Digital Commons Network^™

Evaluation Of Saflufenacil Use In Southern U.S. Rice Production, Garret Brown Montgomery

Theses and Dissertations

Research was conducted in 2012 and 2013 to evaluate the use of saflufenacil in rice (Oryza sativa L.). Studies included a preemergence evaluation of different rates of saflufenacil in comparison to one rate of carfentrazone, a postemergence evaluation of saflufenacil at different rates and carfentrazone at one rate at different postemergence timings, an adjuvant evaluation to assess rice injury and weed control from different adjuvants when mixed with saflufenacil, a Clearfield program evaluation where saflufenacil was compared to other broadleaf herbicides in a Clearfield weed control program, and a cultivar tolerance evaluation where postemergence applications of saflufenacil were compared to …

A Longitudinal Analysis Of Body Mass And Morbidity: Evidence From The Health And Retirement Study, Jamie Boydstun

Theses and Dissertations

This dissertation aimed to investigate the direct and indirect pathways between body mass and three indicators of morbidity – health conditions, disability, and self-rated health status – and how these associations differed across birth cohorts. Using data from the Health and Retirement Study, a nationally representative longitudinal sample of adults age 51 or older, I used latent growth curve modeling to investigate the association of body mass on morbidity for five cohorts. Latent growth curve models allow for changes in body mass, health conditions, disability, and self-rated health over several waves of data to be assessed. To determine if the …

A Correlational Study Of Self-Directed Learning And Entrepreneurial Success In Southeast Kentucky, Frank Tudela Carothers

Theses and Dissertations

Many factors contribute to business and entrepreneurial success. Raw material, labor, capital, and entrepreneurship are common inputs into most business organizations (enterprises). Entrepreneurship is the one factor of production that is needed in all successful business organizations. In Southeast Kentucky, there has been much attention given to small business development and the need for more entrepreneurship. However, little research has been done on the “self-directedness” and “emotional intelligence” that are needed for entrepreneurial success. This study investigated the possible association between self-directed learning and emotional intelligence with entrepreneurial success in a Southeast Kentucky group consisting of independent small business owners. …

Synthesis, Characterization And Optical Properties Of Conjugated Boronate-Linked Materials And Their Applications In Optical Sensing Of Lewis Bases, Min Cai

Theses and Dissertations

Organoboron compounds, with Lewis acidic boron centers, have been emerged as an important class of materials, especially in the area of chemical sensors. Herein, boranes and boronate esters in the sensing perspective were overviewed in Chapter 1. Examples of synthesis and sensing applications of boron-containing conjugated polymers were highlighted.

Boronate ester formation provides the advantages of facile synthesis, tunable optical properties, enhanced stability and planar geometry. Thus, boronate esters, especially dioxaboroles, were proposed to use as alternatives of boranes to design better sensors for Lewis bases. Based on the previous investigation of fluorenyl bis- and poly- dioxaboroles by our group, …

Utilizing Next Generation Sequencing To Generate Bacterial Genomic Sequences For Evolutionary Analysis, Derrick C. Scott

Theses and Dissertations

Many important questions in the field of prokaryotic biology cannot be answered due to the low availability of sequenced and finished genomes. Recent improvements in technology and decreases in price have made the ambition of de novo bacterial genomic sequencing a reality for a wide range of researchers. However, with the advancement of sequencing technology comes the need for an evaluation to determine the most reliable bioinformatics methods in generating a complete and accurate assembly. Biases inherent in the sequencing technology and GC-rich genomes complicate genome assemblies. Here, we sequenced bacterial strains from the GC-rich Caulobacter genus and the closely …

Geographic Disparities In Cancer Mortality To Incidence Ratios, Kyle Buck

Theses and Dissertations

While cancer rates have shown promising trends over the last few decades, not all populations have experienced the same levels of decrease in cancer incidence in mortality rates. Identifying populations suffering from the impacts of the disparities has become a major goal in cancer research.

Most research has focused on the influence of single variables on cancer disparities or on small-scale case studies. Using the information from these analyses, the research conducted in this dissertation tests the relationship of selected variables to an outcome measure, the mortality to incidence ratio (MIR) in search of spatial relationships between the indicators and …

An Evaluation Of A Mediational Model Of Adolescent Global Life Satisfaction, Michael D. Lyons

Theses and Dissertations

This study extended previous research by simultaneously examining determinants and presumed psychosocial mechanisms related to the development of individual differences in adolescent life satisfaction, based on Evans‟ (1994) proposed model. Specifically, this study assessed the relations between personality (extraversion, neuroticism) and environmental experiences (stressful life events) on early adolescents‟ global life satisfaction as mediated by approach and avoidance coping behaviors using a sample of 529 students from one middle school in the south eastern United States. The results of this study found partial evidence to support Evans‟ model. Statistically significant relations were found for a number of individual pathways between …

The Prevalence Rate And Neurocognitive Morbidity Associated With Obstructive Sleep Apnea In Children With Sickle Cell Disease, Tal Katz

Theses and Dissertations

Sickle-cell disease (SCD) refers to a group of genetic blood disorders resulting from the inheritance of genes for S-type hemoglobin. The disease is life-long and is associated with multiple complications including pain episodes, organ damage, and neurological morbidities such as stroke, and silent cerebral infarcts which often lead to cognitive dysfunction. Obstructive sleep apnea (OSA) is a serious medical condition characterized by intermittent hypoxemia (reduction in blood oxygen levels), hypoxia, and fragmented sleep that can lead patients to suffer from daytime behavioral and cognitive dysfunction and reduced quality of life. Children with SCD are at high risk for developing OSA, …

Differential Expression Of Snmps And Their Underlying Transcriptional Regulation In Chemosensory Pathways Of Drosophila, Richard A. Fandino

Theses and Dissertations

Insects possess complex and diverse chemosensory pathways which have specific phenotypes determined by the regulated expression of specific combinations of genes. While many of these genes (e.g. ORs and GRs) have very narrow expression patterns, associating with only a limited number of chemosensory sensilla, SNMPs show a very broad expression pattern. In Drosophila, SNMP1 and SNMP2 associate with the majority of olfactory and gustatory sensilla, but express in different cell types. In olfactory sensilla, SNMP1 and SNMP2 associate with trichoid or coeloconic neurons respectively, and both additionally express in a variety of sensilla support cells; in gustatory sensilla, SNMP2 expresses …

Mechanical Properties Of Diet And Its Effect On Oral Health, Varsha Kapoor

Theses and Dissertations

The predominant diet fed to captive carnivores consists of ground meat formulated to provide full nutritional requirements. However, this ground meat diet completely lacks the mechanical properties such as toughness, hardness and stiffness of the foods the animals would eat in the wild. The goal of this research was to evaluate the effect of mechanical properties of diet on oral health by comparing prevalence of periodontal disease and calculus accumulation in wild and captive felids. One-way ANOVA analysis of variance indicated that these differences are statistically significant (P

The Development, Implementation, And Testing Of An Interactive Sexual Health Web-Based Application Intervention To Reduce Sexual Risk Behaviors Among College Students, Dawnyéa Dominique Jackson

Theses and Dissertations

College life is often regarded as a time for exploration and growth. One major area of exploration and growth for college students is sex and sexuality. Growth and exploration involves not only learning how to master these life situations, but also experiencing some negative consequences. Negative consequences for college students engaging in sexual risk-taking behaviors often lead to a high prevalence of sexually transmitted infections (STIs), unintended pregnancies, emotional distress, and large healthcare costs. Given the high prevalence of risky sexual behavior among young adults and the highly negative consequences of risky sexual behavior for this population, it is critical …

Functional Characterization Of Fro4 And Fro5: Two Members Of The Ferric Chelate Reductase Family Of Arabidopsis, Grandon Thomas Wilson

Theses and Dissertations

Iron (Fe) is the fourth most abundant element within the earth’s crust and is an essential micronutrient for plants and animals. Fe plays key roles in photosynthesis, respiration and chlorophyll biosynthesis in plants and in hemoglobin in animals. Like Fe, copper (Cu) is also an important micronutrient in plants and is needed for photosynthesis and respiration, especially in the important copper-containing protein plastocyanin. Copper also is important in scavenging reactive oxygen species and ethylene perception. The reduction of Fe3+ to Fe2+ at the root surface of Arabidopsis thaliana during times of Fe deficiency has been a well-characterized process; however, reduction …

Research On Approximate Bayesian Computation, Jiting Xu

Theses and Dissertations

This thesis presents the development of a new numerical algorithm for statistical inference problems that require sampling from distributions which are intractable. We propose to develop our sampling algorithm based on a class of Monte Carlo methods, Approximate Bayesian Computation (ABC), which are specifically designed to deal with this type of likelihood-free inference. ABC has become a fundamental tool for the analysis of complex models when the likelihood function is computationally intractable or challenging to mathematically specify. The central theme of our approach is to enhance the current ABC algorithms by exploiting the structure of the mathematical models via derivative …

Six1 Overexpression Promotes Epithelial– Mesenchymal Transition And Malignant Progression In Models Of Cervical And Colon Cancer, Hanwen Xu

Theses and Dissertations

Inappropriate expression of embryonic genes, particularly homeodomain transcription factors, contributes to tumorigenesis and tumor progression. The overexpression of Six1, a member of the Six family of homeodomain transcription factors, has been found in various human cancers, and is associated with tumor progression and metastasis. We have previously determined that the expression of SIX1 mRNA increased during in vitro progression of human papillomavirus type 16 (HPV16)- immortalized human keratinocytes (HKc/HPV16) toward a differentiation-resistant (HKc/DR) phenotype. However, the mechanism(s) of how Six1 promotes HPV16- mediated transformation remain unknown. In this study, we explored the role of Six1 at early stages and late …

Revisiting Gender Constraints And Benefits In Leisure Tourism: Man-Up, It’S Time To Travel Like A Woman, Holly L. Rabin

Theses and Dissertations

Historically and culturally, women’s leisure has been constrained through time, activity, and experience, as it is intricately woven with elements of freedom and choice, and thus empowerment (Khan, 2011; Henderson, et al., 1989). Previous research of constraints in leisure tourism appears to follow a pattern of inequalities between men and women (Wearing & Wearing, 1988). Women are feeling more independent and selfconfident then ever before in their leisure time and travel (Wilson & Harris, 2006). The purpose of this study is to determine if previous research, statistics, and case studies are still relevant in Millennial females and their solo leisure …

A Multi-Sited Examination Of Pregnancy, Birth And Women’S Perceptions Of Care In Ghana, Jessica M. Posega

Theses and Dissertations

In Ghana, both governmental and non-governmental agencies have been working to reach the 2015 United Nations Millennium Development Goals (MDGs). The fourth and fifth goals are related to reproductive health, reducing infant and maternal mortality respectively. Through a combination of increasing midwifery and nursing training programs, public awareness programs, and programs designed to retain skilled birth attendants. This paper explores how the policies and practices intended to create better birth outcomes in Ghana are perceived by those targeted for intervention, and by the reproductive health workers. Drawing from in-depth interviews with pregnant women, mothers with children under one year, and …

Longitudinal Evaluations Of Objectively Measured Physical Activity: Capturing The Full Spectrum Of Duration And Intensity, Amanda E. Paluch

Theses and Dissertations

Most physical activity research to date narrows its focus toward intensities and durations only encompassed in the Physical Activity Guidelines of moderate to vigorous intensity in at least 10 minute bouts (MVPA-10). Examining activity in this manner excludes light activity and shorter bouts, sometimes referred to as baseline physical activity (BPA) as it consists of the activity accumulated during daily life at durations and/or intensities below what is recommended. This dissertation provides an evaluation of the entire spectrum of physical activity (PA). Physical activity was studied in a unique way by looking at MVPA-10, then adding shorter bouts and light …

Tunable Graphene Chem-Fet And Graphene/Si Heterojunction Chemi-Diode Sensors, Amol Kumar Singh

Theses and Dissertations

Graphene, a two-dimensional material with very high charge carrier concentration, has drawn large research interest for sensing chemical species based upon charge exchange. Atomically thin 2-dimensional arrangement of carbon in hexagonal fashion in graphene, where each carbon atom is attached to 3 neighboring carbon atoms, and presence of π* and π bands imparts it many amazing properties. Some of these properties such as very high mobility, low 1/f and thermal noise, modulation of carrier concentration and Fermi level by electrical, optical, and chemical means, and very high surface to volume ratio make graphene very promising sensing material. In order to …

Genetic Background Influences Behavior And Responses To Epigenetic Changes Induced By A Methyl-Donor Diet, Kimberly R. Shorter

Theses and Dissertations

With recent strides in epigenetics, mainstream media informs the public that we can “beat our genes” by, for instance, changing our diet. Genetics, however, still plays a role in phenotype. Folate and other methyl-donor pathway components are widely supplemented due to their ability to prevent neural tube defects during prenatal development. In addition to vitamins, these compounds are also added to commercial flour, energy drinks, and other supplements. Several lines of evidence suggest that these supplements act through epigenetic mechanisms, including altering DNA methylation. Increasing evidence suggests potential deleterious effects of excessive folate. Given the benefits of these compounds, risk …

Longitudinal Changes In The Inflammatory Potential Of Diet And Risk Of Cancer In Women, Fred Kinyuytabung

Theses and Dissertations

Introduction: The dietary inflammatory index (DII) assesses an individual’s overall diet quality with regards to its inflammatory potential on a continuum from maximally anti-inflammatory (lower or healthier DII scores) to maximally pro-inflammatory (higher or unhealthy DII scores). The DII measured at one point in time has been associated with cancer risk in previous studies; however, data are lacking regarding the change in DII over time and how these changes impact cancer risk. We assessed changes in the DII, and evaluated associations between cumulative history, and changes over time in dietary inflammatory potential, and risk of colorectal cancer (CRC) and breast …

Teachers’ Perceptions Of Esri Story Maps As Effective Teaching Tools, Caitlin Strachan

Theses and Dissertations

The purpose of this study was to explore teachers’ perceptions of Esri Story Maps as effective teaching tools. Story Maps are a relatively new web application within Esri’s web-based GIS platform, ArcGIS Online. They combine digitized, dynamic maps with other story elements (i.e., title, text, legend, popups, and other visuals) to help the creator effectively convey a message. The relative ease associated with using and creating a Story Map as well as the simple, non-technical interface makes them ideal for use as an educational technology. Survey data were collected at several professional development events in the spring of 2014 in …

Using Comparative Metagenomics To Determine The Role Of Atlantic Bottlenose Dolphins (Tursiops Truncatus) As Sentinels For Human Respiratory Health, Sarah H. Stellick Seepaulsingh

Theses and Dissertations

Cetaceans are proposed as sentinel species for assessing the health of marine ecosystems and human coastal populations. This relationship has been based on similarities in the bioaccumulation of pollutants by cetaceans and humans, as well as their susceptibility to infectious disease. Respiratory disease represents a major cause of mortality in humans and cetaceans, and culture-dependent studies and 16S rDNA gene sequencing have identified known human respiratory pathogens from immunocompromised and healthy dolphins.

To broaden our understanding of the microbial community associated with dolphin upper respiratory tracts (URT), we characterized metagenomes generated from the URT of Atlantic bottlenose dolphins (Tursiops truncatus) …

Psychometric Evaluation Of An Executive Function Battery For Pediatric Sickle Cell Disease, Melita T. Stancil

Theses and Dissertations

Sickle Cell Disease (SCD) is a genetic disorder which affects hemoglobin and is associated with high rates of neurologic and neurocognitive deficits. Recent studies have indicated executive functioning (EF) as a common area of impairment for children diagnosed with SCD; however, there is no consensus about which measures of executive function are best to use in clinical practice or research. The purpose of the present research is to assess the properties of a new executive function measure, the “EXAMINER” to determine its utility with the SCD population. Thirty-two children with SCD and 86 demographically-matched controls completed established cognitive measures known …

Role Of Apelin And Endothelin Systems In The Pain Associated With Sickle Cell Disease, Terika Smith

Theses and Dissertations

Sickle cell disease (SCD) is a common genetic blood disorders that is characterized by painful vaso-occlusive episodes (VOEs), which are the major cause of hospitalizations for these patients. One of the mechanisms that may contribute to the development of painful VOEs is the imbalance between vasoconstrictors and vasodilators. This thesis focuses on the vasoconstrictors endothelin-1 (ET-1), which is elevated during VOEs and is pro-nociceptive, and angiotensin II (Ang II) and the vasodilator apelin, which has anti-nociceptive properties. This thesis tested two hypotheses: 1) an imbalance between the vasoconstrictive and pro-nociceptive systems and vasodilatory and anti-nociceptive systems contributes to pain in …

Enhancing Peripheral Opioid Analgesia: Development Of Viral Vector And Small Peptide Therapies, Sherika Smith

Theses and Dissertations

Chronic neuropathic pain often decreases quality of life, incurs high medical costs and is difficult to treat. Neuropathic pain can develop as a result of nerve damage induced by trauma or diseases such as diabetes and cancer. This type of pain is often resistant to standard treatments for chronic pain. Effective and safe treatments for persistent neuropathic pain remain an unmet therapeutic need. The primary objective of this work was to test the hypotheses that peripheral opioid analgesia can be enhanced using a herpes simplex virus vector gene therapy approach and peripheral opioid tolerance can be prevented by blocking opioid …

Muscarinic Modulation Of Basolateral Amygdala, Lei Liu

Theses and Dissertations

The basolateral amygdala (BL) receives a dense cholinergic innervation from the basal forebrain. Despite the importance of muscarinic acetylcholine receptors (mAChRs) in fear learning, consolidation, and extinction, there have been no studies that have systematically investigated the functional role of mAChRs in regulating emotional processing in the BL. To address this critical knowledge gap we combined brain slice whole-cell recording, optogenetics, and immunohistochemistry to determine how muscarine, acting on mAChRs, regulates neuronal oscillations, synaptic transmission and plasticity in the BL.

Neurons in the BL oscillate rhythmically during emotional processing, which are thought to be important to integrate sensory inputs, allow …

Analysis Of Risk Factors Contributing To Home–Based Direct Care Workers (Dcws) Occupational Injury In Long–Term Care, Hanadi Y. Hamadi

Theses and Dissertations

Home–based direct care workers (DCWs) provide care in a unique workplace environment: the patient’s home. The high rate of injuries experienced by this subcategory of healthcare workers compared to other industries and occupations make the need to understand the risk factors for these injuries vital. This study builds on prior research and specifically profiles occupational injury patterns among home–based DCWs who deliver care primarily in patient homes and the association of individual, perceived environmental and ergonomic characteristics on predicting occupational injury. The study used a cross–sectional analysis of secondary data from the 2007 National Home Health Aide Survey (NHHAS), sampling …

Biopolymeric Hydrogels Functionalized With Tobacco Mosaic Virus For In Vitro Three Dimensional Culture And Differentiation Of Stem Cells And In Vivo Tissue Regeneration, Jittima Amie Luckanagul

Theses and Dissertations

Plant viruses have been highlighted among material research due to their well-defined structures in nanoscale, mono-dispersity, stability, and chemical functionalities. Each of the thousands coated protein subunits on a viral nanoparticle can be homogenously modified, chemically, and genetically with a functional ligand leading to a high-density and spatial distribution of ligands on each particle (multivalency). Many reports from our group have clearly shown that virus coated substrates induced the acceleration of bone marrow stromal cells differentiation into bone cells. We hypothesized that this phenomenon could rely on the multivalency that the viral nanoparticle has to offer. Moving to a more …

Mechanistic Investigation Of A Silylation-Based Kinetic Resolution Using Linear Free Energy Relationships And Its Application To Substrate Expansion And Polymer Supported Kinetic Resolutions, Ravish K. Akhani

Theses and Dissertations

This dissertation represents our preliminary mechanistic investigations on the silylation-based kinetic resolution of secondary alcohols, and how we use that knowledge for further expansion of this methodology. Chapter 2 describes how we came up with a preliminary mechanism of our silylation-based methodology using a linear free energy relationship and a rate study. In this chapter, several para substituted triphenylsilyl chlorides were prepared that varied electronically and sterically in order to understand the substituent effects on the rate and the selectivity of the reaction. Selectivity factors and initial rates were experimentally determined for the kinetic resolution reactions with the newly designed …

From Capture To Care: Attention, Digital Media, And The Future Of Composition, Christian D. Smith

Theses and Dissertations

This dissertation investigates the relationship between digital media and cognition as it emerges in the problematic of attention. Specifically, the project examines the workings of attention across three sites (social, neurological, and technological) in order to argue for a renewed cognitive process theory of writing based in attention studies. Using the ancient pedagogical concept of epimeleias--attending to, taking care--my dissertation asks after the ethical and rhetorical stakes of care in context of contemporary higher education. Ultimately, my dissertation aims to provide a foundation for digital literacy practices--literacy narratives, wiki-writing, remix, audio-visual essays, etc.--in light of the increasing shift towards hybrid …