Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Theses and Dissertations

Discipline
Institution
Keyword
Publication Year
File Type

Articles 901 - 930 of 14985

Full-Text Articles in Entire DC Network

Cavernous Distortions, Silas Samuel Quintanilla Dec 2024

Cavernous Distortions, Silas Samuel Quintanilla

Theses and Dissertations

This is a collection of short stories in the style of surreal fiction. They are stories about outsiders, powerlessness, communication, isolation, longing, death, and existentialism. They follow in the tradition of parables, fables, and in the shadow of surrealist masters like Franz Kafka.


The Effects Of Livestock On Mosquito Diversity And Abundance In Hidalgo County, Taylor Nicole Moya Dec 2024

The Effects Of Livestock On Mosquito Diversity And Abundance In Hidalgo County, Taylor Nicole Moya

Theses and Dissertations

Mosquitoes are detrimental to animals and threaten humans. More information is needed on how farm animal presence may impact mosquito abundance and diversity at farms. My goal in this study is to determine if there is any correlation between animal abundance or diversity on a farm and the abundance and diversity of mosquitoes collected. Hidalgo County, Texas, has a subtropical desert climate, ideal for mosquitoes. I hypothesized that the mosquito abundance and diversity indices would increase as the livestock abundance or diversity increases. Adult mosquitoes were collected using two CO2-baited light traps per farm from Spring 2022 to Fall 2022. …


Understanding The Influence Of Traffic And Noise On The Wildlife Community Surrounding Fm106 And Sh100 In South Texas, Anna Rose Mehner Dec 2024

Understanding The Influence Of Traffic And Noise On The Wildlife Community Surrounding Fm106 And Sh100 In South Texas, Anna Rose Mehner

Theses and Dissertations

In South Texas, highways create landscape fragmentation, habitat degradation, and result in wildlife vehicle collisions. Vehicle collisions are the highest known cause of mortality of the endangered ocelot (Leopardus pardalis), which led Texas Department of Transportation to install nine wildlife crossing structures (WCS) on Farm-to-Market 106 and five on State Highway 100. These highways are along Laguna Atascosa National Wildlife Refuge, which is the location of the southernmost breeding population of ocelots in the United States. Many other wildlife species including bobcat (Lynx rufus) and coyote (Canis latrans), are present along these highways and …


Structure Modifications And Alternative Monitoring Designs Of Wildlife Road Mitigation Structures, Madison T. Nadler Dec 2024

Structure Modifications And Alternative Monitoring Designs Of Wildlife Road Mitigation Structures, Madison T. Nadler

Theses and Dissertations

Wildlife mitigation structures are designed to keep animals off roadways while providing them safe passage to the other side and not impeding traffic flow. Camera traps are commonly used to assess the success of these mitigation structures, but there are downfalls to both the methods and structures. Alternative mitigation structure designs are needed to better prevent wildlife from accessing roadways in areas where they should be deterred. Additionally, traditional camera trapping methods do not accurately capture the full wildlife communities that may be utilizing these structures and other survey methods are needed, specifically aimed at small mammals, amphibians, and reptiles. …


Effects Of Metoprolol And Propranolol Beta-Blockers Mixture On Morphological And Physiological Responses In The American Oyster, Andrew Salinas Dec 2024

Effects Of Metoprolol And Propranolol Beta-Blockers Mixture On Morphological And Physiological Responses In The American Oyster, Andrew Salinas

Theses and Dissertations

Beta-blockers are extensively used to treat human cardiovascular conditions yet pose significant risks to non-target aquatic organisms. This study aimed to investigate the effects of short-term exposure (one week) to a beta-blocker’s mixture (low-dose: 50 ng/L propranolol and 250 ng/L metoprolol, and high-dose: 250 ng/L propranolol and 650 ng/L metoprolol) in the American oysters. Histopathological assessments revealed structural damage to gills, connective tissues, and digestive glands in both low- and high-dose treatment groups. Additionally, glucose concentration and pH of the extrapallial fluid significantly declined in the high-dose treatment group. Hemocyte density within connective tissues increased proportionally with dosage. The beta-blocker …


Tc-Ptp-Mediated Regulation Of P38 Mapk Pathway Promotes Uvb-Induced Apoptosis In Skin, Lindsey Susie Shim Dec 2024

Tc-Ptp-Mediated Regulation Of P38 Mapk Pathway Promotes Uvb-Induced Apoptosis In Skin, Lindsey Susie Shim

Theses and Dissertations

T-cell protein tyrosine phosphatase (TC-PTP) is a non-receptor PTP that has been shown to have various roles in signaling pathways. Our previous studies have demonstrated that the TC-PTP deficiency in the epidermis can exacerbate hyperplastic response by inducing epidermal cell proliferation in response to tumor promoter TPA or UVB exposure. This implies that TC-PTP plays a tumor-suppressive role in the epidermis and provides protection against UVB radiation, which is well known to contribute to skin cancer development. The p38 mitogen-activated protein kinase (MAPK) is one of serine/threonine kinases that are activated through environmental stress including UVB. It has been demonstrated …


Technical Potential And Challenges For Agrivoltaic Development In Nigeria, Ifeoluwa Ezekiel Babarinde Dec 2024

Technical Potential And Challenges For Agrivoltaic Development In Nigeria, Ifeoluwa Ezekiel Babarinde

Theses and Dissertations

The co-location of agriculture and solar photovoltaic (PV) infrastructure, known as agrivoltaics, is an increasingly popular practice that offers co-benefits like reduced plant drought stress and improved yields of shade-tolerant crops, particularly in water-scarce agricultural regions. Despite its global growth, knowledge on the technical potential, opportunities, and challenges for agrivoltaic development remains limited in the Global South. Here we address this knowledge gap for Nigeria, Africa’s most populous country, by identifying high-potential regions based on the premise that agrivoltaic co-benefits are generally most pronounced in arable lands with both high solar irradiation and water stress. We find that northern regions, …


Guiding Wildlife: Evaluating Wildlife Exit Designs And Sensor Lights For Safer Highways In South Texas, Rupesh Maharjan Dec 2024

Guiding Wildlife: Evaluating Wildlife Exit Designs And Sensor Lights For Safer Highways In South Texas, Rupesh Maharjan

Theses and Dissertations

Roadside exclusionary fencing is more prevalent on highways to prevent wildlife-vehicle collisions. Although it can mitigate wildlife road mortality by limiting their access to the road, it can also create a barrier for wildlife stranded within the right-of-way. In State Highway 100 of Texas, the Texas Department of Transportation installed ten wildlife exits to allow wildlife to escape the fenced roadway, and a pair of sensor lights on 13 wildlife guards (WGs) to scare off target species (bobcats and coyotes) from crossing the guards and accessing the roadway. In this study, the effectiveness of three wildlife exit (WE) designs were …


Effect Of An Anti-Hiv Polymer Based Nanoformulation On Immune Mediating Cells Within The Gut Associated Lymphoid Tissue And Its Behavioural Impacts, Blessed Ofori Dec 2024

Effect Of An Anti-Hiv Polymer Based Nanoformulation On Immune Mediating Cells Within The Gut Associated Lymphoid Tissue And Its Behavioural Impacts, Blessed Ofori

Theses and Dissertations

This thesis investigates the therapeutic potential of nanoformulated antiretroviral therapy (NF cART) and its implications for HIV-associated chronic inflammation and neurobehavioral outcomes. In the first study, NF cART demonstrated enhanced efficacy in modulating inflammasome activation and reducing viral reservoirs in gut-associated lymphoid tissue (GALT) and the small intestine of HIV-infected humanized mice. Key markers of inflammation (NLRP3, Caspase-1, and IL-1β) and viral replication (LTR and p24 levels) were significantly suppressed with NF cART compared to conventional therapy, though residual LTR expression persisted in the small intestine. In the second study, nanoformulated Emtricitabine uniquely enhanced locomotor activity and reduced anxiety-like behaviors …


Implementing Organic Fertilization Practices To Improve Aloe Vera Growth And Soil Health In The Lower Rio Grande Valley, Isaiah Edward Jaramillo Dec 2024

Implementing Organic Fertilization Practices To Improve Aloe Vera Growth And Soil Health In The Lower Rio Grande Valley, Isaiah Edward Jaramillo

Theses and Dissertations

Aloe vera (L.) (Aloe) Burm. f., is valued for its applications across the cosmetic, medicinal, and food industries due to its leaf gel. In the aloe industry, the extraction of gel from leaves generates significant quantities of organic waste, which presents an opportunity to repurpose this material as an amendment in aloe cultivation. While Aloe is renowned for its resilience, understanding the feasibility of using these organic shavings as a soil fertility amendment in aloe production is critical. This research aims to identify sustainable fertilization methods for Aloe that can maintain and/or improve crop yield while enhancing soil health. This …


The Heroine Among Us: An Analysis Of The Feminine Principle Of The Heroine Archetype In Motion Pictures And Its Implication For Social Discourse, Neldie Gonzales Dec 2024

The Heroine Among Us: An Analysis Of The Feminine Principle Of The Heroine Archetype In Motion Pictures And Its Implication For Social Discourse, Neldie Gonzales

Theses and Dissertations

This thesis explores an emerging myth perceived by the rise of the feminine principle in modern society that challenges traditional gender roles. It forms a connection between the heroines seen in film and those in the real-world. It explains how the characteristics of unity, equality and love align to the feminine principle, the acquisition of which defines the archetypal hero along the hero’s journey as described by Joseph Campbell. This work proposes that stories containing this kind of archetypal hero are seeded by the discourse occurring in real-world society. Conversely, it suggests that when viewed by billions of people, blockbuster …


Investigating The Role Of The Estrous Cycle On Memory In Syrian Hamsters, Laura Emma Garcia Dec 2024

Investigating The Role Of The Estrous Cycle On Memory In Syrian Hamsters, Laura Emma Garcia

Theses and Dissertations

The female reproductive system plays a significant role in cognitive function in humans and animals. For this reason, it is important to study the estrous cycle and memory in the female Syrian hamster as a model to better understand its role on cognition. Like the human female menstrual cycle, the female hamster has inconsistencies and changes in their cycles as they age. Irregular menstrual cycles and the absence of estrogen, the sex hormone necessary for supporting the sexual and reproductive health of a woman, also affect a woman’s brain, including memory (John Hopkins Medicine, 2022). In the present study, we …


3d Bioprinted Coaxial Tubule Optimization For Human Aortic Endothelial Cell Growth, Ilse Gabriela Perez Garcia Dec 2024

3d Bioprinted Coaxial Tubule Optimization For Human Aortic Endothelial Cell Growth, Ilse Gabriela Perez Garcia

Theses and Dissertations

This paper introduces a research study of printing parameter optimization of extruded, cell-laden, 3D bioprinted coaxial tubules, as well as cell interaction observations. Optimization of printing parameters seeks to reduce variability of the tubules’ inner and outer diameters. The tubules were manufactured from a 0.4% Collagen I - 1.6% NaC6H7O6 (Sodium Alginate) bioink, that reaches gelation through interaction with a 3.2% CaCl2 (Calcium Chloride) solution. The bioinks were extruded through a dual syringe pump mechanism connected to a coaxial nozzle, which is mounted on an adapted 3D FDM (Fused Deposition …


Examining Hispanic Beginning Farmers And Ranchers In The Rio Grande Valley Through A Community Capitals Framework, Perla Kimberly Schrock Dec 2024

Examining Hispanic Beginning Farmers And Ranchers In The Rio Grande Valley Through A Community Capitals Framework, Perla Kimberly Schrock

Theses and Dissertations

While existing literature addresses the experiences of beginning farmers and ranchers (BFR), there is a notable gap in research focused on Hispanic beginning farmers and ranchers (HBFR). This study aimed at exploring the unique experiences of HBFR in a predominantly Hispanic region, the Rio Grande Valley (RGV), employed the Community Capitals Framework (Flora et al., 2016). I conducted 16 semi-structured interviews with HBFR and local nonprofit organizations and federal employees, complemented by participant observations. Through thematic and content analysis of the interview transcripts, findings revealed valuable insights into the livelihoods of HBFR. Despite HBFR facing significant challenges, this study demonstrated …


Challenges And Strategies In Science Learning: A Thematic Review And Meta-Analysis, Angelica A. Guanzon Dec 2024

Challenges And Strategies In Science Learning: A Thematic Review And Meta-Analysis, Angelica A. Guanzon

Theses and Dissertations

This study thoroughly explores the relationships between the challenges faced by students and the alternative problem-solving strategies employed. By analyzing these connections, the research aims to offer a comprehensive understanding of how students address difficulties in science learning and the adaptive strategies they apply. Through this research, teachers can gain valuable understanding in adapting learning resources that successfully address diverse needs of students. By identifying specific challenges and correlating effective strategies, targeted interventions are designed to enhance the overall science learning experience. The study emphasizes the importance of a dynamic and adaptable teaching approach that caters to the evolving landscape …


Assessing Cover Crop Adoption Factors In The Rio Grande Valley Through A Social-Ecological Perspective, Mackenzie Feldman Dec 2024

Assessing Cover Crop Adoption Factors In The Rio Grande Valley Through A Social-Ecological Perspective, Mackenzie Feldman

Theses and Dissertations

Reducing agriculture’s negative environmental impacts is crucial for mitigating climate change (White, 2021). Cover crops– non-cash crops grown to benefit subsequent cash crops– can slow erosion, improve soil health, enhance water availability, control pests, and increase biodiversity. Despite these benefits, adoption rates remain low, prompting the USDA and other organizations to fund research on increasing their use. Most studies focus on the Midwest and Northeast, and emphasize individual factors over the relationship between structural factors and individual factors that impact farmers’ decisions to adopt cover crops. This USDA-funded study begins to fill this gap by exploring social-ecological factors and how …


Ecological And Pathological Applications Of The Heat Shock Response, Taylor Rae Stanley Dec 2024

Ecological And Pathological Applications Of The Heat Shock Response, Taylor Rae Stanley

Theses and Dissertations

The heat shock response (HSR) is a cytoprotective stress response pathway that regulates cellular proteostasis. The HSR is an evolutionarily conserved pathway that is essential for normal cellular functioning. Here, we explore the broad ecological and pathological impacts of the HSR. In an ecological context, we perform gene level analysis of the transcriptomes of two closely related sunfish. We found that the more invasive bluegill sunfish has gene expansions in two HSR gene families, the HSP70 family and the HSP90 family compared to the redear sunfish. These gene expansions were also observed in several other teleost fish species and were …


Adsorption Of Harmful Algal Bloom Toxins Using Biochar, Cadianne Chambers Dec 2024

Adsorption Of Harmful Algal Bloom Toxins Using Biochar, Cadianne Chambers

Theses and Dissertations

Harmful Algal Bloom (HAB) events involve the proliferation of microalgae which discharge lethal toxins into fresh and brackish water bodies due to anthropogenic and climatic activities. Common examples of HABs include causative organisms such as Cyanobacteria, Pyrodinium bahamense and more. These genera are known to release potent toxins including Microcystins, and Saxitoxins, respectively, which can seriously endanger human and marine health. Ingestion of these toxins can result in several health problems, such as nausea, vomiting, gastroenteritis, skin irritation, liver damage, paralysis, and respiratory arrest. The Great Lakes, Gulf of Maine, Florida’s coasts, Lake Erie, and Lake Okeechobee have all been …


Investigation Of Reproductive Inhibition During Chronic Heat Stress In C. Elegans, Macy Makenna Nielander Dec 2024

Investigation Of Reproductive Inhibition During Chronic Heat Stress In C. Elegans, Macy Makenna Nielander

Theses and Dissertations

Nearly all organisms experience heterogeneity in environmental conditions that can negatively impact fitness. A common adaptive strategy to reduce the impact of this stress is called facultative diapause, where development and reproduction are temporarily arrested to promote survival. Facultative diapause is characterized by three major criteria, the arrest must be (i) induced by an unfavorable environmental condition, (ii) reversible, and (iii) driven by genetically regulated mechanisms. The aim of this thesis was to determine whether chronic heat-induced inhibition of egg laying in Caenorhabditis elegans represents a novel form of facultative diapause. It was found that the inhibition of egg-laying is …


Malicious Compliance: Examining Revenge Behaviors In Organizations, Patricia Jewel Emily Morrison Dec 2024

Malicious Compliance: Examining Revenge Behaviors In Organizations, Patricia Jewel Emily Morrison

Theses and Dissertations

Revenge is a multifaceted behavior that manifests in various forms. The purpose of this dissertation was to examine a particular form of revenge known as malicious compliance, which has yet to be sufficiently researched. A two-study approach was used to examine malicious compliance. In the first study, qualitative data was collected from an online forum for sharing malicious compliance experiences. In the second study, 352 participants completed a mixed-methods survey online. Data from both studies was analyzed in RStudio and MAXQDA. Study 1 utilized unsupervised machine learning techniques, non-machine learning techniques, and thematic coding techniques to analyze the forum dataset. …


The Design And Implementation Of A Modular Tissue Engineering Test Bed To Pursue An Alternate Pathway Of Cell Culture Based Research, Ryley Patrick Griffin Dec 2024

The Design And Implementation Of A Modular Tissue Engineering Test Bed To Pursue An Alternate Pathway Of Cell Culture Based Research, Ryley Patrick Griffin

Theses and Dissertations

The development of a Modular Automated Tissue Engineering Test Bed (MATETB) is the next step in the development of cheap and easily available in vitro cell regulatory systems for both academic and industrial purposes. This project outlined the framework and requirements for a device that could automatically regulate and collect data on a cell culture through the manipulation of its liquid environment. From this framework, a prototype was built. The device would fulfill cell culture needs while collecting data automatically and allowing for live viewing and imaging of cells. The device was comprised of a mechanical skeleton (MS), an environmental …


Fluorescence Imaging Systems To Detect Contamination On Surfaces Common In Food Processing And Medical Facilities, Benjamin Hu Dec 2024

Fluorescence Imaging Systems To Detect Contamination On Surfaces Common In Food Processing And Medical Facilities, Benjamin Hu

Theses and Dissertations

Biofilm are aggregates of microbial cells encased under an extracellular polymeric substance (EPS) and resist sanitizers or antibiotics. Because of their persistence on various surfaces such as medical devices or industrial piping, biofilm formation is associated with approximately 65% of all microbial infections. Thus, their detection and deactivation are of great importance to public health. Many detection methods such as swabbing require sampling by rubbing , which can be inefficient and challenging. This study proposes the use of handheld multispectral fluorescence imaging systems to detect and deactivate biofilm in situ. We utilized the Contamination and Sanitization Inspection (CSI) and -Disinfection …


Fabrication And Charcaterization Of Pullulan-Collagen Nanofibers Via Forcespinning, Valeria Leon Leal Dec 2024

Fabrication And Charcaterization Of Pullulan-Collagen Nanofibers Via Forcespinning, Valeria Leon Leal

Theses and Dissertations

Extensive research on collagen has spurred advancements in tissue engineering and biomaterial development, given collagen´s pivotal role in regulating various tissue structures across diverse organisms. This study delves into fabricating nanocomposites utilizing collagen, along with silver nanoparticles, chondroitin sulfate and pullulan, for potential applications in antibacterial medical devices, and cell regeneration. Collagen, abundant in the extracellular matrix, provides essential structural support, while silver nanoparticles and chondroitin confer antimicrobial properties, crucial for combating infections. Pullulan, a polysaccharide polymer, serves as a biocompatible carrier for silver nanoparticles whilst being the starting nanofiber forming material. Utilizing Forcespinning® technology, composite nanofibers were successfully synthesized. …


Assessing The Influence Of Native And Invasive Grasses On The Behavior Of Aedes Aegypti In South Texas, Emily Medelez Dec 2024

Assessing The Influence Of Native And Invasive Grasses On The Behavior Of Aedes Aegypti In South Texas, Emily Medelez

Theses and Dissertations

Invasive grasses in South Texas can have widespread negative effects, displacing native species, reducing biodiversity, and posing risks to public health. These grasses may flourish in moist, shaded environments, which not only support their growth but also creates habitats favorable for mosquito activity. This can increase the population and alter the behavior of mosquitoes, potentially raising the risk of disease transmission. In this thesis, I look at the behavior of mosquito species Aedes aegypti, primary vector of the yellow fever virus. I analyzed the influence of oviposition, flight and resting behaviors. I tested the relative attraction of Aedes mosquitoes …


Microwave-Assisted Green Synthesis Of Spiroindolinopyranopyrazoles, Esther Owusu Dec 2024

Microwave-Assisted Green Synthesis Of Spiroindolinopyranopyrazoles, Esther Owusu

Theses and Dissertations

Green Chemistry, usually known as sustainable chemistry, is widely implemented worldwide to safeguard human health and the environment. Recent investigations in organic synthesis and chemical transformation have demonstrated that green chemistry techniques are significantly reducing both chemical waste and reaction time. In order to fulfill this ecological requirement, it is crucial to lessen the utilization of perilous solvents and noxious chemicals, while also creating innovative reaction methods that decrease the production of trash. The implementation of such methodologies can greatly enhance the field of green chemistry. A more environmentally friendly synthetic method was utilized to generate spiro chemicals and their …


Soil Biogeography And Community Assembly In Polar Regions, Jesse Jorna Nov 2024

Soil Biogeography And Community Assembly In Polar Regions, Jesse Jorna

Theses and Dissertations

The polar regions provide community ecologists with natural microcosms, that include reduced species diversity, steep environmental gradients and limited human perturbance. Soil biodiversity in the polar regions is poorly understood, and the driving forces behind community compositions can range in scale from glacial forces 20,000 years ago to the impact of a researcher's footstep. Here, we present the results of an investigation of the driving factors behind biodiversity in Arctic and Antarctic soils, with specific attention to the role of community assembly processes. We suggest a framework for investigating the effects of inter-bacterial community processes like facilitation and argue for …


Enhancing Muscle Health And Modulating Immune Response With Galectin-1 In Lgmd2b/R2 Models, Stefannia Esparza Pulido Nov 2024

Enhancing Muscle Health And Modulating Immune Response With Galectin-1 In Lgmd2b/R2 Models, Stefannia Esparza Pulido

Theses and Dissertations

Limb-Girdle Muscular Dystrophy Type 2B/R2 (LGMD2B/R2) is a type of dysferlinopathy, a progressive muscle-wasting disorder caused by mutations in the dysferlin gene. Hallmarks of the disease include chronic inflammation, impaired muscle regeneration, and eventual muscle degeneration. Currently, no FDA-approved therapies are available for dysferlinopathies. Recombinant human Galectin-1 (rHsGal-1) has shown multiple roles in maintaining skeletal muscle homeostasis, promoting muscle repair, enhancing myogenesis, and modulating inflammation by downregulating the NF-κB pathway. The ability of rHsGal-1 to modulate the immune response is particularly promising for therapeutic applications in patients with LGMD2B/R2. In this study, we evaluated the effects of rHsGal-1 in a …


Barbie, Taylor Michelle Gale Nov 2024

Barbie, Taylor Michelle Gale

Theses and Dissertations

The stereotypes placed over men and women throughout various forms of media, including film and TV, song, printed media, and even through objects like toys, have a large impact on society as a whole. Kumari and Joshi (2015) explain that media plays an important role in sharing information concerning what deems to be the fabric of contemporary culture, which can aid in changing, or perpetuating long standing societal norms. This study identifies how Greta Gerwig's Barbie (2023) approaches the themes of the portrayal of women in the media through the Barbie film, examining themes such as objectification, self-objectification, and the …


Rare Sugars And Dairy Ingredients: A Synergistic Pairing For The Reduction Of Food Waste And Sugar Consumption, Melinda Michelle Moss Nov 2024

Rare Sugars And Dairy Ingredients: A Synergistic Pairing For The Reduction Of Food Waste And Sugar Consumption, Melinda Michelle Moss

Theses and Dissertations

In the future, sustainability in the dairy industry will require creative and scale-able solutions for better utilization of the primary solid component in milk: lactose. One promising avenue of “up-cycling” underutilized lactose is converting it to valuable rare sugars. Rare sugars like D-tagatose and D-allulose are increasing in popularity extremely quickly. D-tagatose and D-allulose are hexose sugars, D-allulose being an epimer of D-fructose and D-tagatose an isomer of D-galactose. They have excellent functional properties in food systems with clean sweetness profiles similar to sucrose. Critically, they also have excellent nutritional characteristics, such as low caloric values and low glycemic indices. …


Ionic Nanomedicines And Biocompatible Hydrogel: Synthesis, Characterization And Application In Cancer And Drug Delivery, Mujeebat Bashiru Nov 2024

Ionic Nanomedicines And Biocompatible Hydrogel: Synthesis, Characterization And Application In Cancer And Drug Delivery, Mujeebat Bashiru

Theses and Dissertations

This dissertation is focused on the development of novel class of ionic materials (IMs), and ionic nanomedicines (INMs) for cancer treatment. These IMs are composed of two therapeutics combined via electrostatic attraction. The impact of various counterions on the drug’s cytotoxic and photophysical properties are unveiled. Moreover, the mechanism of internalization, enhanced toxicity of these materials is investigated by determining their cellular uptake, subcellular localization, and cell death mechanism. Furthermore, the in vivo bioimaging capabilities of the drugs is investigated to validate their potential for clinical relevance. The second part of this dissertation is focused on the synthesis of biocompatible …