Digital Commons Network^™

Engineering Of Bio-Based And Synthetic Polymers: Synthesis And Application In Superabsorbent Materials And Antibacterial Agents, Jihyeon Hwang

Theses and Dissertations

A polymer consists of a large number of monomer units, which can be obtained naturally or via a chemical process called polymerization. Polymers are important materials that are used in our daily life. Life would not be possible without these polymers, either from plant biomass or petroleum-derived synthetic polymers. The substitution of petroleum-derived to biomass-based polymers has been highlighted to mitigate adverse environmental impact. However, the use of bio-based polymers is still a significant challenge for more demanding applications. In this dissertation work, the engineering of both bio-based and synthetic polymers and their properties are investigated.

In Chapter 1, the …

Coordination Environment And Thermodynamics Of Colloidal Quantum Dots In Polar Solvents, Nuwanthaka Prasad Jayaweera Millaniyage

Theses and Dissertations

Colloidal semiconductor quantum dots (QDs) have been extensively investigated due to their attractive properties such as size-tunable absorption and emission spectra, large molar extinction coefficients, and significant photostability. These properties make them promising candidates for optoelectronic, photocatalytic, and biomedical applications. Common synthetic procedures of QDs produce nanocrystals capped with long-chain fatty acid derivatives which are stabilized in high boiling point solvents. Especially for bioimaging applications, the exchange of these native hydrophobic ligands with hydrophilic ligands should be performed, while preserving the smaller hydrodynamic radius. The coordination environment and thermodynamic parameters of the ligand exchanges should be carefully investigated to engineer …

B-Cell-Specific Mhcii Promotes Host-Microbiome Symbiosis, Mary Melissa Roland

Theses and Dissertations

Classical major histocompatibility complex class II (MHCII) molecules are cell surface glycoproteins that bind and present peptide antigens on the surface of antigen presenting cells (APCs). MHCII:peptide complexes engage T cell receptors (TCRs) and CD4 co-receptors thereby facilitating cognate interactions between CD4+ T cells and APCs, which is responsible for the development of antigen-specific reactions and long-lived immunity; so called TD antibody responses. This is a critical step in the host’s response to pathogens, commensals, environmental stimuli and tumors. IgA is the dominant antibody isotype secreted into the gut and it is thought that most of the IgA in the …

Customer Discovery And Applied Research And Development For An Environmental Nanotechnology, Paul Michael Vecchiarelli

Theses and Dissertations

Technology transfer is a process by which an innovative technology, typically produced in a non-commercial setting such as academia, is developed into a potential market opportunity. The first phase of technology transfer, once a technology has been developed, is to identify a customer segment and determine a value proposition that describes what need the technology will fulfill for them. This phase has been systematized into a framework known as customer discovery. Success in customer discovery will indicate technological gaps, such as scale-up, prototyping, and realistic testing, that are needed to deliver the value proposition to the initial customer. Both phases …

Substance Use Disorder Treatment Among African American Men Living In The Rural South Of The United States, Serge Raoul Wandji

Theses and Dissertations

Substance use disorders (SUD) affect more than 40 million Americans. African American (AA) men are disproportionally affected by the negative health and social consequences of SUD, and men in rural areas may be particularly at risk due to disadvantaged socioeconomic conditions and persistent race-related stressors such as perceived discrimination. The overall purpose of this study is to advance the understanding of factors associated with SUD treatment acceptance and relapse potential among Southern rural AA men.

This purpose was achieved by determining differences in treatment acceptance and relapse potential by race and gender among rural residents admitted in a SUD treatment …

Ultra-Processed Food Consumption And Risk Of Liver Cancer, Longgang Zhao

Theses and Dissertations

Background: Studies have shown positive associations between ultra-processed food (UPF) intake and obesity and type 2 diabetes, two risk factors for liver cancer. However, the relationship between UPF intake and liver cancer has scarcely been studied. We aimed to evaluate the association between UPF intake and the risk of liver cancer in three prospective cohorts and further explore the role of genetic predisposition to fatty liver diseases and biomarkers of liver health on modifying the association.

Methods: We used data from the Nurses’ Health Study (1986-2012), the Health Professionals Follow-up Study (1986-2012), and UK Biobank (2006-2020). Diet was assessed with …

An Investigation Of The Galenic Influence On The Artistic Depiction Of Anatomical Concepts During The Renaissance, Fatima Amjad

Theses and Dissertations

The Renaissance era was a period marked by an intellectual and artistic resurgence in Europe, during which artists sought inspiration from Classical sources. This resulted in a move away from stylized medieval aesthetics and towards a renewed emphasis on accuracy and humanity in art. Renaissance artists developed art styles that emphasized perspective, proportion, and anatomy, creating more lifelike and naturalistic representations of the human figure and the natural world. The adoption of naturalism and individualism in the arts paired with the rediscovery and retranslation of ancient anatomical texts propelled artists and anatomists to deepen their understanding of the human body. …

How Do They Do It: A Narrative Of Disabled Public School Instrumental Ensemble Conductors And Their Positive Working Relationships With Their Administrators, Lia Alexandria Patterson Snead

Theses and Dissertations

As the leader of the instrumental ensemble, the conductor’s role is important on and off the stage. Public school conductors have especially demanding jobs because they must act as a conduit between composer and ensemble as well as handle all administrative duties pertaining to running a music program. Subsequently, this results in a heavier workload than the average teacher. The demanding workload can add to any preexisting issues for disabled ensemble conductors who struggle at work due to insufficient support from their administrators. The lack of strong administrative support for disabled or impaired faculty and staff may be due to …

Implementing Meaningful Problem-Based Learning In A Middle School Science Classroom, Celestine Banks Pough

Theses and Dissertations

The purpose of this action research study was to explore the impact of problem-based learning on science instruction in my eighth-grade college preparatory classroom. Constructivism was the framework for this study. Problem-based learning is based on constructivist principles, and it served as the instructional model for this study. PBL can foster the use of problem-solving skills, critical thinking skills, and communication skills, which are needed in the 21st century. This research study was centered around three research questions. The first question asked about the impact PBL has on students’ science achievement. The second question asked how does PBL impact students’ …

Evaluating Health Awareness In Cancer Genetics Amongst The Black And African American Community In South Carolina, Annika Jaliya Gadson

Theses and Dissertations

Historically minoritized individuals are underrepresented in genomic research which limits the ability to fully understand genetic variation within the population (Sirugo et al., 2019). This creates bias that questions the effectiveness of guidelines for genetic testing, predictive risk values, and medical management. Disparities in cancer genetics may be attributed to historical events that have cultivated mistrust in research and medicine, institutional bias, provider skepticism in patient reporting of medical symptoms, and limited access to genetic testing (Saulsberry et al., 2013). More exploration is needed to better understand how to increase access and awareness of cancer genetic services to Black and …

An Autonomous Aerial Drone System For Water Fluorescence Mapping And Targeted Sampling, Kazi Ragib Ishraq Sanim

Theses and Dissertations

At present, aerial drones, also known as Uncrewed Aircraft Systems (UAS) or Unmanned Aerial Vehicles (UAV), are increasingly used in time and effort-heavy scientific exploration applications. One such application is inspecting the physical, chemical, and biological state of water bodies. This thesis presents a novel autonomous system capable of sensing water properties and collecting up to three 250 mL water samples from multiple sampling locations. The system features a customized aerial drone with an in-house built fluorescence sensor and pumping mechanism. It can also map the gradient of fluorescent content across the body of water to determine the best sampling …

Supporting Lgbtq+ Ela Students Through Action Research, Nicole Mustaccio

Theses and Dissertations

English Language Arts curriculums traditionally include canonical authors such as Walt Whitman, Langston Hughes, and William Shakespeare. However, educators may not discuss the writers’ nonnormative sexuality. Moreover, educators may avoid teaching literature from a queer perspective, whether due to discomfort with LGBTQ+ terminology or because of a lack of professional development opportunities related to queer authors and queer theory.

In response to this problem of practice, I conducted this action research study to change the heteronormative culture at my high school. By providing professional development to fellow English Language Arts teachers, I sought to encourage the inclusion of LGBTQ+ authors …

Exploring The Current Training Of Undergraduate Geology Students And Teaching Spatial Skills To Improve Student Outcomes, Ann Marie Klyce

Theses and Dissertations

Spatial skills, which represent the ability to mentally manipulate objects (Schneider & McGrew, 2012; Atit et al., 2020) have been shown to be correlated with entrance, persistence and success in STEM (Shea et al., 2001; Wai et al., 2009). Specifically, these skills have been shown to be necessary to geologists and geoscientists (Hegarty, 2014; Gagnier et al., 2016). While we recognize the importance of these skills, explicit training in them is rarely offered (NRC 2006). Consequently, cognitive scientists and discipline based education researchers have begun concerted efforts to offer training in spatial skills to improve student outcomes (e.g. Uttal et …

Learning To Let Go: Becoming A More Collaborative And Compassionate Director, Catherine Joy Thomas

Theses and Dissertations

This thesis examines all the directorial projects I’ve had the pleasure of working on throughout my time at UofSC, both as an assistant and as a director. Because I am completing my MFA without the mentor I originally started this journey with, my path has not been linear but, instead, a series of stepping stones in all shapes and sizes, guided by different directors and unofficial mentors who have various styles and approaches to theatre. These projects have molded my directorial approach in different ways, and I have become a better collaborator and leader because of them. This thesis examines …

Molecular Devices For Measuring Weak Solvophobic Interactions And The Development Of Pedagogical Tools For Organic Chemistry Students, Alexander N. Manzewitsch

Theses and Dissertations

The main topics of this dissertation are: 1) the development and discussion of a new molecular balance for measuring alkyl-alkyl interactions in a wide array of organic solvents, 2) the development of linear solvation energy relationships between solvent interaction parameters and solvent accessible surface area (SASA) in CH-arene interactions, and 3) the development of online resources for helping undergraduate students perform organic chemistry mechanisms problems well.

The solvophobic effect, that is the forced association between two solutes due to intermolecular attraction of the solvent molecules, is ubiquitous in organic chemistry and responsible for many significant phenomena thereof. However, there is …

Multilevel Description Of Spotted Fever Group Rickettsia Among Humans, Animals, And The Environment In Miraflores, Colombia, And South Carolina, Usa, Lidia Gual Gonzalez

Theses and Dissertations

Tick-borne diseases are emerging worldwide due to environmental shifts caused by land fragmentation and climate change. Among the most important ones spotted fever group rickettsioses (SFGRs) are of particular interest due to their wide species variety and high pathogenicity. Given the global spotted fever group rickettsia (SFGR) distribution, evaluation and comparison of different populations is critical to better understand these pathogens' epidemiology and unravel the risk factors affecting disease occurrence. Consequently, this dissertation investigates SFGR highlighting the One Health framework, assessing animals, humans, and the environment. The first part includes an evaluation at the household level using human and canine …

“Oh My God, Everyone Was Staring At Us”: The Experiences Of Transracial Fostering From The Perspective Of White Foster Parents Raising Black Youth, Christian Holmes Gorchow

Theses and Dissertations

Racial-ethnic identity is an essential component of a Black child’s development. Little is known about how transracial foster parents support Black foster children’s racial-ethnic identity development. The purpose of this dissertation was to address this gap by: (1) exploring transracial foster parents’ racial socialization practices as it relates to the care of Black foster children, (2) understanding transracial foster parents’ experiences with addressing racism and racial bias directed towards Black foster children, and (3) exploring transracial foster parents’ knowledge as it relates to the cultural needs of Black foster children. Using a thematic analytic approach, a sample of 8 White …

Female Infertility And Maternal And Infant Outcomes In South Carolina – The Role Of Insurance Type, Chelsea Mencio Norregaard

Theses and Dissertations

The overall objective of this research study was to examine the association between fertility treatments and maternal and infant birth outcomes, and to understand what role insurance type plays in these associations.

This retrospective statewide cohort study utilized population-based birth certificate data from January 2018 – December 2021in South Carolina, linked to all-payer claims data for outpatient services, inpatient admissions/discharges, and emergency department visits. Key exposure variables included insurance type and fertility treatment, depending on Aim. Key outcomes of interest included fertility treatment (Aim 1); maternal outcomes (Aim 2) including severe maternal morbidity, cesarean delivery without medical indication, elective labor …

The Relation Between Adhd Symptoms And Life Satisfaction/Self-Esteem Among Youth: Family Structure And Parenting Practices As Moderators, Yvette Rother

Theses and Dissertations

Children and adolescents with attention-deficit/hyperactivity disorder (ADHD) may be particularly vulnerable to lower life satisfaction and self-esteem, given negative perceptions about their abilities and self, as well as related impairments in academic, social, and interpersonal functioning. Family factors, such as family structure and parenting behaviors, can impact youth development and behaviors. However, it is unclear what role family factors play in the relation between ADHD symptoms and life satisfaction and self-esteem among youth. This study therefore examined whether ADHD symptoms have an impact on the life satisfaction and self-esteem of children and adolescents in grades 4-12. Moreover, it explored whether …

Ideologies Of Race, Gender, And Religion In Pronunciation Perception At Evangelical Esl Programs, Ruthanne Joy Wenger Hughes

Theses and Dissertations

Nonnative English speakers are often judged based on their accent, but accent is perceived as well as produced. Race, gender, and religion interact to create complex and nuanced figures of personhood (Agha, 2005) impacting teachers' perceptions of students. Teachers' individual differences, including language proficiency, exposure to language, and previous training, also affect pronunciation ratings (e.g., Kang, 2008, 2012; Kang & Rubin, 2009). This dissertation investigated English as a second language teachers at evangelical English programs in South Carolina, addressing how teacher backgrounds interacted with institutionally circulating ideologies of race, gender, and religion, and these factors' impact on ratings of student …

Real-Time Facial Expression Recognition Using Edge Ai Accelerators, Mark Heath Smith

Theses and Dissertations

Facial expression recognition is a popular and challenging area of research in machine learning applications. Facial expressions are critical to human communication and allow us to convey complex thoughts and emotions beyond spoken language. The complexity of facial expressions creates a difficult problem for computer vision systems, especially edge computing systems. Current Deep Learning (DL) methods rely on large-scale Convolutional Neural Networks (CNN) which require millions of floating point operations (FLOPS) to accomplish similar image classification tasks. However, on edge and IoT devices, large-scale convolutional models can cause problems due to memory and power limitations. The intent of this work …

Neurodevelopmental And Transient Impacts Of Brain Kynurenic Acid Elevation And Sleep-Wake Behavior, Katherine Rentschler

Theses and Dissertations

Sleep is vital for healthy cognition and mood. Sleep dysregulation is implicated in psychiatric disorders such as schizophrenia and bipolar disorder. Sex differences in sleep and arousal dysregulation are prominent in patients with psychotic disorders. Elevated levels of the neuroactive tryptophan metabolite, kynurenic acid (KYNA), have been found in cerebrospinal fluid and postmortem brain tissue samples from patients with psychotic disorders. KYNA is an astrocyte derived antagonist at N-methyl-D-aspartate (NMDA) glutamate receptors and α7 nicotinic acetylcholine (α7nACh) receptors. KYNA is synthesized in the brain from its biological precursor, kynurenine, via the enzyme kynurenine aminotransferase II (KAT II), a potential therapeutic …

Volume Change Measurements Of Cancer Cells In A Microfluidics Platform, Yukuan Yu

Theses and Dissertations

Understanding the function of aquaporins in transcellular transport is vital for homeostasis, pathophysiology, and translational potential in AQP-based diagnostics and therapeutics. Microfluidics device has the potential to evaluate the function of aquaporins with precise control and manipulate micro-scale fluid due to good optical quality and short processing distance. This work has two parts: cell culture in a microfluidic chip to characterize aquaporins’ function and visualization of single cell volume change under osmotic pressure shock in a homemade imaging dish. For the first part, we established a microfluidics platform for future modification and measurement of the dynamic volume change of biological …

Connecting Their Stories: Black Educators’ Experiences Within Cultural Heritage Institutions That Document The Long Arc Of The Civil Rights Movement, Constance Marie Caddell

Theses and Dissertations

This study aims to examine Black educators’ experiences within cultural heritage institutions that are documenting topics that include the long arc of the American Civil Rights Movement. Black educators are powerful conduits of the African American story because they align with African American cultural heritage institution’s goals to foster equality, identity, pride, and honor in the community. These shared goals lead to Black educators using teaching methods that liberate, advocate, and empower students. This allows them to share new knowledge, strategies, techniques, and concepts on diverse topics. Considering their fundamental mission, it is essential to gain an awareness of the …

Impact Of Virtual Models On Students’ Multilevel Understanding Of An Organic Reaction, Eli Martin

Theses and Dissertations

As the number of STEM opportunities and the need for a scientifically literate society increases, educators in STEM fields require tools that help support these needs. Chemistry is one STEM content area that would benefit from exploring educational technology that supports conceptual understanding. An action research study was conducted to understand how students engage with the content and virtual representation to develop their understanding of a chemical reaction. This convergent mixed methods study looked at the effect of dynamic virtual molecular representation on students' ability to understand a reaction mechanism at the symbolic and subparticulate level by measuring content knowledge …

Rhetorical New Materialism, Queers, And Cringe, Katherine Anne Schell

Theses and Dissertations

Cringe, the negative reflexive reaction we experience when we witness something embarrassing or awkward, has a bad reputation in the queer community. In online and physical queer spaces, there is a pervading belief that “cringe culture” must be antithetical to queerness, that no queer community could possibly achieve liberation until it has eradicated the threat of cringe. This thesis revises that cringe vs. queer positioning by reimagining cringe as its own rhythm of queerness and examining the productive aspects of cringe through engagement with thinkers like Karen Barad and Eve Kosofsky Sedgwick. The thesis, formatted as a response to a …

The Impact Of Opendyslexic Font On The Reading Comprehension Of Tier Ii And Tier Iii Reading Intervention Students, William David Whitmire

Theses and Dissertations

This mixed methods action research project measured the effect of OpenDyslexic font on the reading comprehension of MTSS Tier II and Tier III reading intervention students. A review of the literature revealed little research about OpenDyslexic font or its effect on reading comprehension. The study consisted of a 7-week period with 4^th grade Tier II and Tier III reading intervention students using OpenDyslexic font while reviewing previously taught comprehension strategies before end of the year testing. Results show positive growth for Tier II reading intervention students and results were inconclusive for Tier III students.

Genetic Testing For Autism: The Autistic Adult Perspective, Thomas Scott Dent

Theses and Dissertations

Many professional medical organizations recommend some level of genetic testing as standard of care for those diagnosed with autism spectrum disorder. However, genetic testing related to the diagnosis of autism is seen as controversial by many in the autistic community. While opinions about genetic testing have been well-documented from the perspective of the parents of autistic children, our understanding of the autistic adult perspective remains limited. We implemented a descriptive, web-based survey of autistic adults to assess their awareness of, attitudes towards, and interests in genetic testing for autism (n = 145). Our data demonstrated that half of our participants …

Genomic Analysis Of Exophiala Sp. Etnp2018, A Marine Fungal Strain Isolated From An Oxygen Minimum Zone, Margaret Kelly Bernish

Theses and Dissertations

Microbial metabolic activity is central to biogeochemical cycling in virtually all ecosystems. Fungi are important parts of microbial communities, serving as decomposers, parasites, and symbionts. Most of our understanding of fungal ecology is derived from the study of isolated, cultured terrestrial fungi. However, the marine environment includes thousands of divergent, uncultured fungi. A number of these species, which include saprobes, parasites, and endophytes, can survive and sporulate in a wide range of salinities. Other such species face the additional challenge of limited nutrient accessibility. The genus Exophiala includes agents of mycoses in both humans and in marine animals. This research …

Exploration Into The Relationship Between Colitis And Depression: A Potential Role For The Aryl Hydrocarbon Receptor, Kasie Lynn Roark

Theses and Dissertations

Inflammatory Bowel Disease (IBD) is a group of chronic gastrointestinal disorders with unclear etiology comprised of two defined disorders – Crohn’s Disease (CD) and Ulcerative Colitis (UC). IBD leads to chronic pain, socially isolating symptoms, and an overall reduction in patient quality of life. There is currently no cure for IBD. Due to decreased mucous production and weakening of the colonic epithelial lining, gut-microbiota and their metabolites can invade the intestinal lamina propria and circulate systemically, a term known as “leaky gut”. Recent studies show a relationship exists between peripheral inflammation, such as IBD, and depression. The gut-brain axis (GBA) …