Digital Commons Network^™

Salt Marsh Health And Biomass Responses To A Changing Environment, Gwen Joelle Miller

Theses and Dissertations

Coastal salt marshes are important ecosystems not only for their aesthetic beauty but also for their ecosystem services that they provide including improving water quality, providing protection from storm surges and hurricanes, and carbon sequestration. With climate change, including drought, warmer temperatures and sea-level rise, these systems are going to be impacted. Understanding how salt marshes will respond, or already have responded, to climate change will help us be better prepared for the future. By scripting a model to project how marshes may migrate with sea-level rise, I discover that salt marshes within Beaufort and Jasper counties, South Carolina will …

The Intergenerational Effects Of Adverse Childhood Experiences On Children’S Emergency Department Utilization And Depression And Anxiety In South Carolina, Eboni E. Haynes

Theses and Dissertations

Adult exposure to adverse childhood experiences (ACEs) is common in the U.S., with over half of adults reporting exposure to at least one ACE. Childhood trauma is associated with risk factors for premature death, disability, poor physical and mental health, and lower quality of life in adults. Traumatic experiences also influence parenting behaviors later in life, placing offspring at an increased risk of ACE exposure. Few studies have explored the intergenerational effects of ACEs on the health and well-being of offspring. This study sought to identify whether associations existed between caregiver ACE exposures and emergency department (ED) utilization for sick …

Evidence For P53-Mediated Induction Of Wrap53a In Response To Dna Damage, Anne Shelton Hucks

Theses and Dissertations

p53 is a powerful tumor suppressor mutated in approximately half of all cancers. Its mRNA is stabilized post-transcriptionally via complementary base pairing with the transcript of its antisense gene, WRAP53α; without this interaction, p53 protein cannot accumulate enough to carry out its many functions related to apoptosis, cell cycle arrest, and DNA damage repair. Previous studies have shown that WRAP53α is induced in response to DNA damage. The purpose of this study was to determine which transcription factors might be responsible for this induction. After identifying three putative p53 binding sites on the WRAP53α promoter, we used chromatin immunoprecipitation …

Study Of The Inflammatory And Fibrotic Pathology In The Gut Following Microcystin Exposure Under Conditions Of Non-Alcoholic Fatty Liver Disease., Sutapa Sarkar

Theses and Dissertations

Non-alcoholic fatty liver disease (NAFLD) has become a global pandemic with increased risks of chronic inflammation in obese and elderly population. It has become a major public health concern due to the unavailability of proper therapeutic approaches. NAFLD is a condition of the liver involving wide spectrum of events including accumulation of fat in the liver and inflammation, which can progress to a fibrotic and cirrhotic phenotype, often termed as non-alcoholic steatohepatitis (NASH). In this backdrop, exposure to environmental toxins from harmful algal blooms could prove detrimental to the overweight, obese or elderly population. NAFLD not only affects the liver …

Cationic Cobaltocene Derivatives And Polyelectrolyte Membranes For Energy Storage Applications, Tianyu Zhu

Theses and Dissertations

Metal-containing polyelectrolytes (or metallo-polyelectrolytes) represent a new class of polymeric materials with distinct properties compared to traditional organo- polyelectrolytes or neutral metallopolymers. This emerging class of synthetic materials is ubiquitous for a myriad of utilities ranging from traditional electrolyte chemistry to biomedicals to sustainable applications, to name just a few. This dissertation work is focused on the design, synthesis, characterization and application of advanced metallo- cations and metallo-polyelectrolytes for energy storage applications. First, a template method to prepare metallo-polyelectrolytes based on cationic cobaltocene and polyethylene backbone was described. The resulting membranes are mechanically tough, ionically conductive and chemically inert. Second, …

Green Forest Businesses As A Method To Improve Communities In Unesco’S East Usambara Biosphere Reserve In Tanzania, Myoung Su Ko

Theses and Dissertations

A number of developing countries, especially those in Africa which have experienced former colonization, are still struggling with exploitation of their natural resources. Throughout the development of environmental management, the strategy of natural resource management has evolved from mistreating the environment for economic and social development, to separating human activities from the environment for extreme environmental protection, to ensuring the interaction between human life and environment for sustainable development. Although an abundance of natural resources, and particularly forests, exist in the protected areas, the residents in communities surrounding protected areas are usually economically and socially poor.

With this situation, the …

Molecular Modeling Of Tethered Polyelectrolytes For Novel Biomedical Applications, Merina Jahan

Theses and Dissertations

Current research trends throughout the world focus on designing intelligent materi- als and systems for diverse applications in all courses of life. Biomaterials research encompasses a major part in this revolution due to the increased effort in fulfilling unmet medical needs to treat complex physiological and neurodegenerative disorders. Polymers play inevitable roles in these research endeavors for their ubiquitous pres- ence in biological systems. Therefore, it is crucial to understand how the polymeric molecules interact within diverse biological environments, to efficiently engineer them for various drug delivery and biosensing systems. The use of experimental design and selection of different polymers …

The Judgement Of Southern Motherhood In Works By Doris Betts, Gail Godwin, Dorothy Allison, And Kaye Gibbons, Jennifer Martin

Theses and Dissertations

My dissertation considers depictions of mothers in the works of four southern women writers published between the late 1970s and the early 1990s. During this period there was a conservative backlash to the progressive second-wave feminist movement. The tensions that women experienced between the ideas of feminism and the traditions in the South that women should aspire to motherhood above all other enterprises and should enact motherhood as selfless servants to their children and husbands are apparent in the fictional works examined in this study.

I consider texts by Doris Betts, Gail Godwin, Dorothy Allison, and Kaye Gibbons to explore …

Investigation Of Electrostatic Interactions Towards Controlling Silylation-Based Kinetic Resolutions And Exploring The Effect Of The Polymer Backbone On Silylation-Based Kinetic Resolutions Employing A Polymer-Supported Triphenylsilyl Chloride, Tian Zhang

Theses and Dissertations

This dissertation focuses on studies of silylation-based kinetic resolution methodology developed by the Wiskur group, which is a powerful method for the separation of a single enantiomer from a mixture of racemic secondary alcohols. Chapter 1 introduces the background of our silylation-based kinetic resolution..

Chapter 2 involves mechanistic studies of electrostatic interactions in controlling enantioselectivities of our silylation-based kinetic resolution. Electrostatic interactions between a silylated isothiourea intermediate and an ester π system is determined via linear free energy relationship study. To be specific, how variations in sterics and electronics affect the selectivity of a silylation-based kinetic resolution.

Chapter 3 is …

Women’S Socio-Economic Empowerment And Uptake Of Hiv Testing In Ethiopia, Dawit Alemu

Theses and Dissertations

Introduction: Sub-Sahran Africa constitute two-thirds of all people living with HIV in the world. HIV infection rate is high in the continent with women comprising 56% of new HIV infections among adults 15 and older. Women 15 to 24 are the most affected constituting 66 % of new infections occurring among this age group. The purpose of this study was to examine how gender power relations between men and women affect health seeking behavior, particularly HIV testing, among Ethiopian women age15 to 49.

Methods: The Ethiopian Demographic and Health Survey (EDHS) from 2016 served as the data source for …

Using Long Time Series Of Satellite Remote Sensing Data To Assess The Impact Of Climate And Anthropogenic Changes In The Mesopotamian Marshes, Iraq, Reyadh Albarakat

Theses and Dissertations

In the recent past, the Mesopotamia region has been rich in all forms of biological diversity, characterized by a fertile living environment and natural habitats full of rare birds, wild animals, aquatic animals, and diverse plants. Its natural abundance and geographical location have allowed it to be break or transit point for millions of migratory birds from Russia to South Africa. It is a breeding ground for many species of Persian Gulf fish. Despite all this historical, environmental and economic richness, they have been neglected as a result of the combination of a number of human and climatic factors, which …

Contexts Of Recovery And Displacement: Investigating The Impact Of The 2015 South Carolina Floods Across Communities, Van Phan

Theses and Dissertations

In October 2015, South Carolina was devastated by weather complications related to hurricane Joaquin that lead to historic amounts of rainfall and flash floods that destroyed local communities and infrastructure, ultimately displacing over 400,000 people. Natural disasters are destructive and have shown to be correlated with a variety of negative outcomes, including high levels of stress and hopelessness. These effects can be even more pronounced when compounded with displacement as these victims not only have to deal with the usual consequences in the aftermath of a natural disaster, but also the stress of integrating themselves into a different community and …

The Continuum Of Support For Building Intimacy Knowledge In College For Students With Intellectual And Developmental Disability, Chelsea Vanhorn Stinnett

Theses and Dissertations

Adults with intellectual disability report the same relational and sexual intimacy needs as those without disability, yet experience barriers in accessing intimacy education and engaging in intimacy. Postsecondary education (PSE) programs for students with intellectual disability allow for college students to experience a higher level of autonomy in choice-making they may not have experienced in their family home. The Continuum of Support for Intimacy Knowledge in College Survey (CoSIK-C) was used to examine how PSE programs support college students in building their intimacy knowledge, intimacy education professional development opportunities for PSE staff members, and staff perceptions on factors that could …

Implementing The Flex Model Of Blended Learning In A World History Classroom: How Blended Learning Affects Student Engagement And Mastery, Kristin N. Davis

Theses and Dissertations

In the following action research plan, an explanatory sequential mixed methods research study of the implementation of the Flex model of blended learning in a World History classroom is presented. The study and its findings are used to measure mastery of, engagement with, and understanding of historical concepts presented in a six-week unit on the Enlightenment and the various revolutions this period in history caused. Data collection and analysis, including data from pre- and post-tests, Likert scale surveys, exit tickets, and student artifacts, are discussed. The pre- and post-tests were analyzed quantitatively using descriptive statistics (minimum and maximum score, average …

Learning The Land: Indians, Settlers, And Slaves In The Southern Borderlands, 1500-1850, William Cane West

Theses and Dissertations

Between 1500 and 1850, Native Americans, Europeans, and enslaved African Americans competed for territory within the landscape of the lower Arkansas Valley. The complex transitional environment between delta bottomlands, interior highlands, and Great Plains fostered the co-existence of competing Native and Euro-American claims to regional sovereignty and settlement well into the nineteenth century. The geopolitical divides often hinged on debates over environmental resources and scientific practices. Indigenous polities from the Mississippians to the Quapaws and Osages adapted to environmental changes to establish and maintain their borders in the face of European colonial presence. In the nineteenth century, Cherokees and white …

Children See Race; Teachers Should Too: Challenging Bias, Stereotypes, And Prejudice Through Children's Literature, Alexandra J. Jenkins

Theses and Dissertations

This dissertation examines the impacts of antibias culturally responsive literature on kindergarten children and teachers through qualitative action research conducted in one classroom over the course of twelve weeks. It examines how young children in this kindergarten classroom use what they have learned from and about antibias culturally responsive literature in their daily play, writing, conversations, and interactions. I clarify the process through which kindergarteners transform in relation to the understanding of their and others' cultures. In the research, two types of strategies were used: (1) critical research and (2) narrative inquiry. Data was collected from whole group discussions set …

Motivational And Physiological Dysregulation Due To Development And Onset Of Obesity Via Melanocortin 4 Receptor +/- Haploinsufficiency, Alex Steiner

Theses and Dissertations

Obesity is one of the leading most health risks around the world, being especially problematic in the United States. A combination of high-fat diets and genetic abnormalities are to blame for the ever-growing number of obese individuals.

Melanocortin 4 receptors are vital for regulating energy expenditure and feeding behaviors; mutations of the receptors have been found to be the leading monogenetic cause of obesity. Using MC4R +/- haploinsufficient rats being fed a range of dietary fat, we investigated the physiological and motivational differences using a locomotor task, an operant task with fixed and progressive ratios, as well as a distraction …

Analysis Of Hpv16 Variants In The Carolina Women’S Care Study And A Comparison Of Gene Expression Profiles Of Exfoliated Cervical Cells From Women Who Either Clear Or Do Not Clear An Hpv16 Infection, Erica Shirlene Green

Theses and Dissertations

Human papillomavirus (HPV) is the etiologic agent for cervical cancer with HPV type 16 (HPV16) being found in about 50% of cervical cancers worldwide. HPVs vary in genomic (DNA) sequence not only between types, but also within types, known as variants. Variants of a particular HPV type may differ by up to 2% in nucleotide sequence in the coding region and up to 5% in the noncoding region. Variants within HPV16 have been identified and grouped into six distinct phylogenetic branches, which segregate geographically: European (E), Asian-American (As.A), African-1 (Af-1), African-2 (Af- 2), Asian (As), and North American (NA). However, …

Assessing The Competitive Advantage Of Carbonic Anhydrase In Estuarine Microalgae Through Removed Enzymatic Activity, Eilea R. Knotts

Theses and Dissertations

Carbon concentrating mechanisms (CCMs) are used by photoautotrophs to overcome possible limitations in carbon acquisition but the competitive strategies and efficiencies of these mechanisms among photosynthesizers can be variable. The diversity in carbon acquisition abilities establishes the potential for alterations in community structure with shifting carbon concentrations. Given the role of phytoplankton and benthic microalgae (BMA) in the trophodynamics of estuaries, understanding the mechanisms of carbon acquisition in these systems is important in predicting how primary productivity and nutrient cycling might change in response to increasing concentrations of atmospheric CO2. Our approach to investigate whether induced carbon limitation would show …

Discovery Of Materials Through Applied Machine Learning, Travis Williams

Theses and Dissertations

Advances in artificial intelligence technology, specifically machine learning, have cre- ated opportunities in the material sciences to accelerate material discovery and gain fundamental understanding of the interaction between certain the constituent ele- ments of a material and the properties expressed by that material. Application of machine learning to experimental materials discovery is slow due to the monetary and temporal cost of experimental data, but parallel techniques such as continuous com- positional gradients or high-throughput characterization setups are capable of gener- ating larger amounts of data than the typical experimental process, and therefore are suitable for combination with machine learning. A …

Investigating The Relationship Of Copd, Lung Cancer, And Polycyclic Aromatic Hydrocarbons From Ambient Air Pollution, Daniel John Kilpatrick

Theses and Dissertations

Polycylic aromatic hydrocarbons (PAHs) are a group of chemically-related compounds with a well-established body of evidence of adverse human health impacts. Additionally, there is a growing area of research on the health outcomes following PAH exposure via air pollution, specifically with chronic obstructive pulmonary disorder (COPD) and lung cancer. The purpose of this dissertation was to investigate the strength of associations among PAHs, COPD, and lung cancer from ambient (outdoor) air pollution. The first objective was to determine if there is a potential environmental link among PAHs, COPD, and lung cancer occurrence among nonsmokers using data from the National Health …

Modeling Neutron Interaction Inside A 2d Reactor Using Monte Carlo Method, A. S. M. Fakhrul Islam

Theses and Dissertations

Scientists and engineers have been working for many years to develop accurate approaches to analyzing nuclear power reactors using computer codes that closely model the behavior of neutrons in a reactor core. The Monte Carlo simulation method is capable of treating complex geometries with a high level of resolution and fidelity to model neutron interactions inside a reactor core. With the requirement of accurate modeling in reactor physics and dynamics and great innovation of computer technology, Monte Carlo method is becoming an ever more powerful tool and receiving rising attention. In this study, Monte Carlo method is used to model …

Heterogeneous Ozonation Of Model Drinking Water Contaminants Using Cbv-720 Zeolite, Benson Maxwell Solomon

Theses and Dissertations

Advanced Oxidation Processes (AOPs) are designed to remove aqueous organic contaminants through their reaction with hydroxyl radicals (HO∙). Ozone is classified as an AOP due to its ability to produce hydroxyl radicals, as well as its ability to oxidize a wide range of organic contaminants. Due to the unselective nature of hydroxyl radicals, many organic and inorganic co-solutes can act as scavengers, reducing the efficiency of an AOP. Here we show a probe system for testing the hypothesis that adsorptive ozonation of contaminants may yield a more selective environment that favors neutral contaminant oxidation over oxidation of co-solutes.

Initial experiments …

The Development Of Multi-Functional System That Combine Patterned Hydrogels, Plasmin-Degradable Nanoparticles And Stem Cells For Applications In Tissue Engineering And Growth Factors Delivery, Safaa I. Kader

Theses and Dissertations

This thesis spots the light on the development of a novel multi-functionalized system for application in tissue engineering and on-demand morphogens delivery. Three types of materials used in this study are synthetic polymer, biopolymer, and nanomaterials. Polyethylene glycol (PEG), a synthetic polymer was chosen in this study because of its high biocompatibility, non-immunogenicity, inert nature, ease of modification, and reduces protein denaturation to provide a wide range of physical and mechanical properties. Here, PEG is used one time as a hydrogel, linear polyethylene glycol-co-lactide (LPELA), and another time as peptide-PEG based nanoparticles (PxSPCP). Gelatin, a natural polymer has been widely …

Population And Kin Structure Of Hawksbill Turtles: Insights On Natal Homing Precision, Time To Maturity And The Male Component Of The Breeding Population, Kathryn Erin Levasseur

Theses and Dissertations

Marine turtles have long endured population declines and face a growing number of contemporary threats, highlighting the need for population assessments and conservation action. Research on these species, however, remains a challenge due to complex and extensive oceanic life cycles that hinder direct observation. The pelagic, post-hatchling life stage is particularly difficult to track, preventing empirical research of fundamental behavior and life history traits such as natal homing precision and time to sexual maturity. Also, much of our current knowledge of marine turtles comes from nesting females and hatchlings, stages of the life cycle that are easy to observe. Far …

Examining Women’S Perceptions Of Maternity Care In Public And Private Sectors Of National Guard Hospitals In Saudi Arabia: A Qualitative Study, Hanin M. Almahmoud

Theses and Dissertations

Every second, a baby is born. The process of birth is a complex one – biologically, medically, and emotionally. In particular, women in labor need both physical and emotional care. They need to be heard, to be comforted, and to be safe.

Women’s satisfaction can be used as a legitimate way to measure the quality of maternity care. Moreover, when health systems practice patient-centered care and listen to women’s concerns and what they want out of their care, it can lead to improvements in their satisfaction. Hospitals in Saudi Arabia are considered to be among the best and most technologically …

Macromolecular Engineering Of Biomass Polymers And Stimuli-Responsive Materials Towards Enhanced Thermomechanical Properties, Meghan E. Lamm

Theses and Dissertations

Commodity polymers are used in every aspect of daily life, and most of these polymeric materials are synthesized using petroleum-derived sources. There are direct environmental consequences to this petroleum dependence including greenhouse gas emissions and climate change. Biomass-based polymers show promise for the mitigation on negative environmental impact, in comparison with petroleum-derived counterparts. However, some biopolymers suffer from low chain entanglement due to bulky or long side chain structures, resulting in poor mechanical properties. In this dissertation work, macromolecular engineering is used to design biomass-derived polymers featuring a variety of structures and functionalities. Additionally, biopolymer properties (including thermomechanical enhancement) and …

Hiv Care Location: An Evaluation Of Single Versus Multi Facility Utilization Of Hiv/Aids Care Services And Patient Health Outcomes And Clinical Indicators In South Carolina, Melanie Gwynn

Theses and Dissertations

Background: On the HIV/AIDS care continuum, the “retention in care” metric does not distinguish between single-facility (SF) or multi-clinic utilization (MC), also described as HIV care location (or type). SF utilization is vital as it has been linked optimal clinical outcomes among People Living with HIV/AIDS (PLWH). Published research detailing the prevalence of HIV care type and its association with health outcomes/clinical indicators, has been studied only in limited urban settings. Additionally, coinfections such as sexually transmitted infections (STIs), have yet to be evaluated as potential predictive factors for HIV care type.

Methods: A cross-sectional design was used …

Larval Fish Mortality And Vertical Chlorophyll Structures: Reexamination Of The Stable Ocean Hypothesis In The Southern California Current, Brendan D. Turley

Theses and Dissertations

The natural mortality of fishes is an important component for understanding population dynamics. The larval stages of pelagic fishes living in the open ocean are particularly vulnerable to high rates of mortality, and fluctuations in these rates are thought to exert a large influence on the number of fish maturing into the spawning population. Early stage larval fishes are thought to undergo a critical period after hatching when they must find food or succumb to starvation. While the availability of suitable food for larval fishes is, on average, too low in the open ocean to support survival, patchy distributions of …

Wireless Rf Induced Energy Absorption And Heating Of Lanthanum-Nickel Alloy In The Near-Field, Michael Dillon Lindsay

Theses and Dissertations

This thesis will investigate whether and how a synthetic metal-magnetic alloy absorbs enough near-field electromagnetic (EM) radiation for heating. Although resistive elements could be used for indirect heating, a wireless radio frequency (RF) method is explored because of its advantages in its non-intrusive nature and its ability to direct or focus energy within a specific area. For our case, the RF heating process relies on the materials ability to absorb sufficient RF energy due to the induced currents. We expect there to be significant surface resistance due to the conductivity and magnetic permeability of the material and thus heat. This …