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Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç
Central Line-Associated Blood Stream Infections: Characteristics And Risk Factors Formortality Over A 5.5-Year Period, Aynur Ati̇lla, Zahi̇de Doğanay, Hale Kefeli̇ Çeli̇k, Mehmet Derya Demi̇rağ, Süleyman Sirri Kiliç
Turkish Journal of Medical Sciences
Background/aim: Central line-associated bloodstream infections (CLABSIs) are associated with substantial morbidity and mortality and the infection rates vary in a wide range (high: 62.5%; low: 20%) in developing countries. We aimed to investigate the characteristics and the risk factors for mortality in patients with CLABSIs in intensive care units (ICUs) and provide the relevant data. Materials and methods: The electronic medical records database and file records obtained through active surveillance by an infection control committee of a hospital were screened to identify patients with CLABSIs hospitalized from January 2008 through July 2013. Results: A total of 166 CLABSI episodes in …
Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran
Patients' Attitudes And Knowledge About Drug Use: A Survey In Turkish Family Healthcare Centres And State Hospitals, Ahmet Akici, Sali̇h Mollahali̇loğlu, Başak Dönertaş, Şenay Özgülcü, Ali̇ Alkan, Nesri̇n Fi̇li̇z Başaran
Turkish Journal of Medical Sciences
Background/aim: Irrational drug use is a common problem. This study aimed to evaluate patients' knowledge and habits concerning drug use, and compare them in terms of some sociodemographic characteristics. Materials and methods: A face-to-face questionnaire was given to outpatients from family healthcare centres (FHCs) and state hospitals (SHs) in 12 provinces in Turkey during May 2010. A total of 4470 patients (FHCs: 2209; SHs: 2261) responded to the questionnaire (response rate: 93.1%). Results: Getting prescriptions without a physical examination was common (second place in FHCs; third place in SHs); 51.0% stated that they wanted physicians to prescribe drugs that they …
Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam
Epidemiology And Analysis Of Invasive Fungal Infections In Patients Withhematological Malignancies: A Single-Center Real-Life Experience, Nur Soyer, Hati̇ce Demet Ki̇per Ünal, Fi̇li̇z Vural, Fahri̇ Şahi̇n, Mahmut Töbü, Ayhan Dönmez, Murat Tombuloğlu, Bi̇lgi̇n Arda, Güray Saydam
Turkish Journal of Medical Sciences
Background/aim: Invasive fungal infection (IFI) causes morbidity and mortality among patients with hematological malignancies. We evaluated the incidence and treatment characteristics of IFIs between October 2012 and December 2013. Materials and methods: Patients who received chemotherapy or stem cell transplantation were retrospectively evaluated. Fungal infections were classified according to EORTC criteria.Results: Prophylaxis and antifungal therapy were given in 30.5% and 23.6% of 522 chemotherapy courses, respectively. The incidence of proven/probable IFI was 6.7%. The incidence of IFI among patients who received prophylaxis was significantly higher than among those who did not receive it (11.3% vs. 4.6%, P = 0.005). There …
The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan
The Importance Of Routine Bedside Biliary Ultrasonography In The Management Of Patients Admitted To The Emergency Department With Isolated Acute Epigastric Pain, Vermi̇ Değerli̇, Tanzer Korkmaz, Hülya Mollamehmetoğlu, Cem Ertan
Turkish Journal of Medical Sciences
Background/aim: The aim of our study was to emphasize the importance of routine bedside biliary ultrasonography (USG) for the differential diagnosis of biliary tract disorders in patients admitted with acute isolated epigastric pain. Materials and methods: Adult patients who were admitted to the emergency department with acute isolated epigastric pain were included in the study. Emergency residents (ERs) were asked whether they planned to perform biliary USG during the initial evaluation and following diagnosis/treatment (secondary evaluation) of these patients. Bedside biliary USG examinations were performed by a sonologist and a radiologist evaluated the video recordings. Results: A total of 103 …
Antibacterial Resistance Patterns And Incidence Of Hospital-Acquired Staphylococcus Aureus Bacteremia In A Tertiary Care Educational Hospital In Turkey: A Perspective From 2001 To 2013, Oğuz Reşat Si̇pahi̇, Serhat Uysal, Sabi̇re Şöhret Aydemi̇r, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feri̇ha Çi̇lli̇, Tansu Yamazhan, Bi̇lgi̇n Arda, Hi̇lal Si̇pahi̇, Sercan Ulusoy
Antibacterial Resistance Patterns And Incidence Of Hospital-Acquired Staphylococcus Aureus Bacteremia In A Tertiary Care Educational Hospital In Turkey: A Perspective From 2001 To 2013, Oğuz Reşat Si̇pahi̇, Serhat Uysal, Sabi̇re Şöhret Aydemi̇r, Hüsnü Pullukçu, Meltem Taşbakan, Alper Tünger, Fatma Feri̇ha Çi̇lli̇, Tansu Yamazhan, Bi̇lgi̇n Arda, Hi̇lal Si̇pahi̇, Sercan Ulusoy
Turkish Journal of Medical Sciences
Background/aim: Staphylococcus aureus is an important nosocomial pathogen and a successful antimicrobial-resistance developer. In this study we retrospectively evaluated the resistance patterns and incidence of microbiologically confirmed nosocomial bacteremia (MCNB) related S. aureus strains between 2001 and 2013. Materials and methods: Any patient in whom S. aureus was isolated in at least one set of blood cultures (sent to the bacteriology laboratory 72 h after hospital admission) was considered to have MCNB. Results: The methicillin-resistant S. aureus (MRSA) rate in 2001 was 73.8% whereas it was 36.2% in 2013. When the 2001-2003 and 2011?2013 periods were compared, resistance to oxacillin, …
The Comparison Of Various Disinfectants? Efficacy On Staphylococcus Aureus And Pseudomonas Aeruginosa Biofilm Layers, Hati̇ce Köse, Nur Yapar
The Comparison Of Various Disinfectants? Efficacy On Staphylococcus Aureus And Pseudomonas Aeruginosa Biofilm Layers, Hati̇ce Köse, Nur Yapar
Turkish Journal of Medical Sciences
Background/aim: Because biofilms are resistant to antibiotics and biocides, they usually cause chronic persistent infections, which are arduous to cure and have high mortality and morbidity. Our study aimed to investigate the efficiency of orthophthalaldehyde, peracetic acid, hydrogen peroxide, and sodium hypochlorite on Pseudomonas aeruginosa and Staphylococcus aureus biofilm layers and live microbial cells. Materials and methods: Biofilm layers were determined by crystal violet assay and live microbial cells were determined using a resazurin assay. Results: For Pseudomonas aeruginosa, sodium hypochlorite showed the most influential disinfection because it diminished 83.6% of the biofilm layer and decreased 99.7% of live microbial …
Intralesional Epidermal Growth Factor Therapy Fordiabetic Foot Ulcers: An Evaluation Of 15 Cases, Meltem Taşbakan, Ilgin Yildirim Şi̇mşi̇r, Si̇nan Mermer, Serhat Uysal, Anil Murat Öztürk, Şevki̇ Çeti̇nkalp
Intralesional Epidermal Growth Factor Therapy Fordiabetic Foot Ulcers: An Evaluation Of 15 Cases, Meltem Taşbakan, Ilgin Yildirim Şi̇mşi̇r, Si̇nan Mermer, Serhat Uysal, Anil Murat Öztürk, Şevki̇ Çeti̇nkalp
Turkish Journal of Medical Sciences
Background/aim: Intralesional recombinant epidermal growth factor (EGF) is a new treatment approach for diabetic foot ulcer, approved in 2006. EGF therapy is given as an adjunct to the standard treatment regimen of antibiotics, surgery, and hyperbaric oxygen. EGF accelerates the healing of diabetic foot ulcers and reduces healing time. This single-center study was conducted to evaluate the outcomes of intralesional EGF therapy in patients with diabetic foot ulcers.Materials and methods: We present the data of the follow-up patients treated in our clinics. Fifteen patients with diabetic foot ulcers or infections, who had been followed up and treated in our clinics, …
Surveillance Of Preventive Measures For Ventilator Associated Pneumonia (Vap) And Its Rate In Makkah Region Hospitals, Saudi Arabia, Ahmad Banjar, Mohammed Felemban, Khalid Dhafar, Zohair Gazzaz, Badr Al Harthi, Mukhtiar Baig, Kasim Al Khatib, Jameela Zakaria, Kawther Hawsawi, Lilma Isahac, Arbi Akbar
Surveillance Of Preventive Measures For Ventilator Associated Pneumonia (Vap) And Its Rate In Makkah Region Hospitals, Saudi Arabia, Ahmad Banjar, Mohammed Felemban, Khalid Dhafar, Zohair Gazzaz, Badr Al Harthi, Mukhtiar Baig, Kasim Al Khatib, Jameela Zakaria, Kawther Hawsawi, Lilma Isahac, Arbi Akbar
Turkish Journal of Medical Sciences
Background/aim: The present study aimed to assess the VAP rate and to identify VAP prevention activities in public sector hospitals situated in the Makkah Region, Saudi Arabia (SA). Materials and methods: In this cross-sectional study, the VAP data from 13 public sector hospitals were collected from January to December 2013 and analyzed using SPSS 16. Results: The overall VAP rate in Makkah Region hospitals was 6.89 cases per 1000 ventilator-days. There was a significant difference in VAP rate among the hospitals of the Makkah Region (P < 0.001). There was no significant difference in the VAP rate among hospitals, which were using only one, two, or all three VAP preventive approaches (P = 0.26) accredited by the Joint Commission International (JCI) and Central Board for Accreditation of Health Care Institution (CBAHI) (P = 0.12), and using the form in intensive care units (ICUs) (P = 0.85). There was a significant difference in the VAP rate among hospitals having different bed capacities (P < 0.001), data regularly collected (P = 0.03), and had a team to supervise the VAP project (P = 0.04). Conclusion: The VAP rate in Makkah Region hospitals is 6.89 cases per 1000 ventilator-days.
Increased Il-17 And Tgf-Ss Serum Levels In Peripheral Blood Of Patients With Ss-Thalassemia Major: Implication For Continual Transfusions Role In T Helper 17-Mediated Proinflammatory Responses, Rasoul Baharlou, Mohammad Hassan Davami, Abbas Ahmadi-Vasmehjani, Morteza Ebrahimi
Increased Il-17 And Tgf-Ss Serum Levels In Peripheral Blood Of Patients With Ss-Thalassemia Major: Implication For Continual Transfusions Role In T Helper 17-Mediated Proinflammatory Responses, Rasoul Baharlou, Mohammad Hassan Davami, Abbas Ahmadi-Vasmehjani, Morteza Ebrahimi
Turkish Journal of Medical Sciences
Background/aim: Recent studies have shown that IL-17-producing CD4+ T helper (Th17) cells play an important role in proinflammatory processes. In this report we analyzed IL-17, IL-21, and TGF-β serum levels in the peripheral blood of Iranian beta-thalassemia major patients that clinically exhibited splenectomy and iron overload. Materials and methods: Blood samples were collected from 43 beta-thalassemia patients and 43 healthy individuals with no history of malignancies or autoimmune disorders. Then serum levels of IL-17, IL-21, and TGF-β were measured by enzyme linked immunosorbent assay (ELISA). Results: The levels of IL-17 (P = 0.005) and TGF-β (P < 0.001) were significantly higher in the thalassemia patients compared to the healthy control. No significant differences in the level of serum IL-21 was observed between the patients and controls. There were no significant differences in serum levels of IL-17, IL-21, and TGF-β between patients with high or low serum levels of ferritin. Conclusion: Multiple blood transfusions cause constant immune stimulation, as a result of repeated exposure to new alloantigens. This might have significant effects on the stimulation of cytokine producing cells in those patients and cytokine profile can be used as a related marker for assessing disease severity and consequently therapeutic intervention.
Comparison Of Galactomannan, Beta-D-Glucan, And Aspergillus Dna In Sera Of High-Risk Adult Patients With Hematological Malignancies For The Diagnosis Of Invasive Aspergillosis, Gülçi̇n Bölük, Esra Kazak, Fahi̇r Özkalemkaş, Beyza Ener, Hali̇s Akalin, Harun Ağca, Yildiz Okuturlar, Kürşad Keski̇n, Başak Burgazlioğlu, Ridvan Ali̇
Comparison Of Galactomannan, Beta-D-Glucan, And Aspergillus Dna In Sera Of High-Risk Adult Patients With Hematological Malignancies For The Diagnosis Of Invasive Aspergillosis, Gülçi̇n Bölük, Esra Kazak, Fahi̇r Özkalemkaş, Beyza Ener, Hali̇s Akalin, Harun Ağca, Yildiz Okuturlar, Kürşad Keski̇n, Başak Burgazlioğlu, Ridvan Ali̇
Turkish Journal of Medical Sciences
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Does The Course Of Laboratory Parameters Help Us To Predict The Outcome Of Cchf?, Sümeyye Kazancioğlu, Esragül Akinci, Ali̇ye Baştuğ, Bi̇rcan Kayaaslan, Ayşe But, Hali̇de Aslaner, Seli̇m Sirri Eren, Meltem Arzu Yetki̇n, Hurrem Bodur
Does The Course Of Laboratory Parameters Help Us To Predict The Outcome Of Cchf?, Sümeyye Kazancioğlu, Esragül Akinci, Ali̇ye Baştuğ, Bi̇rcan Kayaaslan, Ayşe But, Hali̇de Aslaner, Seli̇m Sirri Eren, Meltem Arzu Yetki̇n, Hurrem Bodur
Turkish Journal of Medical Sciences
Abstrat Background/aim: This study was performed to identify the characteristics distinguishing fatal and nonfatal cases of patients diagnosed with Crimean-Congo hemorrhagic fever (CCHF). Materials and methods: A total of 92 patients with confirmed diagnosis of CCHF in 2009-2013 were included in the study. Results: A high level of urea and aPTT on the third day of hospital stay, diarrhea, somnolence, and the interval from the beginning of the symptoms to hospital admission were independently associated with fatality. Each 10-unit increase in aPTT and urea levels increased the fatality rate by 3.379-fold and 1.236-fold, respectively. Delay in hospital admission increased the …
The Prevalence Of Tularemia In Occupational Groups That Have Contact With Animals, Fati̇h Büyük, Özgür Çelebi̇, Eli̇f Çeli̇k, Beki̇r Çelebi̇, Selçuk Kiliç, Ali̇ye Gülmez Sağlam, Doğan Akça, Mehmet Doğanay, Sali̇h Otlu, Mi̇tat Şahi̇n
The Prevalence Of Tularemia In Occupational Groups That Have Contact With Animals, Fati̇h Büyük, Özgür Çelebi̇, Eli̇f Çeli̇k, Beki̇r Çelebi̇, Selçuk Kiliç, Ali̇ye Gülmez Sağlam, Doğan Akça, Mehmet Doğanay, Sali̇h Otlu, Mi̇tat Şahi̇n
Turkish Journal of Medical Sciences
Background/aim: The aim of the current study was to investigate the presence of antibodies against Francisella tularensis in individuals in different occupations that have contact with animals in the Kars region of northeastern Turkey. Materials and methods: A total of 201 blood samples specifically including 103 farmers, 45 clinical veterinarians, 42 butchers, and 11 hunters were analyzed. The results of the study were reported in relation to some sociodemographic features (age, sex, occupation, and experience) of the volunteers. The presence of antibodies was determined by a microagglutination (MA) test. In addition, positive sera were confirmed using an ELISA kit. Results: …
The Role Of 18f-Fdg Pet-Ct In The Detection Of Unknown Primary Malignancy: A Retrospective Study, Olga Yaylali, Fatma Suna Kiraç, Doğangün Yüksel
The Role Of 18f-Fdg Pet-Ct In The Detection Of Unknown Primary Malignancy: A Retrospective Study, Olga Yaylali, Fatma Suna Kiraç, Doğangün Yüksel
Turkish Journal of Medical Sciences
Background/aim: This study aimed to retrospectively evaluate the role of 18F-FDG PET/CT imaging in the detection of unknown primary tumor sites in patients with a suspicious malignancy. Materials and methods: We retrospectively examined the 18F-FDG PET/CT images of 50 unknown primary malignancy patients. The malignancy of the lesions with increased 18F-FDG uptake on PET images was defined by interpreting the nondiagnostic CT images that were obtained with the PET study. The primary tumor site was decided according to the combined PET/CT findings, and the results were subsequently confirmed with a histopathological examination. Results: Fifty patients (29 M; 21 F) aged …
Traditional Practices Of Konya Women During Pregnancy, Birth, The Postpartumperiod, And Newborn Care, Berri̇n Okka, Yasemi̇n Durduran, Nesli̇han Değerli̇ Kodaz
Traditional Practices Of Konya Women During Pregnancy, Birth, The Postpartumperiod, And Newborn Care, Berri̇n Okka, Yasemi̇n Durduran, Nesli̇han Değerli̇ Kodaz
Turkish Journal of Medical Sciences
Background/aim: The purpose of the present study was to identify traditional practices and the extent to which they are practiced by mothers during pregnancy, birth, the postpartum period, and newborn care. Materials and methods: This study was conducted in the city center of Konya (Turkey). Data were collected through questionnaires completed by volunteers. The research sample comprised 450 mothers, all of whom had given birth to at least one live baby. The forms were completed during face-to-face interviews. Results: Some traditional pregnancy practices were followed by 70.7% of the participants. Of the women who performed these practices, 57.4% consciously chose …
The Utility Of The Timi Risk Index On Admission For Predicting Angiographic No-Reflow After Primary Percutaneous Coronary Intervention In Patients With Stemi, Hali̇t Acet, Faruk Ertaş, Mehmet Ata Akil, Mehmet Zi̇hni̇ Bi̇li̇k, Mesut Aydi̇n, Ni̇hat Polat, Abdulkadi̇r Yildiz, Murat Yüksel, Leyla Çi̇ftçi̇, Necdet Özaydoğdu, Mehmet Özbek, Sai̇t Alan, Ni̇zametti̇n Toprak
The Utility Of The Timi Risk Index On Admission For Predicting Angiographic No-Reflow After Primary Percutaneous Coronary Intervention In Patients With Stemi, Hali̇t Acet, Faruk Ertaş, Mehmet Ata Akil, Mehmet Zi̇hni̇ Bi̇li̇k, Mesut Aydi̇n, Ni̇hat Polat, Abdulkadi̇r Yildiz, Murat Yüksel, Leyla Çi̇ftçi̇, Necdet Özaydoğdu, Mehmet Özbek, Sai̇t Alan, Ni̇zametti̇n Toprak
Turkish Journal of Medical Sciences
Background/aim: The thrombolysis in myocardial infarction (TIMI) risk score (TRS), and the TIMI risk index (TRI) have been reported in coronary artery disease patients. We investigated whether admission TRI is associated with no-reflow (NRF) in patients undergoing primary percutaneous coronary intervention (p-PCI). Materials and methods: ST-segment elevation myocardial infarction (STEMI) patients treated with p-PCI were included in the study. TRI was calculated on admission using specified variables. We defined the angiographic NRF phenomenon as a coronary TIMI flow grade of ≤2 after the vessel was recanalized or a TIMI flow grade of 3 together with a final myocardial blush grade …
Seroprevalence Of Measles, Mumps, Rubella, And Varicella Amongphysicians And Nurses In Jordan, Faris Ghalib Bakri, Zakaria Mohammad Abdelrahim, Alqahira Samih Alkalbani, Ghada Mohammad Khrais, Deena Shamroukh, Ferial Ahmad Hayajneh, Azmi Mahafza
Seroprevalence Of Measles, Mumps, Rubella, And Varicella Amongphysicians And Nurses In Jordan, Faris Ghalib Bakri, Zakaria Mohammad Abdelrahim, Alqahira Samih Alkalbani, Ghada Mohammad Khrais, Deena Shamroukh, Ferial Ahmad Hayajneh, Azmi Mahafza
Turkish Journal of Medical Sciences
Background/aim: Measles, mumps, rubella, and varicella can affect susceptible healthcare workers who might subsequently spread the infection to susceptible patients and workers. Here, we aim to determine the seroprevalence of these infections among physicians and nurses and to compare the history of varicella with the results of varicella antibodies among study participants. Materials and methods: Two randomly selected groups, one group of physicians and one of nurses, from a university hospital in Jordan were interviewed and their serum IgG antibodies were measured. Results: The physicians and nurses group had 252 and 241 participants, respectively. The physicians group had significantly more …
Evaluation Of Tetanus Antibody Levels In Adults In Yozgat, Turkey, Çi̇ğdem Kader, Mehmet Balci, Ayşe Erbay
Evaluation Of Tetanus Antibody Levels In Adults In Yozgat, Turkey, Çi̇ğdem Kader, Mehmet Balci, Ayşe Erbay
Turkish Journal of Medical Sciences
Background/aim: To assess the immune status against tetanus in relation to self-declared vaccination status among an adult population in Yozgat, Turkey. Methods: Questionnaires and blood specimens were collected from 267 individuals over 18 years of age in Yozgat, Turkey. Antitetanus antibodies were determined quantitatively by enzyme-linked immunosorbent assay. Results: Among the 267 subjects (mean age 43.4 ± 15.6; male:female, 133:134) 168 (62.9%) had protective level of tetanus antibody titers. There was a characteristic distribution of the tetanus antibody titers in different age groups as it dropped with increasing age. Protective immunity was obtained in 74.1% of urban and 47.9% of …
Potential Drug?Drug Interactions In A Medical Intensive Care Unit Of A University Hospital, Medi̇ne Gülçebi̇ İdri̇z Oğlu, Esra Küçüki̇brahi̇moğlu, Ati̇la Karaalp, Özlem Sarikaya, Mahluga Demirkapu, Fi̇li̇z Onat, Mehmet Zafer Gören
Potential Drug?Drug Interactions In A Medical Intensive Care Unit Of A University Hospital, Medi̇ne Gülçebi̇ İdri̇z Oğlu, Esra Küçüki̇brahi̇moğlu, Ati̇la Karaalp, Özlem Sarikaya, Mahluga Demirkapu, Fi̇li̇z Onat, Mehmet Zafer Gören
Turkish Journal of Medical Sciences
Background/aim: Drug-drug interactions (DDIs) can impact patient safety. Occurrence of clinically important DDIs is higher for intensive care unit (ICU) patients. This observational study aimed to evaluate the potential DDIs in medical ICU patients of a university hospital. Materials and methods: The Medical Pharmacology Department organized consultation reports for ICU patients in order to detect the DDIs. To focus on clinically important DDIs, interactions in the C, D, or X risk rating categories of the Lexi-Interact online database were analyzed. Frequency and clinical risk rating categories of DDIs were detected. Relationship between number of prescriptions and DDIs were assessed. The …
Determination Of Virulence And Multidrug Resistance Genes With Polymerase Chain Reaction Method In Vancomycin-Sensitive And -Resistant Enterococci Isolated From Clinical Samples*, Şükran Saba Çopur, Fi̇kret Şahi̇n, Juli̇de Sedef Göçmen
Determination Of Virulence And Multidrug Resistance Genes With Polymerase Chain Reaction Method In Vancomycin-Sensitive And -Resistant Enterococci Isolated From Clinical Samples*, Şükran Saba Çopur, Fi̇kret Şahi̇n, Juli̇de Sedef Göçmen
Turkish Journal of Medical Sciences
Background/aim: Enterococci play an important role in nosocomial infections. Therefore, this study investigates multidrug resistance (MDR)1 gene areas in the pathogenicity of enterococci and virulence genes in both vancomycin-sensitive enterococci (VSE) and vancomycin-resistant enterococci (VRE) strains. Materials and methods: Virulence genes and MDR genes of enterococci were investigated by polymerase chain reaction (PCR). Results: We evaluated a total of 116 isolates, 93 being VRE and 23 being VSE. In this study, 95.6% of VRE (n = 93) were Enterococcus faecium (n = 89) and 4.3% were E. faecalis (n = 4), while 17.4% of VSE (n = 23) were E. …
Investigating The In Vitro Synergistic Activities Of Several Antibiotic Combinationsagainst Carbapenem-Resistant Acinetobacter Baumannii Isolates, Sevi̇m Yavaş, Meltem Arzu Yetki̇n, Bi̇rcan Kayaaslan, Ali̇ye Baştuğ, Hali̇de Aslaner, Ayşe But, Di̇lek Kanyilmaz, Berri̇n Sari, Esragül Akinci, Hurrem Bodur
Investigating The In Vitro Synergistic Activities Of Several Antibiotic Combinationsagainst Carbapenem-Resistant Acinetobacter Baumannii Isolates, Sevi̇m Yavaş, Meltem Arzu Yetki̇n, Bi̇rcan Kayaaslan, Ali̇ye Baştuğ, Hali̇de Aslaner, Ayşe But, Di̇lek Kanyilmaz, Berri̇n Sari, Esragül Akinci, Hurrem Bodur
Turkish Journal of Medical Sciences
Background/aim: Acinetobacter baumannii (A. baumannii) is one of the most common healthcare-associated infectious agents worldwide. The aim of this study was to investigate the in vitro synergistic activities of several antibiotic combinations against carbapenem-resistant (CR) A. baumannii isolates. Materials and methods: Eighteen CR A. baumannii strains were isolated from the patients who were hospitalized in the intensive care unit between June 2012 and August 2012. The in vitro effects of single and binary combinations of meropenem (MEM), colistin (CST), tigecycline (TGC), and sulbactam (SUL) on these isolates were determined using the Epsilometer test (E-test) method. Results: All 18 isolates were …
Evaluation Of Borrelia Burgdorferi Sensu Lato Seroprevalencein The Province Of Bolu, Turkey, Özlem Bucak, Mücahi̇de Esra Koçoğlu, Teki̇n Taş, Firat Zafer Mengeloğlu
Evaluation Of Borrelia Burgdorferi Sensu Lato Seroprevalencein The Province Of Bolu, Turkey, Özlem Bucak, Mücahi̇de Esra Koçoğlu, Teki̇n Taş, Firat Zafer Mengeloğlu
Turkish Journal of Medical Sciences
Background/aim: The aim of the present study was to determine the seroprevalence of Borrelia burgdorferi sensu lato in the city center and the province of Bolu, Turkey. Materials and methods: A stratified sampling method was used to determine the study population. A total of 196 blood samples were collected. A questionnaire was completed by each participant in the study. ELISA was performed and positive serologic results were confirmed using western blotting. Data were analyzed statistically using the chi-square test. Results: Seropositivity rates of B. burgdorferi IgM and IgG were determined as 14.8% (29/196) and 13.7% (27/196) respectively by ELISA. A …
Colistin Efficacy In The Treatment Of Multidrug-Resistant And Extremelydrug-Resistant Gram-Negative Bacterial Infections*, Çi̇ğdem Banu Çeti̇n, Deni̇z Özer Türk, Şebnem Şenol, Gönül Di̇nç Horasan, Özlem Tünger
Colistin Efficacy In The Treatment Of Multidrug-Resistant And Extremelydrug-Resistant Gram-Negative Bacterial Infections*, Çi̇ğdem Banu Çeti̇n, Deni̇z Özer Türk, Şebnem Şenol, Gönül Di̇nç Horasan, Özlem Tünger
Turkish Journal of Medical Sciences
Background/aim: Colistin is used as a salvage therapy for multidrug-resistant and extremely drug-resistant gram-negative bacterial infections. Our aim was to evaluate colistin efficiency and toxicity in the treatment of these resistant gram-negative bacterial infections. Materials and methods: This is a retrospective study carried out in a tertiary care hospital during 2011-2013. Study data were collected from the medical records and consultations of the infectious diseases clinic. Results: The study group included 158 patients with nosocomial infections and 136 (86.1%) of them were hospitalized in the ICU. Respiratory tract infections were the most commonly observed ones (n = 103, 65.2%). The …
Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r
Determination Of Reference Range With The Indirect Method Of The 25-Hydroxyvitamind3 Test In The Balıkesir Region, Turkey, Medi̇ne Alpdemi̇r, Mehmet Fati̇h Alpdemi̇r
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to determine the reference ranges of 25-hydroxyvitamin D3 (25(OH)vitD3) by an indirect method using data obtained from patients over the course of 3 years. Materials and methods: The 25(OH)vitD3 test results of the patients who applied to the medical biochemistry laboratory of Balıkesir State Hospital between the years of 2010 and 2014 were analyzed. Patient data were retrospectively taken from the laboratory information system. The 25(OH)vitD3 levels of patients were examined after exclusion of outliers. Patients were divided into subgroups according to season, sex, and age. The central 95% reference intervals were calculated …
A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz
A Persistently Low Hbv Dna Level Is A Predictor Of Spontaneous Hbsag Clearance In Patients With Chronic Hepatitis B, Alpay Ari, Şebnem Çalik, Selma Tosun, Si̇bel Özsu Caymaz
Turkish Journal of Medical Sciences
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The Utility Of Ebus-Tbna In Mediastinal Or Hilar Lymph Node Evaluation In Extrapulmonary Malignancy, Onur Fevzi̇ Erer, Ceyda Anar, Serhat Erol, Seri̇r Özkan
The Utility Of Ebus-Tbna In Mediastinal Or Hilar Lymph Node Evaluation In Extrapulmonary Malignancy, Onur Fevzi̇ Erer, Ceyda Anar, Serhat Erol, Seri̇r Özkan
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine the diagnostic performance of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of mediastinal and hilar lymph nodes (LNs) in patients with known extrapulmonary malignancy. Materials and methods: Between March 2011 and August 2013, 378 EBUS-TBNA procedures were performed. Sixty-three (16.6%) of these were performed on known extrapulmonary malignancy patients. Results: There were 28 male and 35 female patients, with median ages of 65 years (min-max: 53-87) and 57 years (min-max: 39-76), respectively. From the 63 cases, 138 lymph nodes (LNs) were sampled with EBUS-TBNA (median: 2 LNs/patient; min-max: 1-4). …
An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l
An Analysis Of The Incidence Of Measles In Turkey Since 1960, Deni̇z Çalişkan, Bi̇rgül Pi̇yal, Recep Akdur, Mi̇ne Esi̇n Ocaktan, Ceylan Yozgatligi̇l
Turkish Journal of Medical Sciences
Background/aim: The aims of this study were to evaluate measles incidence and the effect of elimination strategy interventions on the disease from 1960 to 2014 in Turkey. The administration of measles vaccine started in the rural regions in 1970; it was carried out as a campaign along with the National Vaccine Campaign in 1985, and it has been employed as combined measles, mumps, and rubella under the scope of the Measles Elimination Program (MEP) since 2006 in Turkey. While a dramatic decrease in the reporting of measles was observed between 2000 and 2010, the number of the cases has increased …
The Clinical And Laboratory Characteristics, Treatments, And Outcomes Of Patients With Brucella Epididymo-Orchitis (Beo) Compared To Those Without Beo*, Hasan Naz, Pinar Korkmaz, Fi̇gen Çevi̇k, Nevi̇l Aykin
The Clinical And Laboratory Characteristics, Treatments, And Outcomes Of Patients With Brucella Epididymo-Orchitis (Beo) Compared To Those Without Beo*, Hasan Naz, Pinar Korkmaz, Fi̇gen Çevi̇k, Nevi̇l Aykin
Turkish Journal of Medical Sciences
Background/aim: We aim to describe the clinical and laboratory characteristics, treatment, and outcomes of 21 patients with Brucella epididymo-orchitis (BEO) from Eskişehir Yunus Emre State Hospital, Turkey. Materials and methods: A total of 21 patients with BEO who were diagnosed and followed in the Infectious Diseases Clinic between June 2001 and June 2013 were evaluated retrospectively. Results: One hundred and twenty-eight of 192 patients evaluated throughout the study were male and BEO was determined in 21 (16.4%) patients. A total of 18 (85.7%) patients had a titer of ≥1:160 in standard agglutination test (STA). Three patients with STA
An Investigation On The Prevalence And Efficiency Of Immunochromatographic Testing In Suspected Malarial Patients Of Rawalpindi And Islamabad, Pakistan, Saima Jabeen, Sobia Kanwal, Mazhar Qayyum, Umair Farrukh, Shahzad Abdul Hameed
An Investigation On The Prevalence And Efficiency Of Immunochromatographic Testing In Suspected Malarial Patients Of Rawalpindi And Islamabad, Pakistan, Saima Jabeen, Sobia Kanwal, Mazhar Qayyum, Umair Farrukh, Shahzad Abdul Hameed
Turkish Journal of Medical Sciences
Background/aim: The prevalences of Plasmodium falciparum and Plasmodium vivax are increasing rapidly in Pakistan, but recent data on the epidemiology of malaria are not properly reported with scarce diagnostic methods for quick diagnosis. This study was designed to determine the current prevalence and distribution of Plasmodium species in the vicinity of Rawalpindi and Islamabad and report on the validity of the immunochromatographic test (ICT) in diagnosing malarial infections. Materials and methods: A total of 1500 blood samples obtained from a local hospital were screened during the course of this study via microscopic examination and ICT. Results: It was seen that …
Interlukine-17 And Tgf-Ss Levels In Patients With Acute Brucellosisbefore And After Treatment, Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani
Interlukine-17 And Tgf-Ss Levels In Patients With Acute Brucellosisbefore And After Treatment, Masoomeh Sofian, Amitis Ramezani, Alia Mousavi, Mohammad Banifazl, Shima Cherei, Ali Cherei, Arezoo Aghakhani
Turkish Journal of Medical Sciences
Background/aim: T-helper cell type 1 (Th1)/Th2 cytokine balance is involved in the resistance or susceptibility to Brucella infection. The analysis of cytokine levels is valuable to determine the role of the immune system in Brucella prognosis. The aim of this study was to investigate the levels of serum interleukin-17 (IL-17) and transforming growth factor beta (TGF-β) and their alterations with treatment in patients with acute brucellosis. Materials and methods: TGF-β was tested in 33 acute brucellosis patients and 19 controls and IL-17 was analyzed in 40 patients and 12 controls. Cytokine levels were tested in controls and patients before and …
The Efficacy Of Oral Ribavirin On Clinical And Laboratory Parameters Incrimean?Congo Hemorrhagic Fever: An Observational Study From Turkey*, Günay Ertem, Meli̇ha Çağla Sönmezer, Fati̇h Temoçi̇n, Çi̇ğdem Ataman Hati̇poğlu, Necla Tülek, Behi̇ç Oral
The Efficacy Of Oral Ribavirin On Clinical And Laboratory Parameters Incrimean?Congo Hemorrhagic Fever: An Observational Study From Turkey*, Günay Ertem, Meli̇ha Çağla Sönmezer, Fati̇h Temoçi̇n, Çi̇ğdem Ataman Hati̇poğlu, Necla Tülek, Behi̇ç Oral
Turkish Journal of Medical Sciences
Background/aim: In this observational study, the effects of oral ribavirin on clinical and laboratory parameters and blood products use in patients with Crimean-Congo hemorrhagic fever (CCHF) were evaluated. Materials and methods: CCHF patients (n = 100) who were hospitalized between 2007 and 2010 were included. Oral ribavirin was administered to 56 patients with symptom duration less than 5 days. Forty-four patients did not receive ribavirin (control group). The patients that received ribavirin in the first 3 days following the initiation of symptoms were designated as Group 1 (n = 29) and the others were designated as Group 2. Results: Ribavirin-treated …