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A Click Chemistry Amplified Nanopore Assay For High Performance Testing Of Protein Biomarkers In Diseases, Xiaoqin Wang
A Click Chemistry Amplified Nanopore Assay For High Performance Testing Of Protein Biomarkers In Diseases, Xiaoqin Wang
Theses and Dissertations
Nanopore detection technology enables nanometer-scale single-molecule detection, yielding valuable insights into analyte molecules' properties such as size, shape, charge, and concentration. Due to its label-free nature, high sensitivity, and real-time capabilities, it finds widespread application in genomics, proteomics, drug discovery, and environmental monitoring. Click chemistry, encompassing the attachment of a probe or substrate to a biomolecule, termed bioconjugation, features the copper-catalyzed azide-alkyne cycloaddition as a quintessential reaction, forming a 5-membered heteroatom ring. This study harnesses this reaction to craft single-strand DNA probes for nanopore testing, leveraging copper's catalytic properties for signal amplification. Host-guest reaction, a noncovalent bond between molecules, specifically …
Understanding The Relationship Between Neonatal Dairy Calves’ Gut Microbiota And Incidence Of Diarrhea Using Full-Length 16s Rrna Gene Amplicon Sequencing And Machine Learning, Jalyn Grace Hawkins
Understanding The Relationship Between Neonatal Dairy Calves’ Gut Microbiota And Incidence Of Diarrhea Using Full-Length 16s Rrna Gene Amplicon Sequencing And Machine Learning, Jalyn Grace Hawkins
Theses and Dissertations
A healthy gut microbiome is crucial for the development, growth, and health of dairy calves; however, diarrhea in pre-weaned calves is highly prevalent, difficult to treat, and causes detrimental effects to the dairy industry. This study characterized early gut microbiota using longread-based 16S rRNA gene sequencing and investigated its associations with calf diarrhea and colostrum microbiota. The full-length 16S rRNA gene was amplified and sequenced on a Nanopore sequencer. We identified shared bacterial species in colostrum and calf feces, whose abundance in calf feces reduced with age. Diarrheic calves exhibited differing gut diversity before, during, and after diarrhea, and harbored …
Evaluation Of Copper Sulfate Treatment To Preclude Hatching Of Trematode Eggs, With Notes On The Influence Of Temperature On Miracidial Development And Hatching Of Drepanocephalus Spathans., Logan R. S. Robison
Evaluation Of Copper Sulfate Treatment To Preclude Hatching Of Trematode Eggs, With Notes On The Influence Of Temperature On Miracidial Development And Hatching Of Drepanocephalus Spathans., Logan R. S. Robison
Theses and Dissertations
Catfish aquaculture remains the largest sector of the U.S. aquaculture industry, grossing ~$447 million in sales in 2022. Producers are plagued by annual losses associated with the trematode Bolbophorus damnificus. Management focuses on controlling the snail intermediate hosts using copper sulfate. Herein, the effects of copper on larval stages of the trematode Drepanocephalus spathans and Austrodiplostomum compactum eggs were investigated. Results indicate copper treatments currently used to control snails are ineffective at precluding hatching of trematode eggs. Higher doses prevented trematode eggs from hatching, although these levels are likely impractical in a commercial setting. A second study investigated the effects …
Windows Into Changing Landscapes: Bioarchaeological And Geophysical Analysis Of The Grenada Yellow Fever Cemetery, M. Kathryn Mckenna
Windows Into Changing Landscapes: Bioarchaeological And Geophysical Analysis Of The Grenada Yellow Fever Cemetery, M. Kathryn Mckenna
Theses and Dissertations
This project focuses on the Yellow Fever Cemetery of Grenada, Mississippi through geophysical and biological methods. A ground penetrating radar survey was conducted to investigate the landscape and burial patterns in relation to the use of the cemetery throughout high periods of mortality such as a yellow fever epidemic. Additionally, biological methods were used in the analysis of an individual recovered as part of a salvage archaeology event from the cemetery. The multifaceted approach aims to uncover more about the cemetery, landscape, and community as it has changed over time with the influence of extreme events such as the yellow …
An Agent-Based Modeling Of Permafrost Melting And Virus Exposure Due To Climate Change, Nishat Ara Mozid
An Agent-Based Modeling Of Permafrost Melting And Virus Exposure Due To Climate Change, Nishat Ara Mozid
Theses and Dissertations
Climate change has affected human life and natural system significantly. Particularly, there is specific evidence of change in the Arctic region for climate warming. One of the consequences of climate change is the process of permafrost degradation and thawing rate of active layer. Permafrost is defined as frozen grounds that exists at a temperature of or below 0℃ for at least two consecutive years, consists of ice and novel pathogens which are frozen for a long time. Anthrax may cause a serious threat for local environment and livestock due to permafrost melting. The study introduces an agent-based modeling of permafrost …
Assessment Of Tripeptides Self-Assembly & Er Stress On Cell Viability And Exosome Secretion In Mda-Mb231, Azmat Parveen
Assessment Of Tripeptides Self-Assembly & Er Stress On Cell Viability And Exosome Secretion In Mda-Mb231, Azmat Parveen
Theses and Dissertations
This study delves into the effects of tripeptides KYpF and WYpK(NBD) on MDA-MB-231 cells, uncovering KYpF's ability to reduce cell proliferation and exosome secretion in peptide treated cells. Conversely, WYpK(NBD) demonstrated significant toxicity at 10 μM. These insights pave the way for optimizing peptide-based cellular treatments for exosome secretion purposes.
Evolving Community Preparedness: Analysis Of United States Pandemic Health Disaster Readiness, Jessy Rugeyo
Evolving Community Preparedness: Analysis Of United States Pandemic Health Disaster Readiness, Jessy Rugeyo
Theses and Dissertations
The COVID-19 pandemic has shown substantial gaps in counties' preparedness and response capacity across the United States. This study analyzes the relationship between county-level pandemic preparedness and confirmed COVID-19 cases using secondary data from the FEMA's National Household Survey (NHS) and county-level COVID-19 data from the CDC. The data show a negative relationship between preparedness levels and COVID-19 positive rates, highlighting the necessity of proactive readiness measures. Individual risk assessment, motivation for preparedness, and socioeconomic variables have a major influence on confirmed cases. Higher levels of education, income, and preparedness are associated with lower positive rates, emphasizing the importance of …
Optimization Of Mass Spectrometry-Based Methods For Low-Input And Spatial Proteomics, Andikan Jones Nwosu
Optimization Of Mass Spectrometry-Based Methods For Low-Input And Spatial Proteomics, Andikan Jones Nwosu
Theses and Dissertations
Eukaryotic cells are highly heterogeneous. These cells are arranged into different compartments, carrying out separate functions and facilitating biological processes. Proteins are the effector biomolecules targeted to subcellular locations that help fulfill specific tasks in living organisms. Spatial proteomics can help unravel molecularly how protein abundance and localization are altered in cells, which is not feasible in traditional bulk-scale proteomics. To achieve this, our lab has developed a miniaturized sample processing platform called nanoPOTS, reduced separation columns' inner diameter to increase ionization efficiency and concentrate analytes for mass spectrometers and optimized data acquisition modes for increasing proteome coverage in spatial …
Synthesis And Characterization Of Medicinally Privileged Aza Heterocycles, Nneoma James
Synthesis And Characterization Of Medicinally Privileged Aza Heterocycles, Nneoma James
Theses and Dissertations
Four-membered cyclic amides, commonly known as β-lactams, have played a crucial role in drug discovery research since its discovery by Alexander Fleming in 1928 from Penicillium notatum. The β-lactam antibiotics are broadly effective against several bacterial infections through acylating the transpeptidase involved in cross-linking peptides to form peptidoglycan or periplasmic murein, which is a fundamental constituent of the bacterial cell wall for both the gram-positive (ten or more layers) and gram-negative (one or two layers) bacteria. Although for more than eight decades, β-lactams have been recognized as antibiotics, later, other medicinal activities of β-lactam derivatives have been reported, including lowering …
Engaging Telepsychology As A Culturally Appropriate Communicative Approach For Mental Health Intervention For Women In Ondo State, Nigeria, Toyosi Motilola Olola
Engaging Telepsychology As A Culturally Appropriate Communicative Approach For Mental Health Intervention For Women In Ondo State, Nigeria, Toyosi Motilola Olola
Theses and Dissertations
Background: Assessing the mental health issues among Nigerian women is complex due to cultural norms, stigmatization, and traditional beliefs, which often lead to the concealment of mental health problems. Mental health issues are frequently seen through a spiritual or supernatural lens, exacerbating stigma and preventing proper medical care. There is also a lack of comprehensive data on help-seeking behaviors, with many women relying on religious leaders and traditional healers for support. Telepsychology can solve these communication challenges by offering a confidential and accessible platform that bridges traditional beliefs and modern mental health care. This study explores cultural influences on help-seeking …
Encompassing ‘Himdag’ (Indigenous Way Of Life) To Address Cardiometabolic Disease In American Indian And Alaska Native Communities Through Research, Policy And Action, Heather Medicine Bear
Encompassing ‘Himdag’ (Indigenous Way Of Life) To Address Cardiometabolic Disease In American Indian And Alaska Native Communities Through Research, Policy And Action, Heather Medicine Bear
Theses and Dissertations
Cardiometabolic diseases (CMD), encompassing conditions such as cardiovascular disease, diabetes, kidney disease and non-alcoholic fatty liver disease, present a significant health burden within American Indian and Alaska Native (AI/AN) communities. This dissertation, through the culmination of three products, including a scoping review, policy brief and strategic planning toolkit, seeks to understand and address CMD in tribal communities through an Indigenous lens. Product #1, Interventions for Cardiometabolic Health in American Indian and Alaska Native Communities: A Scoping Review, entails a thorough review of implemented CMD interventions targeting AI/AN communities to understand programmatic, clinical, and community-based prevention strategies. By synthesizing available evidence, …
Exploring The Dark And Gothic: An Analysis Of Edgar Allan Poe And Nathaniel Hawthorne’S Gothic Elements In American Literature, Alejandra Serna
Exploring The Dark And Gothic: An Analysis Of Edgar Allan Poe And Nathaniel Hawthorne’S Gothic Elements In American Literature, Alejandra Serna
Theses and Dissertations
This paper examines the significant contributions of Edgar Allan Poe and Nathaniel Hawthorne to the development of American Gothic literature. Poe’s stories “The Tell-Tale Heart” and “The Black Cat” are renowned for their psychological elements and exploration of the human psyche, while Hawthorne’s “The Birthmark” questions the nature of evil as a universal human experience. By examining the ways in which these authors engage with themes of mental disorders, symbolism, and science versus nature, this thesis explores how such work by Poe and Hawthorne play in shaping the readers' understanding of the darker elements of American Gothic literature and its …
Optimization Of A Sers-Based Vertical Flow Immunoassay Utilizing A Plasmonic Syringe Filter For Rapid Biomarker Detection And Quantification, Anthony Abeiku Amissah
Optimization Of A Sers-Based Vertical Flow Immunoassay Utilizing A Plasmonic Syringe Filter For Rapid Biomarker Detection And Quantification, Anthony Abeiku Amissah
Theses and Dissertations
Many current diagnostic tools for accurate disease detection and quantification are often tedious and involve multiple complex steps. Consequently, there is a critical need for alternative point-of-care devices that are affordable and deliver rapid and reliable results. Recently, surface-enhanced Raman spectroscopy (SERS) has emerged as a highly effective analytical method, enhancing Raman scattering of molecules adsorbed onto nanoparticles and allowing for low-level detection and quantitative chemical analysis. In this study, we employ SERS to develop a rapid diagnostic test using human immunoglobulin G (hIgG) as a model biomarker because it is abundant in human serum, cheap, readily available, and well-understood. …
Enabling Novel Nanopore Sensing Approaches For Personalized Medicine Through Chemical Modifications To Analytes, Zehui Zhang
Enabling Novel Nanopore Sensing Approaches For Personalized Medicine Through Chemical Modifications To Analytes, Zehui Zhang
Theses and Dissertations
Nanopore sensors have garnered significant attention recently, not only for their groundbreaking advancements in single-molecule DNA sequencing but also for their diverse applications in stochastic sensing, single-molecule chemistry, and protein unfolding. The interaction of single molecules with the nanopore sensing interface leads to characteristic ionic current modulations, reflecting the composition, charge, distribution, structure, and sequence of the translocating molecule. With the electrical resistive pulse nanopore sensing, its single-molecule sensitivity and specificity have opened doors to numerous potential applications in personalized medicine. I will discuss recent advancements in the sensitivity and specificity of personalized medicine using nanopore sensors, focusing on proteomic …
Site-Specific Conjugation Of Antibodies With Peptides Mediated By Microbial Transglutaminase ( Mtg ) For Adsorption To Gold Nanoparticles, Kwame Osei
Theses and Dissertations
Developing innovative methods that leverage the distinct characteristics of gold nanoparticles (AuNPs) has the potential to significantly advance detection technologies for addressing biological threats and improving disease intervention. However, there are challenges associated with anchoring selective recognition elements, such as antibodies, onto the surface of AuNPs. Despite extensive research, current conjugation approaches for antibody-AuNPs are not universally applicable to all antibodies, are pH-sensitive, result in random orientations that reduce activity, and/or exhibit limited stability. Resolving these issues is crucial to realizing the full potential of AuNP-based assays and promoting their widespread adoption and implementation in the field of diagnostics. The …
Application And Development Of Ceragenins In Medical Device Coatings For Clinical Settings, Elliot E. Sherren
Application And Development Of Ceragenins In Medical Device Coatings For Clinical Settings, Elliot E. Sherren
Theses and Dissertations
Hospital-acquired infections (HAIs) pose a significant and increasing threat to global health. One primary cause of this threat is increasing antibiotic resistance. As traditional antibiotics continue to grow less effective, there is an urgent need for novel antimicrobial strategies. This work explores the potential of ceragenins, also known as cationic steroid antimicrobials (CSAs), as a promising alternative to combat HAIs. Specifically, we investigated potential roles that CSAs can play in the context of multiple medical device coatings in healthcare settings. Ceragenins are synthetic mimic of antimicrobial peptides (AMPs) which exhibit broad-spectrum antimicrobial activity against many common pathogens that have been …
Evaluating The Influence Of Perfluorooctane Sulfonic Acid Exposure On Blood Glucose Levels: A Comprehensive Multiple Regression Analysis Considering Confounding Factors, Henry Mensah
Theses and Dissertations
Perfluorooctane sulfonate (PFOS) are widely used for industrial and commercial purposes and have received increasing attention due to their adverse effects on health. This thesis investigates the relationship between PFOS exposure and blood glucose levels, considering potential confounding factors. Regression analysis was conducted on a dataset comprising demographic, lifestyle, and biomarker data from a diverse population sample. Sex exhibited a significant role, with females demonstrating an 11.77% increase in blood glucose levels in response to PFOS exposure compared to males, supported by a p-value of 1.04 × 109. Body mass index (BMI) also played a pivotal role, revealing a 2.17% …
Assessment For Sustainable Transportation Systems In Egypt, Hagar Mohamed Fares
Assessment For Sustainable Transportation Systems In Egypt, Hagar Mohamed Fares
Theses and Dissertations
The assessment of a sustainable transportation system poses a significant challenge for local governments, as it dramatically influences the promotion of environmentally friendly modes of transportation with the objective of safeguarding the public's welfare and health in their daily activities. The integration of such assessment should be implemented from the initial stages of system planning to its operational and maintenance phases, particularly in light of the increasing number of urban development activities nationwide. In order to facilitate decision-making processes, it is imperative to establish an efficient rating system that incorporates cultural and social constraints and comprehensively considers the three dimensions …
Design And Fabrication Of Passive Microfluidic Devices For Enhancing Membrane-Based Biosensors, Tanner N. Wells
Design And Fabrication Of Passive Microfluidic Devices For Enhancing Membrane-Based Biosensors, Tanner N. Wells
Theses and Dissertations
Microfluidic devices and systems have demonstrated wide applicability in sample processing and analysis. The ability to integrate sample processing and analysis into a single platform is a key benefit of microfluidic technologies. This dissertation describes the design and fabrication two types of microfluidic devices developed to enhance membrane-based biosensors. First is a device for collecting particles into a highly confined region, locally enhancing their concentration. Second is a device for size-based particle separation capable of separating differently sized particles into separate streams. Both types of devices are fabricated with a thin top layer, providing a platform for synthetic membrane-based technologies. …
Rapid, Direct Screening Of Priority Metal Contaminants In Environmental Systems With Reactive 3 D-Printed Cone Spray Ionization-Mass Spectrometry ( 3 D- Pcsi-Ms ), Jonathan Nzubechi Chilaka
Rapid, Direct Screening Of Priority Metal Contaminants In Environmental Systems With Reactive 3 D-Printed Cone Spray Ionization-Mass Spectrometry ( 3 D- Pcsi-Ms ), Jonathan Nzubechi Chilaka
Theses and Dissertations
Trace metal species are relatively common in our environment, and although some are essential to sustain life, exposure to elevated levels of toxic metals can detrimentally affect both human and animal health. Correspondingly, monitoring of such contaminants in environmental systems is critical to public safety. While various methods exist for sensitive and selective metal analysis for such applications, there remains a need for a rapid, cost-effective, and, ideally, portable solution for expedited results and more impactful remediation and sustainability initiatives. Here, we investigate the use of 3D-printed cone spray ionization-mass spectrometry (3D-PCSI-MS), a newer, spray-based ambient ionization method, with specialty …
Using Discrete-Event Simulation To Balance Staff Allocation And Patient Flow Between Clinic And Surgery In A Pediatric Hospital Setting, John Forbus
Theses and Dissertations
We review the problem of a system-level balanced scheduling scenario. A hospital clinic has a queue for patients needing care. After being seen in clinic, many require follow-up surgery, for which they also wait in a queue. The rate-limiting factor is physician availability for both clinic visits and surgical cases. Much existing work has been done to optimize clinic appointments, as well as to optimize surgical appointments. This novel approach models the entire patient journey at the system level, through both clinic and surgery, to optimize the total patient experience. A discrete-event simulation model of the system is built based …
From Crisis To Aftermath: The Role Of Nursing Professional Development Educators During The Covid-19 Pandemic: A Realist Case Study, Kimberly Kanner
From Crisis To Aftermath: The Role Of Nursing Professional Development Educators During The Covid-19 Pandemic: A Realist Case Study, Kimberly Kanner
Theses and Dissertations
The purpose of this qualitative, realistic inquiry case study was to examine and understand the experiences of NPD educators as they assisted new graduate nurses transitioning into clinical nursing practice during the COVID-19 pandemic in acute care hospitals in the state of New York. Moreover, this research study sought to understand how the COVID-19 pandemic brought about changes to the NPD educator's role and their ability to assist new graduate nurses transitioning into clinical practice post-pandemic. The sample included NPD educators from acute care hospitals in the state of New York. Data collection included semi-structured interviews and document collection. The …
Identifying Immunogenic Pneumococcal Proteins With Roles In Colonization Of Human Epithelium, Abigail Cassibry
Identifying Immunogenic Pneumococcal Proteins With Roles In Colonization Of Human Epithelium, Abigail Cassibry
Theses and Dissertations
Streptococcus pneumoniae (pneumococcus) is a Gram positive opportunistic bacterium that is a primary cause of pneumonia in young children and immunocompromised individuals. This microorganism colonizes the nasopharynx of all age groups and health levels and is easily transmitted through respiratory droplets or aerosols. While capsule-based vaccines are available, these are becoming more obsolete as S. pneumoniae strains are undergoing serotype replacement, thus evading detection, and antibiotic resistant strains are increasing in prevalence. This study has taken a different approach by identifying immunogenic proteins that elicit antibodies which block attachment of bacteria to host epithelial cells. Proteins with the most potential …
Conservation At The Speed Of Light: Applications Of Non-Invasive Technologies For Assessing Physiological Phenomena In Amphibians, Li-Dunn Chen
Theses and Dissertations
The Anthropocene epoch in which we are currently living, also known as the Holocene, has brought about unprecedented losses in planet Earth’s biodiversity. Numerous extirpations of floral and faunal species have been influenced by human encroachment and more specifically, the exploitation of such species and the respective habitats in which they reside. It is this notion that has propelled many scientists to take up intellectual arms in an effort to protect these invaluable resources. The purpose of this research was to develop technologies to measure and evaluate various variables that influence animal physiology, specifically in amphibians who represent the most …
Effect Of Metaphylaxis In High-Risk Stocker Heifers On The Nasopharyngeal Microbiome, Resistome, And Antimicrobial Resistance Of Mannheimia Haemolytica, William Byrn Crosby
Effect Of Metaphylaxis In High-Risk Stocker Heifers On The Nasopharyngeal Microbiome, Resistome, And Antimicrobial Resistance Of Mannheimia Haemolytica, William Byrn Crosby
Theses and Dissertations
Bovine respiratory disease (BRD) is the leading cause of morbidity in feeder and stocker cattle, resulting in large impacts on economics of stocker and feedlot operations. One of the most effective means of controlling BRD is the mass administration of antimicrobials (AM) at arrival or “metaphylaxis”, potentially leading to increased antimicrobial resistance (AMR). Mannheimia haemolytica (MH), the most commonly isolated bacterial pathogen in BRD cases in feedlot cattle, has been shown to have integrative-conjugative elements (ICE), which are mobile genetic elements that have the ability to integrate themselves in the host genome. Notably, these ICE have been shown to contain …
Collective Bodies And Individual Experiences: The Case Of Chamber Tomb Four At Nikoleika Aigio, Achaea, Greece, Daniel David Dillon
Collective Bodies And Individual Experiences: The Case Of Chamber Tomb Four At Nikoleika Aigio, Achaea, Greece, Daniel David Dillon
Theses and Dissertations
The end of the Bronze Age was a tumultuous period throughout the Mediterranean, seeing the fall of the major palatial economy in Greece. This project seeks to reconstruct the lived experiences of individuals interred at the Nikoleika cemetery in eastern Achaea, utilizing a variety of methods to analyze biological profiles and pathological conditions. Through the analysis of the 55 burials of Chamber Tomb Four, it was found that low levels of pathology and the presence of locally-produced goods may emphasize the self-sufficient nature of Achaea during the Bronze Age. The osteobiographies of three primary burials also revealed a great deal …
Evaluating The Bull Breeding Soundness Evaluation’S Utility As A Tool For Preventing Reproductive Inefficiency, Todd Galen Gunderson
Evaluating The Bull Breeding Soundness Evaluation’S Utility As A Tool For Preventing Reproductive Inefficiency, Todd Galen Gunderson
Theses and Dissertations
One of the most impactful challenges beef cow-calf producers face is the need to optimize reproductive efficiency. The ability of a veterinarian to identify potential sources of reproductive inefficiency is a valuable service they can offer. The breeding soundness evaluation (BSE) is one tool veterinarians use to identify subfertile bulls prior to use. This body of research shows that producers who have a defined breeding season have higher odds of hiring a veterinarian to perform BSEs, and that as breeding season length decreases, the probability of a management strategy that uses BSEs being profitable increases. Furthermore, not all veterinarians use …
Evaluating The Vertical Transmission Potential Of Salmonella Reading In Broiler Breeders, Abubakar Shitu Isah
Evaluating The Vertical Transmission Potential Of Salmonella Reading In Broiler Breeders, Abubakar Shitu Isah
Theses and Dissertations
Salmonellosis, a significant foodborne illness in humans, is caused by Salmonella, with poultry and poultry products acting as significant reservoirs and sources of human infection. Salmonella enterica subspecies enterica serotype Reading has recently emerged as a notable foodborne pathogen responsible for extensive multistate human outbreaks in North America. This study focused on evaluating the capacity of the emerged serotype to colonize broiler breeder reproductive tissues and potentially contaminate eggs, indicating the potential for vertical transmission. For this investigation, two Salmonella Reading strains were utilized, one associated with outbreaks and another non-outbreak strain. Both strains were initially modified with bioluminescent marker …
Disruptors And Resilience Capabilities Of Pharmaceutical Supply Chains Exposed To Rare Catastrophic Disasters: Case Studies Of One Localized And One Global Disaster, Jeanne-Marie Elizabeth Lawrence
Disruptors And Resilience Capabilities Of Pharmaceutical Supply Chains Exposed To Rare Catastrophic Disasters: Case Studies Of One Localized And One Global Disaster, Jeanne-Marie Elizabeth Lawrence
Theses and Dissertations
In recent years, rare catastrophic disasters have triggered pharmaceutical supply chain disruptions, resulting in product shortages and other problems that have negatively impacted healthcare delivery. Since the health sector is part of many nations’ critical infrastructure, ensuring minimal disruption in the supporting supply chains is an essential aspect of national security. While traditional risk management approaches have proven adequate for handling independent routine operational risks, these methods are inadequate for infrequent disruptive risks that propagate further risks, producing a domino effect in complex systems. Since today’s pharmaceutical supply chains have many characteristics of complex systems, elucidating the disruptive risks and …
Evaluating The Effects Of Key Virulence-Associated Genes In Estimating The Virulence Of Escherichia Coli, Using Embryo Lethality Assay And Experimental Infection Studies, Fozol Korim Ovi
Theses and Dissertations
Avian pathogenic Escherichia coli (APEC) causes a wide range of diseases in chickens called colibacillosis, resulting a substantial economic loss to the poultry industry. This dissertation aims at addressing this disease by exploring key virulence-associated genes (VAGs), swarming motility (SM), and multi-locus sequence types (MLST) of E. coli isolates obtained from colibacillosis-infected or asymptomatic commercial hens. Secondly, by classifying the E. coli isolates into different virulence categories based on the presence of five key VAGs [iroN, ompT, hlyF, iutA, and iss]. Finally, by performing embryo lethality assays and experimental infection studies to establish the effect of these VAGs. Our findings …