationship Between First-Year Expectations And Persistence For Students Who Self-Identify As Having Not Declared A Major, Shane Combs

USF Tampa Graduate Theses and Dissertations

This research aligned with protocols established by the Florida Board of Governors in 2016 to form a new funding model tied to the institution's performance. The literature review highlighted a disparity between students' expectations and the reality of college which could negatively impact persistence, and therefore funding to the institution. This quantitative study utilized the Beginning of College Survey of Student Engagement (BCSSE) to explore the correlation between incoming, undeclared FTIC students' expectations of co-curricular involvement, faculty interaction, and learning support services utilization and their persistence to the end of the second fall semester. The sample consisted of 1,042 respondents …

Novel Roles Of The Blm Syndrome Dna Helicase In Genome Maintenance And Mitochondrial Regulation, Brian B. Rodemoyer

USF Tampa Graduate Theses and Dissertations

Bloom syndrome (BS) is an extremely rare autosomal recessive genetic disorder caused by defects in the BLM gene. Patients with BS display a broad phenotypic spectrum including abnormally short stature, microcephaly, sun sensitivity, insulin resistance, perpetual oxidative stress, and a ~300-fold greater propensity for developing cancer than the general population. As such, BS patients typically do not live past their 20’s. The BLM gene encodes the BLM helicase, a member of the highly conserved RecQ family of 3’ to 5’ DNA helicases. Most of our cellular understanding of BLM is through its role in DNA damage repair through the homologous …

Development Of Antimicrobial Guanidinylate Polycarbonates, Menglin Xue

USF Tampa Graduate Theses and Dissertations

The World Health Organization (WHO) has identified the emergence of antibiotic resistance as one of the top 10 threats to public health. This is exemplified by serious threats such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecalis (VREF), and the urgent threat posed by Clostridioides difficile to human health. As part of a multifaceted combat strategy against these pathogenic bacteria, host-defense peptide (HDP)-mimicking polymers have proven to be resourceful and promising. However, a vast majority of antibiotic polymer applications were limited to topical applications due to their potential systematic toxicity. Herein, we report the design and synthesis of a …

Zinc-Mediated Reductive Acylation And Silylation Of Various P-Quinone Derivatives, Katrinah I. Tirado

USF Tampa Graduate Theses and Dissertations

Quinones are compounds containing cyclohexadiene diones and can be found in a variety of biological systems. Quinones participate in redox cycling to initiate the formation of free radicals which contributed to their overall biological activity. When quinones are reduced by either biological or chemical reductants, they can become unstable and undergo autoxidation back to their quinoidal form. One way to avoid autoxidation is the use of protected hydroquinones. Many protected hydroquinones in literature have been shown to be efficient in drug delivery as probes or molecular containers or they can act like prodrugs to be released into active forms to …

Withaferin A And Immune Checkpoint Blocker Therapy For The Treatment Of Non-Small Cell Lung Cancer, Roukiah Khalil

USF Tampa Graduate Theses and Dissertations

Lung cancer is the first cause of cancer-related deaths in both men and women with an overall five-year survival rate of 28%. Although immune checkpoint blockers (ICBs) are currently FDA-approved for the treatment of non-small cell lung cancer (NSCLC), only 17-20% of patients achieve durable responses by the induction of immunologic memory. The lack of response in most patients can be attributed to the tumor-intrinsic or tumor-extrinsic immune resistance mechanisms. A biomarker of importance is the Programmed Death Ligand-1 (PD-L1), as higher PD-L1 expression is usually associated with a better response to ICBs. Although studies have attempted to combine ICBs …

Examining Patient Satisfaction And Treatment Effectiveness For Hispanic Adolescents Receiving Intensive Mental Health Services For Depression, Myesha M. Morgan

USF Tampa Graduate Theses and Dissertations

Behavioral Activation (BA) is a treatment approach that has demonstrated promising outcomes for the adolescent population (Martin & Oliver, 2019). However, more studies are needed to examine its effectiveness with Hispanic adolescents. The prevalence and severity of depressive symptoms tend to be higher among Hispanic adolescents in comparison to their non-Hispanic White peers (Pratt & Brody, 2014). In addition, depressive symptoms are associated with poor social, academic, and later health outcomes (Naicker et al., 2013; Owens, Stevenson, Hadwin, 2012). Given the lack of prior investigations on the effectiveness of BA for Hispanic adolescents, this study aimed to fill a gap …

A Culturally Responsive And Sustaining Pre-School: Collaborative Approaches To Curriculum In An Underserved Florida Community, Dana R. Roberts

USF Tampa Graduate Theses and Dissertations

The early childhood education and childcare (ECE&C) sector in America “is a textbook example of a broken market” (Yellen, 2021) that operates as a “non-system” (Berlin, 2021). This manifests itself through the low-quality of its teaching cadre (Cassidy et al., 2019). This failure hits disadvantage families hardest (Chafouleas et al., 2016) - a reality that is particularly apparent in St. Petersburg, Florida’s Midtown neighborhoods where one out of every two children attending ECE programs are not meeting State school readiness standards (Florida OEL, 2020). In this study, I propose a culturally-responsive (Gay, 2018), culturally sustaining (Ladson-Billings, 2021c), and equity-based continuous …

Applied Analysis For Learning Architectures, Himanshu Singh

USF Tampa Graduate Theses and Dissertations

Modern data science problems revolves around the Koopman operator Cφ (or Composition operator) approach, which provides the best-fit linear approximator to the dynamical system by which the dynamics can be advanced under the discretization. The solution provided by Koopman in the data driven methods is in the sense of strong operator topology, which is nothing better then the point-wise convergence of data (snapshots) in the underlying Hilbert space. Chapter 2 provides the details about the aforementioned issues with essential counter-examples. Thereafter, provable convergence guarantee phenomena is demonstrated by the Liouville weighted composition operators Af,φ over the Fock space by providing …

From Other And From World: Expanding The Current Model Of Existential Isolation, Roger Young Jr.

USF Tampa Graduate Theses and Dissertations

Extant research investigating the nature of existential isolation (EI) has focused primarily on the experience of the gap between one’s mind and the minds of others (self-other EI). The general purpose of the current research was to begin exploring the experience of the gap between one’s mind and the world (self-world EI). This purpose was carried out across three studies. A pilot study confirms that self-world EI is a relatively common experience that usually involves meaning violation or dissociation, and results in psychological discomfort and self-doubt. Study 1 found that self-world existential isolation produces more “EI affect” (e.g., nervous, afraid, …

Development And Application Of Γ-Aa Peptide On Enzyme Mimetic And Biomolecular Agents, Meng Gu

USF Tampa Graduate Theses and Dissertations

This dissertation investigates the multifaceted utility of γ-AA peptides in various biological contexts, highlighting their capability in mimicking bioactive proteins, facilitating novel drug discovery, and obstructing protein-protein interactions. Initially, we introduced the design of an ingenious γ-AA peptide scaffold that replicates the hydrolysis capabilities of natural enzymes, with the intention to overcome their stability limitations. Notably, the designed catalyst exhibited excellent esterase activity with the coordination of Zn2+. Subsequently, optimization of a linear γ-AA peptide compound through a dimeric strategy resulted in P3-1, a potent inhibitor of amyloid-β 42. Evidenced by both in vivo and in vitro experiments, its potential …

Organizing And Communicating Health: A Culture-Centered And Necrocapitalist Inquiry Of Groundwater Contamination In Rural West Bengal, Parameswari Mukherjee

USF Tampa Graduate Theses and Dissertations

As a discursive point of praxis, this dissertation project seeks to record knowledge from below around the overlaps between health, water and health interventions emerging from rural communities located in North 24 Parganas and Purulia in West Bengal that are disproportionately impacted by water-insecurity. My dissertation also documents how multiple-stakeholders such as local NGOs, international NGOs, non-profits, and donor agencies organize access to safe water and health interventions for the water-insecure communities located in North 24 Parganas and Purulia. The integration of the CCA and necrocapitalism afford theoretical and methodological guidance in this dissertation to help document the localocentric stories …

Transformation Zone Schools And School Change Processes: Experiences Of Families, Jesse Strong

USF Tampa Graduate Theses and Dissertations

AbstractFor many years schools located within concentrated areas of poverty in an urban school county in south Florida have experienced alarmingly high teacher turnover rates and alarmingly low academic performance scores. In 2015, in a lauded exposé printed by the Tampa Bay Times, five schools, all of which would go on to become part of the Transformation Zone initiative, were featured in a series of articles, entitled The Failure Factories (Fitzpatrick et al., 2015). The purpose of this study was to explore how school policy and process changes enacted from these articles may have affected those students and families. Historically, …

Characterization And Implementation Of An All-In-One Heating, Impedance, And Pulsing Device For Molecular Delivery Applications, Alex Otten

USF Tampa Graduate Theses and Dissertations

Cancer impacts millions of Americans every year, with an estimated 1.9 million new cases and 600,000 deaths predicted to occur in 2023 [1]. Medical professionals and scientists have developed several techniques and procedures to combat this disease including gene therapies, surgeries, and chemotherapies. Several of these techniques incorporate the use of pulsed electric fields to deliver molecular material to treat, or directly destroy, the cells of the tumor. These pulsed electric field techniques are known as gene electrotransfer, electrochemotherapy, and irreversible electroporation. All three techniques utilize different electrical parameters to achieve their target tumor reduction or expression goals. Efforts to …

Synthesis Of Constrained N-Heterocyclic Peptidomimetics And Development Of Strain-Release Reagents, Kyle P. Pedretty

USF Tampa Graduate Theses and Dissertations

Part 1:The initial portion of this dissertation delves into the enhancement of β-sheet secondary structure stability through modification of the peptide backbone while examining the conformational characteristics of peptides featuring N-amino substituents. The investigation consists of two major studies, presented in separate sections. The first study outlines various approaches to achieve stable β-hairpin folds by introducing N-amino substituents to peptide strands. A novel method utilizing on-resin Mitsunobu cyclization between α-hydrazino acid residues and a serine or homoserine side chain was utilized to incorporate pyrazolidinone and tetrahydropyridazinone dipeptide constraints. To evaluate the impact of cyclic N-amino peptide building blocks on β-hairpin …

Exploring Novel Two Dimensional Diluted Magnetic Semiconductors And Heterostructures For Spintronics Applications, Thi Hai Yen Pham

USF Tampa Graduate Theses and Dissertations

Atomically thin transition metal dichalcogenide (TMD) semiconductors hold enormous potential for modern optoelectronic devices, magnetic sensing, and quantum communications. Long-range ferromagnetism can be induced in TMD monolayers by introducing a small amount of magnetic dopants to form diluted magnetic semiconductors (DMSs), making them promising candidates for applications in ultralow-power and ultracompact spintronic nanodevices. This dissertation research aims to address two contemporary challenges in the fields of nano-magnetism and spintronics: controllability of magnetic dopants in TMD monolayers in the form of MX2 (M = W, Mo; X = S, Se) and understanding the fundamental physical mechanisms that give rise to magnetism …

Continuous Time Dynamic Mode Decomposition In The Presence Of Partial Knowledge And Streaming Data, Efrain H. Gonzalez

USF Tampa Graduate Theses and Dissertations

Dynamic mode decomposition (DMD) is a physically interpretable data driven technique for modeling dynamical systems. The DMD method uses time series data where each data point is referred to as a snapshot and represents the value of the state at a particular moment in time. The important patterns found in the data are extracted and then used to create a model for the system. Once the important pieces have been obtained reduced order modeling can be used to reduce the complexity of the model.

But, DMD has evolved since its inception. After its association with the Koopman operator, DMD has …

Adsorption Of Long And Short Per- And Polyfluoroalkyl Substances (Pfas) Onto Granular Activated Carbon And Porous Organic Polymers, Yan Zhang

USF Tampa Graduate Theses and Dissertations

Per- and polyfluoroalkyl substances (PFAS) are man-made environmental contaminants causing increasing global concern due to their adverse effect on environmental and human health. Conventional treatment methods are ineffective in removing short-chain PFAS because of their hydrophilicity and resistance to degradation. This study is to design an appropriate adsorption system to remove both long- and short-chain PFSA at environmentally relevant concentrations and conditions. Four primary research tasks were designed to evaluate the performance of a structurally-tunable and chemically-stable porous organic polymers (POPs) for PFAS removal under realistic environmental conditions, including the assessment of POPs’ performance without co-contaminants (Chapter 2), the assessment …

Saudi Teachers' Perceptions Of Accommodating Diverse Students, Including Those With Special Needs, In Inclusive Classrooms, Ahmed Ali Alqahtani

USF Tampa Graduate Theses and Dissertations

General education in Saudi Arabia has undergone significant transformations since the adoption of full inclusion in schools, resulting in an increase in the number of students with special needs integrated into general education classrooms. The goal of this policy change was to boost inclusivity in Saudi education, but questions have been raised regarding the preparedness of general education teachers to effectively meet the increasingly diverse needs of their students. This study explores Saudi general education teachers' understanding of inclusive practices, their perspectives on the impact of inclusivity on student learning outcomes, and their perceptions of their own preparedness to implement …

Classification Of Finite Topological Quandles And Shelves Via Posets, Hitakshi Lahrani

USF Tampa Graduate Theses and Dissertations

The objective of this dissertation is to investigate finite topological quandles and topological shelves. Precisely, we give a classification of both finite topological quandles and topological shelves using the theory of posets. For quandles with more than one orbit, we prove the following Theorem.

Proposition 0.0.1. Let X be a finite quandle with n orbits X₁, ... , X_n. Then any right continuous poset on X is n-partite with vertex sets X₁, ... , X_n.

For connected quandles, we prove the following Theorem.

Theorem 0.0.2. There is no T …

Exploratory Data-Driven Models For Water Quality: A Case Study For Tampa Bay Water, Sandra Sekyere

USF Tampa Graduate Theses and Dissertations

Water, a crucial resource for sustaining life, covers approximately 70% of the earth's surface. Nonetheless, the quality of water is deteriorating rapidly due to the rapid growth of urban areas and industries, which is a worrying trend causing harm to human health and the ecosystem. Water quality forecasting has a key role in water resources management by enabling effective pollution control, ecosystem monitoring, and decision-making.

Previously, traditional statistical models were used to forecast water quality, but they were unable to examine the non-linear relationships between water quality parameters, and they assumed that all datasets were distributed normally. This study uses …

Acetate-Encapsulated Linolenic Acid Liposomes Reduce Sars-Cov-2 And Rsv Infection, Andrew R. Mcgill

USF Tampa Graduate Theses and Dissertations

Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is an ongoing pandemic-endemic. In the United States, it remains the third leading cause of death in 2022. SARS-CoV-2, an RNA virus, has a genome prone to rapid mutation, generating variant species capable of resisting therapies and vaccination efforts. However, it has been estimated that more than 40% of SARS-CoV-2 infections may be asymptomatic, which calls into question any biological differences between the asymptomatic and afflicted groups. Additionally, Respiratory Syncytial Virus (RSV) is the most significant cause of bronchiolitis and asthma in neonates, with an increasing burden on the …

Advances In Multiagent Systems Control: Multiplex Information Networks-Based Approaches And Beyond, Kimberly Witke

USF Tampa Graduate Theses and Dissertations

Multiagent systems control designs offer numerous advantages to increasingly complex civilian, military, and scientific tasks ranging from intelligent satellite swarm controls or autonomous traffic controls to remote triage and repair or remote wildlife observation, where the performance of a single agent is insufficient to execute the task at hand. Traditional methods in multiagent systems controls, however, have been infeasible for use in scalable, large-group formation controls.

With this in mind, the contribution of this dissertation is to bridge the gap in knowledge through both theoretical and experimental validation of multiagent systems control architectures. It addresses the challenges presented by unreliable, …

Novel Genetic Interactions Of The Sgs1 Helicase In The Maintenance Of Genome Integrity, Sonia Vidushi Gupta

USF Tampa Graduate Theses and Dissertations

Mutagenesis and genome instability are characteristics of cancer cells. People afflictedwith Bloom’s syndrome due to mutations in the BLM gene suffer from reduced life expectancy, accelerated aging, sensitivity to sun exposure, immune system abnormalities and increased risk of cancer. The predisposition to cancer is typically due to abnormal DNA repair that results in chromosome breakage and rearrangements. The homologous recombination factor Sgs1, which is a RecQ-like helicase and an ortholog of the human BLM helicase, functions primarily in DNA repair, but has also been implicated in other cellular functions like replication. Several functions of BLM such as its involvement in …

Deep Learning Enhancement And Privacy-Preserving Deep Learning: A Data-Centric Approach, Hung S. Nguyen

USF Tampa Graduate Theses and Dissertations

Deep Learning and its applications have become attractive to a lot of research recentlybecause of its capability to capture important information from large amounts of data. While most of the work focuses on finding the best model parameters, improving machine learning performance from data perspective still needs more attention. In this work, we propose techniques to enhance the robustness of deep learning classification by tackling data issue. Specifically, our data processing proposals aim to alleviate the impacts of class-imbalanced data and non- IID data in deep learning classification and federated learning scenarios. In addition, data pre-processing strategies such that dimensionality …

Travel And Migration Behaviors Of Migrants From Puerto Rico During Disasters, Lauren C. Carter

USF Tampa Graduate Theses and Dissertations

COVID-19 and Hurricane Maria were both unprecedented disasters in Puerto Rico. Hurricane Maria caused of billions of dollars in damage and took thousands of lives in 2017, while COVID-19 challenged Puerto Rico’s already crippled healthcare infrastructure in 2020. In the literature, there were few studies that explored how compound disasters affect island nations, let alone in a hypothetical worst-case scenario of a major hurricane during a novel (pre-vaccine) pandemic. In this dissertation, I studied how such a compound disaster would impact travel behaviors of migrants from Puerto Rico to the US in three distinct studies. The first study analyzed the …

Analysis Of Ostds Failure Potential Due To Sea-Level Rise And Other Inundation Factors: An Integrated Geo-Spatial Analysis, Alec Colarusso

USF Tampa Graduate Theses and Dissertations

While many aspects of climate change are well-studied, the vulnerability of Onsite Sewage Treatment and Disposal Systems (OSTDS) to sea-level rise (SLR) has not been thoroughly examined despite the potentially significant environmental impacts, including nutrient and pathogen loading. Research gaps include the need to determine the suitability of models to predict groundwater inundation due to SLR and the consequent impact on OSTDS. As such, this study aims to compare Bathtub/hydrostatic and physics-based/MODFLOW/3D numerical modeling methods of simulating groundwater inundation from SLR to identify OSTDS vulnerability to failure due to a reduction in the height of the vadose zone (saturation or …

Applications In Opioid Analysis With Faims Through Control Of Vapor Phase Solvent Modifiers, Nathan Grimes

USF Tampa Graduate Theses and Dissertations

Field Asymmetric Ion Mobility Spectrometry (FAIMS), often coupled with mass spectrometry (MS), offers rapid analytical ion filtration, useful in reducing matrix interference and differentiating isomeric compounds. This study focuses on augmenting FAIMS-MS analyses through the incorporation of gas phase solvents, or "modifiers," inducing dynamic microsolvation, a particularly potent method of analysis enhancement.

Initially, the research utilized a bubbler-based system, incorporating a humidity sensor, improving modifier concentration control when using water. Our application in opioid detection and differentiation revealed considerable advancements. Notably, an increased peak capacity in an opioid mixture and successful separation of the isobaric opioid pair, alfentanil and ortho-isopropyl …

A Qualitative Study Of Facilitators And Barriers Perceived By Black Students And Their Effect On Advanced Placement Course Enrollment In High School, Austin R. Cole

USF Tampa Graduate Theses and Dissertations

Advanced Placement (AP) classes can provide many benefits to students. The rigorous curriculum gives students an academic challenge to expand their educational abilities (The College Board, 2014). However, students of color are often underrepresented in AP participation (The College Board, 2014). Research has investigated factors among students of color that predict participation and success in AP courses, suggesting that family SES and prior academic achievement (Dixson et al., 2017; Ndura et al., 2003), and racial barriers impact students’ ability to choose to take AP courses (Jeffries & Silvernail, 2017; Walker & Pearsall, 2012). This study addressed a gap in the …

Utilization Of Detonation Nanodiamonds: Nanocarrier For Gene Therapy In Non-Small Cell Lung Cancer, Allan E. Gutierrez

USF Tampa Graduate Theses and Dissertations

Lung cancer is one of the most prevalent and high mortality cancers in the world. Two different categories of lung cancer are non-small cell lung cancer which makes up 85% of cases, and small cell lung cancer which makes up the remaining 15% of cases. A significant risk factor that can lead to lung cancer is cigarette smoking (CS) however non-smoking cases i.e., secondhand CS, exposure to certain toxins and family history are on the rise. Both the main types of lung cancer have different system of stages, different ranges of treatment, and consequently low survival rates. Unfortunately, detection and …