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Effects Of Inter-Male Status Challenge And Psychopathic Traits On Sexual Aggression, Amy M. Hoffmann

USF Tampa Graduate Theses and Dissertations

Sexual aggression (SA) is a serious social problem that has been linked to a variety of negative physical and mental health outcomes for survivors and produces significant monetary costs to society. In the past five decades, a wealth of research has improved our understanding of the individual and sociocultural factors that contribute to SA perpetration; however, epistemological differences in theoretical approaches to the subject (i.e., evolutionary, feminist) have resulted in gaps in the empirical literature. Informed by both feminist and evolutionary perspectives, this study attempts to examine the ways in which same-gender interpersonal interactions and individual psychopathology interact to produce …

Construction Of Giant 2d And 3d Metallo-Supramolecules Based On Pyrylium Salts Chemistry, Yiming Li

USF Tampa Graduate Theses and Dissertations

Pyrylium salts are a type of six-membered cationic heterocycles with one positively charged oxygen atom. Since the discovery of pyrylium salts in 1911, such salts have been underappreciated for a long time. Until 1960s, the importance of pyrylium salts has been realized as versatile precursors in a variety of organic syntheses. Due to their high reactivity towards various nucleophiles, pyrylium salts were widely used for the convenient synthesis of diverse heterocyclic compounds. Starting from 1980s, the high reactive feature of pyrylium salts were further utilized to synthesize viologen polymers with pyridinium salts in the backbones. During the past two decades, …

Genome Maintenance Roles Of Polycomb Transcriptional Repressors Bmi1 And Rnf2, Anthony Richard Sanchez Iv

USF Tampa Graduate Theses and Dissertations

The coordination of transcription, replication, and DNA damage response (DDR) is vital for maintaining normal cellular homeostasis. All of these processes take place on the chromatin and thus, the temporal and spatial separation of the factors responsible are necessary for each to be correctly completed. Here we detail several novel processes contributing to this network.

BMI1 is a component of the Polycomb Repressive Complex 1 (PRC1) which plays a key role in maintaining epigenetic silencing programs during development. Recently, BMI1 and other members of PRC1 like RNF2 have been implicated gene silencing during the DDR; however, the mechanism through which …

Active Deep Learning Method To Automate Unbiased Stereology Cell Counting, Saeed Alahmari

USF Tampa Graduate Theses and Dissertations

Cell quantification in histopathology images plays a significant role in understanding and diagnosing diseases such as cancer and Alzheimers. The gold-standard for quantifying cells in tissue sections is the unbiased stereology approach. Unfortunately, in unbiased stereology current practices rely on a well-trained human to manually count hundreds of cells in microscopy images. However, this human-based manual approach is time-consuming, labor-intensive, subject to human errors, recognition bias, fatigue, variable training, poor reproducibility, and inter-observer error. Thus, the lack of high-throughput technology for automating unbiased stereology analyses remains a major obstacle to further progress in a wide range of neuroscience and cancer …

Spatial Heterogeneity Utilization In Ct Images For Lung Nodule Classication, Dmitrii Cherezov

USF Tampa Graduate Theses and Dissertations

Lung cancer (LC) is leading in the number of deaths among the other types of cancer. According to the American Cancer Society, 135,720 deaths during 2020 in the USA will be associated with LC. The patient 5-year survival rate of 16\% was reported in 1986 and 19% in 2019. One of the reasons why survival rate remains low is that the majority of patients diagnosed with cancer had stages III and IV. In contrast, a 5-year survival rate of 70% was reported for patients of stage IA after surgical resection in the National Lung Screening Trial.

CT screening detects a …

Mechanistic And Translational Studies On Skeletal Malignancies, Jeremy Mcguire

USF Tampa Graduate Theses and Dissertations

New treatment strategies are desperately needed for treating skeletal malignancy. Skeletal malignancies can be either primary cancer that originated in the bone, such as osteosarcoma, or metastatic cancer that spread from another organ to the skeleton, as in the case of breast or prostate cancer. In this thesis, I will detail two projects that focus on the discovery of new treatment strategies for both primary skeletal malignancy and metastatic skeletal malignancy.

The first project focuses on the primary skeletal malignancy, osteosarcoma, a rare cancer that is commonly diagnosed in children and young adults and metastasizes to the lungs. The survival …

The Effects Of Surface-Water Flow On The Quality Of Groundwater And Surface-Water Systems, Quanghee Yi

USF Tampa Graduate Theses and Dissertations

My research has focused on the effects of surface-water flow on the quality of groundwater and surfacewater systems. For the first part of my research (Chapter 2 ), I s tudied the effects of s urface flow system changes in the water-conservation areas and canals in southeast Florida on the quality of groundwater in the surficial aquifer system.

For the second part of my research, by developing analytical models using the superposition method, I investigated the effects of bidirectional surface-water flow on the conservative contaminant concentrations (Chapter 4) and mean residence time (Chapter 5) in streams and rivers as well …

Horror’S Aesthetic Exchange: Immersion, Abstraction And Annihilation, Ashley Morgan Steinbach

USF Tampa Graduate Theses and Dissertations

This thesis uncovers a remote entanglement of phenomenological experience and abstract aesthetics in postmodern horror, a space that historically celebrates the former and critically undervalues the latter. Framed as a case study, I mobilize close readings of Alex Garland’s science fiction horror film, Annihilation (2018), to complicate the immersion/abstraction binary that implicitly structures much of contemporary horror scholarship. By recovering horror’s distanced and decentered forms and aesthetics I point to the interdependent faculty of a composite aesthetic collaboration.

These collaborations, which I refer to as aesthetic exchanges, place pressure on the localized emphasis of horror’s situated assaultive and reactive positions. …

Bio-Electrochemical Denitrification Systems And Applications For Nitrogen Removal In On-Site Wastewater Treatment, Kamal Ziad Taha

USF Tampa Graduate Theses and Dissertations

Denitrification experiments using biological cathodes (biocathodes) were conducted in three separate experiments. The first experiment was to observe whether the rate of denitrification in biocathodes could be increased with added ammonium at mass (mg/L) ratios of 0.100 (2.5/25), 0.05 (1.25/25), 0.0250 (0.625/25), and 0.0125 (0.3125/25) (parts ammonium to nitrate (NH4+-N/ NO3--N). The purpose of the ammonium present was to provide the microorganisms a starting nitrogen source for assimilation to biomass which, in theory, would encourage the removal of nitrate through dissimilatory denitrification. As mixed cultures were used, ratios tested were based on simplifying future operation of scaled-up biocathodes applied to …

Intensive Longitudinal Data Analyses And Sample Size Considerations In Intervention Studies With Dynamic Structural Equation Modeling, Zhiyao Yi

USF Tampa Graduate Theses and Dissertations

Dynamic structural equation modeling (DSEM) has been proposed to analyze intensive longitudinal data (ILD). This dissertation provided a tutorial for the DSEM model specification practices in the context of intervention designs. Specifically, I illustrated using equations, verbal descriptions, and figures three two-level DSEM models based on three common intervention designs, including a single-arm trial with repeated measurements before and during intervention, randomized control trial (RCT) with repeated measurements during intervention, and RCT with repeated measurements before and during intervention. Mplus syntax and results from the analysis were also provided for each model along with the interpretations and inferences of parameter …

Biological And Proteomic Characterization Of Cornus Officinalis On Human 1.1b4 Pancreatic Β Cells: Exploring Use For T1d Interventional Application, Arielle E. Tawfik

USF Tampa Graduate Theses and Dissertations

Type 1 diabetes (T1D) is an autoimmune disease resulting in the loss of pancreatic β cells and subsequent loss of insulin production. Exogenous insulin coupled with continuous glucose monitoring is the only treatment for T1D. Therefore, novel interventional therapies are needed that can inhibit the autoimmune destruction and increase β cell proliferation and function. Based on initial in vitro studies, traditional Chinese medicine (TCM) extract, Cornus officinalis, may be able to serve in this function. CO has been used for 2 millennia for its glucose regulating potential and has shown efficacy in animal models but rarely studied in the context …

Before The Storm: Water And Energy Utilities, Human Vulnerability And Disaster Risk, Cori D. Bender

USF Tampa Graduate Theses and Dissertations

Increasingly communities are impacted by slow-onset and sudden hazards. With reports of disasters affecting millions of people and with severe impacts on lives and livelihoods, there is a focus on creating cities that make human settlement inclusive, safe, resilient and sustainable. Within this focus are the mandates that safe drinking water, energy and wastewater sanitation are the right of all people living on the planet. This research addresses water and energy insecurity, highlights the gaps in community level perceptions of water and energy, and global-local dynamics that impact disaster vulnerability through a political-ecology lens.

This work examines how disaster resilience …

Eppm And Its Effectiveness In Advertisements Of Colorectal Cancer Screening Among Young Adults, Anh T. Nguyen

USF Tampa Graduate Theses and Dissertations

Colorectal cancer is one of the deadliest types of cancer around the world and in the United States, yet it could be highly preventable by following the recommended guidelines of getting screened by the age of 50 and above. The focus of this study was on the Extended Parallel Process Model and sought to understand the efficacy and threat components in the fear appeal messages in the context of colorectal cancer screenings. Specifically, the study examined how young adults react when being exposed to those messages and whether they intended to discuss with their parents about it. The study also …

Examining Role Breadth, Efficacy, And Attitudes Toward Trauma-Informed Care In Elementary School Educators, Mikayla J. Drymond

USF Tampa Graduate Theses and Dissertations

Children growing up below the poverty line are at heightened risk for developing complex symptoms of trauma caused by repeated exposures to a variety of traumatic events. The detrimental effects of repeated traumatic exposures on developing children living in low-income environments are now considered a public health concern (APA Presidential Task Force on Posttraumatic Stress Disorder and Trauma in Children and Adolescents, 2008; Crosby, Howell, & Thomas, 2018). Increased awareness of the negative effects of trauma early in life and the need for combative care has accelerated the movement for educators to become trauma-informed, which can be demonstrated through altered …

“Placing Our Breasts On A Hot Kerosene Lantern”: A Critical Study Of Microfinancialization In The Lives Of Women Entrepreneurs In The Informal Economic Sector In Ibadan, Nigeria, Olubukola Olayiwola

USF Tampa Graduate Theses and Dissertations

This study uses an anthropological perspective to investigate everyday lived experience of women borrowers and entrepreneurs (in the informal economic sector in Ibadan, Nigeria) relating to microfinancialization. Study such as this becomes important given the popular Yoruba metaphor “owo komulelanta” (“Placing our breasts on a hot kerosene lantern”) women borrowers use to express their experience particularly in their attempts to make repayments of MFB loans. Hence, there is a need to pay close attention and listen more carefully to operators of the informal sector and borrowers of MFB loans. This study employs ethnographic mixed methods to generate data in various …

Biogeochemical Cycling Of Nutrients And Carbon In Subtropical Wetlands, Lauren N. Griffiths

USF Tampa Graduate Theses and Dissertations

As human development intensifies, ecosystems around the word are being exponentially destroyed and degraded. Wetlands have the capacity to mitigate some of the possible problems by retaining nutrients and carbon, keeping them from harming downstream ecosystems or being released into the atmosphere. This project focuses on the processes that make wetlands successful by studying two unique ecosystems: 1) a created urban stormwater treatment wetland and 2) mangrove wetlands in Florida and Puerto Rico that were affected by hurricanes in 2017.

The first phase of this study investigates the role of sedimentation and vegetative and algal uptake of nutrients to retain …

Features Of Borderline Personality And Related Psychopathologies As A Contemporaneously And Temporally Connected Network, Haya Fatimah

USF Tampa Graduate Theses and Dissertations

In contrast with the latent variable models, network psychometricians have proposed that symptoms co-occur not because of an underlying common cause but because of direct dynamic associations among symptoms. This empirical study aims to elucidate how features of with borderline personality disorder, depression, and anxiety interact with one another and form a network. Specifically, I aimed to identify a potential causal structure among the features of BPD, depression, and anxiety while identifying the most influential features. Participants were 37 undergraduate students between the ages of 18 and 26 recruited from University of South Florida SONA pool. Following baseline assessment, participants …

Using Observations From The Uaw-Ford Ergonomic Assessment Tool To Predict Distal Upper Extremity Musculoskeletal Disorders, Zachariah T. Brandes-Powell

USF Tampa Graduate Theses and Dissertations

Distal upper extremity (DUE) musculoskeletal disorders (MSDs) affect thousands of workers annually. Job tasks can have a significant amount of MSD risk depending on the presence of certain risk factors The UAW-Ford Ergonomic Surveillance Tool (EST) is a method specifically designed for the UAW and Ford Motor Company to assess MSD risk in its facilities. The purpose of this report is to evaluate which risk factors in the UAW-Ford EST predict the risk of developing DUE MSDs. Data collected by a previous study on four UAW-Ford automotive manufacturing plants were analyzed. Target jobs were selected based on associated First Time …

Polychlorinated Biphenyls, Organochlorine Pesticides, And Polycyclic Aromatic Hydrocarbons In Snapper (Family Lutjanidae) From Cuba And The Wider Gulf Of Mexico, Brigid E. Carr

USF Tampa Graduate Theses and Dissertations

The Snapper species assemblage is economically and environmentally important to all three countries bordering the Gulf of Mexico (GoM). Polycyclic aromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were investigated in seven snapper species located in the GoM, with a specific focus on the those caught along the northwestern coast of Cuba. Hepatic samples were processed using QuEChERs extraction methodology and analyzed using gas chromatography with tandem mass spectrometry (GC-MS/MS). Nearly all fish included in this study contained detectable amounts of all three groups of these contaminants, regardless of location, and across all regions of the Gulf, indicating …

Microbial Community Structures In Three Bahamian Blue Holes, Meghan J. Gordon

USF Tampa Graduate Theses and Dissertations

This study used 16S rDNA metagenomics and water chemistry to conduct an examination of microbial community dynamics and biogeochemistry in three physically adjacent, sunlit blue holes with variable hydrologic regimes on San Salvador Island, Bahamas. Church and Watling’s Blue Holes are holomictic with relatively clear waters, while Inkwell Blue Hole hosts density stratification and waters stained brown with tannins. Based on water color and clarity and physicochemical profiles, I hypothesized Church and Watling’s Blue Holes would be dominated by oxigenic photoautotrophs, and that the bottom layer of Inkwell would be characterized by euxinic (anoxic and sulfidic) conditions and host primarily …

Development Of A Benthic Foraminifera Based Marine Biotic Index (Foram-Ambi) For The Gulf Of Mexico: A Decision Support Tool, Bryan O'Malley

USF Tampa Graduate Theses and Dissertations

The Gulf of Mexico (GoM) is an economically important region (e.g. oil and gas, fisheries) and with the expansion of oil drilling, harmful algal bloom events, oil blowouts, dead zones, anthropogenic eutrophication and contaminant loading, it is important that the ecological quality statuses (EcoQS) of different localities in the Gulf are closely monitored. The EcoQS, as implemented by the European Water Framework Directive, is an effective tool for monitoring ecological health and developing reference conditions. One such index used to define EcoQS is the AZTI Marine Biotic Index (AMBI), which pairs species abundance with environmental stressors. Benthic foraminifera are ideal …

Water Quality And Sustainability Assessment Of Rural Water Systems In The Comarca Ngäbe-Buglé, Panama, Corbyn Cools

USF Tampa Graduate Theses and Dissertations

Over the last four decades significant progress has been made on providing people access to improved drinking water. The Joint Monitoring Program (JMP) estimates that 6.7 billion people have access to at least basic drinking water services. In spite of this great achievement 785 million people still lack even basic services and eighty percent of which live in rural areas. To further complicate matters, those with access to services experience interruptions or non-functionality for handpumps and piped system long before the intended design life of the system. In the Comarca Ngäbe-Buglé province in Panama there is very little information on …

Investigating The Isotope Signatures Of Dissolved Iron In The Southern Atlantic Ocean, Brent A. Summers

USF Tampa Graduate Theses and Dissertations

Iron (Fe), used as a cofactor in nitrogen fixation and photosynthesis by oceanic microorganisms, has extremely low dissolved concentrations in the surface ocean, leading to widespread limitation of phytoplankton growth. Dissolved Fe isotope ratios (δ56Fe) have been shown to be useful in helping to quantify the sources and cycling of Fe in the oceans if Fe source signatures and fractionation processes are well understood. Here, this thesis presents data from GEOTRACES section GA10W, and investigate the isotopic signature of sediment-derived dissolved Fe from the South Atlantic margins. My results show that there are both shallow (δ56Fe of -0.2‰) and deep …

Development Of An Organic Processor Assembly (Opa) For Sustainable Resource Recovery To Enable Long-Duration, Deep-Space Human Exploration (Loddshe), Talon James Bullard

USF Tampa Graduate Theses and Dissertations

Long-Duration, Deep-Space Human Exploration (LoDDSHE) missions demand robust and reliable technologies to ensure crew health, safety, and mission success. In situ food production will become essential for these missions for crew nutrition, morale, and in the event of delays or failures. At a current estimated cost $10,000/lb, mass and volume limitations will restrict necessary resources. For an anticipated thirty-month mission to Mars, these costs will increase due to more frequent resupply shipments and lengthened transit times, creating additional financial and logistical challenges (Pickett et al., 2019). Increased resource and waste recovery to achieve nearly closed-loop systems will mitigate many of …

Hyaluronic Acid Coated Targeted Lipid Micellar Nanoparticle As A Delivery Vehicle For Lapatinib And Ketoconazole In Egfr Mutated Lung Cancer, Nadia Tasnim Ahmed

USF Tampa Graduate Theses and Dissertations

Background: According to the American Cancer Society, lung cancer was accountable for over 142,000 deaths in the USA in 2019. Common mutations related to lung cancer mainly occur in TP53, EGFR, and KRAS genes. Lapatinib is a small molecule tyrosine kinase inhibitor which acts reversibly on both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2). Overexpression of EGFR leads to increased production and signaling of proteins that cause upregulation of cellular proliferation, cholesterol synthesis and resistance to apoptosis. Ketoconazole is an imidazole antifungal agent which works principally by inhibiting the enzyme cytochrome P450 14α-demethylase (CYP51A1) …

Aligning Voice And Communication With Identity – A Survey On Transgender And Gender Diverse Populations, Rachel T. Chalom

USF Tampa Graduate Theses and Dissertations

Purpose: This research has two goals. The first goal is to examine transgender (TG) and gender diverse (GD) voice and communication functioning and the impact of voice on their everyday lives. The second goal is to examine the knowledge, attitudes, and beliefs speech-language pathologists (SLP) have about the TG and GD community and to investigate the relationship between self- and listener-perception and its correspondence to quality of life (QoL).

Methods: A total of 59 participants took part in this research. The research was separated into two parts, the first included 24 TG and GD individuals who participated in a Qualtrics …

Discovery And Characterization Of Small Molecule Inhibitors Of Bromodomains, Md Rezaul Karim

USF Tampa Graduate Theses and Dissertations

The epigenetic “reader” modules bromodomains (BRDs) exert their diverse cellular functions through the recognition of acetylated lysines on histones and other proteins. Small molecule inhibitors of bromodomains have emerged as a promising therapeutic strategy to treat atherosclerotic cardiovascular diseases and cancers. Therefore, a large number of small molecule bromodomain inhibitors have been developed in the last decade, some of which are currently being assessed in the clinic. However, the success of bromodomain inhibitors is currently limited to the bromodomain and extra-terminal domain (BET) subfamily.

To address these, bromodomains outside the BET subfamily (non-BETs) such as TAF1, BRD7/9, TRIM28, and BRD8 …

Medical Model Vs. Eco-Behavioral Model: School Psychologists’ Conceptualization Of Consultation, Patricia Y. Hanson

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to explore the ways in which school psychologists conceptualize culturally responsive consultation based on their description of using an ecological approach or an intrapsychic approach to consultation. Additionally, this study aimed to address barriers school psychologists may face when providing culturally responsive consultation based on the consultation method they describe using. I conducted a secondary analysis of 1 to 2-hour, semi-structured interviews of 15 school psychologists throughout the United States. I used a constructivist paradigm to understand participants’ approaches to consultation and how these approaches related to their descriptions of culturally responsive consultation. I …

Electrospun Nanofibrous Membrane Based Glucose Sensor With Integration Of Potentiostat Circuit, Kavyashree Puttananjegowda

USF Tampa Graduate Theses and Dissertations

Although wearable and portable biomedical devices are the pillar of modern and smart societies, a large portion the device infrastructure is still under development, operates with poor monitoring and automation, and lacks sufficient communication among components. Moreover, demand for wearable bio-medical devices is expected to increase in the coming years. This situation presents a unique opportunity for electrical engineers to design novel strategies that allow point-of-care diagnostics to satisfy the increasing demand of wearable bio-medical devices. For example, in the medical field there is a rising diabetic population base, high demand for miniature and low-power diagnostic devices, and the need …

Impact Of Heat-Related Illness And Natural Environments On Behavioral Health Related Emergency And Hospital Utilization In Florida, Natasha Kurji

USF Tampa Graduate Theses and Dissertations

Behavioral health disorders are the leading cause of disability in the United States and are known to have multidimensional effect on wellbeing. Several environmental factors are known to impact behavioral health such as weather (i.e. heat) and access to natural environments (i.e. parks and beaches). The study goals were to identify contextual factors that increase the co-occurrence of heat-related illness and behavioral health disorders, illustrate the re-utilization patterns of these co-occurring cases in Florida emergency and inpatient settings, and explore the association between behavioral health disorders such as anxiety and depression, and natural environments such as parks and beaches. The …