Digital Commons Network^™

Describing The Experiences Of Canadian Genetic Counseling Students Studying In The United States, Madeline Emma Ladouceur

Theses and Dissertations

There are fewer and smaller genetic counseling master’s programs in Canada compared to the United States, which makes it challenging for prospective Canadian students to train in their home country. We investigated which factors influenced Canadian students to apply or not to apply to American genetic counseling training programs, as well as the experiences of those Canadians who attended a program in the United States. We predicted that Canadian students applied to American genetic counseling training programs primarily because of limited training opportunities in Canada and a competitive application process across North America. We used a mixed method, online survey …

The Submission Of A Section 513(G) Request For Information, Morgan Ashley Lano

Theses and Dissertations

The Food and Drug Administration designates all medical devices into one of three general classes contingent on their intended use, indications for use, and potential risk to the user. This classification dictates the further path the device must take to be approved for the commercial market. Section 513(g) of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 360c(g)) is submitted in order to gain the agency’s unofficial classification and suggested regulatory requirements. The Coagulation Companion (MicroVide) is a device designed to fluorescently quantify a key enzyme involved in the coagulation cascade, plasmin, in pediatric patients. clot formation and degradation …

Effectiveness Of An Ecowellness Intervention For College Aged Individuals With A Developmental Disability, Olivia Jean Lewis

Theses and Dissertations

Nature has the ability to heal many psychological wounds from anxiety and depression, stress, post traumatic stress disorder, and behavioral concerns. As a result, clinicians are recognizing the power of nature as a tool in the healing process. The purpose of this dissertation, which consists of one completed systematic review and a multiple probe single case study is to (a) provide background information on the current literature regarding nature, (b) create a manualized EcoWellness treatment intervention, and (c) test the effectiveness of the treatment intervention in order to provide practicing counselors with a potential new intervention to increase psychological wellbeing …

Assessing Identification Of Newly Diagnosed Breast Cancer Patients For Referral To Genetic Counseling, Corinne Marie Locke

Theses and Dissertations

Since 1998, the National Comprehensive Cancer Network (NCCN) guidelines have specified clinical indications for genetic testing for breast cancer susceptibility genes, but retrospective studies have shown that, despite meeting the NCCN criteria, patients are not always advised of the option of genetic testing. Further compounding this issue, studies have shown that cancer family history intake and documented family history can be incomplete even when taken by oncology providers. At this study site and other cancer centers in the country, patients with a new diagnosis of breast cancer are referred for genetic counseling by their cancer care team if they are …

Three Essays On Banking And Other Financial Institutions, Xiaonan Ma

Theses and Dissertations

This paper shows that access to payday lending affects societal health outcomes such as opioid-related mortality. I find that states allowing payday lending experience 1.5 lives lost per 100,000 population every year, which amounts to one-third of its mean value. I interpret this result in line with the increased consumption of opioid pills after accessing to payday lending. Accordingly, the effects are more pronounced in areas with low socioeconomic status. Confounding events, time trends, or systematic differences between states allowing and prohibiting payday lending are unlikely to explain the association between payday lending access and opioid mortality. Overall, my findings …

Life In The Time Of Covid-19: The Everyday Impacts Of The Pandemic In Amman, Jordan, Patrick Mckenzie

Theses and Dissertations

The COVID-19 pandemic and the responses taken to combat it caused enormous changes to the everyday lives of people around the world. Jordan, in its early success against the virus and with its large refugee population, represents a unique country in which to study these everyday impacts. From May to August of 2021, I conducted ethnographic fieldwork in the Jordanian capital city of Amman while working with the refugee nongovernmental organization the Collateral Repair Project. In this thesis, I explore the COVID-19 Spectacle, examining the ways in which policies and discourses at the national and international scales bled into the …

Mindset, Stereotype Threat, And The Fear Of Failure: Why Female Students Leave A Secondary High Honors Mathematics Pathway, Annabelle Merg

Theses and Dissertations

The disproportionate attrition of female students in STEM is well documented in higher education but less well understood at the secondary level. In a large, public high school in an affluent, highly educated city, the high honors mathematics pathway is the only math pathway that has not yet achieved gender parity, an implication for future educational and economic equity. Female students leave this pathway at significantly higher rates than male students, especially during and immediately after the first course. Through an explanatory, mixed methods approach, this study found that these female students are not less well prepared than their male …

Assessing Parental Satisfaction Of Current Fragile X Syndrome Resources Provided At Diagnosis, Megan Michalski

Theses and Dissertations

Diagnosis of a child with fragile X syndrome (FXS) is associated with parental anxiety. Existing literature recommends FXS resources, but there has not been a formal assessment of when parents learn about these resources, or their satisfaction with them. Studies have demonstrated negative feelings surrounding the diagnostic experience of FXS. This exploratory analysis assessed the gap in knowledge on parental satisfaction of the recommended resources from healthcare providers during the time of diagnosis. We predicted parents would not be satisfied with the way resources were presented to them. We discussed parental satisfaction or dissatisfaction, utility of the recommended resources, and …

Suas And Deep Learning For High-Resolution Monitoring Of Tidal Marshes In Coastal South Carolina, Grayson R. Morgan

Theses and Dissertations

Tidal marshes are dynamic environments, now more than ever threatened by both natural and anthropogenic forces. Best practices for monitoring tidal marshes, as well as the environmental factors that affect them, have been studied for more than 40 years. With recent technological advances in remote sensing, new capabilities for monitoring tidal marshes have emerged. One of these new opportunities and challenges is hyper-spatial resolution imagery (<10 >cm) that can be captured by small unmanned aerial systems (sUAS). Aside from enhanced visualization, structure-from-motion (SfM) technology can derive dense point clouds from overlapped sUAS images for high resolution digital elevation models (DEMs). …

An Analysis Of Wet Bulb Globe Temperature Estimation Methods And Microclimate Heat Variability In Columbia, South Carolina, Stafford Mullin

Theses and Dissertations

Extreme heat is the leading cause of weather-related deaths in the United States and poses major health risks in the wake of rising global average temperatures. Wet bulb globe temperature (WBGT) is a holistic measure of human heat stress, but is not feasible to implement in most settings because the equipment is expensive and troublesome to operate. This research evaluates the performance of WBGT estimation methods using more standard meteorological variables, measured in-situ and a local National Weather Service Automated Surface Observing Station, and examines how WBGT and its components vary across two distinct microclimates in Columbia, SC. Results indicate …

Examining Parental Disclosure To Unaffected Siblings Of Children Diagnosed With Rett Syndrome, Rachel Nicely

Theses and Dissertations

Rett syndrome is a neurodevelopmental disorder that is inherited in an X-linked dominant manner due to pathogenic variants in the MECP2 gene that are almost always de novo. It is one of the most common causes of developmental delay and intellectual disability in females and occurs in about 1 in 10,000 females. While there is valuable literature surrounding the impact of a neurodevelopmental diagnosis on unaffected siblings, there are no articles about the impact of a disclosure of Rett syndrome to unaffected siblings and the needs of parents during this disclosure. This study aimed to examine the disclosure process …

Graph Neural Network And Phylogenetic Tree Construction, Gaofeng Pan

Theses and Dissertations

Deep Learning had been widely used in computational biology research in past few years. A great amount of deep learning methods were proposed to solve bioinformatics problems, such as gene function prediction, protein interaction classification, drug effects analysis, and so on; most of these methods yield better solutions than traditional computing methods. However, few methods were proposed to solve problems encountered in evolutionary biology research. In this dissertation, two neural network learning methods are proposed to solve the problems of genome location prediction and median genome generation encountered in phylogenetic tree construction; the ability of neural network learning models on …

Understanding The Genomic Influence And Virulence Capabilities Of Environmentally Isolated Vibrios, Shannon Elizabeth Pipes

Theses and Dissertations

The genus Vibrio consists of Gram-negative bacteria that possess a curved rod shape and are routinely isolated from estuarine and coastal salt water. Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus are the major three species that contribute to human disease worldwide, and a variety of other Vibrio species contribute to persistent problems in the aquaculture and fishing industries. The CDC estimates that vibrios cause 80,000 cases of disease each year in the United States alone, however, this number is thought to be underestimated, since some disease is only self-limiting, meaning patients may not seek medical treatment and have …

Moderating Effects Of Parental Feeding Practices And Emotional Eating On Dietary Intake Among Overweight African American Adolescents, Mary Quattlebaum

Theses and Dissertations

This study examined the effects of parental feeding practices and adolescent emotional eating (EE) on dietary outcomes among overweight African American adolescents. Based on Family Systems Theory, it was hypothesized that parental feeding practices, such as parental monitoring and responsibility, would buffer the effects of EE on poor dietary quality, whereas practices such as concern about a child’s weight, restriction, and pressure-to-eat would exacerbate this relationship. Adolescents (N = 127; Mage = 12.83 ۫.74; MBMI % = 96.61 ± 4.14) provided baseline data from the Families Improving Together (FIT) for a Weight Loss trial and an ancillary study. Dietary outcomes …

Investigating The Role Of Stressful Life Events And Emotion Regulation As Potential Antecedents Of Gratitude In Early Adolescents, Olivia Schmitke

Theses and Dissertations

ABSTRACTThe construct of gratitude has gained interest over the last decade along with the rise of positive psychology. Gratitude’s significant relations with psychological and psychosocial factors have been shown in prior research, although support for such relations in children and adolescents exists, to date the literature is more robust around adults. Additionally, presumed antecedents of individual differences in gratitude have been acknowledged. The present study included a sample of 1872 middle school students and aimed to build on previous work to explore the influence of emotion regulation (i.e., cognitive reappraisal and expressive suppression) in the development of gratitude among youth …

Sexual Health Education For Children With Neurodevelopmental Disorders: Genetic Counselor And Pediatrician Perspectives, Mary Catherine Smith

Theses and Dissertations

Many barriers prevent individuals with disabilities from receiving appropriate sexual health education (SHE), including deficits in socialcommunication skills and lack of resources and trained educators. There are few guidelines specifically addressing how to accommodate for providing SHE to individuals with disabilities. Healthcare professionals who are trained in working with adolescents with disabilities, such as pediatric genetic counselors, developmental-behavioral pediatricians (DBP), and neurodevelopmental disabilities (NDD) subspecialty pediatricians, could fill this gap. The purpose of the current study was to assess what informational items pediatric genetic counselors, DBP, and NDD subspecialty pediatricians felt were most essential to include in SHE for children …

Infertility Education For Men With Cystic Fibrosis And Its Effects: Outlooks On Fertility And Birth Control, Allison Elizabeth Perez Szczepanski

Theses and Dissertations

Many men with Cystic Fibrosis (CF) are infertile; however, few studies have evaluated fertility outlook of men with CF since the advent of modulator therapy. As predicted survival and quality of life improve, family planning is an area of increased interest for the CF community. The current study surveyed men with CF to explore their outlook on fertility, family planning, and birth control use with the option to receive a home fertility test and follow-up interview with study staff.

Seventy-five men with CF completed the survey and 53 (71%) believed they were likely infertile. Most recalled learning about infertility between …

Predicting Lower Body Soft Tissue Injuries In American Football With Gps Data, Nicholas Tice

Theses and Dissertations

It is of utmost importance to sports organizations that they keep their players as healthy as possible and contributing to the success of the team. Advancements in technology and investments by sports clubs have allowed researchers to better understand the role of load management in high-level athletes to mitigate injury risk. Through GPS tracking data provided by a collaborating Division I American college football team, we seek to predict lower body soft tissue injuries in future training sessions and reduce the number of potentially avoidable injuries within the organization. The difficulty of analyzing the injury data set is that the …

Gatekeeping Blackness: Roles, Relationships, And Pressures Of Black Television Journalists At A Time Of Racial Reckoning, Denetra Walker

Theses and Dissertations

Building on Du Bois’ (1903) concept of double-consciousness, Critical Race Theory, and communications theories including Gatekeeping, this dissertation aims to provide understanding of the experiences of Black broadcast journalists at a racially contentious time in American history. In 2020-2021, following the deaths of Black Americans at the hands of police and subsequent Black Lives Matter protests, and during a global pandemic, a “racial reckoning” ensued throughout the nation. The reckoning, which continued through the writing of this dissertation, was a salient issue for news media. Through my positionality as a Black female forever journalist, I interviewed 29 Black journalists who …

Resurrecting A Nation Through Silk And Diplomacy: American Material Culture And Foreign Relations During The Reconstruction Era, Paige Weaver

Theses and Dissertations

The Reconstruction Era, a time of immense change in American culture and society, is often conceptualized as a wholly domestic affair; however, a closer analysis of the work of American diplomats scattered throughout the world reveals the impact of foreign policies and relationships on the development of the nation state, as well as cultural values. With this broadened perspective, Reconstruction becomes a more complicated period of entangled international concerns and influences in a globally connected world.

This thesis argues that intricate international relations and complex foreign policies helped shape American identity and values at home. Diplomats abroad in countries such …

Adsorption Of Microcystins To Sediment Affects Their Bioavailability And Remediation, Ashley Womer

Theses and Dissertations

The freshwater harmful algae Microcystis spp produces a family of toxins called microcystins1. These species of algae are known to release microcystins from their cells directly into the surrounding water2. This creates an array of human health risks depending on the fate and transport of the toxins in the water column3,4. Risk modelling and previous literature has shown that sediment is a sink for free microcystin, microcystin can be stably adsorbed to sediment for hundreds of years, and its adsorption to sediment is determined by the sediment adsorption partitioning coefficient (Kd)5,6,7. In this work it is hypothesized that the sediment …

Associations Between Child Characteristics And Maternal Mental Health In Families Of Children With Autism, Fragile X Syndrome, And Autism Associated With Fragile X Syndrome, Tiffany Nicole Worley

Theses and Dissertations

The present study examined the association between various child characteristics and maternal mental health concerns in three high-risk groups of mothers ± those of children with non-syndromic autism spectrum disorder (NSASD), mothers of children with fragile X syndrome (FXS), and mothers of children with fragile X syndrome and autism (FXS+ASD). Research has shown that mothers of children with NSASD and FXS are thought to share a degree of genetic vulnerability to mental health concerns it is key to examine the various other factors that may contribute to difficulties within the family system and maternal stress, depression, and anxiety.

Participants for …

On Providing Efficient Real-Time Solutions To Motion Planning Problems Of High Complexity, Marios Xanthidis

Theses and Dissertations

The holy grail of robotics is producing robotic systems capable of efficiently executing all the tasks that are hard, or even impossible, for humans. Humans, undoubtedly, from both a hardware and software perspective, are extremely complex systems capable of executing many complicated tasks. Thus, the complexity of many state-of-the-art robotic systems is also expected to progressively increase, with the goal to match or even surpass human abilities. Recent developments have emphasized mostly hardware, providing highly complex robots with exceptional capabilities. On the other hand, they have illustrated that one important bottleneck of realizing such systems as a common reality is …

Bricks For Building Empathy: An Action Research Study Assessing The Impact Of Robotics On Elementary Students’ Empathy Towards Individuals With Disabilities, Emily A. Yow

Theses and Dissertations

Empathy helps us understand and respond appropriately to how others feel. It allows us to establish meaningful connections to those around us at home, school, work, and in society. The education system has realized the importance of social-emotional skills and have started implementing programs to help students develop these skills. Businesses have also started developing principles and practices that center around empathy and perspective-taking. The purpose of this action research was to assess the impact of robotics on fifth grade students’ empathy towards people with disabilities. This study aimed to answer the following research questions: (1) How does using robotics …

High School Students’ Math And Science Motivation Profiles: Stability And Relationship With Their Stem Career Aspirations, Jiali Zheng

Theses and Dissertations

Motivation to study mathematics and science is an important influencing factor of career aspirations in STEM fields which predicts STEM major choice in college and STEM careers after graduation. Using restricted data from a nationally representative sample HSLS:09, the current study identified U.S. high school students’ motivation profiles in mathematics and science courses in 9^th and 11^th grade, examined the stability of these profiles across the two time points, and studied the association between 11^th grade motivation profiles and STEM career aspirations. Differences between male and female students in motivation profiles, profile stability and career aspirations were …

Inheritance And Appropriation: Confronting Privilege In Magical Young Adult Fiction, Natalie Jipson

Theses and Dissertations

This thesis investigates the way that magical ability and the lack thereof has been racialized through the deployment of blood-based models of inheritance in young adult fantasy literature. Because of the connection between blood and biology, texts that only allow magical transmission from parent to child place significant limits on who can access witchery, creating systems of privilege that enforce racial and classed hierarchies. I will use magical novels written by Laurie Forest, Graci Kim, Nnedi Okorafor, Amy Rose Capetta, and Daniel José Older to illustrate the hierarchies created by blood-based models, as well as to demonstrate the possibilities that …

Gonorrhea: Core Areas And State Policies, Jessica Purser

Theses and Dissertations

This research looked at gonorrhea rates both from a community perspective and at the state level. Using hot spot analysis, means differences, and quantile regression, we found that education, specifically the percent of people over the age of 25 with less than a high school education, was the dominant factor at the state level while core areas of gonorrhea exist in the PeeDee and western Lowcountry regions of South Carolina in 2017 and 2018. Risky sexual behaviors are well-defined in the literature for individual persons, but this shows that looking at societal and community factors is important.

This is a …

Trajectories And Psychiatric Consequences Of Inhibitory Control In Young Males With Fragile X Syndrome, Erin Hunt

Theses and Dissertations

Inhibitory control (IC), the ability to suppress inappropriate responses, emerges late in the first year of life and improves across typical development, concurrent with brain maturation. The development of IC is critical to various social-emotional and behavioral functions, with IC deficits being linked to numerous psychiatric conditions, including attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). Fragile X syndrome (FXS) is a single-gene disorder characterized by IC deficits, and elevated rates of ADHD and ASD, making it a useful model for understanding the early development and consequences of IC. In this longitudinal study, we characterized IC trajectories across multiple time …

Associations Of The Fto Gene And Risk Of Acute Myeloid Leukemia, Avery Ulrich

Theses and Dissertations

Background Acute Myeloid Leukemia (AML) is a blood cancer that affects ~70,000 people each year in the US. The Fat Mass and Obesity (FTO) gene on chromosome 16 has been reported to be associated with obesity, solid tumor cancers (lung, renal, breast, prostate, pancreatic, endometrial), and more recently with hematologic malignancies, like AML. In this thesis, we test the hypothesis that inherited variants within the FTO gene are associated with an increased risk of AML. Methods Using the DISCOVeRY-BMT (Determining the Influence of Susceptibility COnveying Variants Related to one-Year mortality after Blood and Marrow Transplantation), a well-powered genome-wide association study …

Interrogating Rosa Montero’S Transition To Consensus: The Literary Interview As Lieu De Mémoire, Adrienne D. Banko

Theses and Dissertations

Looking from our 21st century viewpoint, the collection of interviews España para ti…para siempre (1976) and Cinco años de País (1982) can be seen as artifacts of the Spanish Transition to democracy and should be regarded as collections of “places of memory.” Many scholars chronicling the Transition and its impacts have positioned Rosa Montero as a prominent feminist writer of the period. However, her journalistic writing demonstrates her mediatic role as linchpin between the social and political transitions interwoven into the foundation of Spain’s democratic emergence from Francoism. These works were published at a particular moment of consensus in …