Digital Commons Network^™

Investigating Spatiotemporal Trends Using Precursory Signatures: Implications To Develop Short-Term Earthquake Forecasting Techniques In Sumatra-Andaman Region, Ramya Jeyaraman J

Theses and Dissertations

Earthquake forecasting is a challenging field due to Earth's heterogeneous nature. This research aims to develop a short-term earthquake forecasting model by analyzing spatiotemporal trends and precursory signatures in the Sumatra-Andaman region, known for its high seismic activity and tsunami risk. The study adopts an interdisciplinary approach, integrating solid earth tides (SET), micro shocks, and outgoing longwave radiation (OLR) to gain deeper insights into seismic nucleation processes. The research begins by using Singular Spectral Analysis (SSA) to identify potential seismically vulnerable areas through the analysis of irregularities in SET.

A spatiotemporal analysis of micro shocks is conducted to assess the …

Biodegradable Polymeric Microspheres For Magnetically Guided Drug Delivery To Tumors, Tyler Payson Green

Theses and Dissertations

This thesis investigates the feasibility of utilizing biodegradable polymeric microspheres loaded with the anticancer drug 5-fluorouracil (5FU) and superparamagnetic iron oxide nanoparticles (SPIONs) to magnetically deliver the cancer therapeutic 5FU to a target tumor in the human body. The primary method of material loading consisted of a w/o/w double emulsion mechanism which 1) loads and protects 5FU in the inner water phase consisting of distilled water and polyvinyl alcohol (PVA), 2) dispersed SPIONs in the biodegradable polymeric organic phase consisting of methylene chloride (MeCl2) for eventual magnetic transport, and 3) suspended these w/o emulsion droplets in an outer aqueous phase …

Biofabrication Of Tissue Constructs Using Protein-In-Polysaccharide Bioinks For Muscle Regeneration, Harshavardhan B

Theses and Dissertations

Myocardial infarction (MI) and volumetric muscle loss (VML) are debilitating conditions that severely affect patient quality of life and challenge healthcare systems, particularly in diagnosis and treatment. Conventional therapies often result in long recovery periods with limited functional restoration. Advances in regenerative medicine, especially extrusion-based 3D bioprinting, offer promising potential to improve the regeneration of complex tissues by precisely depositing cells and biomaterials layer-by-layer to create tailored tissue constructs.

A critical challenge in muscle tissue regeneration is developing protein-polysaccharide bioinks that closely mimic the native muscle tissue microenvironment. In this study, two protein-inpolysaccharide bioinks (alginate-fibrinogen and methylcellulose-gelatin-alginate) were developed to …

Utilizing Cultural Responsive Literacy Practices In Order To Increase Reading Engagement In Primary Aged Readers, Molly E. Young

Theses and Dissertations

The purpose of this conceptual research was to explore how culturally responsive literacy practices and various theoretical frameworks can be integrated to enhance reading engagement among primary-aged readers. This study examines the connections among several relevant theoretical frameworks and identifies common themes related to reading engagement. The theories that guided this research include Culturally Responsive Teaching (CRT), Culturally Sustaining Pedagogy (CSP), Funds of Knowledge (FoK), Self-Efficacy, and Self-Determination Theory (SDT). The conceptual framework highlights common themes across these frameworks, such as the importance of professional development and pre-service teacher programs, the significance of recognizing student strengths and backgrounds, and the …

Preparation And Efficacy Evaluation Of Chicken Egg Yolk Sourced Igy Against The Venoms Of Cobra, Krait, Russell’S Viper, And Saw-Scaled Viper, Gayathri G

Theses and Dissertations

Envenomation resulting from snakebites is widely recognized as an alarming health risk in tropical and sub-tropical areas. The big four snakes including Naja naja, Bungarus caeruleus, Daboia russelli, Echis carinatus are responsible for most of the envenomation in India. The current therapy for snake envenomation is immunoglobulins, produced from serum or plasma of horses or sheep. To overcome the drawbacks of current antivenom, chicken egg yolk (IgY) antibodies have recently emerged as one of the most promising research avenues.

In this study, the efficacy of chicken egg yolk sourced antisnake venom (ASV) IgY against the big four venoms was evaluated …

Design And Analysis Of Optimal Energy Efficient Routing Protocols For Lifetime Maximization And Qos Enhancement In Wireless Body Area Networks, Karthikeyan S

Theses and Dissertations

In recent times, Wireless Body Area Networks (WBAN) a subsection of Wireless Sensor Networks (WSN) a promising technology for the future healthcare realm with cutting-edge technologies that can assist healthcare professionals like doctors, nurses and biomedical engineers which enables one-to-one care by implementing Tele-Medicine and Tele-Health solutions. Machine Learning (ML) and Internet of Things (IoT) enabled medical big data is the future of the healthcare sector and Medical Technology-based industries leading to applications in other sectors such as fitness tracking for commercial purposes, Sportsperson health monitoring to track their day-to-day activities and wearable devices for critical and emergency care.

Recent …

A Comprehensive Ml And Ai Framework For Intersection Safety: Assessing Contributing Factors, Surrogate Safety Measures, Non-Compliance Behaviors, And Cost-Inclusive Methodology, Deep Patel

Theses and Dissertations

Intersection safety, particularly in traffic management, has emerged as a pressing concern due to its substantial contribution to road crashes and fatalities. In recent years, understanding road users' behavior and conflicts at intersections has become essential for evaluating traffic safety. According to the Federal Highway Administration (FHWA), in 2020, over 50% of fatal and injury crashes occurred at or near intersections, necessitating further investigation. This study addresses this issue through an innovative blend of comprehensive literature review, advanced machine learning algorithms, artificial intelligence (AI) technologies, surrogate safety measures (SSMs), non-compliance behavior, and emphasizing the economic aspects of traffic incidents. First, …

An Examination Of Civil Asset Forfeiture In South Carolina, Jeffrey Trowbridge

Theses and Dissertations

Civil asset forfeiture allows the government to seize and forfeit property that is associated with criminal activity without arresting or charging the property owner. Although expansive in its potential application, little is understood about the characteristics of civil asset forfeiture cases, the property owners involved in forfeiture cases, or the characteristics of any criminal cases pursued parallel to the civil cases. Utilizing open-source, public court records, this dissertation provides an exploratory analysis of these gaps in the literature by examining the types of civil asset forfeiture used, the value of asset forfeiture cases, how money from asset forfeiture is divided …

Augmented Reality (Ar) And Virtual Reality (Vr)-Based Data Visualization Frameworks For The Manufacturing Industry, Nitol Saha

Theses and Dissertations

Industry 4.0 is transforming the manufacturing industry by integrating digital technologies throughout the production lifecycle, leading to the development of smart factories. The integration of Augmented Reality (AR) and Virtual Reality (VR) alongside smart manufacturing is transforming traditional industry practices by establishing a robust cyber-physical infrastructure, enhanced data visualization, and improved task execution. This thesis aims to develop AR and VR-based data visualization frameworks for the manufacturing industry, focusing on detailed implementation strategies, initial results, and key findings of these frameworks. One major focus of these frameworks is the generalization of the technological assets so that these frameworks can be …

Impacts Of Ing4-Deficiency On Hematopoietic Stem And Progenitor Cells & Characterizing The Concerns Of Novice Stem Graduate Teaching Assistant, Georgina Alice Anderson

Theses and Dissertations

The hematopoietic compartment is tasked with the establishment and maintenance of the entire blood program in steady-state and in response to stress. Key to this process are hematopoietic stem cells (HSCs), which possess the unique ability to self-renew and differentiate to replenish blood cells throughout an organism’s lifetime. Recent work has illustrated the vast mechanisms involved in regulating stress-induced hematopoiesis, including cytokine-mediated lineage bias, gene signature changes in aged HSCs associated with chronic inflammation, the impact of clonal hematopoiesis and stress tolerance. Inhibitor of Growth 4 (Ing4) has been identified as a critical regulator of HSC homeostasis. We show that …

Mitochondrial Function In The Maternal Brain: A New Perspective On Gestational Stress And Pathology Of Postpartum Depression, Erin Rene Gorman-Sandler

Theses and Dissertations

Postpartum depression (PPD) is a major psychiatric complication of childbirth, affecting up to 20% of mothers, yet remains understudied. Mitochondria, dynamic organelles crucial for cell homeostasis and energy production, share links with many of the proposed mechanisms underlying PPD pathology. Brain mitochondrial function is affected by stress, a major risk factor for development of PPD, and is linked to avoidance and social behaviors. Considering the importance of mitochondria in regulating brain function and behavior, we hypothesized that mitochondrial dysfunction is associated with behavioral alterations in a chronic stress-induced rat model of PPD. Chronic mild unpredictable (CMUS) stress during late gestation …

Plankton Dynamics In A Temperate Estuary:Size Structure And Trophic Implications, Nayan Mallick

Theses and Dissertations

Estuarine ecosystems provide goods and services to around 45% of the entire human population. In recent times, these ecosystems have been severely affected by multiple stressors such as pollution, eutrophication, harmful algal blooms, sea level rise, and, most importantly, climate change. Increasing temperature associated with climate change can have pervasive impacts throughout the ecosystem’s functions and processes. Plankton, a conspicuous member of estuarine food web, are among the first to respond to the changes in temperature due to their high sensitivity to changing environmental conditions.

In this dissertation, I investigated the plankton dynamics in an estuarine ecosystem through a combination …

Popular Justice Or Populist Justice? Penal Populism And Its Impact On Democracy, Kuan-Wu Chen

Theses and Dissertations

Populism, a pervasive phenomenon in contemporary politics, manifests as an anti-establishment, anti-pluralistic, morally charged framing that advocates for direct rule between leader and populace. Among its variants, penal populism emerges as a particularly concerning manifestation. It is characterized by a leader's deployment of panicking, punitive, and politically targeted rhetoric to enhance social control and accrue political capital rather than address crime prevention. This research argues that penal populism poses the most significant threat to democratic rule, as evidenced by theoretical, framing, and mobilization analyses. A novel categorization of populist variants is proposed based on dimensions of social categorization and exclusivity. …

Harvesting Health: The Role Of City Policy In Urban Agriculture And The Downstream Effects On Youth, Lesley Leake

Theses and Dissertations

Contextualizing environmental health within the socio-ecological framework, acknowledges the diverse factors at play in the environment-human dynamic. The research design, methods, and study populations of each chapter vary to match the socio-ecological level(s) of focus and reinforce the translational and interdisciplinary nature of this research. Chapter 2 examines the policy-supports for urban agriculture using a mixed-methods case-study of the City of Charleston, SC to understand how municipal policy (societal) impacts urban agriculture implementation (community) and what impact this has on residents (relationship and individual). Chapter 3 centers on the potential impact of urban farms (community) and their programming (community and …

Information Exchange Through Social Networks Links To Adoption Of Child Feeding Practices In Nepal, Mohammad Masudur Rahman

Theses and Dissertations

While there have been notable decreases in child undernutrition (i.e., stunting) over the past few decades, it remains a major concern in Nepal, with 25% of children under the age of five experiencing chronic undernourishment. There is considerable scope for improving nutrition-related behaviors to address this ongoing issue. In Nepal, knowledge regarding appropriate child feeding practices is often inadequate, and thus additional sources of accurate information are required. Information through multiple sources (i.e., interpersonal communication, mass media, and mobile SMS) provides opportunity to reach households who inadequately practice childcare. Information improves knowledge and information exchange (i.e., receiving or sharing) usually …

Systemic Inflammation And Neurocognitive Deficits In School-Age Children With Sickle Cell Disease., Elizabeth A. Gillooly

Theses and Dissertations

Sickle cell disease (SCD) causes inflammation that contributes to poor clinical outcomes, including cerebrovascular disease (CVD). CVD can take several forms in SCD, including neurocognitive deficits without visible cerebral infarction. The role of chronic inflammation in cognitive development in SCD has received little attention to-date. We aimed to study novel markers of systemic inflammation: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and the systemic inflammation index (SII) to describe developmental trends and relationships to cognitive outcomes in SCD at early elementary school-age. Sixty-one children with SCD and no history of stroke were identified who completed an early elementary school age cognitive …

Vascular Calcification In A Mouse Model Of Chronic Kidney Disease And In Human Peripheral Arterial Disease, Breanna Pederson

Theses and Dissertations

Vascular calcification is a process in which calcium and phosphate crystallize to form hydroxyapatite in the extracellular matrix of blood vessels. There are two forms of arterial calcification: intimal and medial, which occur via different etiologies. Intimal calcification is associated with atherosclerosis and occurs in the layer of endothelial cells adjacent to the artery lumen. Medial arterial calcification (MAC) is independent of atherosclerosis and occurs in the middle, muscular layer of the artery. MAC is strongly associated with aging, diabetes mellitus, and chronic kidney disease (CKD). MAC is frequently in patients with peripheral arterial disease (PAD). Most studies to date …

Impact Of A Mathematics Review On Students' Chemistry Self-Efficacy And Problem-Solving Skills In An Undergraduate Chemistry Course, Antoinette Marie Gayle

Theses and Dissertations

Mathematics is an integral part of chemistry courses, and the application of arithmetic and algebraic knowledge is important for solving calculation-based problems in undergraduate general chemistry. Students begin undergraduate chemistry with varying levels of mathematics skills and experience which may impact their ability to solve problems and understand the content in chemistry courses. Utilizing a convergent mixed methodology, this action research study evaluated the impact of an in-class mathematics review intervention on students’ chemistry self-efficacy and problem-solving abilities in general chemistry. Mathematics review sessions were conducted in undergraduate general chemistry classes with 40 first-year students at a small university college …

Teacher Perception Of International Baccalaureate Middle Years Programme Implementation, Lorene Michelle Lloyd-Peay

Theses and Dissertations

The rural, Title I, underperforming, priority schools in the study encounter several challenges when implementing the International Baccalaureate Middle Years Program (IBMYP) framework. Successful implementation is contingent on how the teachers perceive these challenges. This research aims to understand how teachers' perspective on the IBMYP affects programme implementation. Understanding the experiences and perspectives of teachers increased my and the school district’s ability to support the effective implementation of the IBMYP framework. The research questions focused on gathering data to determine teacher perspectives about the IBMYP, how those perspectives affect programme implementation, and the factors that appear to enhance or impede …

The Impact Of Pbis Programs On Discipline Referrals In A Secondary School, Tameika Shantrelle Valentine

Theses and Dissertations

This study investigates the impact of Positive Behavioral Interventions and Supports (PBIS) on discipline within a secondary school setting. PBIS is a proactive approach to establishing the behavioral supports and social culture needed for all students to achieve social, emotional, and academic success. The research focuses on a comprehensive analysis of disciplinary records before and after the implementation of PBIS, comparing metrics including the number of disciplinary referrals, suspensions, and expulsions. Additionally, qualitative data from teacher surveys provided insights into changes in school climate and perceptions of behavior management. Preliminary findings suggest that the adoption of PBIS impacted a significant …

Integrating Data-Driven And Mechanism-Driven Modeling In Drug Discovery And Hepatotoxicity Evaluation, Xuelian Jia

Theses and Dissertations

The pharmacological activities and hepatotoxicity significantly influence the success or failure of new drugs during drug discovery and development. Traditional experimental methods, such as animal models, are costly and time-consuming for chemical testing. There is a great need to develop in vitro and computational modeling to help identify the pharmacological activities and hepatotoxicity potential in the early stage of drug discovery and safety evaluation. In this dissertation, new computational models and associated modeling frameworks were described for predicting the biological profile and hepatotoxicity of chemicals. Firstly, a novel data mining and Quantitative Structure-Activity Relationship (QSAR) workflow was developed to construct …

"Remember Me": A Narrative Analysis On Latino Representation In Disney's Coco And Encanto, Angie Nicole Vega

Theses and Dissertations

This study explores the authenticity of Latino representation in Disney animated films by reviewing the visuals, symbols, and themes incorporated into the animations. Using a narrative analysis method, the study examines themes present in the films, including characters, setting, music, and language, to uncover deeper meanings and cultural references. Through this analysis, the study aims to identify commonalities in how Latino culture is represented in mainstream media and to uncover any underlying messages or biases that may be present. The findings of the study suggest that both films showcase Latino culture in a positive and celebratory manner, highlighting the importance …

Distracted Driving: Identification, Contributing Factors, And Safety Countermeasures, Ahmed Sajid Hasan

Theses and Dissertations

Distracted driving is a hazardous behavior responsible for 25% of all fatal traffic crashes in New Jersey. While traditional methods such as surveys, videos, and simulations have been used to identify and evaluate distracted driving events, these approaches primarily provide cross-sectional data that fails to capture the true rate of distraction on the road. This study addresses this limitation by collecting longitudinal data on distracted driving events across selected corridors in New Jersey. A data collection team continuously drove through these corridors, manually counting and video recording driver distraction events. The collected data was then analyzed to assess the significance …

Injectable Hydrogels That Can Measure Radiation At Body Temperature, Daniel Joseph Ball

Theses and Dissertations

Hydrogel-based radiation dosimeters are used to calibrate and validate radiation delivered by linear accelerators used in radiotherapy. Specifically, Fricke hydrogel-based dosimeters containing ferrous ion complexes oxidize upon exposure to radiation, leading to a change in optical density that can be measured via a color change in a photometric reagent. While gelatin-based Fricke hydrogels are routinely used to measure radiation, these hydrogels are unstable at body temperature, and it is currently not possible to noninvasively measure radiation dose inside a patient. This study reports the synthesis and characterization of self-forming hydrogels containing Fricke components that are stable at body temperature. The …

Use Of Pulsed Electric Fields And Hydrogen Peroxide For Pre And Postharvest Strategies To Reduce Microbial Loads On Fresh Produce, Zachary Rosenzweig

Theses and Dissertations

Several issues exist within the agricultural industry surrounding failure to prevent pathogen transfer to plants preharvest and failure to decontaminate foods postharvest. Fresh produce, like leafy greens, pose a large threat to public safety if contaminated because they are minimally processed and often eaten raw. Numerous outbreaks have been linked to fresh produce in recent decades, with irrigation water emerging as a potential source. These outbreaks have severe economic repercussions and can contribute to millions of hospitalizations and deaths each year, worldwide. This thesis focuses on the usage of pulsed electric fields (PEF) and hydrogen peroxide (H2O2) as a means …

Deciphering Evolutionary Co-Option By Studying The Origin Of Self-Fertility In Caenorhabditis Nematodes, Jonathan P. Harbin

Theses and Dissertations

In my research, I examined the characteristics of male and female sex-determination mutants in C. nigoni and investigated the regulatory pathway they define. This work tested whether flexibility in the sex-determination pathway was a preexisting condition that favored the origin of self-fertility in Caenorhabditis. Furthermore, I developed an approach for using interspecies hybrid mutants to assess the robustness of the C. nigoni pathway. My findings showed that the C. nigoni pathway is highly robust and canalized, suggesting that changes leading to self-fertility must have involved the impairment of this canalization in the germ line, to allow eventual alteration of germ …

Nanofiber-Hydrogel Composite Scaffold Fabrication Methods For Peripheral Nerve Regeneration, Jacob Lee Carter

Theses and Dissertations

Nerve graft conduits (NGCs) are a rapidly advancing field for treating peripheral nerve injuries that aim to guide the growth of regenerating axons across damaged gaps. A more effective NGC can be manufactured by combining the use of nanofibers to act as guidewires within a 3-D hydrogel that imitates the extracellular matrix of nerve tissue. Several methods have been developed to embed aligned nanofibers in an ordered architecture within a hydrogel matrix. The first method involves layer-by-layer additive manufacturing to create NGCs with rows of polycaprolactone (PCL) nanofibers surrounded by a gelatin methacrylate (GelMe) hydrogel in a 3-D structure. A …

Incorporating Culturally Relevant Practices To Improve Self-Efficacy And Engagement For Students With Disability Labels, Jennifer Chestnut Zingaro

Theses and Dissertations

The purpose of this study was to explore the lived experience of middle school students with disability labels in the pull-out resource ELA setting when their teacher included culturally relevant practices. This study utilized qualitative teacher research inquiry methods, and data collection methods included student surveys, teacher journaling of class discussions and observations, and examination of student work samples. This study came about through the lack of culturally relevant pedagogy in the segregated, special education middle school ELA program. Students with disability labels who test below grade level on standardized assessments are placed in a small group, homogeneous classroom with …

Improving Ligand Pharmacokinetics Via Bioisosteric Substitution Of Amides With 1, 2, 3-Triazoles While Maintaining Dopamine D4 Receptor Selectivity And Potency, Mohammad Alkhatib

Theses and Dissertations

Several neurophysiological functions, such as attention, cognition, and emotional regulation, are regulated by the binding of dopamine on G-Protein coupled receptors. D4Rs are mainly located in the prefrontal cortex and the hippocampus and are known to have a key role in decision-making, memory formation, cognition, and attention. Administration of D4Rs- selective ligands during the preclinical studies enhance the outcomes and the results in animal models suffering from neuropsychiatric disorders, including ADHD, substance use disorders (SUD), and Alzheimer's disease. Recently, we reported a group of D4R-selective ligands with different efficacies depending on their phenylpiperazine ring scaffold to illustrate D4R function during …

Sweating The Small Stuff: Exploring Consequence Assignments And Academic Outcomes In A No-Excuses Charter Network, John G. Stevens

Theses and Dissertations

Schools utilize a range of consequences to maintain order and safety. Some employ zero-tolerance policies accompanied by exclusionary tactics like suspension (Martinez, 2009; Muschert et al., 2014). Suspensions are criticized for their disproportionate assignment to students who are Black, male, assigned an IEP, and receiving lunch assistance (Cholewa et al., 2018; Skiba et al., 2002), as well as their deleterious associations with academic achievement (Chu & Ready, 2018; Morris & Perry, 2014; Noltemeyer et al., 2015). Charter schools espousing a no-excuses philosophy often adopt a “Sweat-the-Small-Stuff” (STSS) approach focused on correcting minor (mis)behaviors to prevent more egregious ones (Whitman, 2008). …