Digital Commons Network^™

Pax7 Expression And Color Pattern Development In Two Populations Of Metriaclima ‘Msobo’ From Lake Malawi, Africa, Sonya Anzaldua

Theses and Dissertations

In Lake Malawi, 450-600 species have evolved from one riverine ancestor within the past million years. The dynamic speciation of Lake Malawi’s endemic fauna has coincided with a diversification of color patterns, driven by sexual selection. Little is known about the genes determining male color pattern, despite its importance during population divergence and speciation. This study attempts to identify genes underlying the divergence of male color patterns between two populations of Metriaclima ‘msobo’ from Lake Malawi. Adult males from the Lundo population display blue and black vertical bars, while adult males from the Magunga population have blue and black blotches. …

The Look Of Pedagogical Content Knowledge In Middle School Statistics, Dhimitraq Duni

Theses and Dissertations

In this study, I attempt to examine the nature of pedagogical content knowledge (Shulman, 1986) that teachers exhibit while observing computer-animated animations that bring up pedagogical issues in the classroom. In-service teachers were asked to view different animations and react to different prompts about the animations. Later, teachers were interviewed to prompt more discussion of pedagogical issues with the intention of clarifying their stance and their knowledge of pedagogy. The computer animations were utilized as a surrogate for classroom teaching, highlighting issues that could be otherwise overlooked during live teaching observation.

Adults With Cystic Fibrosis: Self-Management And Health Outcomes, Amanda Rose Lambie

Theses and Dissertations

This dissertation is comprised of three manuscripts for publication reporting on adults living with cystic fibrosis, self-management behaviors and health outcomes. Chapter I explores what is known about adults living with cystic fibrosis (CF) and the factors impacting their self-management, including the complexities of a health maintenance regime required for survival while integrating and balancing the realities of adulthood. The review of literature provides direction for future research and implications for adult-focused CF studies. Chapter II is a manuscript describing the characteristics of prognostic survival models utilized in adult CF research and provides an overview of their development, validation, predictive …

Worldwide Distribution Of The Human Apolipoprotein E Gene - The Association Between Apoe, Subsistence, And Latitude, Tiffany S. Ho

Theses and Dissertations

The human apolipoprotein E gene (APOE) plays an important role in metabolizing lipids, regulating plasma cholesterol, and maintaining biological function. Structural differences in APOE variants impact cholesterol absorption and health risk, so that alleles serve as biomarkers for numerous cardiovascular and neurological diseases (Lai 2015). Variant differences are determined by changes in two single nucleotide polymorphisms (SNPs), rs429358 and rs7412. Distribution of alleles varies across populations. Allele frequencies in populations have been shown to be associated with cultural and environmental factors, including subsistence strategy and latitude (Eisenberg 2010).

This study aims to provide a cross-population, genetic association study …

Testing Social Bond Theory On Hispanic Youth, Carla Alvarez

Theses and Dissertations

Hirschi's social bond theory plays a substantial role in the explanation of juvenile delinquency. While social bond theory appears to play an important role in explaining delinquency among Non- Hispanic Whites, research on Hispanic populations is limited. The purpose of this study is to test the validity of social bond theory within the context of delinquency among a sample of Hispanic youth. In this research, self-administered surveys were given to 169 middle school students at United Independent School District (UISD) in Laredo, Texas. Assault, school delinquency, and public disturbance were used as measures of delinquency. Multiple regression analyses were employed …

Grieving Behaviors During Parental Bereavement In Western Societies, Victor A. Luna

Theses and Dissertations

This paper will examine the grieving behaviors of parents who have lost a child. More specifically, it will discuss how grieving behaviors that are deemed appropriate depend on one’s gender, and how societal norms discourage behaviors that are deemed inappropriate. The focus will be on industrialized Western societies.

Slave To The Rhythm: Variation In The Acoustic Signaling Of Picoides Woodpeckers, Alex Baer

Theses and Dissertations

We explored rhythmic variation in acoustic signals by geography across four species of Picoides woodpeckers. We hypothesized that there would be an effect of geographic location on the cadence of drums and rattle-type calls. No significant effect was observed. However, drum cadence was observed to significantly impact conspecific recognition in playbacks.

Long Vacation In Bk, Doll Chao

Theses and Dissertations

The diary of a transcontinental search for self and place, a journey through obtuse politics, cultural oppression, and loneliness - this film is the document of a lost generation of Taiwanese youth and its conflict with China, swirling in a transpacific gyre of sound, image, and text.

How The Egg Rolls: A Morphological Analysis Of Egg Shape In The Context Of Displacement Dynamics, Ian R. Hays

Theses and Dissertations

Very little is known about how morphology effects the motion, stability and the resulting viability of avian eggs. The limited research that exists focuses on the pyriform or ‘pointed’ egg shapes found in the Alcidea family. This unusual shell form is thought to suppress displacement and prevents egg loss on the cliffside nesting habitat of the Uria genera. Unfortunately, these studies never isolated or quantify the specific morphological features (elongation, asymmetry and conicality) of these pyriform eggs, which limits their applicability to other taxa and hampers a robust proof of concept. We isolated each feature as a variable, produced models …

Singing And Stress, Joseline Lopez

Theses and Dissertations

College students use various methods to cope with stress. The effects of singing on stress, have been scarcely examined in students with little to no singing experience while in their natural environments. College students' stress levels were examined before and after singing. A significant decrease in stress levels was found.

Disordered: Conversations About Mental Health And Society, Rachel Brown

Theses and Dissertations

Disordered is a collaborative, participatory street art project designed to destigmatize mental health challenges like depression and anxiety, and reframe health as a societal issue. Through social practice and guerrilla strategies, Disordered intervenes in public spaces, creating conversations, stickers and metal signs to inspire personal, social and political transformations.

The Role Of Mdm2 In Dna Damage Signaling, Stanley Tam

Theses and Dissertations

The overexpression of the oncogene MDM2 is common in a variety of human cancers. MDM2 overexpression is known to increase genome instability in cells by delaying DNA double strand break repair and γH2AX levels. This study explores the knockdown of MDM2 and how it may affect DNA damage signaling.

Factors Of Annual Reproductive Success In North American Barn Swallows (Hirundo Rustica Erythrogaster) In Shared Greenspace, Joseph Czeisel

Theses and Dissertations

This study examined three metrics related to barn swallow reproductive success in shared greenspace. Earlier nesting dates were positively related to reproductive output and survival rate. Anthropogenic disturbance was not found to influence productivity. The distance of nests inside structures predicted survival rate. The monitoring of additional seasons is recommended.

Better Than Before, Makia Harper

Theses and Dissertations

Better than Before is an experiential art installation that profiles the life of James Isreal, a Vietnam vet who shares a spiritual journey that is filled with self-discovery, introspection, and hope in the midst of war and abhorrent racism. His poignant retrospective follows his struggle to find peace in the midst of trauma and disease, providing life lessons that transcend the pangs of adversity and the unknown.

Transcendent Realities: The Search For Meaning In The Modernisms Of Yeats, Joyce, And Pound, David A. Price

Theses and Dissertations

This dissertation examines the binary of transcendence and immanence in the poetry of W. B. Yeats, The Cantos of Ezra Pound, and James Joyce’s Ulysses. Utilizing a theoretical lens provided primarily through the writings of Jacques Derrida and an historical context established by Charles Taylor’s A Secular Age, the paper argues that the literary texts of Yeats, Pound, and Joyce deconstruct a Western cultural history of a transcendent-immanent binary and seek to revive elements of the transcendent as a cure to the consequences of the dominant materialist-immanent worldview of Enlightenment modernity. This paper relies on the distinction between twentieth century …

Floral Symmetry Genes Elucidate The Development And Evolution Of Oil-Bee Pollinated Flowers Of Malpighiaceae And Krameriaceae, Farahnoz N. Khojayori

Theses and Dissertations

Specialization on insect and animal pollinators is thought to be the driving force for the evolution of floral traits. Specifically in the New World (NW), the oil-bee pollination syndrome has led to the convergence of floral characters in two distantly related families of core eudicots, Malpighiaceae and Krameriaceae. Both families display a flag-like structure that establishes a zygomorphic flower and floral oil rewards in epithelial elaiophores. These traits work concomitantly to attract and reward female oil-bees that help fertilize these flowers and in return receive oils. The underlying genetics of floral zygomorphy were studied in several clades of core eudicots, …

Secondary Student Information Literacy Self-Efficacy Vs. Performance, Jen Spisak

Theses and Dissertations

The amount of information in the world has grown exponentially in the last generation. Students often believe that growing up as digital natives means they have advanced information literacy skills. However, school librarians are not seeing evidence of this in their schools. The purpose of this study was to determine if secondary students overestimate their information literacy (IL) abilities, if relationships exist between IL self-efficacy and performance, and if grade level or self-efficacy level changes those relationships. To accomplish this, data were collected from two middle schools and three high schools from a total of 397 students in grades 6, …

Rep-Dna Complexes And Their Role In Aav Dna Transactions, Vishaka Santosh

Theses and Dissertations

Adeno-associated Virus (AAV) Rep proteins are multifunctional proteins that carry out various DNA transactions required for the life cycle of AAV. The Rep proteins have been found to be important for genome replication, gene regulation, site-specific integration and play an essential role in genome packaging. There are two main groups of Rep proteins: large and small Reps; both groups are SF3 helicase family members. During DNA packaging, studies have shown that the small Rep proteins are critical to produce fully packed particles. Using stopped-flow kinetic analysis, we show a significant difference in helicase activity between the small and large Rep …

Assessing Baseline And Post-Discharge Risk Factors In Subjects With And Without Sleep Apnea Undergoing Endoscopy With Deep Sedation, Mercedes E. Weir

Theses and Dissertations

ABSTRACT

ASSESSING BASELINE AND POST-DISCHARGE RISK FACTORS IN SUBJECTS WITH AND WITHOUT SLEEP APNEA UNDERGOING ENDOSCOPY WITH DEEP SEDATION

Background: Outpatient procedures encompass over 60% of all surgeries in the United States, and the prevalence of obstructive sleep apnea (OSA) remains high among adult surgical ambulatory patients. Ambulatory surgery poses problems for patients with OSA because narcotics and anesthetics used during surgery can complicate the negative effects of OSA, leading to cardiac events, brain hypoxia, and even death. This study was designed to evaluate the prevalence of cardiopulmonary risk factors among post endoscopic patients with diagnosed and undiagnosed sleep apnea. …

Toward Biologically-Inspired Self-Healing, Resilient Architectures For Digital Instrumentation And Control Systems And Embedded Devices, Shawkat Sabah Khairullah

Theses and Dissertations

Digital Instrumentation and Control (I&C) systems in safety-related applications of next generation industrial automation systems require high levels of resilience against different fault classes. One of the more essential concepts for achieving this goal is the notion of resilient and survivable digital I&C systems. In recent years, self-healing concepts based on biological physiology have received attention for the design of robust digital systems. However, many of these approaches have not been architected from the outset with safety in mind, nor have they been targeted for the automation community where a significant need exists. This dissertation presents a new self-healing digital …

Structural Stress And Otherness: How Do They Influence Psychological Stress?, Christine Dewilde

Theses and Dissertations

Background: The Theory of Cultural Distress offers a framework for understanding the potential outcomes in patients who do not receive care that incorporates their cultural beliefs (DeWilde & Burton, 2017).This study represents initial steps in researching the theory byexploring the layering of stressors that place the patient at risk for Cultural Distress. Methods: Utilized aCross-sectional descriptive correlational analysis of intersecting identities (Structural Stressors), ethnicity-related stressors (Otherness) and ethnic-identity (Otherness) to develop understanding of the potential effects of these variables on psychological stress. Independent variables included intersecting identities, perceived ethnic discrimination, concern for stereotype confirmation, own group conformity pressure, and …

An Intervention Study On Mindfulness Meditation And Mindfulness, Stress, Flourishing, And Academic Achievement In A First-Year Experience Seminar, Elizabeth S. Bambacus

Theses and Dissertations

This study investigated the two research questions, 1) what are the relationships among the pretest latent variables mindfulness, stress, and flourishing and the manifest variables GPA and retention in first-year college students in a first-year experience seminar and 2) will there be differences in mindfulness, stress, flourishing, GPA, and retention between groups of students in a first-year experience seminar who received a brief mindfulness intervention and those who did not? To answer these questions, the author analyzed secondary data collected from 373 first-year college students at a large public research university who took Introduction to the University (UNIV 101).

The …

Language, Literacy, And Conscientização In American Public Schools, Julie Ward

Theses and Dissertations

Language, Literacy, and Conscientização in American Public Schools synthesizes poststructural language theory to critique literacy teaching and assessment norms in American public schools in order to theorize a pedagogy of racial and economic justice that embraces globalization and immigration. Chapter I creates a theoretical framework for language that rests firmly on both Lev Vygotsky’s and Jacques Lacan’s sociohistorical approach to language acquisition and language use. Mikhail Bakhtin’s work demonstrates the heteroglossic nature of discourse, while Antonio Gramsci politicizes this framework through an understanding of hegemony. Chapter II sketches ethnographic research on teaching practices of various American communities, focusing on ideology …

Regulation Of Hcn Channel Function By Direct Camp Binding And Singlet Oxygen, Vinaykumar Idikuda

Theses and Dissertations

Hyperpolarization-activated, cyclic-nucleotide gated ion channels (HCN channels) are activated by membrane hyperpolarization and modulated by cyclic nucleotides. HCN channels are important to maintain the resting membrane potential and input resistance in neurons and have important physiological functions in the brain and heart. Four mammalian HCN isoforms, HCN1-4, and the isoform cloned from sea urchin, spHCN, have been extensively studied. Among these, only spHCN channel shows a voltage dependent inactivation. Previous studies have shown that the ligand binding in mHCN2 channel is activity dependent: cAMP binding increases along with channel opening or channels in the open state have higher binding affinity …

Galantamine's Deconstruction In The Quest Of A Pam Pharmacophore, Malaika Argade

Theses and Dissertations

Alzheimer’s disease is a progressive neurodegenerative disorder generally affecting people above the age of 65 years. Even though the pathophysiological hallmarks of AD were established more than a hundred years ago, there is yet to be a drug that can stop its characteristic neuronal damage. Of the five currently FDA-approved drugs, galantamine has a unique mechanism of action. Apart from being an AChE inhibitor, galantamine can effectively potentiate (positive allosteric modulator) the effect of agonists at nAChRs at concentrations lower than those required for its action as an AChE inhibitor. Perhaps the clinical benefits observed with galantamine are associated mainly …

The Role Of Ceramide In Neutrophil Elastase Induced Inflammation In The Lungs, Sophia Karandashova

Theses and Dissertations

Alterations to sphingolipid metabolism are associated with increased pulmonary inflammation, but the impact of inflammatory mediators, such as neutrophil elastase (NE), on airway sphingolipid homeostasis remains unknown. NE is a protease associated CF lung disease progression, and can be found in up to micromolar concentrations in patient airways. While sphingolipids have been investigated in the context of CF, the focus has been on loss of cystic fibrosis transmembrane conductance regulator (CFTR) function. Here, we present a novel observation: oropharyngeal aspiration of NE increases airway ceramides in mice. Using a previously characterized mouse model of NE-induced inflammation, we demonstrate that NE …

Biosensing And Catalysis Applications Of Nanoporous Gold (Npg) And Platinum-Speckled Nanoporous Gold (Npg-Pt) Electrodes, Christopher J. Freeman

Theses and Dissertations

The importance of porous materials has risen substantially in the last few decades due to their ability to reduce the size and cost of bioanalytical devices and fuel cells. First, this work aims to describe the fabrication of nanoporous gold (NPG) electrodes that are resistant to electrode passivation due to fibrinogen biofouling in redox solutions. The effect on potentiometric and voltammetric experiments was seen as a deviation from ideal behavior on planar gold electrodes, whereas NPG electrodes were consistently behaving in a Nernstian fashion at low concentrations of ferri-ferrocyanide (£100 mM). An improvement in electrode behavior on NPG electrodes versus …

Improving Realtime 3-D Tracking Of High Dose Rate Radiation Source Using A Flat Panel Detector, Leo Uchechukwu Udeji

Theses and Dissertations

Previous research ¹ on this subject tracked the presumed exact path the HDR source would follow in real-time, during breast brachytherapy treatments in other to ensure accurate dose delivery and effectively confirm actual source position. As a continuation, this research has three objectives. Firstly, we will extract information from patient DICOM file which will be used to perform evaluations, then we will establish communication between our C program and the new Varex Paxscan flat panel detector (FPD). Finally, we will try to embed our C codes into a MATLAB graphical user interface (GUI) This research will attempt to improve the …

Exogenous Fniii 12-14 Regulates Tgf-Β1-Induced Markers, Hilmi M. Humeid

Theses and Dissertations

The extracellular matrix protein Fibronectin (FN) plays an important role in cell contractility, differentiation, growth, adhesion, and migration. The 12th -14th Type III repeats of FN (FNIII 12-14), also referred to as the Heparin-II domain, comprise a highly promiscuous growth factor (GF) binding region. This binding domain aids in cellular signaling initiated from the ECM. Additionally, FN has the ability to assemble into fibrils under certain conditions, mostly observed during cell contractile processes such as those that initiate due to upregulation of Transforming Growth Factor Beta 1 (TGF-β1) [1], [2]. Previous work from our lab has shown that self-assembly of …

Molecular Brain Adaptations To Ethanol: Role Of Glycogen Synthase Kinase-3 Beta In The Transition To Excessive Consumption, Andrew D. Van Der Vaart

Theses and Dissertations

Alcoholism is a complex neuropsychiatric disease that is characterized by compulsive alcohol use and intensifying cravings and withdrawals, often culminating in physiologic dependency. Fundamental alterations in brain chemistry underlie the transition from initial ethanol exposure to repetitive excessive use. Key mediators of this adaptation include changes in gene expression and signal transduction. Here we investigated gene expression pathways in prefrontal cortex and nucleus accumbens following acute or chronic ethanol treatment, to identify genes with potentially conserved involvement in the long-term response of the corticolimbic system to repeated ethanol exposure. We investigated Gsk3b, which encodes glycogen synthase kinase 3-beta, as a …