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Factors Affecting Treatment Success In Community-Acquired Pneumonia, Canan Gündüz, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Aykut Çi̇lli̇, Oğuz Kilinç, Ayşin Şakar Coşkun
Factors Affecting Treatment Success In Community-Acquired Pneumonia, Canan Gündüz, Mehmet Sezai̇ Taşbakan, Abdullah Sayiner, Aykut Çi̇lli̇, Oğuz Kilinç, Ayşin Şakar Coşkun
Turkish Journal of Medical Sciences
Background/aim: Treatment failure in hospitalized patients with community-acquired pneumonia is a major cause of mortality. The aim of this study was to evaluate the factors affecting treatment success in community-acquired pneumonia. Materials and methods: A total of 537 patients (mean age: 66.1 ± 15.8 years, 365 males) registered to the Turkish Thoracic Society Pneumonia Database were analyzed. Of these, clinical improvement or cure, defined as treatment success, was achieved in 477, whereas 60 patients had treatment failure and/or died. Results: Lower numbers of neutrophils (5989.9 ± 6237.3 vs. 8495.6 ± 7279.5/mm3), higher blood urea levels (66.1 ± 42.1 vs. 51.2 …
Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r
Genotypic Analysis Of Escherichia Coli Strains That Cause Urosepsis In The Aegean Region, Betül Gi̇ray, Füsun Bahri̇ye Uçar, Sabi̇re Şöhret Aydemi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to characterize strains genotypically, to determine their phylogenetic relationships, to investigate the presence of the papG gene, and to compare their antibiotic susceptibility test results. Materials and methods: Seventy pathogenic E. coli strains were isolated from both urine and blood cultures of patients with the preliminary diagnosis of urosepsis who were referred to the Ege University Faculty of Medicine, Bacteriology Laboratory of Medical Microbiology Department in İzmir. All of these strains were examined for the papG gene and phylogenetic groups with the multiplex polymerase chain reaction technique. Pulsed-field gel electrophoresis and multilocus sequence …
Distribution Of Hepatitis C Virus Genotypes Among Intravenous Drug Users In The Çukurova Region Of Turkey, Enver Üçbi̇lek, Bahri̇ Abayli, Mahmut Bakir Koyuncu, Durdane Midikli, Süveyda Gözüküçük, Alper Akdağ, Osman Özdoğan, Engi̇n Altintaş, Orhan Sezgi̇n
Distribution Of Hepatitis C Virus Genotypes Among Intravenous Drug Users In The Çukurova Region Of Turkey, Enver Üçbi̇lek, Bahri̇ Abayli, Mahmut Bakir Koyuncu, Durdane Midikli, Süveyda Gözüküçük, Alper Akdağ, Osman Özdoğan, Engi̇n Altintaş, Orhan Sezgi̇n
Turkish Journal of Medical Sciences
Background/aim: The most common hepatitis C virus (HCV) genotype in Turkey is genotype 1. However, there has not been a study about the distribution of HCV genotypes among intravenous drug users (IVDUs) in the Çukurova region of Turkey. This study was planned to understand if there is a difference between IVDUs and the normal population. Materials and methods: Between May 2010 and May 2014, anti-HCV positive IVDUs who applied to the 6 hospitals in the Çukurova region of Turkey were included in this study. Their HCV genotypes were studied. Results: Ninety-seven anti-HCV positive IVDUs were screened in terms of HCV …
Cytomegalovirus Hepatitis In 49 Pediatric Patients With Normal Immunity, Hasan Tezer, Sali̇ha Kanik Yüksek, Belgi̇n Gülhan, Asli Nur Özkaya Parlakay, Ceyda Tuna Kirsaçlioğlu
Cytomegalovirus Hepatitis In 49 Pediatric Patients With Normal Immunity, Hasan Tezer, Sali̇ha Kanik Yüksek, Belgi̇n Gülhan, Asli Nur Özkaya Parlakay, Ceyda Tuna Kirsaçlioğlu
Turkish Journal of Medical Sciences
Background/aim: Cytomegalovirus (CMV) hepatitis is generally asymptomatic or rarely can lead to severe complications in immunocompetent hosts. This study aims to evaluate CMV hepatitis in immunocompetent young children, which is discussed relatively rarely in the literature. Materials and methods: A retrospective review of 49 pediatric patients with CMV hepatitis from January 2005 to December 2010 was performed. Results: The median age of the patients was 5.81 ± 6.49 months and 57.1% were female. Complaints were prolonged jaundice, vomiting, diarrhea, and abdominal distension. Seventeen patients (34.6%) had congenital or probable congenital CMV infection, while 32/49 (65.3%) had perinatal CMV infection. CMV …
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
The Effects Of Balneotherapy On Acute, Process-Related, And Cumulative Peripheral Cardiac Responses And Pulmonary Functions In Patients With Musculoskeletal Disorders, Senem Şaş, Şeyda Toprak Çelenay, Derya Özer Kaya
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the effects of balneotherapy on acute, process-related, and cumulative peripheral cardiac responses and pulmonary functions in patients with musculoskeletal disorders. Materials and methods: Ninety-eight patients with musculoskeletal disorders referred to physiotherapy with balneotherapy were recruited. The patients received balneotherapy for 20 min 5 times per week for 2 weeks. Blood pressure and pulse were measured at the 0th, 5th, 10th, 20th, and 30th minutes during the 1st and 10th sessions. All patients were subjected to pulmonary function testing before balneotherapy and after the 10th session. Results: It was found that systolic blood pressure decreased …
Evaluation Of Epidemiological Characteristics And Risk Factors Affecting Mortality In Patients With Candidemia, Fatma Yilmaz Karadağ, Pinar Ergen, Özlem Aydin, Arzu Doğru, Berri̇n Tanidir, Mustafa Haluk Vahaboğlu
Evaluation Of Epidemiological Characteristics And Risk Factors Affecting Mortality In Patients With Candidemia, Fatma Yilmaz Karadağ, Pinar Ergen, Özlem Aydin, Arzu Doğru, Berri̇n Tanidir, Mustafa Haluk Vahaboğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine epidemiologic characters of patients with candidemia and to evaluate risk factors that can affect mortality rates among these patients. Materials and methods: Patients admitted to the İstanbul Medeniyet University Göztepe Training Hospital between 2009 and 2011 who had a positive blood culture for Candida spp. during hospitalization were studied retrospectively for demographic characteristics and risk factors. Statistical comparisons were estimated with the Stata 12 package. Independent variables associated with mortality were estimated by Cox regression analyses. Results: A total of 89 patients were identified with a positive blood culture. Of the …
Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang
Clinical Characteristics And Outcome Of Brucella Endocarditis, Na Du, Feng Wang
Turkish Journal of Medical Sciences
Background/aim: Brucella endocarditis, which is a rare condition, is the most common cause of death in human brucellosis, leading to severe cardiac complications. By collecting and analyzing clinical cases, we analyzed the clinical characteristics and outcome of Brucella endocarditis in endemic areas in China. Materials and methods: Presented here are 5 cases of Brucella endocarditis, all managed uniformly. We present the clinical, serological, and echocardiographic features; the therapeutic approach; and the follow-up of five patients with Brucella endocarditis. Results: There was a predominance of aortic involvement (4 cases) and a high incidence of left ventricular failure (5 cases). Polymerase chain …
Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci
Pityriasis Rosea: A Natural History Of Pediatric Cases In Thecentral Anatolia Region Of Turkey, Emi̇ne Çölgeçen, Çi̇ğdem Kader, Yilmaz Ulaş, Pinar Öztürk, Öznur Küçük, Mehmet Balci
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the demographic, clinical, and epidemiological features of pityriasis rosea (PR) in a cohort of 46 children in Yozgat, a city in the Central Anatolia Region of Turkey. Materials and methods: Forty-six children with PR were monitored at regular intervals (1, 2, 4, and 12 weeks) for 3 months from the time of diagnosis. A complete evaluation of the patient was performed at each visit. Results: The average age of patients at time of diagnosis was 12 ± 3.9 years. Cases were most common in the winter (rainy, snowy months; n = 14, 31%). Fifteen …
Treatment Efficacy And Superinfection Rates In Complicated Urinarytract Infections Treated With Ertapenem Or Piperacillin Tazobactam, Murat Di̇zbay, Hasan Selçuk Özger, Ömer Karaşahi̇n, Emi̇ne Füsun Karaşahi̇n
Treatment Efficacy And Superinfection Rates In Complicated Urinarytract Infections Treated With Ertapenem Or Piperacillin Tazobactam, Murat Di̇zbay, Hasan Selçuk Özger, Ömer Karaşahi̇n, Emi̇ne Füsun Karaşahi̇n
Turkish Journal of Medical Sciences
Background/aim: In this retrospective study, the efficacy of ertapenem and piperacillin tazobactam was compared in the treatment of complicated urinary tract infections (cUTIs). Treatment responses were also evaluated for both antibiotics. Materials and methods: A total of 230 patients were enrolled in the study. Of these, 170 received ertapenem and 60 received piperacillin-tazobactam. Results: In both groups, urine cultures after 48 h were negative for the initial uropathogen. The frequency of superinfection was 29.4% in the ertapenem group and 8.3% in the piperacillin-tazobactam group over the duration of treatment (P < 0.05). Urinary catheterization increased the superinfection risk 2.88-fold in the ertapenem group and diabetes mellitus increased the risk 8.50-fold in the piperacillin-tazobactam group (CI: 1.44-5.76 and 1.16-62.09, respectively, P < 0.05). The main pathogen isolated from superinfection in the ertapenem group after 48 h was Enterococcus spp. (71.4%). Conclusion: Both ertapenem and piperacillin-tazobactam were effective in the treatment of cUTIs caused by ESBL-producing microorganisms. A high frequency of superinfection in the ertapenem group was the result of Enterococcus and Pseudomonas spp., against which ertapenem is not active. In the presence of urinary catheterization, diabetes mellitus, and urological intervention, patients should be closely monitored for the development of a superinfection, especially patients receiving ertapenem.
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Exploring Cyp2b6 Activity By Measuring The Presence Ofnevirapine Hydroxy Metabolites In Plasma, Suzana Mustafa, Norul Badriah Hassan, Soo Choon Tan, Mahiran Mustafa, Ahmad Kashfi Ab Rahman, Lee Lee Low, Wan Nazirah Wan Yusuf
Turkish Journal of Medical Sciences
Background/aim: Nevirapine is a reverse-transcriptase inhibitor widely used in combination therapy to treat HIV infection. Nevirapine is extensively metabolized in the liver and CYP2B6 is mainly responsible for oxidation of 3-hydroxynevirapine (3-OH NVP). This study aims to explore CYP2B6 activity by measuring 2-hydroxynevirapine (2-OH NVP) and 3-OH NVP in plasma and to identify factors associated with nevirapine pharmacokinetic parameters. Materials and methods: A total of 112 patients were recruited and treated with nevirapine-based antiretroviral therapy. Plasma nevirapine and metabolite concentrations were assayed using high-performance liquid chromatography via liquid-liquid extraction. Results: Thirty-nine (34.8%) of the patients had no 3-OH NVP detected …
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Growing Oxa-23 Type Strains Among Carbapenem-Resistant Acinetobacter Baumannii And Tigecycline As An Alternate Combination Therapy, Şeri̇fe Altun, Zeli̇ha Koçak Tufan, Belgi̇n Altun, Ufuk Önde, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
Background/aim: The increasing prevalence and global spread of difficult-to-treat carbapenem-resistant Acinetobacter baumannii has become a serious problem. The aim of this study is to investigate the resistance patterns and tigecycline sensitivity of carbapenem-resistant A. baumannii strains. Materials and methods: Acinetobacter strains that were carbapenem-resistant and collected mainly from intensive care units were included into this study. The antibiotic sensitivity/resistance of the strains to other antibiotics and tigecycline were noted. Presence of blaOXA-23, blaOXA-48, blaOXA58, and NDM-1 was investigated by PCR. Results: In total, 44 carbapenem-resistant A. baumannii strains were detected. In addition, 57% (25/44) showed resistance to netilmicin and 2% …
Frequency Of Twelve Carcinogenic Human Papilloma Virus Types Among Women From The South Backa Region, Vojvodina, Serbia, Gordana Kovacevic, Natasa Nikolic, Aleksandra Jovanovic-Galovic, Ivana Hrnjakovic-Cvjetkovic, Dusan Vuleta, Aleksandra Patic, Jelena Radovanov, Vesna Milosevic
Frequency Of Twelve Carcinogenic Human Papilloma Virus Types Among Women From The South Backa Region, Vojvodina, Serbia, Gordana Kovacevic, Natasa Nikolic, Aleksandra Jovanovic-Galovic, Ivana Hrnjakovic-Cvjetkovic, Dusan Vuleta, Aleksandra Patic, Jelena Radovanov, Vesna Milosevic
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the presence and age distribution of different oncogenic human papilloma virus (HPV) types in women in the South Backa region and its relationship to Pap results. Materials and methods: In a group of 1087 women with normal and abnormal cytology, the commercial HR HPV Real-TM kit (Sacace Biotechnologies, Italy) was used. Results: Overall, 50.5% of the women were HPV positive. The presence of HPV types 18, 31, 51, and 58 was significantly influenced by age, while the presence of HPV types 16 and 45 was significantly influenced by cervical cytology. Results …
Impact Of Antimicrobial Drug Restrictions On Doctors? Behaviors, Oğuz Karabay, Sali̇h Hoşoğlu, Ertuğrul Güçlü, Şeri̇fe Akalin, Fatma Aybala Altay, Emsal Aydin, Bahadir Ceylan, Aygül Çeli̇k, İlhami̇ Çeli̇k, Tuna Demi̇rdal, Kezi̇ban Demi̇rli̇, Nuretti̇n Erben, Ünal Erkorkmaz, Serpi̇l Erol, Ömer Evi̇rgen
Impact Of Antimicrobial Drug Restrictions On Doctors? Behaviors, Oğuz Karabay, Sali̇h Hoşoğlu, Ertuğrul Güçlü, Şeri̇fe Akalin, Fatma Aybala Altay, Emsal Aydin, Bahadir Ceylan, Aygül Çeli̇k, İlhami̇ Çeli̇k, Tuna Demi̇rdal, Kezi̇ban Demi̇rli̇, Nuretti̇n Erben, Ünal Erkorkmaz, Serpi̇l Erol, Ömer Evi̇rgen
Turkish Journal of Medical Sciences
Background/aim: Broad-spectrum antibiotics have become available for use only with the approval of infectious disease specialists (IDSs) since 2003 in Turkey. This study aimed to analyze the tendencies of doctors who are not disease specialists (non-IDSs) towards the restriction of antibiotics. Materials and methods: A questionnaire form was prepared, which included a total of 22 questions about the impact of antibiotic restriction (AR) policy, the role of IDSs in the restriction, and the perception of this change in antibiotic consumption. The questionnaire was completed by each participating physician. Results: A total of 1906 specialists from 20 cities in Turkey participated …
Cost Analysis And Evaluation Of Nosocomial Infections In Intensive Care Units, Uğur Kostakoğlu, Sedat Saylan, Mevlüt Karataş, Serap İskender, Fi̇rdevs Aksoy, Gürdal Yilmaz
Cost Analysis And Evaluation Of Nosocomial Infections In Intensive Care Units, Uğur Kostakoğlu, Sedat Saylan, Mevlüt Karataş, Serap İskender, Fi̇rdevs Aksoy, Gürdal Yilmaz
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to evaluate nosocomial infections occurring in our hospital intensive care units (ICUs) and the risk factors for these, and to determine the effect of these infections on mortality and cost. Materials and methods: This retrospective study was performed via infection control committee surveillance data, ICU records, and information processing data between 1 January and 31 December 2013 at the Kanuni Education and Research Hospital. Results: A total of 309 nosocomial infections were observed in 205 out of 566 patients. The density of nosocomial infections was 25.4 in 1000 patient days. Hospitalization was prolonged, …
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
The Common Genetic Variants Of Toll-Like Receptor And Susceptibilityto Adenoid Hypertrophy: A Hospital-Based Cohort Study, Mehmet Ali̇ Babademez, Tali̇h Özdaş, Si̇bel Özdaş
Turkish Journal of Medical Sciences
Background/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH. Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software. Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = …
Mucormycosis: A 10-Year Experience At A Tertiary Care Center In Turkey, Süheyla Kömür, Ayşe Seza İnal, Behi̇ce Kurtaran, Aslihan Ulu, Aysun Uğuz, Hasan Sali̇h Zeki̇ Aksu, Yeşi̇m Taşova
Mucormycosis: A 10-Year Experience At A Tertiary Care Center In Turkey, Süheyla Kömür, Ayşe Seza İnal, Behi̇ce Kurtaran, Aslihan Ulu, Aysun Uğuz, Hasan Sali̇h Zeki̇ Aksu, Yeşi̇m Taşova
Turkish Journal of Medical Sciences
Background/aim: Mucormycosis is a rare invasive fungal infection most commonly encountered in the immunocompromised host. We analyzed 51 adult patients treated for mucormycosis between 2003 and 2013 and recorded at a tertiary university hospital in Turkey. Materials and methods: We examined the following data for all patients: age, sex, predisposing disease, symptoms, treatment, surgical procedure, concomitant infections, intensive care requirement, and outcomes. Results: During the study period 51 cases of mucormycosis were documented; 54.9% of the patients were female. The mean age was 44.2 ± 18.2 years. Rhinocerebral presentation was reported in 94.1% of patients. Almost all patients (88.2%) had …
Neopterin, Homocysteine, And Adma Levels During And After Urticaria Attack, Sali̇m Kemal Tuncer, Ümi̇t Kaldirim, Yusuf Emrah Eyi̇, Ali̇ Osman Yildirim, Şafak Eki̇nci̇, Kemal Kara, Murat Eroğlu, Muzaffer Öztosun, Selahatti̇n Özyürek, Murat Durusu, Mustafa Güleç, Tuncer Çayci, Özcan Altinel, Hüseyi̇n Levent Yamanel
Neopterin, Homocysteine, And Adma Levels During And After Urticaria Attack, Sali̇m Kemal Tuncer, Ümi̇t Kaldirim, Yusuf Emrah Eyi̇, Ali̇ Osman Yildirim, Şafak Eki̇nci̇, Kemal Kara, Murat Eroğlu, Muzaffer Öztosun, Selahatti̇n Özyürek, Murat Durusu, Mustafa Güleç, Tuncer Çayci, Özcan Altinel, Hüseyi̇n Levent Yamanel
Turkish Journal of Medical Sciences
Background/aim: Urticaria is a vascular skin reaction characterized with papules and plaques. Neopterin is accepted as an immunologic marker and an indicator of activation of the immune system. Homocysteine and asymmetric dimethylarginine (ADMA) are the markers of increased vascular resistance. Alteration in vascular resistance has a role in the pathogenesis of urticaria. We aimed to investigate whether there is a relationship between urticaria and neopterin, homocysteine, or ADMA. Materials and methods: The study is designed as a prospective descriptive study and patients with a diagnosis of urticaria in the emergency department were included in the study. Demographic data and characteristics …
Pharyngeal Carriage Rate Of Neisseria Meningitidis Before And After Thehajj Pilgrimage, In Zahedan (Southeastern Iran), 2012, Maliheh Metanat, Batool Sharifi-Mood, Sara Sanei-Moghaddam, Nahid Sepehri Rad
Pharyngeal Carriage Rate Of Neisseria Meningitidis Before And After Thehajj Pilgrimage, In Zahedan (Southeastern Iran), 2012, Maliheh Metanat, Batool Sharifi-Mood, Sara Sanei-Moghaddam, Nahid Sepehri Rad
Turkish Journal of Medical Sciences
Background/aim: The annual Hajj pilgrimage to Mecca, which attracts more than 3 million Muslim pilgrims from around the world, has played a role in the global spread of meningococcal infection. We aimed to compare pharyngeal carriage of Neisseria meningitidis in Hajj pilgrims before departure and after returning to Iran, Zahedan. Materials and methods: This prospective and cross-sectional study was conducted among Hajj pilgrims in Zahedan (southeast Iran) in 2012. We studied all pilgrims who agreed to participate in this study and who met the inclusion criteria. Sampling was done by swabbing the posterior pharyngeal wall through the mouth with direct …
Characterization Of Klebsiella Isolates By Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (Maldi-Tof Ms) And Determination Of Antimicrobial Resistance With Vitek 2 Advanced Expert System (Aes), Alper Karagöz, Sümeyra Acar, Hani̇fi̇ Körkoca
Characterization Of Klebsiella Isolates By Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (Maldi-Tof Ms) And Determination Of Antimicrobial Resistance With Vitek 2 Advanced Expert System (Aes), Alper Karagöz, Sümeyra Acar, Hani̇fi̇ Körkoca
Turkish Journal of Medical Sciences
Background/aim: The purpose of the study was to evaluate the performance of the VITEK mass spectrometry (MS) (bioMérieux, France) system for the identification of Klebsiella spp. isolated from different sources. Moreover, while assessing the ability of the VITEK 2 automated expert system (AES) to recognize antimicrobial resistance patterns, the researchers have extended the study to compare VITEK 2 with the routine antimicrobial susceptibility testing method. Materials and methods: This study tested 51 Klebsiella spp. isolates that were isolated from environmental examples and clinical examples. Results of conventional methods and the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) MS were compared. Then, any …
Pcr Investigation Of Panton-Valentine Leukocidin, Enterotoxin, Exfoliative Toxin,And Agr Genes In Staphylococcus Aureus Strains Isolated From Psoriasis Patients, Juli̇de Sedef Göçmen, Neri̇man Şahi̇ner, Mukadder Koçak, Zeynep Ceren Karahan
Pcr Investigation Of Panton-Valentine Leukocidin, Enterotoxin, Exfoliative Toxin,And Agr Genes In Staphylococcus Aureus Strains Isolated From Psoriasis Patients, Juli̇de Sedef Göçmen, Neri̇man Şahi̇ner, Mukadder Koçak, Zeynep Ceren Karahan
Turkish Journal of Medical Sciences
Background/aim: Staphylococcus aureus colonization is a determiner of disease activation in psoriasis patients. Here we evaluate the presence of genes encoding Panton-Valentine leukocidin (PVL), enterotoxins, TSST-1, exfoliative toxins, and the accessory gene regulatory locus by polymerase chain reaction (PCR) in S. aureus isolates obtained from healthy and diseased skin regions and anterior nares of psoriasis patients and healthy controls. Materials and methods: The presence of PVL and toxin genes was investigated, and agr typing was performed by PCR. Results: Eighteen of the isolated strains carried the sei, 1 carried the seb-sec, and 1 carried the seg1397645907enterotoxin gene. Eight of the …
Differences In The Effectiveness Of Serum Biomarkers For The Diagnosis Of Bacterial Infections In Adult And Elderly Patients Admitted To The Emergency Department, Hava Yilmaz, Lati̇f Duran, Kerametti̇n Yanik, Mehmet Altuntaş, Mustafa Sünbül
Differences In The Effectiveness Of Serum Biomarkers For The Diagnosis Of Bacterial Infections In Adult And Elderly Patients Admitted To The Emergency Department, Hava Yilmaz, Lati̇f Duran, Kerametti̇n Yanik, Mehmet Altuntaş, Mustafa Sünbül
Turkish Journal of Medical Sciences
Background/aim: This study aimed to evaluate the superiority of procalcitonin (PCT), C-reactive protein (CRP) levels, white blood cell (WBC) counts, and erythrocyte sedimentation rate (ESR) in discriminating among infection, systemic inflammatory response syndrome (SIRS), and sepsis, and their differences according to age groups. Materials and methods: The patients were divided into an adult group and a geriatric group (over 65 years) and classified according to the presence of infection, SIRS, and sepsis. The patients' laboratory values (PCT, CRP, WBC, ESR), demographic characteristics, and vital signs were taken into consideration. Results: When the laboratory parameters were evaluated, there were no significant …
Prospective Investigation Of The Hypothalamo?Pituitary?Adrenalaxis In Patients With Tularemia, Hayati̇ Demi̇raslan, Yasi̇n Şi̇mşek, Fati̇h Tanriverdi̇, Mehmet Doğanay, Hasan Fahretti̇n Keleştemur
Prospective Investigation Of The Hypothalamo?Pituitary?Adrenalaxis In Patients With Tularemia, Hayati̇ Demi̇raslan, Yasi̇n Şi̇mşek, Fati̇h Tanriverdi̇, Mehmet Doğanay, Hasan Fahretti̇n Keleştemur
Turkish Journal of Medical Sciences
Background/aim: To investigate prospectively the hypothalamo-pituitary-adrenal (HPA) axis by adrenocorticotropic hormone (ACTH) stimulation test. Materials and methods: Tularemia was diagnosed according to guidelines. An ACTH stimulation test (1 µg) and a dexamethasone suppression test (DST; 1 mg) were performed in patients in the acute phase of tularemia before antibiotic treatment and in the chronic phase. Results: Nineteen patients (mean age: 41.0 ± 13.2 years; 57.9% female) with tularemia were enrolled in the study in 2011 and 2012. Cortisol response to ACTH stimulation test was sufficient in all patients during the acute phase. After the DST, the cortisol was not suppressed …
Diagnostic And Prognostic Value Of Procalcitonin And Strem-1 Levels In Sepsis*, Hali̇m Bayram, Özlem Tünger, Melek Çi̇vi̇, Müni̇p Hakan Yüceyar, Cevval Ulman, Gönül Di̇nç Horasan, Çi̇ğdem Banu Çeti̇n
Diagnostic And Prognostic Value Of Procalcitonin And Strem-1 Levels In Sepsis*, Hali̇m Bayram, Özlem Tünger, Melek Çi̇vi̇, Müni̇p Hakan Yüceyar, Cevval Ulman, Gönül Di̇nç Horasan, Çi̇ğdem Banu Çeti̇n
Turkish Journal of Medical Sciences
Background/aim: Sepsis is still a major cause of morbidity and mortality despite the improvements in diagnosis and treatment. The aim of this study was to investigate the values of procalcitonin and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the differential diagnosis of patients with sepsis and noninfectious systemic inflammatory response syndrome (NI-SIRS) and measure their importance in the prognosis of patients with sepsis. Materials and methods: This prospective study included 41 NI-SIRS and 33 sepsis patients hospitalized in Celal Bayar University Hospital, Manisa, Turkey. Blood samples were taken from NI-SIRS patients on days 0 and 3 and from …
Serologic Testing For Celiac Disease In Young People With Elevated Transaminases, Juanli Yuan, Jinyan Gao, Yonghong Yao, Hongbing Chen
Serologic Testing For Celiac Disease In Young People With Elevated Transaminases, Juanli Yuan, Jinyan Gao, Yonghong Yao, Hongbing Chen
Turkish Journal of Medical Sciences
Background/aim: A cryptogenic elevation of transaminases is the most common hepatic manifestation in celiac disease (CD). In adult patients and pediatric patients with cryptogenic hypertransaminasemia, the prevalence of CD was 4% and 12%, respectively. However, there are no related data from China in this regard. We aimed to investigate the status of CD in young Chinese patients with elevated transaminases. Materials and methods: A total of 125 patients with elevated transaminases and 125 healthy individuals as controls with matched age and sex were involved in the study. Serum markers of hepatitis B were determined in patients with elevated transaminases. All …
In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün
In Vitro Efficacy Of Frozen Erythrocytes: Implementation Of New Strategicblood Stores To Alleviate Resource Shortage (Issue Revisited), Riza Aytaç Çeti̇nkaya, Soner Yilmaz, İbrahi̇m Eker, Ayteki̇n Ünlü, Meti̇n Uyanik, Serkan Tapan, Ahmet Pekoğlu, Ali̇ye Aysel Pekel, Zerri̇n Ertaş, Orhan Gürsel, Uğur Haci̇ Muşabak, Sebahatti̇n Yilmaz, İsmai̇l Yaşar Avci, Ahmet Türker Çeti̇n, Can Polat Eyi̇gün
Turkish Journal of Medical Sciences
Background/aim: Currently, the provision of blood products largely depends on walking blood banks and limited amounts of stored blood with short shelf lives. We aimed to compare the efficacy of erythrocyte concentrate (ECs) by pre- and postfreezing in vitro tests. Materials and methods: In our study, 10 ECs were glycerolized, frozen, thawed, and then deglycerolized using the Naval Blood Research Laboratory method. In addition to using the standard tests, ATP and 2,3-DPG levels and the viability of erythrocytes were also determined. Results: The prefreezing mean viability rates of erythrocytes changed from 89.7 ± 13.7% to 98.6 ± 1.8% after thawing …
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Epidemiological And Clinical Characteristics And Management Of Oropharyngeal Tularemia Outbreak, Mustafa Önder Uzun, Kerametti̇n Yanik, Müge Erdem, Uğur Kostakoğlu, Gürdal Yilmaz, Yeli̇z Tanriverdi̇ Çayci
Turkish Journal of Medical Sciences
Background/aim: The purpose of this study was to determine the epidemiological and clinical characteristics of patients diagnosed with tularemia and the effectiveness of the administered treatments. Materials and methods: Patients treated in our hospital between January 2009 and March 2011 and diagnosed with tularemia were evaluated retrospectively. Patients' epidemiological and clinical characteristics, administered treatments, and posttreatment findings were recorded on patient monitoring forms. Results: At anamnesis, 29% of patients used water from wells and 71% used water from the network supply; moreover, 48.4% had a history of contact with animals and 87.1% a history of lethargy. At physical examination, 96.8% …
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Antibiofilm Activity Of Trans-Cinnamaldehyde, P-Coumaric, And Ferulic Acids On Uropathogenic Escherichia Coli, Barbara Kot, Jolanta Wicha, Malgorzata Piechota, Katarzyna Wolska, Agata Gruzewska
Turkish Journal of Medical Sciences
Background/aim: Biofilm on urinary catheters results in persistent infections that are resistant to antibiotics. In this study, phytochemicals were assessed as alternative antimicrobials in preventing and inactivating E. coli biofilm on urinary catheters. Materials and methods: Biofilm prevention was tested using catheter fragments inoculated with E. coli and treated with trans-cinnamaldehyde, p-coumaric, and ferulic acids (0%, 0.1%, 0.25%, and 0.5%) for 0, 1, 3, and 5 days. Inactivation of E. coli biofilm with the same agents at concentrations of 0%, 1%, 1.25%, or 1.5% used for 0, 1, 3, or 5 days was also evaluated. Results: All used concentrations of …
Efficacy Of Entecavir Treatment Among Chronic Hepatitis B Nucleos(T)Ide-Naïve And -Experienced Patients, Kadi̇r Çağatay Bi̇çer, Alpay Ari, Vecdi̇ Evren Genç, Si̇bel Özsu Caymaz, Meltem Avci, Fatma Bal
Efficacy Of Entecavir Treatment Among Chronic Hepatitis B Nucleos(T)Ide-Naïve And -Experienced Patients, Kadi̇r Çağatay Bi̇çer, Alpay Ari, Vecdi̇ Evren Genç, Si̇bel Özsu Caymaz, Meltem Avci, Fatma Bal
Turkish Journal of Medical Sciences
To evaluate the efficacy of entecavir (ETV) among chronic hepatitis B (CHB) nucleos(t)ide-naïve and -experienced patients in clinical practice. Materials and methods: In this retrospective study 85 CHB patients who had been receiving ETV and who attended our clinic since 2007 were included. Fifty patients were nucleos(t)ide analogue (NA)-naïve. Factors including sex, positive HBeAg, baseline HBV DNA level, baseline alanine aminotransferase level, and prior lamivudine (LAM) resistance were evaluated in terms of their predictive role in treatment response, which was defined as a serum HBV DNA decrease of
Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut
Investigation Of Tnf-Alpha Gene (G308a) And Gstp1 Gene (Ile105val) Polymorphisms In Turkish Patients With Retinopathy Of Prematurity, Mehmet Türe, Meral Yildiz, Mutlu Karkucak, Emi̇ne Tuna Gülten, Deni̇z Siğirli, Ahmet Tuncer Özmen, Tahsi̇n Yakut
Turkish Journal of Medical Sciences
Retinopathy of prematurity (ROP) is one of the most frequent causes of blindness in newborn babies. Currently, its etiology is not fully understood. In this study we aimed to investigate the correlation between a patient group with ROP and a control group in terms of the tumor necrosis factor-alpha (TNF-alpha) (G308A) gene and glutathione-S-transferase P1 (GSTP1) (Ile105Val) gene polymorphism. Materials and methods: Sixty-two patients diagnosed with ROP and 58 control subjects were included in this study. For TNF-alpha (G308A) gene and GSTP1 (Ile105Val) gene polymorphisms, the polymerase chain reaction-restriction fragment length polymorphism method was used. In statistical analysis the significance …
Effects On Quinolone Resistance Due To The Biofilm Formation Activity In Ureaplasma Urealyticum, Chunyan Feng, Ya Huang, Yunsong Yu, Guorong Duan, Yuying Dai, Ke Dong, Qingtian Li
Effects On Quinolone Resistance Due To The Biofilm Formation Activity In Ureaplasma Urealyticum, Chunyan Feng, Ya Huang, Yunsong Yu, Guorong Duan, Yuying Dai, Ke Dong, Qingtian Li
Turkish Journal of Medical Sciences
To detect the effects on quinolone resistance due to biofilm formation activity in Ureaplasma urealyticum. Materials and methods: An improved checkerboard dilution susceptibility test was used to analyze the quinolone resistance of clinical Ureaplasma isolates and a postbiofilm formation susceptibility assay was used to compare the effects on the quinolone susceptibility between pre- and postbiofilm formations. Several important functional gene expressions were detected to evaluate their roles in the process of the quinolone resistance mechanism. Results: The quinolone-resistant isolates produced more biofilms than the sensitive isolates. In both the quinolone-resistant and -sensitive groups, the minimal inhibitory concentrations after biofilm formation …