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Using The Consolidated Framework For Implementation Research To Investigate Daily Pre-Exposure Prophylaxis (Emtricitabine/Tenofovir Df) Implementation Via Community-Based Hiv Testing Sites In Florida, Deanne E. Turner

USF Tampa Graduate Theses and Dissertations

Background: Pre-exposure prophylaxis (PrEP) is a daily pill that can reduce a person’s chances of acquiring HIV. HIV testing and counseling is a critical point during which non-clinical staff could intervene, discuss and/or refer clients for PrEP. However, not all HIV testing/counseling staff take part in PrEP implementation in the same way. This study investigated: 1) the underlying PrEP implementation subgroups of staff who perform HIV testing and 2) PrEP implementation as a function of key constructs from the Consolidated Framework for Implementation Research (CFIR).

Methods: This study was a mixed methods concurrent triangulation design, in which qualitative and quantitative …

Understanding The Adoption Process Of An Hpv Vaccine School-Entry Requirement In Puerto Rico, Coralia Vázquez-Otero

USF Tampa Graduate Theses and Dissertations

Human Papillomavirus (HPV) is the most common sexually transmitted infection (STI) in the US. Infection with low-risk HPV (i.e., 6 and 11) can cause genital warts, and persistent infection with high-risk HPV types (i.e., HPV 16 and 18) can progress to cancer. Currently, there is an HPV vaccine that is recommended for boys and girls, aged 11 to 12. Healthy People 2020 established a national objective of 80% completion of HPV vaccination among children aged 13 to 15 years old. Although the HPV vaccine is proven to be a safe and effective primary prevention strategy, uptake and completion rates remain …

The Potential Of Marine Microbes, Flora And Fauna In Drug Discovery, Santana Alexa Lavonia Thomas

USF Tampa Graduate Theses and Dissertations

Natural products are chemical compounds synthesized by a living organism. These compounds have been utilized by humans from ancient times to the present for their pharmacological and biological activities. Terrestrial organisms are considered a lucrative source of bioactive compounds and chemical diversity. Within the past 60 years, the marine environment has presented its potential as a validated source for structural diversity and biologically active compounds. Technology has given access from shallow waters down to the abyssal plane for exploration and investigation of the inhabitants. Marine organisms have displayed their benefits in the pharmaceutical industry with the approval of several marine-derived …

Security Framework For The Internet Of Things Leveraging Network Telescopes And Machine Learning, Farooq Israr Ahmed Shaikh

USF Tampa Graduate Theses and Dissertations

The recent advancements in computing and sensor technologies, coupled with improvements in embedded system design methodologies, have resulted in the novel paradigm called the Internet of Things (IoT). IoT is essentially a network of small embedded devices enabled with sensing capabilities that can interact with multiple entities to relay information about their environments. This sensing information can also be stored in the cloud for further analysis, thereby reducing storage requirements on the devices themselves. The above factors, coupled with the ever increasing needs of modern society to stay connected at all times, has resulted in IoT technology penetrating all facets …

Novel Insights Into The Multifaceted Roles Of Blm In The Maintenance Of Genome Stability, Vivek M. Shastri

USF Tampa Graduate Theses and Dissertations

Genomic instability is a hallmark of disorders in which DNA replication and repair genes are dysfunctional. The tumor suppressor RECQ helicase gene BLM encodes the 3’-5’ DNA Bloom syndrome helicase BLM, which plays important roles during DNA replication, recombination and repair to maintain genome stability. Mutations within BLM cause Bloom syndrome, an autosomal recessive disorder characterized by growth defects, immunodeficiency, >10-fold higher sister chromatid exchange compared to normal cells, and an increased predisposition to a wide range of cancers from an early age. Single nucleotide polymorphisms or SNPs in BLM have been reported to be associated with susceptibility to a …

Documenting Evolution: Comparing And Contrasting Late Mesozoic And Late Cenozoic Molluscan Patterns, Joshua Slattery

USF Tampa Graduate Theses and Dissertations

Despite major advances, evolutionary theory still has numerous shortcomings in terms of fully understanding the controls on speciation and diversification. A major factor limiting our knowledge is how biology and paleobiology view speciation from separate micro- and macro-evolutionary perspectives, respectively. Biologists typically examine microevolutionary changes within species from various biogeographic, behavioral, morphological, and genetic perspectives, which contrasts to the macroevolutionary approach of most paleobiologists, who have examined the same phenomena at larger scales but with the standpoint of time, have also concentrated on aspects of global or regional diversification (e.g., richness, origination rates, and extinction rates) over the long-term. Noticeably …

A Retrospective Study Of The Opioid Epidemic And Fentanyl Related Overdose Fatality Cases In A Florida West Coast Medical Examiner District Population, Anne Terese Powell

USF Tampa Graduate Theses and Dissertations

Opioids are scheduled by the propensity for misuse and abuse with a high rate of dependency and risk of fatal overdose. Opioids can be divided into different classes, including, natural, synthetic, and semi-synthetic. Opiates are naturally occurring and come directly from the opium poppy plant; whereas the semi synthetics opioids are chemical modifications of the poppy plant. Synthetic opioids attach to the opioid receptor but contain no part of the poppy plant. The increased variety and frequency in opioid prescriptions contributed to an opioid epidemic in the United States which is still on going.

According to the CDC, the opioid …

Controlled Wetting Using Ultrasonic Vibration, Matthew A. Trapuzzano

USF Tampa Graduate Theses and Dissertations

Many industrial processes such as printing and cleaning, as well as products like adhesives, coatings, and biological testing devices, rely on the wetting of liquids on a surfaces. Wetting is commonly controlled through material selection, coatings, and/or surface texture, but these means are sensitive to environmental conditions. Wetting is influenced by variables like surface tension, density, the surface chemistry, local energy barriers like surface roughness, and how the droplet is placed on the surface. Wetting of droplets can also be influenced externally in many ways such as introducing surfactants, applying electrical fields, or by dynamically excitation. Low-frequency, high amplitude vibration …

Anton Wilhelm Amo's Philosophy And Reception: From The Origins Through The Encyclopédie, Dwight Kenneth Lewis Jr.

USF Tampa Graduate Theses and Dissertations

Diversity and the concept of race are, or should be, central concerns both for the history of philosophy and for our current political reality. Within academic philosophy, these concerns are expressed in the growing demand for minority representation within the canon, which is overwhelmingly white and male, especially in early modern philosophy. Furthermore, until now, historians of philosophy have not spent the time necessary to uncover various designations such as “Negro”, “Moor”, “Ethiopian”, etc., in early modern Europe, and from there to understand how these shaped philosophical reflections on human diversity. In my research, I relate Anton Wilhelm Amo (c. …

Relationships Between Major, Performance, Time On Academic Activities, Social Activities, And Gender Of First-Year Traditional Students, Denise Darby

USF Tampa Graduate Theses and Dissertations

Higher education institutions are tasked with providing opportunities in and out of the classroom that provide students opportunities for a successful college experience. First year student expectations of the college experience initially influence selection of academic and social activities. Unmet or unrealistic expectations may lead to poor academic outcomes, stunted social development, and attrition.

This study focused on traditional first year students at the onset of their college career. Through selection of anticipated field of major study, GPA, and extracurricular activities, students initially identify potential academic activities and potential social activities. This study provided quantitative data in an effort to …

The Modified Synchronization Modulation Technique Revealed Mechanisms Of Na,K-Atpase, Pengfei Liang

USF Tampa Graduate Theses and Dissertations

The Na/K pumps are essential for living system and widely expressed in all eukaryotic cell membranes. By actively transporting sodium ions out of and potassium ions into the plasma membrane, Na/K pumps creates both an electrical and a chemical gradient across the plasma membrane, which are crucial for maintaining membrane potential, cell volume, and secondary active transporting of other solutes, etc.

Previously, oscillating electric field with a frequency close to the mean physiological turnover rate was used to synchronize and modulate the Na/K pump molecules. Results showed that the turnover rate of Na/K pumps can be accelerated by folds. However, …

Environmental Legacies Of Pre-Contact And Historic Land Use In Antigua, West Indies, Anthony Richard Tricarico

USF Tampa Graduate Theses and Dissertations

Hurricanes Irma and Maria have recently demonstrated once again the susceptibility of contemporary populations across the Caribbean to climate-driven events. For islands such as Antigua in the eastern Caribbean, this vulnerability is partly a legacy of prior land use. As such, the actions of pre-Contact and historic period inhabitants are intertwined with contemporary socio-ecological challenges faced by Antiguans today. This research sought to understand the relationship between land use and land degradation from ca. AD 100 to the present in eastern Antigua utilizing two markers of anthropic activity: soil stability and soil quality. Specifically, this research sought to examine how …

Support Received From The Dissertation Advisor And The Graduate Student Success Of Doctoral Students Majoring In The Sciences, Brittany N. Sheehy

USF Tampa Graduate Theses and Dissertations

This quantitative study utilized surveys to explore how science doctoral students receive support from their dissertation advisors and its relationship to graduate student success outcomes. The survey was distributed to active doctoral students majoring in the sciences at one large, public, Southeastern University. Within examining how the support science doctoral students receives relates to graduate student success outcomes, the study also examined additional factors that could influence graduate student success such as the participant size of the laboratory group, experience with undergraduate research, and time in program.

Findings revealed that on average science doctoral students report receiving more psychosocial support …

High-Resolution Investigation Of Event Driven Sedimentation: Response And Evolution Of The Deepwater Horizon Blowout In The Sedimentary System, Rebekka A. Larson

USF Tampa Graduate Theses and Dissertations

This Dissertation combines the investigation of the sedimentological impacts of the Deepwater Horizon (DwH) blowout event in the deep-sea benthos, with the refinement and advancement of methods and approaches for high-resolution investigations of events preserved in sedimentary records. An approach that combined, rapid collection of cores, a continued annual time series collection of cores, and high-resolution sampling and analyses, in particular short-lived Radioisotopes (SLRad), enabled the temporal resolution required to detect the sedimentary response to the short-duration DwH event, and evaluate post-event sedimentation patterns at a comparable time scale (months).

The collection of 179 sediment cores from 80 sites between …

Exploring Variations In Diet And Migration From Late Antiquity To The Early Medieval Period In The Veneto, Italy: A Biochemical Analysis, Ashley B. Maxwell

USF Tampa Graduate Theses and Dissertations

This project tests the hypothesis that the Langobard migration into the Roman/Byzantine Veneto (northeastern Italy) resulted in significant dietary changes from Late Antiquity (4-5th centuries AD) to the Early Medieval period (6-8th centuries AD). At the end of the Great Germanic Migrations in AD 568, Langobards from Pannonia entered and occupied two-thirds of the Italian peninsula. It is unclear how large these migrations were, as historical documents exaggerate mass movements; however, conservative estimates suggest they made up 8% of the areas they occupied. The degree to which the Langobards influenced economic change and subsistence in this area is poorly understood. …

American Converts To Islam: Identity, Racialization, And Authenticity, Patrick M. Casey

USF Tampa Graduate Theses and Dissertations

Working within a social identity theory model, which posits that identities gain or lose salience depending on the situation and the actors, this study brings into focus the identity management of Americans who have converted to Islam. More specifically, this study of American Muslim converts seeks to understand how the authenticity of their religious identities is challenged and affirmed by others and themselves. Thirty-nine in-depth interviews were examined and interpreted using the insights of narrative analysis and racialization theory. The first finding is that although converts may tell a variety of different stories about how and why they converted to …

Leadership Advocacy, Ethical Negotiations, And Resignations To High-Stakes Assessment: A Pilgrimage, Jennifer Galbraith Canady

USF Tampa Graduate Theses and Dissertations

The purpose of my study is to explore the stories of the ethical tensions K-12 educational administrators navigate when implementing high-stakes assessment policy in a culture of measurement during testing season. Some educational leaders, in particular K-12 school and district administrators, struggle with the tensions existing between their own personal belief systems, organizational dilemmas, and the requirements of enacting high-stakes assessment policies. Using narrative inquiry as method, I collected and analyzed four school administrators selected who expressed frustration with enacting high-stakes assessment policies. The participants include a middle principal, a middle school assistant principal, a high school assistant principal, and …

Genetic Testing And The Power Of The Provider: Women’S Experiences With Cancer Genetic Testing, Dana Erin Ketcher

USF Tampa Graduate Theses and Dissertations

Genetic testing has become ubiquitous in contemporary society, from determining ancestry to addressing health concerns. This dissertation focused on a qualitative, feminist approach to understand women’s experiences of genetic testing for hereditary cancer syndromes, as well as their perspectives of risk. A total of 33 participants agreed to a semistructured interview and drawing of their family tree (pedigree). Eleven (40.7%) participants had been diagnosed with breast cancer, and 16 (59.3%) participants with ovarian cancer. Thirty-one (93.9%) participants had genetic testing, and of those, 17 (54.8%) had genetic counseling. Participants voiced several reasons why they wanted to undergo genetic testing or …

Force Feedback And Intelligent Workspace Selection For Legged Locomotion Over Uneven Terrain, John Rippetoe

USF Tampa Graduate Theses and Dissertations

Legged robots present an incredible opportunity for humanity to conduct dangerous operations such as search and rescue, disaster recovery, and planetary exploration without ever placing themselves in harms way. The ability of a leg to more freely dictate its shape, orientation, and length gives it tremendous mobility and adaptability demanded of a system intended for operation outside of a controlled environment. However, one only need look at the average cat, dog, or friendly neighborhood squirrel to understand the immense gap that exists between what is possible of legged systems and their current set of capabilities.

Areas of study relevant to …

Genomics And Transcriptomics Approaches To Understanding Drug Resistance Mechanisms In The Malaria Parasite Plasmodium Falciparum, Justin Allan Gibbons

USF Tampa Graduate Theses and Dissertations

The malaria parasite Plasmodium falciparum is responsible for about 500,000 deaths a year and is evolving resistance to the front-line treatment of artemisinin-based combination therapy. Resistance is currently confined to South East Asia, however millions of lives will be at risk if resistance spreads to Africa. Understanding the mechanism of resistance to artemisinins would aid containment strategies to prevent the spread of artemisinin resistance. There is also an urgent need to accelerate drug discovery since drug resistance has already been documented to all existing antimalarials. Here, I report on our efforts to understand the function of the gene k13, the …

Advanced Proteomic And Epigenetic Characterization Of Ethanol-Induced Microglial Activation, Jennifer Guergues Guergues

USF Tampa Graduate Theses and Dissertations

Microglia, the resident immune cells of the brain, can exhibit a broad range of activation phenotypes and have been implicated in several diseases and disorders of the central nervous system. Here, we described a method optimized for sensitive and rapid quantitative proteomic analysis of microglia that involves suspension trapping (S-Trap) for efficient and reproducible protein extraction from a microglial cell count expected from an individual mouse brain (~300K) while also simultaneously providing the first comprehensive proteomic characterization of a novel adult-derived mouse microglial cell line. This enhanced method was used throughout all subsequent works and was especially necessary when we …

Investigating The Role Of The Chromosome 19 Microrna Cluster In Human Trophoblast Differentiation And Infantile Hemangioma, Ezinne Francess Mong

USF Tampa Graduate Theses and Dissertations

Trophoblast differentiation and invasion is essential for normal implantation and establishment of the maternal-fetal interface, which allows for proper nutrient exchange and support of the fetus. For this to occur, cytotrophoblasts must undergo an epithelial to mesenchymal transition and differentiate into migratory and invasive extravillous trophoblasts (EVTs) that invade the maternal decidua and myometrium. Trophoblast differentiation, migration and invasion is highly regulated by a complex network of signaling pathways, adhesion molecules and transcription factors and is important for the remodeling of maternal spiral arteries from low flow, high resistance to high flow, low resistance vessels to allow optimal perfusion of …

Saudi Special Education Preservice Teachers’ Perspective Towards Inclusion, Sarah Binmahfooz

USF Tampa Graduate Theses and Dissertations

In Saudi Arabia, students with disabilities have historically received education in special and segregated schools. As times progressed, regulations and laws changed the manner in which students with disabilities were served. Regulations order that students with disabilities be educated in the least restrictive environment; however, preservice teachers’ perspectives continue to differ in regard to working with students with disabilities in a general education setting. Research has shown that teachers who portray positive attitudes towards inclusion are more likely to work with students with disabilities in an inclusive classroom (Dev & Hayes, 2015). Today, inclusion has occurred in schools around the …

Role Of Oncogenic Protein Kinase C-Iota In Melanoma Progression; A Study Based On Atypical Protein Kinase-C Inhibitors, Wishrawana Sarathi Bandara Ratnayake

USF Tampa Graduate Theses and Dissertations

Irrespective of plentiful efforts to enhance primary prevention and early detection, the number of melanoma cases in the United States has increased steadily over the past 30 years, thus greatly affecting public health and the economy. We have investigated the effects of five novel aPKC inhibitors; 2-acetyl-1,3-cyclopentanedione (ACPD), 3,4-Diaminonaphthalene-2,7-disulfonic acid (DNDA), [4-(5-amino-4-carbamoylimidazol-1-yl)-2,3-dihydroxycyclopentyl] methyl dihydrogen phosphate (ICA-1T) along with its nucleoside analog 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide (ICA-1S) and 8-hydroxy-1,3,6-naphthalenetrisulfonic acid (ζ-Stat) on cell proliferation, apoptosis, migration and invasion of two malignant melanoma cell lines compared to normal melanocyte cell lines. Molecular docking data suggested that both ACPD and DNDA specifically bind to protein kinase …

Respiratory Infections And Risk For Development Of Narcolepsy: Analysis Of The Truven Health Marketscan Database (2008 To 2010) With Additional Assessment Of Incidence And Prevalence, Darren Scheer

USF Tampa Graduate Theses and Dissertations

Background and Significance: Narcolepsy is a chronic neurological disorder. These patients experience various psychiatric and physical comorbid diseases and mortality at an increased rate compared to the general population. Additionally, patients with narcolepsy experience approximately a doubling of various annual healthcare related facility visits, transactions, and costs comparatively. Narcolepsy with cataplexy is generally believed to be more prevalent than narcolepsy without cataplexy. However, incidence and prevalence estimates of narcolepsy (with or without cataplexy) vary widely with few large epidemiological studies conducted worldwide and none in the U.S evaluating these proportions in both children and adults utilizing a large health care …

Variations Of Sedimentary Biogenic Silica In The Gulf Of Mexico During The Deepwater Horizon And Ixtoc-I Oil Spill., Jong Jin Lee

USF Tampa Graduate Theses and Dissertations

The goal of this research is to understand the impacts of the 2010 Deepwater Horizon oil spill and the 1970-1980 IXTOC-I oil spill and other anthropogenic activity (e.g. dam construction) on surface water primary productivity by measuring sedimentary biogenic silica. It is known that sedimentary biogenic silica is distinct from mineral – bound silica, therefore it has been used as a proxy record for surface water primary productivity (e.g. diatom blooms). The Deepwater Horizon oil spill resulted in a widespread Marine Oil Snow Sedimentation and Flocculent Accumulation (MOSSFA) event. The IXTOC-I oil spill was one of the largest oil spills …

Because My Garmin Told Me To: A New Materialist Study Of Agency And Wearable Technology, Michael Repici

USF Tampa Graduate Theses and Dissertations

Wearable technologies are being adopted in increasing numbers and the market space appears poised for continued growth in virtually all areas, from medicine, to self-quantification, to sports. While the overwhelming majority of work on wearables has been done on their medical applications and their role in shaping identity, this dissertation examines the roles that wearable technologies play on the decision-making processes in athletic contexts. Using new materialism and Actor Network Theory as lenses, I attempt to break from the Cartesian model that places human subjectivity and intentionality at the center of a rhetorical situation and, rather, allow that non-human actants …

A Comparison Of High-Tech And Low-Tech Response Modalities To Improve Student Performance And Classroom Behavior, Thomas J. Schulz

USF Tampa Graduate Theses and Dissertations

This study compared the effects of high-tech (e.g., clickers) and low-tech (e.g., response cards) active responding strategies during whole-group English language arts in two first-grade classrooms serving students with and without disabilities. The authors combined an ABAB reversal design with an alternating treatments design to compare the impact of using high-tech (clickers) and low-tech (response cards and hand raising) modalities on academic engagement, accuracy of responding, and disruptive behavior across four teacher-nominated students in two first-grade classrooms. During baseline, the teacher conducted her lesson as planned by having the students raise his/her hand to answer questions. In the intervention phase, …

Implementation Of The Prevent-Teach-Reinforce Model Within Multi-Tiered Systems Of Support For Elementary School Students With Problem Behavior, Sofia Reyes

USF Tampa Graduate Theses and Dissertations

This study evaluated the implementation of the school-based Prevent-Teach-Reinforce (PTR) model within multi-tiered systems of support (MTSS) for elementary school students engaging in high levels of problem behavior. Three students and their classroom teachers in two public schools participated in the team-based PTR process during which they engaged in teaming and goal setting, functional behavior assessment, intervention, and evaluation. A multiple baseline across participants design was used to evaluate the impact of using the PTR model on student problem and replacement behaviors. Direct and indirect observations of student behaviors were conducted across target and generalization academic time periods. Findings indicate …

Zooplankton Community Structure In The Ne Gulf Of Mexico: Impacts Of Environmental Variability And The Deepwater Horizon Oil Spill, Kate M. Dubickas

USF Tampa Graduate Theses and Dissertations

In the northeastern Gulf of Mexico, relating changes in zooplankton communities to environmental factors is crucial to understanding the marine ecosystem and impacts of perturbations such as oil spills on marine ecosystems. Zooplankton samples were collected each year between 2005–2014 in spring and summer in the vicinity of the oil spill (Deepwater Horizon) that occurred in spring 2010. Zooplankton assemblages and environmental conditions significantly differed seasonally, driven by strong variations in zooplankton at continental shelf stations, and by environmental factors including Mississippi River discharge, wind direction, temperature, and chlorophyll concentrations. Total zooplankton abundances were greatest at shelf stations, intermediate at …