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Enzymatic Regulation Of Opioid Antinociception And Tolerance, Lynn Hull Jul 2009

Enzymatic Regulation Of Opioid Antinociception And Tolerance, Lynn Hull

Theses and Dissertations

ENZYMATIC REGULATION OF OPIOID ANTINOCICEPTION AND TOLERANCE By Lynn C. Hull, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2009 Director: William L. Dewey, Ph.D. Department of Pharmacology and Toxicology The involvement of kinases in opioid actions has long been established. The acute actions of opioids, through the Gi/Go G-proteins, cause the inhibition of adenylyl cyclase and therefore a decrease in protein kinase A (PKA) activation. Additionally, acute opioid administration may cause the G-protein to activate the phospholipase C (PLC)-mediated cascade leading to the …

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Approaching Autism: A Qualitative Review Of Maternal And Familial Adaptation Among Families Of Children With Autism, Stephanie A. Williamson Jul 2009

Approaching Autism: A Qualitative Review Of Maternal And Familial Adaptation Among Families Of Children With Autism, Stephanie A. Williamson

Theses and Dissertations

The purpose of this study is to serve as an exploration of family experiences in relation to a child's autism diagnosis. Specifically, it focuses on family adaptation as explained by McCubbin, et al.'s Double ABCX Model (1983). Given that mothers play a crucial role in the family system and are often the primary caregivers for children with disabilities, maternal adaptation is also investigated. This study employs qualitative methods, including in-depth personal and group interviews. Mothers shared their perceptions and experiences surrounding children's autism diagnoses, including initial recognition of atypical behavior and development, the formal diagnosis process, and subsequent transitions within …

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Synergistic Growth Inhibition And Enhancement Of Cell Death By Combination Of Melanoma Differentiation Associated Gene-7 (Mda-7/Il-24) And Cisplatin In Ovarian Cancer Cell Lines, Renyan Liu Jul 2009

Synergistic Growth Inhibition And Enhancement Of Cell Death By Combination Of Melanoma Differentiation Associated Gene-7 (Mda-7/Il-24) And Cisplatin In Ovarian Cancer Cell Lines, Renyan Liu

Theses and Dissertations

Ovarian cancer is the most lethal gynecological malignancy among women. The current first-line treatments for ovarian cancer are cisplatin, carboplatin and paclitaxel. However, resistance to these platinum-based drugs occurs in the large majority of initially responsive tumors, resulting in fully chemoresistant, fatal disease. Therefore, the resistance to cisplatin therapy has been a critical hurdle in the management of recurrent ovarian cancer. The mechanisms responsible for cisplatin resistance are not completely understood. In the search for new therapies to overcome/bypass cisplatin resistance, melanoma differentiation gene-7 (MDA-7) IL-24, which is a new cytokine, has anti-cancer efficacy by suppressing cell growth and inducing …

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Factors Affecting Folic Acid Stability In Micronutrient Fortified Corn Tortillas, Jordan S. Chapman Jul 2009

Factors Affecting Folic Acid Stability In Micronutrient Fortified Corn Tortillas, Jordan S. Chapman

Theses and Dissertations

Folate degradation in micronutrient fortified corn masa and tortillas was evaluated using masa prepared from either nixtamalized corn flour or fresh nixtamal. A laboratory evaluation of the effects of pH, iron, and holding time at elevated temperature on folate loss in corn flour masa failed to show significant differences in any variable-treatment combination. An additional study was conducted at a commercial tortilla mill in Guadalajara, Mexico using masa prepared from fresh nixtamal. Commercial nixtamal was fortified with one of two different micronutrient premixes, containing iron, zinc, riboflavin, thiamin, niacin and either unencapsulated or lipid-encapsulated folic acid. A batch of each …

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An Investigation Of Middle School Student Interest, Perception, And Attitude Toward Technology And Engineering, Kari Marie Cook Jul 2009

An Investigation Of Middle School Student Interest, Perception, And Attitude Toward Technology And Engineering, Kari Marie Cook

Theses and Dissertations

The purpose of this study was to investigate middle school student perception and attitude toward technology and engineering and to better understand how the gender of the teacher, gender of the student, and information provided in technology classes affected their perception and attitude. To accomplish this, the Technology Attitude Scale, and the Pupil's Attitudes Toward Technology—United States assessment instruments were used to form the basis of a new survey instrument focused on technology and engineering perception, use, and interest. The new survey instrument is called the Technology and Engineering Attitude Scale (TEAS) survey. Multiple 7th grade technology engineering classes from …

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An Evaluation Of Bacterial And Fungal Contributions To Organic Matter Decomposition Along A Soil Moisture Gradient, Morgan Rawls Jul 2009

An Evaluation Of Bacterial And Fungal Contributions To Organic Matter Decomposition Along A Soil Moisture Gradient, Morgan Rawls

Theses and Dissertations

The decomposition of plant litter is a critical biological function that aids in nutrient cycling and energy transfers within and between ecosystems. The primary decomposers of dead leaf material are bacteria and fungi, though there is no consensus as to which of these groups is dominant, nor is it known how the abundance and composition of these communities changes over time. The objectives of this study were to examine the relative contributions of bacterial and fungal populations to leaf organic matter (OM) decomposition and to consider the effect of moisture availability on the microbial community. The study was conducted across …

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Intracellular Targets Of Sphingosine-1-Phosphate, Graham Michael Strub Jul 2009

Intracellular Targets Of Sphingosine-1-Phosphate, Graham Michael Strub

Theses and Dissertations

The bioactive lipid mediator sphingosine-1-phosphate (S1P) has emerged as a key regulator of a variety of important physiological functions, including cell growth, cell survival, cell motility, angiogenesis, lymphocyte trafficking, and mast cell function. S1P is formed by two different sphingosine kinases (SphKs) and binds to a family of 5 differentially expressed G-protein coupled receptors (S1PRs). The majority of research to date has focused on the activation of these receptors, but there is compelling evidence to suggest that S1P exerts intracellular functions independent of S1PRs. However no bona fide intracellular targets of S1P have been identified. In my dissertation, I have …

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Motivation In Learners Of Japanese As A Foreign Language: An Analysis Of Profiles And Behaviors, Britainy Dawn Sorenson Jul 2009

Motivation In Learners Of Japanese As A Foreign Language: An Analysis Of Profiles And Behaviors, Britainy Dawn Sorenson

Theses and Dissertations

This thesis examines motivation in English L1 learners of Japanese as a Foreign Language (JFL) by analyzing the students' responses to a questionnaire modeled after Dörnyei's research and an observational instrument called the Motivation Behaviors of Language Learning (MBLL) modeled after Guilloteaux and Dörnyei's (2008) research on motivational teaching strategies on behaviors. The data from the questionnaires were subjected to a discriminative analysis of students answers in relation to a high grade (receiving a B- or higher) or lower (C+ or lower) in their Japanese classes. A Factor Analysis of the data was also carried out. The discriminative results could …

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Co-Occurrence With A Congeneric Species Predicts Life History And Morphological Diversification In The Mexican Livebearing Fish Poelicopsis Baenschi, Laura E. Scott Jul 2009

Co-Occurrence With A Congeneric Species Predicts Life History And Morphological Diversification In The Mexican Livebearing Fish Poelicopsis Baenschi, Laura E. Scott

Theses and Dissertations

Understanding why some species coexist and others do not remains one of the fundamental challenges of ecology. While several lines of evidence suggest that closely related species are unlikely to occupy the same habitat because of competitive exclusion, there are many cases where closely related species do co-occur. Research comparing sympatric and allopatric populations of co-occurring species provides a framework to understand the role of phenotypic diversification in species coexistence. In this study I focus on the livebearing fish Poeciliopsis baenschi and ask if differences in phenotypic traits among populations can be explained by the presence or absence of the …

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Creating An Expected Profile For Affinity 2.5 From A Sample Of Non-Pedophilic, Exclusively Heterosexual, College Age Males, R. D. C. Boardman Jul 2009

Creating An Expected Profile For Affinity 2.5 From A Sample Of Non-Pedophilic, Exclusively Heterosexual, College Age Males, R. D. C. Boardman

Theses and Dissertations

The Affinity 2.0 has been recently upgraded to the Affinity 2.5. Both instruments purport to measure sexual interest using viewing time as a form of measurement using non-pornographic images of people of varying ages and genders. The Affinity 2.5 increased the number of slides by 42.9%. This increase may have impacted the expected Chi square weights established for the Affinity 2.0 for non-pedophilic, exclusively heterosexual males. The purpose of this study was to create new expected Chi square weights for the Affinity 2.5 for non-pedophilic, exclusively heterosexual males. Additionally, this study re-examined the temporal stability of the Affinity 2.0 using …

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Ion Transport Behaviors Upstream And Downstream From The Sampling Cone Of An Inductively Coupled Plasma Mass Spectrometer, Haibin Ma Jul 2009

Ion Transport Behaviors Upstream And Downstream From The Sampling Cone Of An Inductively Coupled Plasma Mass Spectrometer, Haibin Ma

Theses and Dissertations

Inductively coupled plasma - mass spectrometry (ICP-MS) is the technique of choice worldwide for trace elemental determinations because of its excellent ionization ability, low detection limits and fast analysis speeds. However, the ICP-MS still suffers from some disadvantages, such as spectral overlap and severe matrix effects. Matrix effects or interferences, partly arise from changes in the analyte transmission through the interfacial region between the ICP and mass spectrometer with changes in sample matrix. Better understanding of the transmission behaviors of analyte through the sampling and skimmer cones will provide the insights needed to alleviate matrix interferences and to improve the …

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Relaxation Of Vibrationally Excited Trifluorobenzene And Tetrafluorobenzene By Collisions With Carbon Dioxide, Alan M. Johnson Jul 2009

Relaxation Of Vibrationally Excited Trifluorobenzene And Tetrafluorobenzene By Collisions With Carbon Dioxide, Alan M. Johnson

Theses and Dissertations

An investigation into the relaxation of highly vibrationally excited trifluorobenzene and tetrafluorobenzene following collisions with carbon dioxide was performed using diode laser transient absorption spectroscopy. A 248 nm excimer laser prepared the vibrationally hot (E'~41,000 cm-1) fluorobenzene molecules. Large amounts of translational and rotational energy are transferred through collisions between the hot donor molecule and CO2. Rate constants and collisional probabilities were calculated by probing the high J states (J=58~80) of CO2 in the vibrational ground state, 0000, with measurements taken 1 µsec, ¼ the mean gas collision time, following each excimer laser pulse. The energy transfer probability distribution function, …

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The Human Side Of Change: Towards A Pragmatic, Evolutionary Conception Of Cognition And Emotion In Organizational Change, Jason Smith Jul 2009

The Human Side Of Change: Towards A Pragmatic, Evolutionary Conception Of Cognition And Emotion In Organizational Change, Jason Smith

Theses and Dissertations

This dissertation synthesizes and analyzes an emblematic sample of three prevalent psychological approaches to organizational change and learning, giving particular attention to the conception of cognition and emotion. It also explores some of the philosophical and psychological assumptions undergirding these approaches. A web model depicting various epistemological influences is offered as a tool for exploring influences on the psychological research within and beyond this study. A second conceptual model is also offered as a tool for considering the hierarchical treatment and preferential placement of cognition over emotion theory and practice. The project draws on general philosophy, psychology, evolutionary theory, and …

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Sphingosine Kinase 1 Inhibitor, A Novel Inducer Of Autophagy, Daniel Meza Jul 2009

Sphingosine Kinase 1 Inhibitor, A Novel Inducer Of Autophagy, Daniel Meza

Theses and Dissertations

Autophagy is the process of “cell self-eating” which has been implicated both in cell survival and cell death. Sphingosine kinase 1 (SphK1) regulates the intracellular balance between ceramide and sphingosine, bioactive lipids associated with cell death, and sphingosine-1-phosphate (S1P), whose actions are associated with survival and proliferation. Previous studies have implicated upregulation of SphK1 in the induction of autophagy. In this study, SK1-I, a SphK1 specific competitive inhibitor, induced autophagy in a concentration and time dependent manner in HCT116 colorectal carcinoma cells. This autophagic response was observed to be more intense in wild type p53 expressing HCT116 cells than in …

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Time Course Of Vascular Function Changes Following An Acute Maximal Exercise Bout In Obese And Normal Weight Males, R. Lee Franco Jul 2009

Time Course Of Vascular Function Changes Following An Acute Maximal Exercise Bout In Obese And Normal Weight Males, R. Lee Franco

Theses and Dissertations

One of the earliest sub-clinical stages associated with atherosclerosis is endothelial dysfunction (ED), which has been shown to predict future cardiovascular events. Chronic exercise is thought to improve endothelium-dependent vasodilation; however, few studies have evaluated the effects of acute exercise on vascular function (VF). Moreover, studies evaluating ED following an exercise training program lack a standardized time frame in which to measure VF. Although most studies require subjects to abstain from exercise for 24 hours prior to any VF measure, no study to date has assessed VF longer than 24 hours after the cessation of exercise. Additionally, no studies have …

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The Role Of Smpb In The Early Stages Of Trans-Translation, Deanna June Cazier Jul 2009

The Role Of Smpb In The Early Stages Of Trans-Translation, Deanna June Cazier

Theses and Dissertations

Ribosomes stall on defective messenger RNA transcripts in eubacteria. Without a mechanism to release stalled ribosomes, these cells would die. Transfer-messenger RNA (tmRNA) and small protein B (SmpB) reactivate stalled ribosomes in a process known as trans-translation. Together, tmRNA and SmpB mimic alanyl-tRNA, entering the A site of stalled ribosomes and accepting transfer of the stalled polypeptide. A portion of tmRNA is then positioned as a template for the ribosome to resume translating. The tmRNA open reading frame encodes a proteolysis tag to mark the aberrant polypeptide for degradation and a stop codon to release the ribosome. How are tmRNA …

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Triangulation Process: An Examination Of Differentiation And Family Stress As Indicated By Bowen, Michael Robert Whitehead Jul 2009

Triangulation Process: An Examination Of Differentiation And Family Stress As Indicated By Bowen, Michael Robert Whitehead

Theses and Dissertations

This study examined the Bowenian notion that triangulation is precipitated by the interaction between a person's level of differentiation-of-self and the amount of chronic familial emotional anxiety. Another aspect of this study was to examine the relationship between marital quality and child triangulation. The sample for this study was taken from the Flourishing Families project and included only the families that indicated marriage as their relationship status, resulting in a total of 336 families with a target child between the ages of 11 and 14. Initial bivariate analysis indicated that differentiation-of-self, and family stress would be associated with child triangulation. …

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Literary Case Histories And Medical Narratives In Nineteenth-Century Britain, Travis Wade Austin Jul 2009

Literary Case Histories And Medical Narratives In Nineteenth-Century Britain, Travis Wade Austin

Theses and Dissertations

Literature and medicine are not usually seen as related disciplines, but scholars have already begun producing fruitful scholarship regarding historical and aesthetic interactions between them. This thesis adds to that scholarship by examining medicine and literature in nineteenth-century Britain. More specifically, Thomas De Quincey's Confessions of an English Opium-Eater and Robert Louis Stevenson's Strange Case of Dr. Jekyll and Mr. Hyde both use nineteenth-century medical case conventions to tell their stories. Furthermore, because both works deal with addiction, divided selves, and the power that physical substances can have on morality and character, these two works provide an excellent comparison coming …

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Zero-Inflated Censored Regression Models: An Application With Episode Of Care Data, Jonathan P. Prasad Jul 2009

Zero-Inflated Censored Regression Models: An Application With Episode Of Care Data, Jonathan P. Prasad

Theses and Dissertations

The objective of this project is to fit a sequence of increasingly complex zero-inflated censored regression models to a known data set. It is quite common to find censored count data in statistical analyses of health-related data. Modeling such data while ignoring the censoring, zero-inflation, and overdispersion often results in biased parameter estimates. This project develops various regression models that can be used to predict a count response variable that is affected by various predictor variables. The regression parameters are estimated with Bayesian analysis using a Markov chain Monte Carlo (MCMC) algorithm. The tests for model adequacy are discussed and …

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Russian Parenting: Interactions With Relational Aggression Over Time, Emily Kim Keister Jul 2009

Russian Parenting: Interactions With Relational Aggression Over Time, Emily Kim Keister

Theses and Dissertations

The current study considers Russian parenting (psychological control) and child relational aggression across a decade. We used parent and child driven path analyses to test whether peer-directed and romantic relational aggression is associated with psychological control both concurrently as well as longitudinally. Using AMOS, parent and child driven models were compared and the parent driven models were found to have more significant concurrent and longitudinal linkages. Maternal psychological control was significantly stable over time; relational aggression was also stable over time for girls. Maternal psychological control at Time 1 was associated with relational aggression for girls at Time 1 and …

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Numerical Solutions For Stochastic Differential Equations And Some Examples, Yi Luo Jul 2009

Numerical Solutions For Stochastic Differential Equations And Some Examples, Yi Luo

Theses and Dissertations

In this thesis, I will study the qualitative properties of solutions of stochastic differential equations arising in applications by using the numerical methods. It contains two parts. In the first part, I will first review some of the basic theory of the stochastic calculus and the Ito-Taylor expansion for stochastic differential equations (SDEs). Then I will discuss some numerical schemes that come from the Ito-Taylor expansion including their order of convergence. In the second part, I will use some schemes to solve the stochastic Duffing equation, the stochastic Lorenz equation, the stochastic pendulum equation, and the stochastic equations which model …

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Learning English Through Interactive Weblogs: Student Experiences Blogging In The Secondary Esl Classroom, Glori H. Smith Jul 2009

Learning English Through Interactive Weblogs: Student Experiences Blogging In The Secondary Esl Classroom, Glori H. Smith

Theses and Dissertations

This qualitative action research project examined the experiences of high school English language learners as they created personal weblogs and responded to queries on a class weblog. The data from the project demonstrates that blogging as a classroom writing activity is effective in helping students to obtain, process and construct the English language.

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The Grass Seed Pathogen Pyrenophora Semeniperda As A Biocontrol Agent For Annual Brome Grasses, Thomas E. Stewart Jul 2009

The Grass Seed Pathogen Pyrenophora Semeniperda As A Biocontrol Agent For Annual Brome Grasses, Thomas E. Stewart

Theses and Dissertations

Bromus tectorum and other annual brome grasses have invaded many ecosystems of the western United States, and because of an annual-grass influenced alteration of the natural fire cycle on arid western range lands near monocultures are created and conditions in which the native vegetation cannot compete are established. Each year thousands of hectares become near monocultures of annual brome grasses. Pyrenophora semeniperda, a generalist seed pathogen of annual grasses, shows major potential as a possible mycoherbicide that could help in reducing the monocultures created by annual grasses. The purpose of this research was to identify the requirements for isolating …

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Meta-Analysis Using Bayesian Hierarchical Models In Organizational Behavior, Michael David Ulrich Jul 2009

Meta-Analysis Using Bayesian Hierarchical Models In Organizational Behavior, Michael David Ulrich

Theses and Dissertations

Meta-analysis is a tool used to combine the results from multiple studies into one comprehensive analysis. First developed in the 1970s, meta-analysis is a major statistical method in academic, medical, business, and industrial research. There are three traditional ways in which a meta-analysis is conducted: fixed or random effects, and using an empirical Bayesian approach. Derivations for conducting meta-analysis on correlations in the industrial psychology and organizational behavior (OB) discipline were reviewed by Hunter and Schmidt (2004). In this approach, Hunter and Schmidt propose an empirical Bayesian analysis where the results from previous studies are used as a prior. This …

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Presence Of Haemosporidia And Flaviviruses In Breeding Prothonotary Warblers (Protonotaria Citrea): An Analysis Of Spatial And Temporal Trends In Infection Prevalence And Associations With Reproductive Success, Elena Grillo Jul 2009

Presence Of Haemosporidia And Flaviviruses In Breeding Prothonotary Warblers (Protonotaria Citrea): An Analysis Of Spatial And Temporal Trends In Infection Prevalence And Associations With Reproductive Success, Elena Grillo

Theses and Dissertations

As Neotropical migratory birds, Prothonotary Warblers are exposed to parasites in both tropical and temperate regions and may act as dispersal agents between geographic areas. This study identifies the prevalence of Haemosporidia, West Nile Virus (WNV), and St. Louis Encephalitis virus (SLEV) in this species. A total of 71.6% of captured Prothonotary Warblers were infected with Haemosporidia during the 2008 breeding season, and infection prevalence increased throughout the season. This temporal change in prevalence is likely due to infection relapse and transmission of new infections. No correlations between reproductive effort and infection status were observed, nor were any associations between …

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Triptolide Is A Potential Therapeutic Agent For Alzheimer’S Disease, Matthew Allsbrook Jul 2009

Triptolide Is A Potential Therapeutic Agent For Alzheimer’S Disease, Matthew Allsbrook

Theses and Dissertations

Mounting evidence indicates an involvement of inflammation in the pathogenesis of Alzheimer’s disease. While there are other mechanisms involved, it is this role of inflammatory processes that we wish to investigate. Triptolide is the major constituent in the Chinese herb, Tripterygium wilfordii Hook F, and has been used for centuries as part of Chinese herbal medicine. The four ringed structure has close homology to drugs of the steroid class and it has been shown to be beneficial as an anti-inflammatory for rheumatoid arthritis and for treatment of certain cancers. The aim of this study was to evaluate the potential therapeutic …

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Complementary And Alternative Therapy Among American Indians Suffering From Depression And Anxiety, Rhea N. Allery Jul 2009

Complementary And Alternative Therapy Among American Indians Suffering From Depression And Anxiety, Rhea N. Allery

Theses and Dissertations

The American Indian population shows the highest percent of lifetime major depression at 19.17 percent compared to other ethnic groups in the United States. Anxiety among American Indians is ten times higher than other ethnic groups. Because of these statistics, American Indians also have a suicide rate that is 1.5 times higher than the national average. Unfortunately, due to a lack of funding and qualified health care provides for American Indians, improper and insufficient diagnosing and treatment for these diseases causes burden for suffers and their families. Several studies suggest that American Indians are the highest users of complementary and …

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Th2 Specific Immunity And Function Of Peripheral T-Cells Is Regulated By The P56lck Sh3 Domain, Margaret Mccoy Jul 2009

Th2 Specific Immunity And Function Of Peripheral T-Cells Is Regulated By The P56lck Sh3 Domain, Margaret Mccoy

Theses and Dissertations

Proper T-cell activation and effector function are essential for effective immunity. T-cell antigen receptor (TCR) signals are known to regulate the outcome of differentiation, but the mechanisms remain unclear. Recent work from our lab demonstrates that the Src family protein tyrosine kinase, p56Lck, is able to specifically link TCR signals to activation of the Mitogen Activated Protein Kinase (MAPK) pathway through the function of its SH3 domain. The MAPK pathway is known to be involved in T-cell activation downstream of TCR ligation and has previously been implicated in T-helper type 2 (Th2) effector function. We have utilized an Lck SH3 …

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Controlled Synthesis Of Zno Nanowires Towards The Fabrication Of Solar Cells, Dongshan Yu Jun 2009

Controlled Synthesis Of Zno Nanowires Towards The Fabrication Of Solar Cells, Dongshan Yu

Theses and Dissertations

In recent years, quasi-one-dimensional materials have attracted a lot of research attention due to their remarkable properties, and their potential as building blocks for nanoscale electronic and optoelectronic devices. A modified chemical vapor deposition (CVD) method has been used to synthesize ZnO nanowires. Electron microscopy and other characterization techniques show that nanowires having distinct morphologies when grown under different conditions. The effects of reaction parameters including reaction time, temperature, carrier gas flow rate, substrates and catalyst material upon the size, shape, and density of ZnO nanowire arrays have been investigated. Excitonic solar cells —including Gratzel-type cells, organic and hybrid organic/inorganic …

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Heritability Of Autoantibody Levels In A Twin Population, Amal Rastogi Jun 2009

Heritability Of Autoantibody Levels In A Twin Population, Amal Rastogi

Theses and Dissertations

AIM: This study aims to determine what portion of specific autoantibody phenotypes are genetically determined by using a twin model. METHODS: This study specifically examines Anti-Ro(SSA), Anti-La (SSB), Anti-Sn/RNP, Anti-Sm, Anti-Jo-1, Anti-Scl-70, Anti-Tg & Anti-TPO, Anti-dsDNA, Anti-PS, and Anti-cardiolipin antibodies for their heritability. This study examined 104 same-sex adult twins (66 monozygous, 38 dizygous) for the above mentioned autoantibody values. The serum autoantibody values in each subject were quantified using automated ELISA. Descriptive statistics including, distributions, quantiles, and moments were calculated by zygosity for continuous antibody values, subject ages, gender, race and smoking status. Categorical antibody levels were used to …

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