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Articles 121 - 150 of 202
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The Analysis Of The Expression And Phenotype Of The At3g02400 Gene In Arabidopsis Thaliana, Will Gray
The Analysis Of The Expression And Phenotype Of The At3g02400 Gene In Arabidopsis Thaliana, Will Gray
Theses and Dissertations
The involvement of several genes in DNA repair in animals and bacteria, and the induced expression of At3G02400 by Mitomycin C, suggest that this gene is involved in DNA repair in plants. I have tested this hypothesis by studying the regulation of its expression and identifying the function of this gene. To study the expression of this gene, I used a reporter line and bio-computing tools. To identify the function of the gene, I have isolated two T-DNA mutants and screened Targeting Induced Local Lesions in Genomes (TILLING) mutants. T-DNA mutagenesis is the process of inserting transfer DNA into the …
Evaluating The Performance Of Computational Approaches For Identifying Critical Sites In Protein-Coding Dna Sequences, Matthew Lewis Bendall
Evaluating The Performance Of Computational Approaches For Identifying Critical Sites In Protein-Coding Dna Sequences, Matthew Lewis Bendall
Theses and Dissertations
The ability to link a particular phenotype to its causative genotype is one of the most challenging objectives for biological research. Although the genetic code provides an explicit formula for determining the sequence of amino acid phenotypes produced by a given nucleotide sequence, identifying specific residues that are functionally important remains problematic. Many computational approaches have been developed that use patterns observed in DNA sequences to identify these critical sites. However, very few research studies have used empirical data to test whether these approaches are truly able to identify sites of interest.In most empirical studies, the actual protein function and …
Probabilistic Model For Laser Damage To The Human Retina, David A. Wooddell Jr.
Probabilistic Model For Laser Damage To The Human Retina, David A. Wooddell Jr.
Theses and Dissertations
Understanding how lasers interact with media during propagation is a premiere field of physics. The subject area known as laser bioeffects explores laser interactions with biological cells, tissues, organs, and bodies. This research includes laser applications used in medicine, establishes safe exposure limits for industry and academia, and generally studies the many effects of laser light on living creatures. The bioeffects community relies heavily on deterministic modeling and simulation tools to support experimental research into damage thresholds and laser effects. However, recent laser applications require a probabilistic approach to support risk management and analyses methodologies. Some probabilistic models exist, but …
Role Of Extracytoplasmic Function Sigma Factors In Porphyromonas Gingivalis, Suhasini Yanamandra Sai
Role Of Extracytoplasmic Function Sigma Factors In Porphyromonas Gingivalis, Suhasini Yanamandra Sai
Theses and Dissertations
Porphyromonas gingivalis is a major etiological agent that is responsible for the cause and progression of periodontal diseases. The bacterium is exposed to various environmental conditions and oxidative stress conditions while it is in the oral cavity. So, P. gingivalis should have an efficient regulatory system in order to adjust and survive in the oral cavity. But little is known about the regulatory mechanisms that help the bacteria to survive in the oral cavity. So, it is essential to understand and characterize these regulatory mechanisms. The response and adaptation of P. gingivalis to environmental stress conditions occur at the level …
Genomic Instability May Be A Signal Of Human Embryonic Stem Cell Differentiation, Clara Ines Esteban-Perez
Genomic Instability May Be A Signal Of Human Embryonic Stem Cell Differentiation, Clara Ines Esteban-Perez
Theses and Dissertations
Embryonic stem (ES) cells have the ability to maintain pluripotency and self-renewal during in vitro maintenance, which is a key to their clinical applications. ES cells are a model in developmental biology studies due to their potential to differentiate in vitro. Understanding critical pathways of pluripotency, self-renewal, and differentiation during early embryonic development is important for the evaluation of the therapeutic potential of ES cells because of their ability for tumor transformation due to genetic and epigenetic instability acquired during in vitro culture maintenance. Single tandem repeats are sequences of DNA that have been implicated in the deregulation of gene …
A Proteomic Approach To Profiling The Pipping Muscle Of The Broiler Embryo, Adebayo Oluwaseun Sokale
A Proteomic Approach To Profiling The Pipping Muscle Of The Broiler Embryo, Adebayo Oluwaseun Sokale
Theses and Dissertations
The Musculus complexus (pipping muscle) plays a primary role in the hatching of the chick from the eggshell at the end of its embryonic life. Various metabolic and cellular changes have been associated with the pipping muscle during development. These studies profiled the pipping muscle at the molecular level by identifying proteins which are associated with the developmental changes. In the first phase of the study, protein expression profile of the Day 13 chicken embryo pipping muscle was obtained using DDF with nano HPLC mass spectrometric analyzer. Identified proteins were categorized based on Gene Ontology. In the second phase, pipping …
Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger
Spatial Parameters In Therapeutic Spaces: Design Of A Residential Treatment Facility For Eating Disorder Patients, Sarah Beth Basinger
Theses and Dissertations
Can the built environment positively influence the treatment of an eating disorder? Does the built environment play a role in the quality of care, the rehabilitation process and the lasting affects of treatment in eating disorders and if so, what role does it play? What are the important parameters to consider in designing such a space? Currently there are few facilities designed specifically for the treatment of this disorder. Of those facilities, there is a lack of research regarding the effects of the built environment. Therefore, the process of answering these questions must begin by assessing parameters in architectural precedents …
Silica Nanomatrix Effect On The Properties Of Encapsulated Molecules And Silica-Metal Nanoparticles For Bioapplications, Song Liang
Theses and Dissertations
Dye-doped silica nanoparticles (DDSNs) are one of the most popular fluorescent nanomaterials in bioapplications. The first chapter of this dissertation provides an overview of the DDSNs including general fabrication methods, unique properties, and current challenges. In the following three chapters, this dissertation is focused on two challenging areas of DDSN studies. One is the fundamental properties of dye molecules in the DDSNs, and the other is the design of new multifunctional DDSNs for bioapplications. In the first area, the effect of silica nanomatrix on the properties of doped molecules was investigated. Two important molecular properties were covered including the reaction …
Developing Methods To Assess The Potential Effects Of Global Climate Change On Deer Creek Reservoir Using Water Quality Modeling, Reed Earl Chilton
Developing Methods To Assess The Potential Effects Of Global Climate Change On Deer Creek Reservoir Using Water Quality Modeling, Reed Earl Chilton
Theses and Dissertations
To evaluate the potential impacts of future climate change on a temperate reservoir, I used a calibrated water quality and hydrodynamic model validated using three years of data (2007-2009) from Deer Creek Reservoir (Utah). I evaluated the changes due to altered air temperatures, inflow rates, and nutrient loads that might occur under Global Climate Change (GCC). I developed methods to study GCC on reservoirs. I produced Average Water Temperature Plots, Stratification Plots, and Total Concentration Plots. Average Water Temperature Plots show the sensitivity of the water temperature to various parameters. Stratification Plots quantify stratification length and strength as well as …
Biological Investigation Of The Stimulated Flapping Motions Of The Moth, Manduca Sexta, Travis B. Tubbs
Biological Investigation Of The Stimulated Flapping Motions Of The Moth, Manduca Sexta, Travis B. Tubbs
Theses and Dissertations
No abstract provided.
Studies In Organic Synthesis: Part I: Total Synthesis Of Plakortethers F And G Part Ii: Carbon-Hydrogen Insertion On Diazosulfones And Diazosulfonates, Jinu Philip John
Studies In Organic Synthesis: Part I: Total Synthesis Of Plakortethers F And G Part Ii: Carbon-Hydrogen Insertion On Diazosulfones And Diazosulfonates, Jinu Philip John
Theses and Dissertations
This work consists of two independent studies. The first part of the dissertation focuses on the total synthesis of two marine based natural products, Plakortether F and G which represent a class of non-peroxide derivatives of Plakortin related metabolites that are isolated from the Caribbean sponge Plakortis simplex. The selective cytotoxic activity of Plakortethers against the RAW 264-7 cell line (murine macrophage) makes them promising candidates for biological studies. A strategy utilizing desymmetrization of a C2 symmetric intermediate was proposed and demonstrated to be effective for the synthesis of the core of Plakortethers. Initially, the symmetric intermediate could only be …
An Approach To The Synthesis Of Plakortethers A-E, Duminda Shiromalee Liyanage
An Approach To The Synthesis Of Plakortethers A-E, Duminda Shiromalee Liyanage
Theses and Dissertations
No abstract provided.
Modeling And Testing Of Dna Motion For Nanoinjection, Regis Agenor David
Modeling And Testing Of Dna Motion For Nanoinjection, Regis Agenor David
Theses and Dissertations
A new technique, called nanoinjection, is being developed to insert foreign DNA into a living cell. Such DNA transfection is commonly used to create transgenic organisms vital to the study of genetics, immunology, and many other biological sciences. In nanoinjection, DNA, which has a net negative charge, is electrically attracted to a micromachined lance. The lance then pierces the cell membranes, and the voltage on the lance is reversed, repelling the DNA into the cell. It is shown that DNA motion is strongly correlated to ion transport through a process called electrophoresis. Gel electrophoresis is used to move DNA using …
Gene Network Inference And Expression Prediction Using Recurrent Neural Networks And Evolutionary Algorithms, Heather Y. Chan
Gene Network Inference And Expression Prediction Using Recurrent Neural Networks And Evolutionary Algorithms, Heather Y. Chan
Theses and Dissertations
We demonstrate the success of recurrent neural networks in gene network inference and expression prediction using a hybrid of particle swarm optimization and differential evolution to overcome the classic obstacle of local minima in training recurrent neural networks. We also provide an improved validation framework for the evaluation of genetic network modeling systems that will result in better generalization and long-term prediction capability. Success in the modeling of gene regulation and prediction of gene expression will lead to more rapid discovery and development of therapeutic medicine, earlier diagnosis and treatment of adverse conditions, and vast advancements in life science research.
Network Analysis And Comparative Phylogenomics Of Micrornas And Their Respective Messenger Rna Targets Using Twelve Drosophila Species, M Ryan Woodcock
Network Analysis And Comparative Phylogenomics Of Micrornas And Their Respective Messenger Rna Targets Using Twelve Drosophila Species, M Ryan Woodcock
Theses and Dissertations
MicroRNAs represent a special class of small (~21–25 nucleotides) non-coding RNA molecules which exert powerful post-transcriptional control over gene expression in eukaryotes. Indeed microRNAs likely represent the most abundant class of regulators in animal gene regulatory networks. This study describes the recovery and network analyses of a suite of homologous microRNA targets recovered through two different prediction methods for whole gene regions across twelve Drosophila species. Phylogenetic criteria under an accepted tree topology were used as a reference frame to 1) make inference into microRNA-target predictions, 2) study mathematical properties of microRNA-gene regulatory networks, 3) and conduct novel phylogenetic analyses …
The Role Of The Ca2+-Dependent Protein Kinase, Camk-Ii, In Heart And Kidney Development In The Zebrafish, Danio Rerio, Sarah Rothschild
The Role Of The Ca2+-Dependent Protein Kinase, Camk-Ii, In Heart And Kidney Development In The Zebrafish, Danio Rerio, Sarah Rothschild
Theses and Dissertations
Ca2+/calmodulin-dependent protein kinase type II (CaMK-II) is a multifunctional serine/threonine kinase that is ubiquitously expressed throughout the lifespan of metazoans. Mammals encode four genes (α, β, γ, δ) that generate over forty splice-variants. CaMK-II is important in a myriad of functions, including ion channel regulation, cell-cycle progression, and long term potentiation. In adults, alterations in activation of CaMK-II induce cardiac arrhythmias and heart failure. Developmental roles for CaMK-II are not as well understood since mouse knockouts are embryonic lethal. Therefore the identification of other vertebrate CaMK-II genes will add to our understanding of development. Zebrafish encode seven catalytically active CaMK-II …
Inhibition Of The Calcium Plateau Following In Vitro Status Epilepticus Prevents The Development Of Spontaneous Recurrent Epileptiform Discharges, Nisha Nagarkatti
Inhibition Of The Calcium Plateau Following In Vitro Status Epilepticus Prevents The Development Of Spontaneous Recurrent Epileptiform Discharges, Nisha Nagarkatti
Theses and Dissertations
Status epilepticus (SE) is a major clinical emergency resulting in continuous seizure activity that can cause brain injury and many molecular and pathophysiologic changes leading to neuronal plasticity. The neuronal plasticity following SE-induced brain injury can initiate epileptogenesis and lead to the ultimate expression of acquired epilepsy (AE), characterized clinically by spontaneous, recurrent seizures. Epileptogenesis is the process wherein healthy brain tissue is transformed into hyperexcitable neuronal networks that produce AE. Understanding these alterations induced by brain injury is an important clinical challenge and can lend insight into possible new therapeutic targets to halt the development of AE. Currently there …
Assessment Of Pre-Pcr Whole Genome Amplification Of Single Pollen Grains Using Flowering Dogwood (Cornus Florida), Candace Dillon
Assessment Of Pre-Pcr Whole Genome Amplification Of Single Pollen Grains Using Flowering Dogwood (Cornus Florida), Candace Dillon
Theses and Dissertations
Studies of gene flow in natural plant populations often focus on either historical or abiotic dispersal methods (e.g. wind, water, gravity), but there is little information available on contemporary, animal-mediated pollen dispersal patterns. Emerging molecular laboratory techniques allow unprecedented insights into spatial patterns of pollen-mediated gene flow. However, to date, technical challenges have limited their widespread application. The genome of a pollen grain can be amplified via whole genome amplification (WGA) prior to traditional amplification via polymerase chain reaction (PCR) to prevent the stochastic effects associated with low copy number amplification. Even still, WGA can suffer from low success rates …
Laser Levitation Of Solid Particles For Combustion And Gasification Applications, Skigh E. Lewis
Laser Levitation Of Solid Particles For Combustion And Gasification Applications, Skigh E. Lewis
Theses and Dissertations
This dissertation details theoretical and experimental work in the development of a novel combustion diagnostic: laser levitation of solid particles. Theoretical analyses of the forces involved in the suspension of solid particles in a laser beam provide a comprehensive description of the levitation mechanism. Experimental work provides extensive observations and data that describe each of the forces involved, including results from detailed models. Theoretical models establish that a free-convective drag force, light scattering, photon momentum, and other minor forces contribute to the trapping mechanism. The theory quantitatively predicts particle temperature and magnitudes of each of the forces involved. Experimental measurements …
Noncovalent Interaction Of Platinum Planar Amine Compounds With Tryptophan: A Strategy To Interfere With P53-Mdm2 Interactions And Targeting Retroviral Zn Finger-Dna Interaction (Hiv Ncp7), Aaron Bate
Theses and Dissertations
Non-covalent interactions involving π-π stacking play an essential role in self-assembly and molecular recognition processes such as protein folding and DNA/RNA-protein selective recognition. The knowledge gained from these studies could provide insight into possible site recognition complexes, inhibiting or mimicking protein-protein or protein-DNA interactions. Based on molecular modeling as well as HOMO and LUMO energies, several chromophores were selected with a variety of ∆ε values (∆ε= |εHOMO,NAcTrp – εLUMO,chromophores|), high and low, to establish a correlating trend with the modeling and experimental data. The corresponding Pt(dien) compounds were synthesized and their ability to stack to N-acetyl tryptophan was evaluated by …
Cortisol Response Of Non-Suicidal Self-Injurers Versus Non-Self-Injurers Exposed To A Social Rejection Laboratory Stressor, Patrick L. Kerr
Cortisol Response Of Non-Suicidal Self-Injurers Versus Non-Self-Injurers Exposed To A Social Rejection Laboratory Stressor, Patrick L. Kerr
Theses and Dissertations
Non-suicidal self-injury (NSI) represents a growing area of concern in a variety of clinical settings, yet remains a poorly understood phenomenon. An influx of research on the functions of NSI over the past decade has suggested a biopsychosocial emotional regulation model of this behavior. This model proposes that self-injurers engage in NSI to reduce negative emotions, and presupposes that self-injurers are characterized by emotional dysregulation. The present study evaluated the biological component of this model by assessing hypothalamic-pituitary-adrenocortical axis (HPAA) functioning in a group of self-injurers(n=26) and non-injuring healthy controls (n=28). HPAA functioning was assessed via measuring salivary cortisol levels …
The Design And Synthesis Of Zinc(Ii) Ion Fluorescence Sensors, Julius Ngunde Ngwendson
The Design And Synthesis Of Zinc(Ii) Ion Fluorescence Sensors, Julius Ngunde Ngwendson
Theses and Dissertations
This work is a study of a new class of aromatic amines as fluorescent zinc sensors. N-(Carboxymethyl)-N-[3-[(carboxymethyl)amino]-2-methoxy-5-methylphenyl]glycinate exhibits more than 20-fold fluorescence enhancement in the presence of Zn(II) ions when excited at 300 nm. This compound shows a fluorescence emission at 390 nm, which in the presence of Zn(II) ion exhibits a 20 nm emission blue shift. The tetraacetate version, potassium N,N'-(2-methoxy-5-methyl-1,3-phenylene)bis[ N-(carboxymethyl)]glycinate, exhibits a 7-fold sensitivity to Zn(II) ion, and there is no emission band shift observed. Investigations point to the methoxy group for the ratiometric behavior and increased sensitivity to zinc. The diacetate versions—sodium N-(carboxymethyl)- N-(2-methoxyphenyl)glycinate, sodium N,N'-(2-methoxy-5-methyl-1,3-phenylene)bisglycinate …
Selective Non-Peptide Mu-Opioid Receptor Antagonist: Design, Synthesis And Biological Studies, Lindsey Aschenbach
Selective Non-Peptide Mu-Opioid Receptor Antagonist: Design, Synthesis And Biological Studies, Lindsey Aschenbach
Theses and Dissertations
There are currently many opioid agonists available for clinical use as analgesics. However, many of these opioid agonists have notorious side effects including respiratory depression and may lead to addiction and dependence. Problems associated with these opioid agonists are determined to come from their interactions with the mu-opioid receptor. Opioid antagonists, such as naltrexone, have shown to aid in the treatment of opioid addiction. Although naltrexone has high affinity to the mu-opioid receptor, it lacks selectivity. Novel selective mu-opioid receptor antagonists were designed based on the identification of important pharmacophore elements in several known mu-opioid receptor agonists and antagonists. These …
Snp Characterizaiton And Genetic And Molecular Analysis Of Mutants Affecting Fiber Development In Cotton, Chuanfu An
Snp Characterizaiton And Genetic And Molecular Analysis Of Mutants Affecting Fiber Development In Cotton, Chuanfu An
Theses and Dissertations
Cotton (Gossypium spp.) is the world’s leading textile fiber crop, and an important source of oil and protein. Insufficient candidate gene derived-markers suitable for genetic mapping and limited information on genes that control economically important traits are the major impediments to the genetic improvement of Upland cotton (G. hirsutum L.). The objectives of this study were to develop a SNP marker discovery strategy in tetraploid cotton species, SNP characterization and marker development from fiber initiation and elongation related genes, chromosomal assignment of these genes by SNP marker-based deletion analysis or linkage mapping, and genetic and molecular analysis of mutants affecting …
Healing, Learning And Play, Kangana Bhatnagar
Healing, Learning And Play, Kangana Bhatnagar
Theses and Dissertations
Research suggests that the first five years of life are critical for building the foundation for children’s success throughout their schooling and life. Throughout these first years of life there are a number of essential windows of opportunity during which certain kinds of stimuli are needed to help the brain develop and maintain critical connections necessary for learning. This project is a unification of a Child Development Center and a therapeutic center. This center includes children who suffer from bereavement; a broken home, death of a parent or child abuse. These children are provided with therapy by a specialist, and …
Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao
Pyridinium Bisretinoids: Synthesis And Photoactivated Cytotoxicity, Junping Gao
Theses and Dissertations
This thesis discusses pyridinium bisretinoid compounds (PBRs), which were prepared for two purposes: 1) to use them as standards for detection of novel fluorophores in human RPE cells, which may be involved in age-related macular degeneration (AMD), and 2) to use them in the development of a targeted and triggered drug delivery system for cancer therapy. We prepared a selection of PBRs using a one-pot biomimetic method; synthesis, mechanisms for formation, and characterization of these compounds is described. We also explored the photoreactivity of three novel PBR compounds and found that these PBRs form oxidation products under blue-light irradiation. The …
Nmr Structure And Relaxation Studies Of Dhfr From Haloferax Volcanii At High Salt, Bulent Binbuga
Nmr Structure And Relaxation Studies Of Dhfr From Haloferax Volcanii At High Salt, Bulent Binbuga
Theses and Dissertations
The studies of enzymes from extreme sources have gained significance due to their increasing potential applications. The proteins from halophiles (salt loving) have adapted to challenging environmental conditions and require salt for their structure and function. How halophilic proteins adapt to a hypersaline environment is still an intriguing question. It is important to mimic the environmental conditions of the sample under investigation with experimental techniques. In this study, structure and dynamic features of a halophilic enzyme have been investigated under high salt conditions. The acquisition of NMR data on high salt samples has always been problematic. We have devised a …
Economic Impacts Of White-Tailed Deer From Hunting In Mississippi, Micah Whittington Whiteside
Economic Impacts Of White-Tailed Deer From Hunting In Mississippi, Micah Whittington Whiteside
Theses and Dissertations
White-tailed deer (Odocoileus virginianus) are an important ecological, social, and economic resource in Mississippi. Studies have been conducted on expenditures by white-tailed deer hunters, but none have administered a research-based, economic impact assessment for white-tailed deer in Mississippi. The economic impacts and associated values of white-tailed deer in Mississippi through a selfministered mail questionnaire were examined to collect white-tailed deer hunter expenditure data during the 2003/2004 hunting season. Expenditures of white-tailed deer hunters were obtained from a mail survey (N = 1,257, 38.6% response rate) and were used in an input-output model to determine economic impacts for the State. Economic …
An Adaptive Bayesian Approach To Bernoulli-Response Clinical Trials, Andrew W. Stacey
An Adaptive Bayesian Approach To Bernoulli-Response Clinical Trials, Andrew W. Stacey
Theses and Dissertations
Traditional clinical trials have been inefficient in their methods of dose finding and dose allocation. In this paper a four-parameter logistic equation is used to model the outcome of Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-response curve of Phase II and Phase III clinical trials. Because of inherent restrictions in the logistic model, symmetric candidate densities cannot be used, thereby creating asymmetric jumping rules inside the Markov chain Monte Carlo algorithm. An order restricted Metropolis-Hastings algorithm is implemented to account for these limitations. Modeling clinical trials in a Bayesian framework …
Development Of Informative Priors In Microarray Studies, Kassandra M. Fronczyk
Development Of Informative Priors In Microarray Studies, Kassandra M. Fronczyk
Theses and Dissertations
Microarrays measure the abundance of DNA transcripts for thousands of gene sequences, simultaneously facilitating genomic comparisons across tissue types or disease status. These experiments are used to understand fundamental aspects of growth and development and to explore the underlying genetic causes of many diseases. The data from most microarray studies are found in open-access online databases. Bayesian models are ideal for the analysis of microarray data because of their ability to integrate prior information; however, most current Bayesian analyses use empirical or flat priors. We present a Perl script to build an informative prior by mining online databases for similar …