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Distribution Of Viral Genotypes And Extrahepatic Manifestations In Patients With Chronic Hepatitis C In Eastern Turkey, Si̇bel İba Yilmaz, Serpi̇l Erol, Ahmet Özbek, Mehmet Parlak
Distribution Of Viral Genotypes And Extrahepatic Manifestations In Patients With Chronic Hepatitis C In Eastern Turkey, Si̇bel İba Yilmaz, Serpi̇l Erol, Ahmet Özbek, Mehmet Parlak
Turkish Journal of Medical Sciences
To investigate the distribution of viral genotypes, the extrahepatic manifestations, and the relationship between genotypes and extrahepatic manifestations in patients with chronic hepatitis C. Materials and methods: The study included 62 treatment-naive patients with chronic hepatitis C infection. Genotype determination was performed by DNA sequencing analysis. To investigate extrahepatic manifestations, the patients' data, recorded prospectively during the pretreatment period, were analyzed. Results: Genotype determination was successful in 74.2% of the cases. All patients were infected with hepatitis C virus (HCV) genotype 1b. At least 1 extrahepatic manifestation was identified in 37.1% of the patients. The most frequent clinical manifestations were …
Prognostic Value Of Hemostasis-Related Parameters For Prediction Of Organ Dysfunction And Mortality In Sepsis, Dunja Mihajlovic, Dajana Lendak, Gorana Mitic, Tatjana Cebovic, Biljana Draskovic, Aleksandra Novakov, Snezana Brkic
Prognostic Value Of Hemostasis-Related Parameters For Prediction Of Organ Dysfunction And Mortality In Sepsis, Dunja Mihajlovic, Dajana Lendak, Gorana Mitic, Tatjana Cebovic, Biljana Draskovic, Aleksandra Novakov, Snezana Brkic
Turkish Journal of Medical Sciences
Clinical manifestations of sepsis are not caused directly by the invading pathogens, but rather mostly by systemic inflammation that leads to activation of the coagulation system. The aim of this study was to determine whether levels of hemostasis-related parameters measured in intensive care unit admissions are associated with mortality and severity in patients with sepsis. Materials and methods: Eighty-five patients who fulfilled criteria for a diagnosis of sepsis were included in our study. Platelet count, activated partial thromboplastin time (aPTT), prothrombin time (PT), thrombin time, D-dimer, and fibrinogen levels were determined within the first 24 h from sepsis onset. Differences …
The Relationship Between Hepatitis Serology Of Ambulance Attendants Andduration Of Education, Ertuğrul Güçlü, Azi̇z Öğütlü, Oğuz Karabay
The Relationship Between Hepatitis Serology Of Ambulance Attendants Andduration Of Education, Ertuğrul Güçlü, Azi̇z Öğütlü, Oğuz Karabay
Turkish Journal of Medical Sciences
Background/aim: Healthcare workers (HCWs) run the risk of hepatitis B virus (HBV) infection. Studies investigating the HBV and hepatitis C virus (HCV) serology of HCWs have been generally conducted in secondary or tertiary hospitals. In this study we aimed to determine the relationships between education level and HBV and HCV serology and HBV vaccination status of ambulance attendants. Materials and methods: The data of this study were obtained by retrospective review of ambulance personnel files in Sakarya Province, Turkey. Results: Out of 314 ambulance attendants, 216 (68.7%; 78 males, 138 females) were enrolled in this study. The mean length of …
Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş
Clinical Characteristics Of 75 Pandemic H1n1 Influenza Patientsfrom Turkey; Risk Factors For Fatality, Hati̇ce Kiliç, Asi̇ye Kanbay, Ayşegül Karalezli̇, Hati̇ce Canan Hasanoğlu, Can Ateş
Turkish Journal of Medical Sciences
Background/aim: The 2009 influenza A (H1N1) pandemic caused mild to severe illnesses and led to death in some cases. In this study, we aimed to evaluate the relationship between the serum D-dimer levels, CURB-65 scores, and the severity of pneumonia among patients with H1N1 infections. Materials and methods: Sixty-eight patients who had probable H1N1 infections were evaluated by clinical, radiological, and laboratory methods. The H1N1 strain was specified by reverse transcription-polymerase chain reaction. Of 55 patients diagnosed with pneumonia, 18 exhibited H1N1 positivity and 37 patients did not. Results: CURB-65 scores of pneumonia patients with H1N1 (group 1) were higher …
Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk
Elevated Serum Matrix Metalloproteinase-2 And -9 And Their Correlationswith Severity Of Disease In Patients With Community-Acquired Pneumonia, Haci Ahmet Bi̇rcan, Müni̇re Çakir, İlkay Yilmazer Kapulu, Recep Sütcü, Selçuk Kaya, Önder Öztürk
Turkish Journal of Medical Sciences
Background/aim: To determine the role of matrix metalloproteinases (MMPs) and their relationship with the clinical course of community-acquired pneumonia (CAP). Materials and methods: Sixty-two consecutively hospitalized patients with CAP were enrolled and their pneumonia severity index (PSI), time to clinical stability (TCS), treatment response, and complications were recorded. The pre- and posttreatment serum concentrations of MMPs and their inhibitors were analyzed by ELISA. The activities of MMPs were evaluated by gelatin zymography. Results: MMP-2 and -9 serum levels and their activities were higher in CAP patients than controls (P < 0.001 and P < 0.001, respectively). Low-risk patients had lower levels of MMP-2 and TIMP-1 than high-risk patients (P = 0.044, P = 0.001, respectively). Pretreatment serum TIMP-1 level was higher in patients with TCS of >3 days (P = 0.004) and was correlated with oxygenation and …
Distribution And Antifungal Resistance Of Candida Speciesisolated From Intensive Care Units, Pinar Korkmaz, Yeşi̇m Alpay, Fi̇gen Çevi̇k, Nevi̇l Aykin, Ayşe Koygun, Hakki Mustafa Güldüren
Distribution And Antifungal Resistance Of Candida Speciesisolated From Intensive Care Units, Pinar Korkmaz, Yeşi̇m Alpay, Fi̇gen Çevi̇k, Nevi̇l Aykin, Ayşe Koygun, Hakki Mustafa Güldüren
Turkish Journal of Medical Sciences
No abstract provided.
Acute Tuberculosis In The Intensive Care Unit, Kazim Rollas, Ati̇la Kara, Nazmi̇ye Ebru Ortaç Ersoy, Kezban Özmen Süner, Mehmet Nezi̇r Güllü, Serpi̇l Öcal, Arzu Topeli̇
Acute Tuberculosis In The Intensive Care Unit, Kazim Rollas, Ati̇la Kara, Nazmi̇ye Ebru Ortaç Ersoy, Kezban Özmen Süner, Mehmet Nezi̇r Güllü, Serpi̇l Öcal, Arzu Topeli̇
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to determine mortality rates and to evaluate clinical features of patients with active tuberculosis (TB) requiring intensive care unit (ICU) admission. Materials and methods: The medical records of active TB patients requiring ICU admission were retrospectively reviewed over a 5-year period. Results: Sixteen patients with active TB admitted to the ICU were included in the study. Seven (43.8%) patients died in the ICU. The cause of mortality was septic shock in 5 patients and respiratory failure in 2 patients. The Acute Physiology and Chronic Health Evaluation II (APACHE II) and Sequential Organ Failure …
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Role Of Autophagy In The Pathogenesis Of Alzheimer Disease, Muhammet Cemal Kizilarslanoğlu, Zekeri̇ya Ülger
Turkish Journal of Medical Sciences
Alzheimer disease (AD) is the most common progressive neurodegenerative disorder causing increased morbidity and mortality. It is characterized by accumulation of amyloid-β in neurons. As there is no known definitive treatment of this disorder, studies trying to determine its exact pathogenetic pathways and target therapies for these specific pathways are being rapidly conducted. Autophagy is one of the areas of interest in studies on the pathogenesis of AD. It is a process of self-digestion that is thought to be a response to stressors and allows cells to adapt to environmental changes. There is accumulating evidence showing an association between autophagy …
Assessment Of Bloodstream Infections And Risk Factors In An Intensive Care Unit, Aynur Süner, İlkay Karaoğlan, Ayşe Özlem Mete, Mustafa Namiduru, Vuslat Boşnak, İbrahi̇m Baydar
Assessment Of Bloodstream Infections And Risk Factors In An Intensive Care Unit, Aynur Süner, İlkay Karaoğlan, Ayşe Özlem Mete, Mustafa Namiduru, Vuslat Boşnak, İbrahi̇m Baydar
Turkish Journal of Medical Sciences
Background/aim: Nosocomial bloodstream infection (BSI) increases mortality rates, duration of stay in hospital, and treatment costs. This study was conducted to determine the rate and the risk factors of BSIs among intensive care unit patients. Materials and methods: Sixty-four patients with BSIs (patient group) and 79 patients without a nosocomial infection (control group) were enrolled in the study. Centers for Disease Control and Prevention criteria were used for diagnosing BSIs. Potential risk factors were evaluated by multivariate logistic regression model. Results: The BSI development rate was 15.7% (64/407), with an incidence rate of 18.2/1000 patient days. Distribution of pathogens among …
Applicability Of Xpert Mtb/Rif Assay For Routine Diagnosis Of Tuberculosis: A Four-Year Single-Center Experience, Cem Çeli̇k, Mustafa Gökhan Gözel, Mustafa Zahi̇r Bakici, Serdar Berk, Sefa Levent Özşahi̇n, Esra Gültürk
Applicability Of Xpert Mtb/Rif Assay For Routine Diagnosis Of Tuberculosis: A Four-Year Single-Center Experience, Cem Çeli̇k, Mustafa Gökhan Gözel, Mustafa Zahi̇r Bakici, Serdar Berk, Sefa Levent Özşahi̇n, Esra Gültürk
Turkish Journal of Medical Sciences
Background/aim: The aim of this study is to assess the Xpert MTB/RIF assay for diagnosis of the Mycobacterium tuberculosis complex in clinical samples and to compare the results by reference to the diagnostic method, Bactec MGIT 960. Materials and methods: A total of 7407 samples were included from patients not primarily suggesting pulmonary or extrapulmonary tuberculosis (TB), collected from patients required to be screened for TB and excluding TB diagnoses since it was a differential diagnosis. Also included were a total of 411 samples from patients primarily suggesting pulmonary or extrapulmonary TB. Results: In the first group, 152 of 7407 …
Mucocutaneous Manifestations And The Relationship To Cd4 Lymphocyte Counts Among Turkish Hiv/Aids Patients In İstanbul, Turkey, Özlem Altuntaş Aydin, Hayat Kumbasar Karaosmanoğlu, Ramazan Korkusuz, Mehmet Özeren, Özcan Nazlican
Mucocutaneous Manifestations And The Relationship To Cd4 Lymphocyte Counts Among Turkish Hiv/Aids Patients In İstanbul, Turkey, Özlem Altuntaş Aydin, Hayat Kumbasar Karaosmanoğlu, Ramazan Korkusuz, Mehmet Özeren, Özcan Nazlican
Turkish Journal of Medical Sciences
Dermatologic findings differ among countries but no sufficient data about Turkish HIV-infected patients exist in the literature. Therefore, our aim in this study was to document the dermatologic manifestations and their relationships with CD4 cell counts among HIV/AIDS patients visiting our clinic for the first time in İstanbul, Turkey. Materials and methods: A retrospective analysis of 306 HIV/AIDS patients (260 men, mean age: 38.3 years) was done in a tertiary hospital in İstanbul from January 2006 to September 2012. Information on age, sex, transmission routes, socioeconomic and educational status, CD4 counts, and dermatologic findings was collected retrospectively from medical records. …
Relationship Among Mif, Mcp-1, Viral Loads, And Hbs Ag Levelsin Chronic Hepatitis B Patients, Hayati̇ Güneş, Rafet Mete, Murat Aydin, Bi̇rol Topçu, Mustafa Oran, Mustafa Doğan, Oğuzhan Yildirim, İlknur Erdem, Aynur Eren Topkaya, Ahmet Gürel
Relationship Among Mif, Mcp-1, Viral Loads, And Hbs Ag Levelsin Chronic Hepatitis B Patients, Hayati̇ Güneş, Rafet Mete, Murat Aydin, Bi̇rol Topçu, Mustafa Oran, Mustafa Doğan, Oğuzhan Yildirim, İlknur Erdem, Aynur Eren Topkaya, Ahmet Gürel
Turkish Journal of Medical Sciences
Background/aim: To determine whether macrophage migration inhibitory factor (MIF) and monocyte chemoattractant protein-1 (MCP-1) levels in patients with hepatitis B (HB) are different than in normal individuals and whether the HB surface antigen (HBs Ag) level and viral load are correlated with each other and with the two aforementioned parameters. Materials and methods: Sera were obtained from 52 chronic active HB (CAHB) patients and 33 healthy controls, and their MIF and MCP-1 levels were measured. Statistical analyses were performed. A value of P < 0.05 was considered statistically significant. Results: The MIF and MCP-1 values of the control group were increased compared to those of the CAHB group. The MIF and MCP-1 levels were negatively correlated with HBs Ag levels and viral loads. The MIF and MCP-1 levels were positively correlated. The HBs Ag levels and the log10 of the viral loads were positively correlated. Conclusion: We conclude that the negative correlation of MIF and MCP-1 with viral load and HBs Ag levels may be due to T-cell deficiency, antinuclear antibody seropositivity, and/or inhibition of chemokine ligand 2 receptors by viral antigens. More studies with a greater number of subjects are needed to evaluate the potential role of MIF and MCP in CAHB.
High-Risk Febrile Neutropenia And Its Management In Childrenwith Solid Tumors And Lymphoma, Doğan Köse, Meli̇ke Emi̇roğlu, Yavuz Köksal
High-Risk Febrile Neutropenia And Its Management In Childrenwith Solid Tumors And Lymphoma, Doğan Köse, Meli̇ke Emi̇roğlu, Yavuz Köksal
Turkish Journal of Medical Sciences
Background/aim: The clinical characteristics and treatment results of febrile neutropenia attacks that occurred in patients with lymphoma and solid tumors were analyzed. Materials and methods: A total of 50 patients with 94 high-risk attacks were evaluated for malignant diseases in this study. Results: The fever etiology was determined as clinical (50%), microbiological (5.31%), clinical-microbiological (5.31%), or unknown (39.3%). A few of the attacks (21.3%) were observed in lymphoma cases and 77.7% were observed in patients with solid tumors. Patients who were in remission had 59.6% of the attacks, and 39.4% occurred in patients not in remission. Among the groups tested, …
Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur
Ebola Viral Disease: What Should Be Done To Combat The Epidemic In 2014?, Ali̇ye Baştuğ, Hürrem Bodur
Turkish Journal of Medical Sciences
Ebola virus disease (EVD) was defined first in 1976. Since then, more than 24 epidemics have been reported from Africa, predominantly with the Zaire species. On 21 March 2014, the current West Africa outbreak was reported by the World Health Organization, the largest one ever recorded. The Congo epidemic was reported in July 2014. It was considered that the two epidemics had unrelated origins with 96.8% identical genomic sequence of the virus. EVD outbreaks occurred in areas with limited resources but it has a potentially global effect due to the possibility of imported infection and the potential misuse of the …
Is The Diagnosis And Treatment Of Childhood Acute Bacterial Meningitis In Turkey Evidence-Based?, Özden Türel, Mustafa Bakir
Is The Diagnosis And Treatment Of Childhood Acute Bacterial Meningitis In Turkey Evidence-Based?, Özden Türel, Mustafa Bakir
Turkish Journal of Medical Sciences
Evidence-based guidance is likely to significantly improve patient care. We aimed to characterize the adequacy of standard diagnostic methods and treatment in children with acute bacterial meningitis (ABM) in Turkey. Materials and methods: We conducted a retrospective study among children 1 month to 5 years old hospitalized with ABM in İstanbul. The World Health Organization case definition and laboratory criteria were used for diagnosis. Results: Of the 283 cases, 250 were probable and 33 (11.2%) were confirmed as bacterial meningitis. The majority of patients (92%) were treated at 9 governmental hospitals and the remaining 21 at 2 university hospitals. Blood …
Seroprevalences And Associated Risk Factors Of Hepatitis B And C In Adults, Mustafa Yildirim, Selma Çakir, Mehmet Faruk Geyi̇k, Davut Özdemi̇r, Ertuğrul Güçlü, Mehmet Çakir
Seroprevalences And Associated Risk Factors Of Hepatitis B And C In Adults, Mustafa Yildirim, Selma Çakir, Mehmet Faruk Geyi̇k, Davut Özdemi̇r, Ertuğrul Güçlü, Mehmet Çakir
Turkish Journal of Medical Sciences
Chronic hepatitis due to hepatitis B and hepatitis C virus infections is the most common cause of chronic liver disease. In this study we aimed to find out seroprevalences and associated risk factors of hepatitis B and C in adults in Düzce. Materials and methods: The sample of study was determined with a cluster-type sampling method. The study included 1321 people, consisting of 667 women and 654 men who were 18 years or older. A questionnaire about demographic information and risk factors was applied. Results: Seroprevalences of HBsAg, anti-HBs, and anti-HCV were 4.8%, 9.4%, and 0.7%, respectively. HBsAg seroprevalences were …
Evaluation Of Malaria Cases In Individuals After Traveling To Endemic Regions Of The World, Hülya Çaşkurlu, Emi̇ne Pakir, Aslihan Çolak
Evaluation Of Malaria Cases In Individuals After Traveling To Endemic Regions Of The World, Hülya Çaşkurlu, Emi̇ne Pakir, Aslihan Çolak
Turkish Journal of Medical Sciences
This study evaluates types of malaria and treatment success in a series of identified cases among individuals who were presumed to have travelled to regions where malaria is endemic. Materials and methods: In Sema Hospital, 25 cases of malaria (5 in women, 20 in men) were diagnosed during the 6-year period between 2006 and 2012. The mean age of the patients was 34.5 years. Diagnoses were established with thick and thin peripheral blood smears that were parasite-positive. These tests were then compared to the rapid diagnostic test based on Plasmodium falciparum histidine-rich protein 2. Results: All cases demonstrated fever beginning …
Mefv Mutation Frequency And Effect On Disease Severity In Ankylosing Spondylitis, Yüksel Maraş, Ali̇ Akdoğan, Bünyami̇n Kisacik, Levent Kiliç, Engi̇n Yilmaz, Abdurrahman Tufan, Umut Kalyoncu, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Meral Çalgüneri̇
Mefv Mutation Frequency And Effect On Disease Severity In Ankylosing Spondylitis, Yüksel Maraş, Ali̇ Akdoğan, Bünyami̇n Kisacik, Levent Kiliç, Engi̇n Yilmaz, Abdurrahman Tufan, Umut Kalyoncu, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Meral Çalgüneri̇
Turkish Journal of Medical Sciences
To define the frequency of familial Mediterranean fever gene (MEFV) mutations in ankylosing spondylitis (AS) and describe different clinical aspects of MEFV mutation carrier and noncarrier AS patients. Materials and methods: In 112 AS patients, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) scores were calculated. The frequencies of 12 different MEFV mutations were studied by multiplex polymerase chain reaction/reverse hybridization method and were compared to those of previously studied healthy controls for 5 common MEFV mutations. Results: MEFV mutations were identified in 46 of 224 (20%) alleles and in 39 (35%) of AS …
Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir
Effects Of Osteocytes On Vibration-Induced Reflex Muscle Activity In Postmenopausal Women, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan, Muharrem Çi̇dem, Suat Hayri̇ Küçük, Hakan Ekmekçi̇, Cengi̇z Bahadir
Turkish Journal of Medical Sciences
To assess whether osteocytes have an effect on reflex myoelectrical activity during whole-body vibration (WBV) in postmenopausal women. Materials and methods: Participants were classified into 2 groups: the low bone mineral density (BMD) group (n = 37) and normal BMD group (n = 43). Hip BMD was measured using dual-energy X-ray absorptiometry. Surface electromyography data recorded from the adductor longus muscle were processed to obtain vibration-induced reflex myoelectrical activity. Changes in plasma sclerostin (SOST) levels with WBV were expressed as a standardized vibration-induced SOST index. Results: The standardized vibration-induced SOST index was 1.03 ± 0.24 in the low BMD group …
Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya
Attitudes Towards Influenza Vaccination In High Socioeconomic Status Turkish Parents, Suzan Gündüz, Çi̇ğdem Nüket Yüksel, Hale Bozkurt Aktoprak, Meti̇n Canbal, Mehmet Kaya
Turkish Journal of Medical Sciences
To better understand the knowledge, attitudes, and demographic factors that influence the rate of influenza vaccination among high socioeconomic status parents. Materials and methods: questionnaire exploring the attitudes of parents to the influenza vaccine, and their knowledge about influenza and its vaccination, was given to parents of children from 1 through 16 years of age attending the Turgut Özal University Hospital after the 2011/12 influenza season. Results: In the present study, 285 mothers and their children participated and 8.8% (n = 25) of children had the influenza vaccination. Between the vaccinated and nonvaccinated groups, there were statistically significantly differences for …
Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi
Insulin-Like Growth Factor 1, Liver Enzymes, And Insulin Resistance In Patients With Pcos And Hirsutism, Evri̇m Çakir, Oya Topaloğlu, Nujen Çolak Bozkurt, Başak Karbek Bayraktar, Aşkin Güngüneş, Müyesser Sayki Arslan, İlknur Öztürk Ünsal, Esra Tutal, Beki̇r Uçan, Tuncay Deli̇başi
Turkish Journal of Medical Sciences
Hyperinsulinemia and insulin resistance are commonly seen in patients with hirsutism and polycystic ovary syndrome (PCOS), and are associated with cardiovascular disease risk. However, it is not yet known whether insulin-like growth factor I (IGF-I) and alanine transaminase (ALT) produced by the liver play roles in hyperinsulinemia and subclinical atherosclerotic process in patients with PCOS and idiopathic hirsutism (IH). Materials and methods: This was a prospective case-controlled study. The study population consisted of 25 reproductive-age PCOS women, 33 women with IH, and 25 control subjects. Results: Mean IGF-I levels and median ALT levels were higher in patients with IH and …
Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer
Evaluation Of 48-Week Response Of Treatment-Naive Chronic Hepatitis B Patients To 0.5 Mg/Day Entecavir, Servet Kölgeli̇er, Nazlim Aktuğ Demi̇r, Serap Özçi̇men, Şua Sümer
Turkish Journal of Medical Sciences
The hepatitis B virus (HBV) is an important healthcare problem. Chronic hepatitis B infection may present with a wide range of manifestations from inactive carrier state to cirrhosis and hepatocellular cancer. Therefore, treatment is very important in chronic hepatitis B. In this study, the treatment results of 199 chronic hepatitis B patients taking entecavir 0.5 mg/day for 48 weeks were evaluated. Materials and methods: This study retrospectively evaluated data of 199 treatment-naive chronic hepatitis B patients who were treated with entecavir. Results: Of the 199 treatment-naive chronic hepatitis B patients, 141 (70.9%) were males and 58 (29.1%) were females, and …
Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan
Effects Of Whole-Body Vibration On Plasma Sclerostin Level In Healthy Women, Muharrem Çi̇dem, Yunus Karakoç, Hakan Ekmekçi̇, Suat Hayri̇ Küçük, Murat Uludağ, Kerem Gün, Şafak Sahi̇r Karamehmetoğlu, İlhan Karacan
Turkish Journal of Medical Sciences
To determine whether plasma sclerostin levels are affected by applying whole-body vibration treatments. Materials and methods: Following a pilot study, the present prospective, randomized, controlled single-blind study was performed on 16 healthy volunteer women (ages 20 to 40 years). Subjects were randomly divided into 2 groups, and whole-body vibration was applied to the treatment group but not to the controls. The plasma sclerostin levels were measured before the treatment and at the 10th minute after whole-body vibration on the 1st, 2nd, and 5th days of application. Results: The plasma sclerostin level measured at 10 min after the whole-body vibration treatment …
Evaluation Of Patients With Zygomycosis, Onur Kaya, Sema Alp Çavuş, Özge Turhan, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Mustafa Bülent Ertuğrul, Şebnem Şenol, Çi̇ğdem Banu Çeti̇n, Beti̇l Özhak Baysan, Selda Sayin Kutlu, Di̇lek Yeşi̇m Meti̇n, Meltem Avci, Gülşen Mermut, Vi̇ldan Avkan Oğuz, Nur Yapar
Evaluation Of Patients With Zygomycosis, Onur Kaya, Sema Alp Çavuş, Özge Turhan, Meltem Işikgöz Taşbakan, Hüsnü Pullukçu, Mustafa Bülent Ertuğrul, Şebnem Şenol, Çi̇ğdem Banu Çeti̇n, Beti̇l Özhak Baysan, Selda Sayin Kutlu, Di̇lek Yeşi̇m Meti̇n, Meltem Avci, Gülşen Mermut, Vi̇ldan Avkan Oğuz, Nur Yapar
Turkish Journal of Medical Sciences
Zygomycosis is a severe angioinvasive infection caused by Zygomycetes. We retrospectively investigated 16 cases of zygomycosis. Materials and methods: The data of patients, who had been followed between 2004 and 2010 in 8 tertiary-care teaching hospitals, were reviewed. Demographic characteristics, underlying diseases, and clinical signs and symptoms of the patients, as well as diagnostic methods, data obtained by radiological imaging methods, and the therapies, were recorded. Therapeutic approaches, antifungal agents and duration of use, and the characteristics of the cases were identified. Results: The study included 11 female and 5 male subjects. The most common symptoms and clinical signs were …
Detection The Frequency Of Per-1 Type Extended-Spectrum Ss-Lactamase-Producing Acinetobacter Baumannii Clinical Isolates In Turkey: A Multicenter Study, Gülşah Aşik, Mehmet Özdemi̇r, Muhammet Güzel Kurtoğlu, Server Yağci, Lütfi̇ye Öksüz, Mustafa Gül, Mücahi̇de Esra Koçoğlu, Emel Sesli̇ Çeti̇n, Adnan Seyrek, Mustafa Berktaş, Ahmet Ayyildiz, İhsan Hakki Çi̇ftci̇
Detection The Frequency Of Per-1 Type Extended-Spectrum Ss-Lactamase-Producing Acinetobacter Baumannii Clinical Isolates In Turkey: A Multicenter Study, Gülşah Aşik, Mehmet Özdemi̇r, Muhammet Güzel Kurtoğlu, Server Yağci, Lütfi̇ye Öksüz, Mustafa Gül, Mücahi̇de Esra Koçoğlu, Emel Sesli̇ Çeti̇n, Adnan Seyrek, Mustafa Berktaş, Ahmet Ayyildiz, İhsan Hakki Çi̇ftci̇
Turkish Journal of Medical Sciences
\beta-Lactamases are an important resistance mechanism in Acinetobacter baumannii. Pseudomonas extended-resistance (PER-1) type \beta-lactamase-producing strains have been reported from various geographic locations; however, PER-1 type \beta-lactamases from Turkish hospitals have not been investigated extensively. The aim of this study was to determine the prevalence of PER-1 type \beta-lactamases in A. baumannii isolates in various regions of Turkey. Materials and methods: A total of 763 clinical A. baumannii isolates were collected from 9 university hospitals and 2 state hospitals between 2008 and 2011. Molecular amplification of the OXA-51 gene from the A. baumannii genome was performed in order to verify identification …
The Comparison Of Pandemic H1n1 Igg Levels Between H1n1 Influenza-Vaccinated Healthcare Workers And Unvaccinated Healthcare Workers, Aydin Çi̇fci̇, Özlem Erol, Sali̇h Cesur, Nurkan Aksoy, Üçler Kisa
The Comparison Of Pandemic H1n1 Igg Levels Between H1n1 Influenza-Vaccinated Healthcare Workers And Unvaccinated Healthcare Workers, Aydin Çi̇fci̇, Özlem Erol, Sali̇h Cesur, Nurkan Aksoy, Üçler Kisa
Turkish Journal of Medical Sciences
To compare pandemic H1N1 (pH1N1) IgG antibody levels between healthcare workers who were vaccinated with the pH1N1 influenza vaccine and the unvaccinated healthcare workers who were selected as the control group. Materials and methods: A total of 68 healthcare workers were included in this study. Of those, 53 were adults vaccinated with the H1N1 influenza vaccine and 15 were unvaccinated. Serum samples were parsed and stored at -40 °C until they were examined. Results: Of the total 53 vaccinated healthcare workers, 16 (30.1%) were positive for IgG antibodies (titer > 11), 17 (32.0%) were negative for IgG antibodies (titer < 9), and 20 (37.7%) were borderline (titer: 9-11). Of the 15 unvaccinated healthcare workers, 1 (6.6%) was positive for IgG antibodies, 11 (73.3%) were negative for IgG antibodies, and the remaining 3 (20.0%) had borderline values (P = 0.014, P < 0.05). In both groups, there was no statistically significant difference between IgG-negative, IgG-positive, and borderline subjects in terms of age or sex. Conclusion: The IgG antibody level was higher in the vaccinated healthcare workers than among the unvaccinated healthcare workers.
Evaluation Report Of Pediatric Intensive Care Units In Turkey, Benan Bayrakci, Selman Kesi̇ci̇, Tanil Kendi̇rli̇, Gökhan Kalkan, Aydin Sari, Necvan Tokmak, Gökmen Yilmaz, Orkun Baloğlu, İrfan Şencan
Evaluation Report Of Pediatric Intensive Care Units In Turkey, Benan Bayrakci, Selman Kesi̇ci̇, Tanil Kendi̇rli̇, Gökhan Kalkan, Aydin Sari, Necvan Tokmak, Gökmen Yilmaz, Orkun Baloğlu, İrfan Şencan
Turkish Journal of Medical Sciences
To collect data from throughout Turkey in order to facilitate the organization of pediatric intensive care units (PICUs), and to develop short-term immediate action plans and draft long-term strategic plans. Materials and methods: A total of 35 specialists including 17 pediatric critical care (PCC) specialists, 9 PCC fellows in training, and 9 pediatricians working in PICUs evaluated PICUs and their infrastructures, mortality rates, appropriateness of indications for PICU admissions, PICU bed numbers, and utilization of those PICU beds. Results: PICU bed numbers, PCC specialist numbers, and PICU nurse numbers are insufficient in Turkey. The high percentage of inappropriate and inefficient …
Increasing Resistance Of Nosocomial Acinetobacter Baumannii: Are We Going To Be Defeated?, Tümer Güven, Gülruhsar Yilmaz, Hati̇ce Rahmet Güner, Ayşe Kaya Kalem, Fatma Eser, Mehmet Akin Taşyaran
Increasing Resistance Of Nosocomial Acinetobacter Baumannii: Are We Going To Be Defeated?, Tümer Güven, Gülruhsar Yilmaz, Hati̇ce Rahmet Güner, Ayşe Kaya Kalem, Fatma Eser, Mehmet Akin Taşyaran
Turkish Journal of Medical Sciences
To investigate the change of the antibiotic resistance profiles of the nosocomial Acinetobacter baumannii isolates in intensive care units (ICUs) between the years 2008 and 2011. Materials and methods: A. baumannii isolates that were responsible for ICU-acquired nosocomial infections between 2008 and 2011 were included in the study. The susceptibility rates of the antibiotics that are mainly used in the treatment of Acinetobacter infections were compared by years. Clinical and Laboratory Standards Institute criteria were used to determine antimicrobial susceptibility. Results: There were 252 infection episodes detected in 229 hospitalized patients in the ICU that were caused by A. baumannii. …
Acute Q Fever Among Febrile Patients In Zahedan, Southeastern Iran, Maliheh Metanat, Nahid Sepehri Rad, Roya Alavi-Naini, Shahram Shahreki, Batool Sharifi-Mood, Aida Akhavan, Zahra Poormotaseri
Acute Q Fever Among Febrile Patients In Zahedan, Southeastern Iran, Maliheh Metanat, Nahid Sepehri Rad, Roya Alavi-Naini, Shahram Shahreki, Batool Sharifi-Mood, Aida Akhavan, Zahra Poormotaseri
Turkish Journal of Medical Sciences
So far, few studies have been conducted on Q fever in Iran. The objective of this study was to determine the frequency of acute Q fever in febrile patients admitted to Boo-Ali Hospital in Zahedan (southeastern Iran). Materials and methods: In this study, 105 febrile patients suspected of having brucellosis were examined using indirect immunofluorescent assay kit for the detection of Coxiella burnetii IgM and IgG phase antibodies in their serum. Serum with a phase II IgG titer of =>256 and a phase II IgM titer of =>50 was predictive for acute Q fever. Additionally, a 4-fold rise …
An Investigation Of Pulmonary Findings Of Crimean-Congo Haemorrhagic Fever Patients, Gülden Bi̇lgi̇n, Çi̇ğdem Ataman Hati̇poğlu, Şeri̇fe Altun, Cemal Bulut, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
An Investigation Of Pulmonary Findings Of Crimean-Congo Haemorrhagic Fever Patients, Gülden Bi̇lgi̇n, Çi̇ğdem Ataman Hati̇poğlu, Şeri̇fe Altun, Cemal Bulut, Sami̇ Kinikli, Ali̇ Pekcan Demi̇röz
Turkish Journal of Medical Sciences
Crimean-Congo haemorrhagic fever (CCHF) generally affects many organs. In this study a retrospective evaluation of the pulmonary findings of CCHF patients was made. Materials and methods: The records of patients were retrospectively analysed. For each patient an evaluation was made of age, sex, occupation, place of residence, contact with ticks, smoking history, and pulmonary radiological and laboratory findings. A confirmed diagnosis of CCHF was made on determination by enzyme-linked immunosorbent assay or polymerase chain reaction. Results: Of the 128 patients, 48.4% were female. Symptoms of coughing were determined in 18% of patients, sputum in 4.7%, chest pain in 3.9%, dyspnoea …