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Drift Tube Ion Mobility Measurements For Thermochemistry, Kinetics And Polymerization Of Cluster Ions, Ridha Ben Mohsen Mabrouki

Theses and Dissertations

In this work, the Drift Tube Ion Mobility technique is used to study the hydrophobic hydration and solvation of organic ions and measure the thermochemistry and kinetics of ion-molecule reactions. Furthermore, an exploratory study of the intracluster polymerization of isoprene will be presented and discussed. The ion hydration study is focused on the C3H3+ cation1 and Pyridine▪+ radical cation.2 The chemistry of the cyclic C3H3+ cation1 has received considerable attention and continues to be an active area of research.3-7 The binding energies of the first 5 H2O molecules to c-C3H3+ were determined by equilibrium measurements. The measured binding energies of …

The Influence Of Adenoviral Infection And The Group Via Calcium-Independent Phospholipase A2 On Hepatic Lipid Metabolism, William Palmer Wilkins Iii

Theses and Dissertations

Sterol regulatory element-binding proteins (SREBP) are transcription factors that regulate genes involved in lipid metabolism especially in the liver. Therefore, hepatic SREBP is significant regulator of systemic lipid metabolism. Evidence demonstrates that insulin and dietary unsaturated fatty acid (UFA) regulate SREBP1 expression and subsequent SREBP1-mediated gene transcription, events that in many instances result in modulation of systemic fatty acid and triglyceride (TG) homeostasis. A series of investigations was designed to uncover novel regulators of SREBP1. Dietary and exogenous addition of UFA has been shown to regulate SREBP function yet, an endogenous source of UFA capable of modulating SREBP remains elusive. …

Design Synthesis And Evaluation Of Diterpenones As Potent Chemopreventive Agents For Aflatoxin B1 Induced Carcinogenesis In Human Liver Cells, Miguel Angel Zuniga

Theses and Dissertations

DESIGN, SYNTHESIS, AND EVALUATION OF DITERPENONES AS POTENT CHEMOPREVENTIVE AGENTS FOR AFB1 INDUCED CARCINOGENISIS IN HUMAN LIVER CELLS By Miguel A. Zuniga, Ph.D. A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Major Director: Qibing Zhou, Ph.D Assistant Professor Department of Chemistry Terpene quinone methides (TPQMs) have been isolated from a variety of plants and show broad activities against bacteria, fungi, and cancerous cell lines. The biological activity has been attributed to the reactive electrophilic QM moiety, this structural feature has long been recognized as an intermediate in organic …

Phylogeographic Analyses Of Obligate And Facultative Cave Crayfish Species On The Cumberland Plateau Of The Southern Appalachians, Jennifer Elizabeth Buhay

Theses and Dissertations

Cave systems and their unique biota are widely viewed as highly endangered, yet very little is known about basic life history, ecology, distributions, habitat requirements, and evolutionary relationships of subterranean species. The crux of the problem in cave studies is the assumption that traditionally defined morpho-species represent distinct evolutionary lineages. Convergence is exhibited in the morphologies of many animal groups, vertebrate and invertebrate, which leads to confusion in diagnosing species' boundaries, geographic distributions, gene flow routes, and imperilment. This dissertation research includes phylogeographic analyses of freshwater cave-dwelling crayfishes in the Southern Appalachians, a global hotspot of subterranean biodiversity. By examining …

Geologic Map And Structural Analysis Of The Twin Rocks 7.5 Minute Quadrangle, Wayne County, Utah, Samuel C. Sorber

Theses and Dissertations

A new geologic map of the Twin Rocks 7.5 minute quadrangle primarily located within Capitol Reef National Park, south-central Utah, provides stratigraphic and structural detail not previously available. This map has also been instrumental in understanding the evolution and development of fluvial terraces associated with Sulfur Creek and the structural geology of the backlimb of the Miners Mountain uplift. Nine bedrock stratigraphic formations and eight types of Quaternary deposits were mapped throughout the quadrangle. Bedrock stratigraphy ranges in age from Permian to Jurassic. New details absent on previous geologic maps include members of the Chinle and Moenkopi Formations and the …

Dissolution Caves Of Mississippi, Christopher Michael Moore

Theses and Dissertations

The purpose of this project was to distinguish between the karst and pseudokarst caves throughout Mississippi, create an inventory and survey of representative caves and karst features, identify the geology of the rocks hosting the caves, and produce a GIS-based digital karst map. The State of Mississippi is not known for its karst features, yet there are three distinct limestone units that contain dissolution caves: 1) Paleozoic (Mississippian) Tuscumbia Formation limestone; 2) Mesozoic carbonate units; and 3) Cenozoic limestone, Marianna Formation. There are a total of 44 caves known within the state based on past documentation, however the caves listed …

Usage Of Plant Examples In Secondary School Biology Classes, Tamara L. Egner

Theses and Dissertations

Botanists have expressed concern over the dwindling recognition and emphasis of plants that currently exists in the fields of education and research. To ascertain if these claims pertain to high schools in the State of New Jersey, a survey on the frequency of using plant examples for teaching 10 biological principles was randomly distributed to secondary school biology teachers. Results from 80 respondents showed that on average, plants are used as examples in teaching 66% of these biological principles. The primary rationale cited by teachers for low or non-usage of plants was that they preferred animals as teaching examples. Underlying …

Geologic Map Of The Golden Throne Quadrangle, Wayne And Garfield Counties, Utah, Daniel H. Martin

Theses and Dissertations

The Golden Throne Quadrangle is located within Capitol Reef National Park, south-central Utah. Geologic mapping of this 1:24,000 scale 7.5 minute quadrangle began in 2003 as the National Parks Service desired to have geologic maps at this scale produced within the park. Stratigraphically, ten bedrock formations and ten Quaternary deposits are exposed within the Golden Throne Quadrangle. Geologic formations range in age from Permian to Jurassic. This map contains details not included on previous geologic maps including; the members of the Carmel, Chinle, and Moenkopi Formations. Additionally, the Page Sandstone is herein mapped as an independent unit. Structurally the Golden …

Dual-Stage Thermally Actuated Surface-Micromachined Nanopositioners, Neal B. Hubbard

Theses and Dissertations

Nanopositioners have been developed with electrostatic, piezoelectric, magnetic, thermal, and electrochemical actuators. They move with as many as six degrees of freedom; some are composed of multiple stages that stack together. Both macro-scale and micro-scale nanopositioners have been fabricated. A summary of recent research in micropositioning and nanopositioning is presented to set the background for this work. This research project demonstrates that a dual-stage nanopositioner can be created with microelectromechanical systems technology such that the two stages are integrated on a single silicon chip. A nanopositioner is presented that has two stages, one for coarse motion and one for fine …

Lethality Of Bacillus Anthracis Spores Due To Short Duration Heating Measured Using Infrared Spectroscopy, Kristina M. Goetz

Theses and Dissertations

There are a number of analytical and semi-empirical models that describe the behavior of particulate matter in the atmosphere. Many of these require modification for all types of weather, dry versus wet deposition, and overall effects can be quite non-linear. Rainfall (rate, drop size, etc.), snowfall (rate, flake size, etc.), humidity, pressure, temperature, and combination of these greatly affect particle settling and washout rates. To that end, a method for tracking released constituents using the Regional Atmospheric Modeling System (RAMS) microphysics package is developed by modifying one of the hydrometeor categories (hail) in the microphysics package. The RAMS microphysics package …

Syntheses And Characterizations Of Diazaphosphasiletidines, Diazasilastibetidines, And Their Metal Complexes, Brian K. Wegley

Theses and Dissertations

No abstract provided.

A Cognitive-Behavioral Treatment For Depression In Native American Middle-School Students, Lori B. Listug-Lunde

Theses and Dissertations

Depression and suicide are serious conditions among Native American adolescents. Despite the need for effective treatment approaches in this population, there continues to be a dearth of empirical research in this area. Intervention studies examining Native American adults at risk for depression and Native American youth at risk for suicide have found effectiveness utilizing group skill-based interventions. Group cognitive-behavioral therapy has demonstrated effectiveness among Caucasian adolescents; however, its effectiveness has never been examined with Native American youth experiencing depressive symptoms.

The current study modified, implemented, and evaluated a cognitive-behavioral intervention for depression among Native American middle-school students. A modification of …

Terrestrial Movements And Habitat Use Of Gopher Frogs (Rana Capito) At Fort Benning, Georgia, Jonathan H. Neufeldt

Theses and Dissertations

Gopher frogs (Rana capito) were radio-tracked between the 2000 and 2001 breeding seasons to study their terrestrial movements and habitat use in a longleaf pine- sandhill area on the Fort Benning Military Reservation, Georgia. The telemetry research was conducted in response to the need for biological data concerning gopher frog terrestrial habits. Ultimately the data could aid biologists and land managers in describing critical habitat and the development of a management or recovery plan. Twelve gopher frogs were caught at a herpetofaunal array surrounding two neighboring breeding ponds during a post breeding migration, implanted with miniature transmitters, released and radio-tracked …

Characterizing A Rapid Extraction Apparatus For The Removal Of Vocs From Aqueous Samples And Interfacing It With Fast Analysis Systems Such As The Aromatic Specific Laser Ionization Detector., Melissa Jean Meyer

Theses and Dissertations

Analysis of volatile organic compounds (VOCs) is an important analytical task because of the prevalence of these compounds and the detriment they pose to the environment and human health. There are many improvements that are possible in the extraction and detection steps of these analytes. This dissertation will focus on these improvements. In particular, an extraction apparatus was developed in our laboratory for the removal of VOCs from aqueous samples in less than one minute. Also, a detector that is highly selective for aromatic VOCs will be discussed in detail.

Extraction of VOCs from aqueous samples into the gas phase …

The Effect Of Student Journals On Achievement In And Attitudes Toward Science, Holly Cowell

Theses and Dissertations

The purpose of this action research project was to determine if: (a) writing in student journals affected the grades of my students, and (b) if student attitudes were affected by writing in journals and receiving teacher feedback. The research was conducted during the third semester at Triton Regional High School with a total of 49 tenth-grade students enrolled in two Laboratory Biology classes. Students in one class wrote in journals about teacher-posed topics for five minutes on average of once per week. The topics were written to encourage personalization of learning and further interaction with science. An attitude survey was …

Synthetic And Computational Studies On Polycyclic Aromatic Hydrocarbon Derivatives, Nucleoside Analogs And Peptides, Felix Nyuangem Ngassa

Theses and Dissertations

In recent years, the understanding of the structure and functions of biological macromolecules has advanced rapidly, the result of which is a better mechanistic understanding of many biological processes. As an outgrowth of this understanding, organic molecules that react with biological macromolecules (DNA) or adopt conformations responsible for specific functions in biological macromolecules (peptides and proteins) have been synthesized and computational modeling studies performed. Polycyclic aromatic hydrocarbons (PAHs) and β-peptides are among synthetic organic compounds known to interact with natural biological macromolecules. This interaction may affect the specific biological functions of the biomacromolecules. A variety of synthetic methodologies have been …

Survey Attitudes Toward Stem Cell Research, Ejinkonye C. Anekwe

Theses and Dissertations

In the following research study, a self-administered questionnaire was utilized to assess opinions regarding embryonic stem cell research based on three objectives: willingness to accept stem cells, educational background, and religion. A total of 1 13 fixed-alternative questionnaires were distributed to a diverse group of respondents. Nonprobability sampling using the accidental approach was performed. Support of stem cell research was dependent on Question 9, which asked what people thought about the cloning of human embryonic stem cells. The data revealed that most respondents from all groups surveyed opposed stem cell research. Neither education nor religion was a major determinant in …

Reaction Of Arylsulfenyl Chloride Adducts Of Glycals With Vinyl Ethers., Mingming Han

Theses and Dissertations

This Ph.D. dissertation is focused on the stereoselective synthesis of β- C-glycosides. Such carbohydrate derivatives have been found to possess a wide spectrum of physiological activities. They can serve as non-hydrolizable enzyme inhibitors. C-Glycosides have been used as chiral precursors for synthesis of other compounds. The synthesis of β-C-glycosides is based on the fact that, in the presence of Lewis acids, ArSCl adducts of glycals can be converted to active intermediates, episulfonium ions. These intermediates are known to react with a number of C-nucleophiles. In this study, the reaction of ArSCl adducts of glycals with vinyl ethers was investigated. To …

Professional Sports Teams And Fan Relations: A Public Relations Case Study Of The 1998-99 Philadelphia Eagles Football Team, Laura Elizabeth Litrenta

Theses and Dissertations

In professional sports, the field of public relations helps organizations foster positive relationships with their fans. But, when teams suffer losing seasons, recording more losses than wins, these relationships become strained.

The purpose of this study was to reveal how losing seasons affect the bond between professional sports teams and their fans. The results encourage sports relations practitioners to recognize fan needs and develop techniques that can help organizations maintain a more positive relationship with their fans during a losing season.

To examine the relationship between a professional sports team and its fans, this researcher traced the performance of the …

An Interdisciplinary Approach To Integrated Curriculum, Lynda Kozicz Leahey

Theses and Dissertations

The purpose of this study was to explore the effectiveness of the interdisciplinary approach to teaching mathematics and science, specifically Geometry and Biology. The study used an action research design in which two teachers participated in a planned interdisciplinary activity that involved 160 high school students. The site of this study was a high school located in a middle-class, rural-suburban community. Data was gathered using a concept map to measure the amount of conceptual understanding students have of the relationship between Geometry and Biology. Data of those students who were enrolled in both Geometry and Biology were compared to those …

What Effect Will Increased Parental Involvement In Science/Biology At Woodrow Wilson High School Have On The Improvement Of Students Academically?, Lasandra Watkins

Theses and Dissertations

The purpose of this study was to discover whether or not student achievement could be improved through the increased participation of parents/guardians for students enrolled in science classes.

High academic achievement in science courses has been rapidly declining for the past twenty or more years. With this decline in science has come a decline in the overall academic achievement of students.

To turn the tide of students failing to students excelling academically in the sciences, I believe that increasing the level and quality of parental involvement is "the solution" to this problem.

Students in my biology classes will participate in …

Do Smaller Classes Mean Greater Academic Achievement In High School Biology Classes?, Elaine Awalt

Theses and Dissertations

The purpose of this study was to determine if students in small classes would show greater academic achievement in high school biology classes. The study involved two high school biology classes, one with an enrollment of 20 students, and one with an enrollment of 25 students. Both groups of students were given pretests on the subject of invertebrates. A four week study of this topic followed. Teaching techniques and assignments were identical for the two groups. At the end of the four week study a posttest was given to all students.

The results of the pre and posttest were then …

The Effects Of Tactile/Kinesthetic Instructional Strategies In The Biology Classroom, Janice Batten Sees

Theses and Dissertations

The purpose of this study was to determine whether the addition of tactile/kinesthetic instruction to the biology classroom could significantly increase learning. Various kinds of tactile/kinesthetic lessons were taught to three experimental groups who also received visual and auditory instruction. These tactile/kinesthetic lessons included task cards, task puzzles, manipulatives, total body movement, and large floor games. The control group only received visual and auditory instruction. The subjects were 84 College Biology students from Buena Regional High School, a school in rural South Jersey. The classes varied in gender and race. The same instructor taught all classes and the length of …

Environmental Radon Decay Products In Neurological Diseased And Non-Diseased Brains, And Brains Of Cigarette Smokers., Hassaan Ahmad Alkhatib

Theses and Dissertations

The focus of this study was to measure alpha and beta emissions of $\sp{210}$Po (alpha emissions), $\sp{210}$Pb and $\sp{210}$Bi (beta emissions) from brain samples which were obtained at autopsy from persons who were clinically diagnosed with Alzheimer's Disease (AD), Parkinson's Disease (PD), or Controls (no known neurological diseases) and cigarette smokers (SMK). The samples were digested, processed and analyzed for alpha and beta emissions.Measurement of alpha and beta radiation activity in tissues can be used to demonstrate prior exposure of tissues to environmental radioisotopes and/or their decay products. In the present study alpha emissions from brain tissues were measured with …

Physiologically-Based Vision Modeling Applications And Gradient Descent-Based Parameter Adaptation Of Pulse Coupled Neural Networks, Randy P. Broussard

Theses and Dissertations

In this research, pulse coupled neural networks (PCNNs) are analyzed and evaluated for use in primate vision modeling. An adaptive PCNN is developed that automatically sets near-optimal parameter values to achieve a desired output. For vision modeling, a physiologically motivated vision model is developed from current theoretical and experimental biological data. The biological vision processing principles used in this model, such as spatial frequency filtering, competitive feature selection, multiple processing paths, and state dependent modulation are analyzed and implemented to create a PCNN based feature extraction network. This network extracts luminance, orientation, pitch, wavelength, and motion, and can be cascaded …

The Construction Of Effective Cooperative Learning Groups For Successful High School Biology Instruction, Diana I. Probasco

Theses and Dissertations

The purpose of this project was to determine the effect of balancing learning styles in the construction of cooperative learning groups. The investigation attempted to determine if science instruction and subsequent achievement can be enhanced by establishing effective cooperative learning groups. The Learning Style Inventory was used to determine learning styles. Then groups were formed based on either construction of balanced or unbalanced cooperative learning groups. Students then completed group activities as contained in the Celebrate Immunity Team Pack. Pretests and posttests were administered in order to measure cognitive gains. A statistical analysis of the results of the groups showed …

Studies On The 13-Carbaartemisinin Antimalarials: Total Synthesis And Iron(Ii) Bromide-Promoted Rearrangement Of 13-Carba-10-Deoxoartemisinin And Analogs, And, Samarium(Ii) Iodide-Promoted Reductive Cyclization Of Ketones Tethered To Nonactivated Olefins., Pingchen Fan

Theses and Dissertations

Part one is the study of 13-carbaartemisinin analogs as potential antimalarial drugs. Based on knowledge of the artemisinin's chemistry, mode of action, and structure-activity relationship, we proposed 13-carba-10-deoxoartemisinin 6 as an orally active antimalarial. Thus, the total synthesis of 6 was carried out and completed in 12 steps with a yield of 2% starting with ($-$)isopulegol. More analogs were produced from an intermediate in the total synthesis sequence: two stereoisomers of 6, 13-carbaartemisinin, and five tricyclic analogs. In general, the 13-carba analogs showed lower in vitro biological activity than artemisinin 1, only a stereoisomer of 6 displayed comparable activity to …

Genetic Analyses Of Captive And Wild Populations Of Hawaiian Geese., Elizabeth H. Rave

Theses and Dissertations

Preserving genetic diversity is important for maintaining the evolutionary potential and fitness of endangered species such as the Hawaiian goose (Branta sandvicensis), or nene. I used DNA fingerprinting to assess genetic diversity in captive nene from Hawaii and England and in wild nene from Hawaii. I used pedigrees and DNA fingerprinting to assess the effects of inbreeding on reproductive success in captive nene. I determined (1) differences in mean similarity coefficients between unrelated and related nene within and between captive colonies and the relationship between coancestry and similarity coefficients in captive nene from Hawaii, (2) differences in mean similarity coefficients …

Land-Use Change In The Fringe Regions Of Montana's Bob Marshall Wilderness, Brian W. Savage

Theses and Dissertations

No abstract provided.

Spatio-Temporal Pattern Recognition Using Hidden Markov Models, Kenneth H. Fielding

Theses and Dissertations

A new spatio-temporal method for identifying 3D objects found in 2D image sequences is presented. The Hidden Markov Model technique is used as a spatio-temporal classification algorithm to identify 3D objects by the temporal changes in observed shape features. A new information theoretic argument is developed that proves identifying objects based on image sequences can lead to higher classification accuracies than single look methods. A new distance measure is proposed that analyzes the performance of Hidden Markov Models in a multi-class pattern recognition problem. A three class problem identifying moving light display objects provides experimental verification of the sequence processing …