Digital Commons Network^™

Discovery And Mechanistic Study Of Novel Pbd-Targeted Inhibitors Of Plk1 For Prostate Cancer Treatment, Danda Pani Chapagai

Theses and Dissertations

Polo-like kinase 1 (PLK1) is a central player in regulating entry into and progression through mitosis. Inhibition of sub-cellular localization and kinase activity of PLK1 through the Polo-box domain (PBD) is emerging as a viable alternative to ATP binding site directed drugs for which the development of resistant mutants and inhibition of closely related members of the PLK family (tumor suppressor roles) are primary concerns. I describe related novel non-peptidic PBD binding inhibitors, termed abbapolins, identified through successful application of the REPLACE strategy and demonstrate their potent antiproliferative activity in prostate tumors and other cell lines. Furthermore, the abbapolins show …

Mining For Progress: Copper, Conflict, And Corporate Social Responsibility, Fritz Culp

Theses and Dissertations

My dissertation examines how transnational mega-mines efface non-Western ways of knowing and being from the Andes. A growing branch of research is questioning the socio-environmental impacts of mining and the influence of regulatory institutions. Despite remarkable scholarship on the ongoing environmentalism of modern-mining, little critical attention has been given to the industry’s pivot to ‘sustainable’ development and its objectives that remain epistemologically centered on the West. My project addresses these gaps by examining Las Bambas—a large-scale copper mine located in South-Central Peru—and its contrasting objectives that emphasize both environmental ‘conservation’ and the ‘modernization’ of non-Western spaces. Building upon the critical …

Economic Development, Political Processes And Climate Change Adaptation In The Solomon Islands, Adam Christopher Ereth

Theses and Dissertations

Climate change exacerbates existing societal inequalities, including those related to uneven adaptation developments. Often, climate change prompts societies in Oceania to implement adaptation strategies to deal directly and indirectly with related issues. The futures of island nation inhabitants have sparked as much curiosity and inquiry as it has fears of diminished futures for Small Island Developing States (SIDS). Narratives and discourse on climate change adaptation range from engineered solutions to address sea level rise and storm wave issues, to pessimistic retreat with claims that islands are sinking and little can be done but move elsewhere. These disparate realities call into …

Specific Learning Disability: Rates Across A Southeastern State, Joseph T. Ferraracci

Theses and Dissertations

Reading, writing, and mathematics are crucial academic and life skills. Specific Learning Disability (SLD) in these areas is the most common disability in children and account for almost 40% of all students in special education. Special education law permits for the identification of these students in multiple ways; IQ/Achievement Discrepancy, Response to Intervention, or the use of other, alternative research-based procedures (e.g. Pattern of Strengths and Weaknesses Model. There is variability within and across these methods, causing incongruity and inconsistency in rates. Other variables associated with SLD such as socioeconomic status, age, sex, and race also play important roles when …

The Effects Of Exercise Training On Cholesterol Efflux Capacity In The Heritage Family Study, Joshua Adam Hawkins

Theses and Dissertations

Cholesterol efflux capacity (CEC) has been associated with cardiovascular disease risk independent of HDL-C levels. However, the effect of regular exercise on CEC is not yet fully understood. Therefore, we examined the effects of exercise training on CEC in the HERITAGE Family Study. In HERITAGE, subjects participated in an endurance training program that consisted of exercise on a cycle ergometer three times per week for 20 weeks. Global and non-ABCA1 CEC were measured at baseline and post-training in 542 subjects via a cell- based radiolabeled CEC assay. Neither global nor non-ABCA1 CEC significantly changed with training in the whole cohort. …

The Impact Of Cannabis And Alcohol Use On The Management Of Type 1 Diabetes Mellitus, Joshua Eric Sellner

Theses and Dissertations

This dissertation sought to contribute to the evidence-base of diabetes management and acute complications associated with alcohol and cannabis use among individuals with Type 1 Diabetes (T1DM). Three interconnected studies were initiated to complete this goal. First, existing literature surrounding the potential consequences of cannabis consumption among individuals with T1DM were summarized within a systematic review. Study results were combined to provide a single measure of association through a meta-analysis. Second, identified associations were further investigated through a cross-sectional study using the SEARCH for Diabetes in Youth data on alcohol and cannabis use on diabetes management and acute complications including …

Mediator Kinase Inhibitors For Breast Cancer Therapy, Xiaokai Ding

Theses and Dissertations

Breast cancers (BrCa) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic HER2+ BrCa have intrinsic resistance and nearly all eventually become resistant to HER2-targeting therapy. Resistance to HER2-targeting drugs frequently involves transcriptional reprogramming associated with constitutive activation of different signaling pathways. We have investigated the role of CDK8/19 Mediator kinase, a regulator of transcriptional reprogramming, in the response of HER2+ BrCa to HER2-targeting drugs. Selective CDK8/19 inhibitors (senexin B and SNX631) showed synergistic interactions with lapatinib and trastuzumab in a panel …

Comparative Assessment Of The Fate And Toxicity Of Chemically And Biologically Synthesized Silver Nanoparticles Toward Juvenile Clams, Mercenaria Mercenaria, Amar Yasser Al-Rshim

Theses and Dissertations

Engineered nanomaterials (ENMs) with unique nanoscale properties, including novel optical behavior and superparamagnetic, are continually being developed for biomedical and industrial applications. In specific biomedical applications, ENMs are surface-functionalized using polymers, proteins, and other stabilizing agents to facilitate their resistance to salt-induced aggregation. Since their colloidal stability in high ionic-strength matrices, functionalized ENMs are anticipated to be persistent aquatic contaminants. Despite their potential environmental significance, the persistence of surface-functionalized ENMs as individually stabilized nanoparticles in marine environments is largely unknown. Further, few studies have investigated the fundamental factors that influence ENMs uptake and fate/transport processes in ecologically susceptible aquatic biota, …

Comfort Food For The Ears: Exploring Nostalgic Trends In Popular Music Of The Twenty-First Century, April K. Balay

Theses and Dissertations

This thesis will examine trends in twenty-first-century American popular music characterized by a sonority sometimes labeled “retro” or “vintage,” the production of which, I contend, often corresponds to periods of cultural upheaval, and social, political, and economic change. Engaging specifically with music produced during the COVID-19 pandemic of 2020, the economic recession of 2008, and the terrorist attacks of September 11, 2001, my work will strive to update the dialogue between music in this century with the styles of the past that it recalls. By examining music beginning in the year 2001 and analyzing airplay charts and recording techniques, I …

Homestead Vegetable And Poultry Production And Related Practices: An Assessment In Nepal, Shiva Bhandari

Theses and Dissertations

Consumption of nutrients-rich foods like diverse vegetables, eggs, and meat throughout a year remains a challenge in low- and middle-income countries due to poor availability, accessibility, and affordability. One important way to overcome the challenge is to promote households’ own production of these foods and encourage individuals to consume. Improving household production of the foods necessitates understanding whether active participation and performance of frontline workers in the communities and performing improved production-related practices can translate into improved production of nutrients-rich foods. This study had two specific aims. The first aim was to examine demographic, socio-economic, and programmatic determinants of active …

Evaluation Of The Perceived Benefit Of A Psychiatric Resource For Parents Of Children With 22q11.2 Deletion Syndrome, Kayla Blankenship

Theses and Dissertations

The objective of this study was to assess the perceived utility of an educational resource booklet addressing the psychiatric manifestations and mental health considerations within 22q11.2 deletion syndrome (22q11.2DS).

Seventy-three parents of children with 22q11.2DS completed online surveys before and after reading the booklet. The surveys assessed personality factors and feelings of empowerment, worry, self-stigma, and ability to tolerate uncertainty.

Participants reported that the booklet was easy to understand, provided better understanding of 22q11.2DS and mental illness, answered questions about mental illness associated with the condition, improved knowledge of strategies for protecting the mental health of children with the condition, …

The Effects Of The Online Remediation Of Phonological Processing Deficits On Functional Reading Abilities In Students With Dyslexia, Fletcher Bowden

Theses and Dissertations

Dyslexia affects between 5% and 18% of Americans and is caused by difficulty with phonological processing. This study investigates the impact of an online intervention designed to remediate phonological processing deficits on reading accuracy, fluency, and comprehension. It also investigates changes to student self-concept and parent perceptions of their children’s reading attitudes and abilities as a result of the online intervention.

Ten students participated in the intervention; assessments were administered at the beginning and at the midpoint of the treatment. Scores in Phonological Processing and Alternate Phonological Processing, as measured by the CTOPP-2, demonstrated large to very large effect sizes, …

“Why Do I Have To Learn This Anyway?”: A Qualitative Investigative Action Research Study Into The Tension Between The Rural, Working-Class Masculine Student And The Formal Educative Structure, Joshua Matthew Bowers

Theses and Dissertations

The specific problem of practice on which this study was focused is the tension experienced between the rural (National Center for Education Statistics, 2016), workingclass (Draut, 2018) masculine (Connell, 1995) student and the formal educative structure. The purpose of this investigative action research study was to identify and clarify in my context the unique tension experienced between the rural, working-class masculine student and the formal educative structure. This tension I refer to as tention, as tention is a variant of tension (Oxford English Dictionary, 1994, p. 789), and the rural, workingclass masculine student is, at his unique nexus of intersectionality, …

Self Reported Cardiovascular Health And Health Behaviors In Women Veterans, Seth Byland

Theses and Dissertations

Objective: The purpose of this study is to describe self-reported cardiovascular health (CVH) and health behaviors in women veterans (WV). A cardiovascular score will be adapted from the existing American Heart Association CVH score. This score will be used to describe CVH in WV.

Methods: Data was collected from WV using an anonymous online survey. This survey asked questions about CVH, CVH behavior, and military specific questions. CVH scoring was determined by asking 6 questions that scored individuals for a total score from 0 to 12, with 12 being most ideal for CVH health. Scores were tallied and mean scores …

At-Risk Students’ Perception Of The Effectiveness Of Alternative Schools, Tara D. Cunningham Cantey

Theses and Dissertations

The need for new and innovative alternatives to traditional high schools has never been greater. Alternative schools operate today as a secret, hidden educational system, often providing much needed support for at-risk students. These schools often have little to no accountability for student achievement. Enrollment at alternative schools is increasing at an alarming rate mainly due to zero tolerance policies and students feeling disengaged with the traditional methods of education. For many years the education system has been rather traditional in teaching/content delivery format. One of the greatest advancements has been technology. However, during the Covid-19 virus pandemic, beyond the …

Race, Racial Matching, And Cultural Understanding As Predictors Of Treatment Engagement In Youth Mental Health Services, Wendy Chu

Theses and Dissertations

Racially marginalized youth experience barriers that impact their ability to maximally benefit from mental health services; thus, efforts to identify strategies that support youth treatment engagement may address mental health and treatment disparities. This study examined the role of youth race, youth-therapist racial matching, and youthreported therapist cultural understanding on youth’s early treatment engagement in mental health services. The youth sample (n = 1159; M_age = 13.8 years, SD = 2.9; 52.1% female) comprised of 778 (67.1%) Latinx, 221 (19.1%) African American, 139 (12.0%) White, and 21 (1.8%) Asian American clients. The therapist sample (n = 126; Mage …

An Evaluation Of The Impact Of Academic Policies And Athletic Procedures For Student Athletes, Seanta Cleveland

Theses and Dissertations

The current study is an evaluation of the ways academic policies and athletic procedures can impact learning for student athletes as inconsistent practices regarding athletic travel and make-up work can have negative effects on learning for student athletes. A total of 11 participants (i.e., 8 student athletes, 3 faculty members) participated in this qualitative phenomenological study. Chickering’s student development theory and Kolb’s learning theory framed the current inquiry into (1) the needs of student athletes and the ways they process important information (e.g., policies and procedures) and (2) related faculty guidance, student affairs, and the governing body for athletics, practices, …

The Influence Of Perceived Leadership On Teachers’ Job Satisfaction: A Comparative Study Between The United States And China, Jingtong Dou

Theses and Dissertations

The challenge of teacher retention in rural schools is significant for many reasons, not the least of which is that teacher retention problems have been found to be negatively associated with school performances (Ronfeldt, Loeb, & Wyckoff, 2013; Tran & Dou, 2019). Teachers’ job satisfaction is closely related to teacher retention, both of which have been linked to students’ long-term learning outcomes (Chetty, Friedman, & Rockoff, 2014). Principals’ support for teachers has been frequently identified as the most important factor influencing teachers’ job satisfaction and retention (Ladd, 2011). Particularly in rural schools, leadership support, autonomy, professional development, and participation among …

Exploring Genetic Counselors’ Experiences, Language, And Discussion Of Consanguinity In Clinical Practice: A Multinational Perspective, Romy Isabel Fawaz

Theses and Dissertations

Consanguinity, defined as the degree of relationship between closely related individuals, is a widespread historical practice that is not specific to any one religion, population, or region of the world. Genetic counselors regularly ask whether a reproductive couple is consanguineous as part of the review of family history and risk assessment. Couples who are in consanguineous relationship may be subject to negative attitudes and stigma, potentially due to cultural differences and norms at a population level and these attitudes may interplay with questions, answers, and discussions around consanguinity. We hypothesized that genetic counselors may experience some level of discomfort discussing …

Racism-Related State Policies And The Psychological And Physiological Wellbeing Of Black And White Adults, Calley Elizabeth Fisk

Theses and Dissertations

Recent research on how state-policy affects population health outcomes suggests that state contexts are important sites for producing health disparities. In the United States different domains of state policy are historically linked to the livelihood of Black Americans and enacted within a racist system designed to maintain white supremacy. Despite this history and evidence of racial inequities in health outcomes linked to institutional discrimination for Black and white adults, scholars have yet to examine whether racism-related state policies affect the wellbeing of Black and white Americans. Combining a dataset of racism-related state policies with a nationally representative data of older …

Facilitating Role Understanding And Collaboration Between Aspiring School Counselors And Principals: A Pilot Convergent Mixed Methods Design, Shelby Kaitlin Gonzales

Theses and Dissertations

Using a piloted convergent mixed-methods design, I investigated role understanding and collaboration between school counselors and principals. Specifically, this intervention situated aspiring school counselors and principals in a curriculum implementation on the role of their counterpart and then brought the two professions together in a collaborative powerful learning experience (PLE). Neither the Council for Accreditation of Counseling and Related Education Programs (CACREP), American School Counseling Association (ASCA) or National Policy Board for Education Administration (NPBEA) currently require graduate students to learn about the role of their opposite counterpart or collaboration between the two professions before they graduate from their respective …

A Case Study Of Rural Southern Desegregation: How Black Students In A South Carolina Community Experienced Segregated Schooling And The Integration Process, Margo Mcdowell Gore

Theses and Dissertations

My purpose for this study is to shed light on how the African-American community in a small Southern rural community experienced segregated schools and the long school desegregation process. Conflicts over school integration in urban centers like Little Rock drew the media's attention, but how small communities beyond the glare of the media fared is less well understood and documented. Archival data and contemporary media coverage provide a timeline and context for the experiences of this Black community, and oral history interviews were collected and analyzed to document the range of desegregation experiences.

Although the Brown v. Board of Education …

“I Like A Fight”: Margaret Sanger And The First Birth Control Clinic In The United States, Rebecca Linnea Hall

Theses and Dissertations

It is nearly impossible to read the news in the United States today without hearing the name Planned Parenthood, but few Americans know about the origins of this organization. Margaret Sanger founded the Birth Control Clinical Research Bureau, the precursor to Planned Parenthood, in 1923, but this was not the first time she opened a clinic. In this paper, I assess Margaret Sanger’s 1916 opening of the Brownsville Clinic, the first birth control clinic in the United States, and the responses to this event from multiple historical perspectives. I use historical newspapers to demonstrate how popular media, legal experts, and …

Psychophysiological Biomarkers Of Concussion Recovery, Adam Todd Harrison

Theses and Dissertations

Each ach year a growing number of individuals report lingering deficits months-years following concussion. Persistent post-concussion symptoms (PPCS) can negatively impact day-today activities and if left untreated may manifest in severe neurological sequelae resulting in long-term cognitive impairment or advanced neurological degeneration (i.e., CTE). Current clinical diagnostic and prognostic assessments (e.g., symptom reports and neurocognitive testing) lack the sensitivity to quantify neurological function. Accordingly, there is a critical need to identify objective biomarkers specific to PPCS to improve an individual’s quality of life and prevent severe long-term neurological dysfunction.

Psychophysiological measurements (e.g., EEG derived event-related potentials, heart rate variability, and …

Testing Models Of Context-Dependent Outcome Encoding In Reinforcement Learning, William M. Hayes Iv

Theses and Dissertations

Previous studies of reinforcement learning (RL) have established that choice outcomes are encoded in a context-dependent fashion. Several computational models have been proposed to explain context-dependent encoding, including reference point centering and range adaptation models. The former assumes that outcomes are centered around a running estimate of the average reward in each choice context, while the latter assumes that outcomes are compared to the minimum reward and then scaled by an estimate of the range of outcomes in each choice context. However, there are other computational mechanisms that can explain context dependence in RL. In the present study, a frequency …

The Utilization Of Healthcare Chaplains By Genetic Counselors, Elizabeth G. Hollingsworth

Theses and Dissertations

Healthcare chaplains prioritize the spiritual and religious care a patient and their family may need during their healthcare experience. This study investigated the current utilization of healthcare chaplains by genetic counselors, as well as the ability, in time and skill, of the healthcare chaplains to see genetic counseling patients. Lastly, the study investigated if genetic counseling patients would accept a referral to meet with a healthcare chaplain. We hypothesized that genetic counselors are not utilizing healthcare chaplains, healthcare chaplains have the ability to see genetic counseling patients, and genetic counseling patients would consider meeting with a healthcare chaplain.

This study …

“Forward—Upward—On!”: Black Student And Educator Experiences In The Early Years Of School District Five Of Lexington And Richland Counties, Charles A. Holden

Theses and Dissertations

This research utilized historical analysis, narrative inquiry, and oral history to document and analyze Black educational experiences in the Chapin, Dutch Fork, and Irmo communities during segregation and desegregation. Archival materials from the local school district offered insight into district leaders’ attitudes towards Richlex, the only public school available to the area’s Black students between 1953 and 1966, as well as the conditions that district leaders created for Black students and educators. Former students’ stories were centered in both the examination of what the local Black communities accomplished in spite of the unequal conditions of the segregated era and in …

Catalytic Cracking Of Oxygenated Polymer Waste Via Zeolite Catalysts, Andrew Jaeschke

Theses and Dissertations

Plastic recycling has been a prevalent issue since the commercialization of plastics due to lack of adoption and insufficient technology. There are many different types of plastics used in modern day society; however, majority of recycling efforts are focused solely on polyethylene terephthalate (PET) and polyethylene plastics. Some of these overlooked plastics include polyols and polyurethanes, which can be found in a variety of applications including furniture stuffing, adhesives, and insulation foams. Recently, plastic research has turned to catalytic cracking units as a means of plastic recyclability. Catalytic cracking of hydrocarbons is a field dominated by zeolites catalysts, especially ZSM-5. …

For Colored Girls Who Have Experienced Institutional Racism Because The Discipline Code Is Not Enuf: Principals And Assistant Principals, School Discipline Policies, And Discipline Disparities Faced By Black Girls, Lecinda R. Jennings

Theses and Dissertations

For many years, school discipline has been a research focus, particularly the disparities in discipline between Black and White males. Black girls are suspended at a rate that is 5.3 times that of White girls and approximately the same rate as Black boys. Black girls represent the fastest growing group of students who receive discipline disparities. The goal of this case study was to explore if and how principals and assistant principals contribute to discipline disparities faced by Black girls. I discussed the lived experiences of high school administrators to capture their encounters with race, gender, and the implementation of …

Approaches To Teaching Music Counting To Piano Students With Autism Spectrum Disorder, Sunghun Kim

Theses and Dissertations

The purpose of this study was to interview five internationally and nationally recognized professionals currently teaching piano to students with autism spectrum disorder (ASD), and to explore their approaches to teaching music counting to students with ASD. The interview questionnaire contained 5 sections. Sections 1, 2, and 3 focused on teacher experience and training, studio demographics, and educational curriculum. Sections 4 and 5 of the questionnaire focused on pedagogical practices in teaching music counting to piano students with autism spectrum disorder, including questions regarding pedagogical approaches in teaching meter, rhythm, and steady pulse. Section 6 emphasized pedagogical practices to teach …