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The Effects Of Gain Of Function Mutant P53 And P63 On Eps8 And Cxcl5 Expression In Head And Neck Squamous Cell Carcinoma, Rubana Masood

Theses and Dissertations

Head and neck squamous cell carcinoma (HNSCC) is one of the ten most common cancers worldwide, with a survival rate of less than 50%. A class of mutant p53, known as gain of function (GOF) mutant p53, has been found to be expressed in tumors in these patients. GOF mutant p53 not only loses the wild type tumor suppressor functions, but also gains aberrant functions that have been linked to tumorigenesis. In this current study, we utilized a model system consisting of cells derived from HNSCC tumors in order to investigate our hypothesis that GOF mutant p53 enhances, and p63 …

Promontory Culture: The Faunal Evidence, Lindsay Deanne Johansson

Theses and Dissertations

Following excavations in the Promontory Caves and at several open sites in the Provo River Delta region, Steward (1937) characterized the Promontory culture as large game hunters. He based this on the high number of bison bones recovered within the Caves. Excavations at additional Promontory sites along the Wasatch Front contain faunal assemblages which differ significantly from those in the caves, showing that people living at open sites relied more heavily on small game, waterfowl, and aquatic resources than large game. These differences have been mostly attributed to Steward's sampling strategy and lack of screening, but faunal material recovered during …

The Bromus Tectorum-Pyrenophora Semeniperda Pathosystem, Heather Finch

Theses and Dissertations

Variable mortality of Pyrenophora semeniperda--infected Bromus tectorum seeds has been referred to as a "race for survival", stating that seeds that germinate quickly are more likely to escape pathogen-caused mortality. Dormancy status is not the only variable determining outcomes within the Bromus-Pyrenophora pathosystem. Varying temperature and exposure to water may strongly influence germination outcomes of B. tectorum when in the presence of P. semeniperda. Low water potentials characteristic of semi-arid soils are often over-looked in the context of seed pathogens, and are ecologically relevant- especially for plant species that inhabit intermittently dry environments. To adequately characterize the Bromus tectorum-Pyrenophora semeniperda …

Inverted Sequence Identification In Diploid Genomic Scaffold Assembly Via Weighted Max-Cut Reduction, Paul Mark Bodily

Theses and Dissertations

Virtually all genome assemblers to date are designed for use with data from haploid or homozygous diploid genomes. Their use on heterozygous genomic datasets generally results in highly-fragmented, error-prone assemblies, owing to the violation of assumptions during both the contigging and scaffolding phases. Of the two phases, scaffolding is more particularly impacted and algorithms to facilitate the scaffolding of heterozygous data are lacking. We present a stand-alone scaffolding algorithm, ScaffoldScaffolder, designed specifically for scaffolding diploid genomes. A fundamental step in the scaffolding phase is the assignment of sequence orientations to contigs within scaffolds. Deciding such an assignment in the presence …

Cannabinoids Delta-9-Tetrahydrocannabinol (Thc) And Cp55,940 Ablate Specific Chemokine And Cytokine Inflammatory Response In Bv-2 Mouse Microglial Cells Activated With Hiv-1 Pro-Inflammatory Protein Tat, Rebecca Maddux

Theses and Dissertations

Despite the widespread use of Highly Active Anti-retroviral Therapy (HAART) to combat Human Immunodeficiency Virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), HIV-Associated Neurocognitive Disorders (HANDs) still remain a dire issue. HIV can enter the brain through infected monocytes and infect microglia, the resident macrophages within that compartment. Due to its pro-inflammatory properties, HIV regulatory protein Tat (Transactivating protein) may play a role in the progression of neurocognitive disorders. The aim of this project was to determine whether the select cannabinoids THC and CP55,940 could ablate the inflammatory response on BV-2 mouse microglia cells caused by Tat. Within …

Stability And Change In Women's Personality Across The Life Course, Carly D. Lebaron

Theses and Dissertations

The current study sought to examine change and stability of personality in a sample of women over the course of 35 years. Existing research is mixed regarding whether or not personality changes over time or whether it remains stable. Using a sample of 187 women tracked over four time points (approximately 10 years between each time point), change and stability in openness to experience, extraversion, and neuroticism was tested using a stacked multilevel growth curve analysis. Four life course events (transition to parenthood, change in marital status, wife entering or leaving the workforce, and husband retiring) were added as predictors …

Identification Of Multiple Levels Of Trauma Induced Coagulopathy, Jason Newton

Theses and Dissertations

Trauma continues to be a major cause of death across the globe. While the exact causes of trauma differ greatly between the military and civilian lifestyles, the ability to stop bleeding after trauma is paramount for survival. Over the past decade coagulation research has transitioned from a classical understanding of plasma based protein coagulation to the current cell focused research. As part of this shift, platelets have become a central player in hemostasis. Unfortunately little is currently understood about how platelet function is affected by trauma. In an effort to better define platelet function during trauma and the resulting shock …

Experiments With Gmti Radar Using Micro-Doppler, Benjamin Walter Dilsaver

Theses and Dissertations

As objects move, their changing shape produces a signature that can be measured by a radar system. That signature is called the micro-Doppler signature. The micro-Doppler signature of an object is a distinguishing characteristic for certain classes of objects. In this thesis features are extracted from the micro-Doppler signature and are used to classify objects. The scope of the objects is limited to humans walking and traveling vehicles. The micro-Doppler features are able to distinguish the two classes of objects. With a sufficient amount of training data, the micro-Doppler features may be used with learning algorithms to predict unknown objects …

All Animals Will Get Along In Heaven, Camila Nagata

Theses and Dissertations

My final thesis exhibition is directed towards children and parents. My goal is to create a connection between parent and child, and their past, present, and future through memory. Such a connection is accomplished through the implementation of these three different ideas in the artwork: 1) creating different layers of understanding, 2) producing everlasting memories, 3) connecting adult viewers to their past. In addition, I use principles as the foundation for each piece, such as the principles of kindness and learning. These principles are presented to the viewer through parables of current social and political issues, illustrated through my own …

Improving Implicit Learning And Explicit Instruction Of Adult And Child Learners Of Chinese, Li-Hui Kuo

Theses and Dissertations

This study explored the main effects and interaction effects of implicit learning and explicit instructional approaches on the language acquisition of beginning adult and child learners of Chinese and analyzed the successful adult and child learners' learning styles in their information processing time, second language acquisition techniques, and cognitive strategies. Volunteers from Brigham Young University and Wasatch Elementary School were randomly assigned to either an Explicit Instruction Treatment (EIT) or an Implicit Learning Treatment (ILT). Following the treatment, the participants completed an online survey and a vocabulary application test. Results from a 2 x 2 factorial ANOVA indicated that adults …

From Plato To Ipads: Dialogical Opportunities In Twenty-First Century Secondary English Classrooms, Emily Ensign

Theses and Dissertations

Technology offers students and educators an uncharted digital landscape of possibilities. Some educators feel strongly that technology enhances the classroom; others feel that it doesn't necessarily improve traditional teaching methods, and some even feel that it is detrimental to students' ability to focus or engage in face-to-face conversations. My project focuses on critical dialogue as defined by various theorists, and explores whether or not secondary English classrooms that use iPads continue to use the dialogical methods as outlined by these theorists (most of which could not have foreseen today's technological advancements). By relying on these theorists and scholars to provide …

Brain Structures Associated With Temperament And Social Behavior In Rhesus Monkeys: An Mri Study, Andrew C. Chaffin

Theses and Dissertations

Temperament is thought to be the foundation for normative personality and subsequent behaviors later in life. To assess the relationship of early temperament with variation in structural brain development, this study examined rhesus macaque mother-infant behavior, and then three years later, used MRI to assess neurostructural differences. Individual differences in mother-infant interactions and emotionality were then linked to brain differences. Extensive behavioral data obtained over the first year of life under both resting and stressful conditions was used to assess the quality of mother-infant interactions and emotionality. The MRI focused on brain volume in areas thought to be related to …

The Seed Ecology Of Rare And Endangered Gibbens' Beardtongue (Penstemon Gibbensii) And Blowout Penstemon (Penstemon Haydenii), Kassie Lorraine Tilini

Theses and Dissertations

Penstemon gibbensii and Penstemon haydenii are two rare, perennial forbs inhabiting remote areas of the western United States. P. gibbensii is listed as a sensitive species by the Bureau of Land Management (BLM) in Colorado, Utah, and Wyoming (Heidel, 2009). P. haydenii was designated as Endangered by the U.S. Fish and Wildlife Service in 1987 (Heidel, 2012). This thesis research was geared toward helping land managers in their efforts to protect and rehabilitate these species by providing understanding on different aspects of their seed ecology. My first study was a laboratory experiment performed on P. gibbensii and P. haydenii seed …

Exploring The Narrative-Oriented Qualities Of The Learner's Encounter With Unfamiliarity, Jonathan S. Spackman

Theses and Dissertations

Learning, as embodied familiarization, is described as an embodied, non-representational, and non-mechanistic experience. Within this theoretical framework, a qualitative study is presented that offers a deeper understanding of the learner's encounter with unfamiliarity -- a key lived experience of embodied familiarization. Assertions related to encounters with unfamiliarity are made through a multiple case study analysis and a deeper understanding of the assertions is offered by way of a narrative-oriented framework. From this perspective, agentive, concernful, dispositional and meaningful aspects of learning are discernible.

Giving Birth To Empowerment: Motherhood And Autonomy In Greek Tragedy, Maggie Sharon Hoyt

Theses and Dissertations

The Greek tragedies of Classical Athens frequently portray mothers in central roles, but despite this significance, the relationship between mother and child has long been overshadowed in secondary scholarship by the relationship between husband and wife. This study demonstrates the direct relationship between a female character's active possession of her children and her autonomy, or her ability to act in her own interests, in three plays of Euripides: Electra, Medea, and Ion. In general, women who internalize their ownership of their children, expressed on stage both in word and action, have greater influence over the men around them and the …

Design Of A Lighter Than Air Vehicle That Achieves Positive Buoyancy In Air Using A Vacuum, Trent T. Metlen

Theses and Dissertations

Three designs for a Lighter Than Air (LTA) structure that achieve positive buoyancy using a vacuum in place of a lifting gas were proposed and evaluated. The ratio of structure weight to the weight of displaced air was termed Weight/Buoyant Force (W/B) where a W/B1 corresponds to positive buoyancy. Two methods of geometrically stiffening a sphere were investigated and their W/B evaluated. A thin shelled sphere of beryllium stiffened with an isogrid of blade type stiffeners using Ultra High Modulus (UHM) carbon epoxy was predicted to give a W/B= 0.79. A geodesic sphere composed of a frame of cylindrical, UHM, …

Kenneth Burke As Educator: What His Theories Of Aesthetic Form And (Non-Symbolic) Motion/(Symbolic) Action Suggest For Teachers In The Literature Classroom, Tara Brock Boyce

Theses and Dissertations

Burke scholars oftentimes overlook Burke's fundamental role as educator and how his work can and should be applied to the classroom. This paper explores Burke's theoretical works and centers on two concepts important to developing rhetorical skills necessary for functioning and participating in a democratic society: his theory of aesthetic form and his distinction between motion and action. Specifically, this paper (1) clarifies these concepts and explains how they relate to each other and the emotional experience of literature, and (2) demonstrates how these concepts work together to imply a new method of practicing rhetorical criticism in the literature classroom …

Impact Of Self-Fertilization On Fecundity, The Timing Of First Reproduction, And Population Genetic Structure: Is A Mate Worth The Wait?, Serena Caplins

Theses and Dissertations

Organisms capable of self-fertilization typically exhibit two evolutionary syndromes uniting high inbreeding depression with low levels of selfing, or low inbreeding depression and high levels of selfing. This study tests for inbreeding depression in an apparent self-compatible, hermaphroditic marine nemertean worm, Prosorhochmus americanus. Fecundity and timing to first reproduction were assessed in isolated and paired worms. Isolated worms produced significantly more offspring than paired worms and did not show inbreeding avoidance. The selfing rate of natural populations was evaluated using species-specific microsatellites and is consistent with preferential selfing (mean: 0.801), though some outcrossing appears to take place. Population genetic structure …

The Effectiveness Of Using Electropalatography To Remediate A Developmental Speech Sound Disorder In A School-Aged Child With Hearing Impairment, Kristina Lynne Pickett

Theses and Dissertations

Advances in instrumentation and computer technology such as electropalatography (EPG) have offered additional types of feedback to more traditional therapy for individuals with speech disorders, specifically those with hearing impairment. The purpose of this study was to document whether therapeutic integration of EPG visual feedback in combination with traditional articulation therapy for a school-aged child with an articulation disorder secondary to hearing impairment was more effective than traditional therapy alone. One participant received five sessions of each therapy approach. Six adult listeners rated the quality of the participant's production of /r/ in words recorded during the therapy sessions. The EPG …

Evaluating A Social And Emotional Learning Curriculum, Strong Kids, Implemented School-Wide, Thomas Jonathan Kramer

Theses and Dissertations

The goal of this study was to explore whether Strong Kids could result in improved social and emotional competence when implemented as a school-wide universal intervention. No prior studies have examined this question. This study also evaluated whether teachers could implement Strong Kids as it was designed and whether they viewed it as socially valid. It used a non-equivalent control group design. The treatment school in the study involved 348 students and 17 teachers from a Title I school. School demographics indicated that 61% of students were Hispanic, 37% White, and 2% of other ethnicities. Approximately 82% of the students …

Hypersaline Lake Environments Exhibit Reduced Microbial Dormancy, Joshua Christopher Vert

Theses and Dissertations

From acid seeps and deep-sea thermal vents to glacial ice and hypersaline lakes, extreme environments contain relatively simplified communities consisting of extremophiles that have evolved to survive and thrive under adverse abiotic conditions. In more neutral environments, microorganisms use dormancy as a common life history strategy to weather temporal fluctuations of resources or stresses until more 'optimal' conditions are present. It is unclear if dormancy is an essential survival mechanism for microorganisms in extreme environments; however, recent studies suggest that extreme environments may create stable conditions for extremophiles to the extent that dormancy is of less ecological importance. Using lake …

Identification And Differentiation Of Tier 1 Bacterial Agents Using Gas Chromatography-Mass Spectrometry, Dan Li

Theses and Dissertations

A simple method was developed for detection and differentiation of five Tier 1 bacterial agents, including Bacillus anthracis, Francisella tularensis, Yersinia pestis, Burkholderia pseudomallei and Burkholderia mallei as well as their closely related near neighbors by gas chromatography-mass spectrometry (GC-MS). Generally, different classes of compounds can be used as biomarkers for biowarfare agent detection, including nucleic acids (i.e., DNA or RNA), proteins (i.e., antibodies), carbohydrates (i.e., sugars), lipopolysaccharides, lipids (i.e., fatty acids) and small molecules. One-step thermochemolysis (TCM) was developed to provide GC-MS detectable biomarker signatures, including sugars, fatty acids and small molecules. Solid phase micro-extraction (SPME) was used for …

Thymidine Kinase 1: Diagnostic And Prognostic Significance In Malignancy, Melissa Marie Alegre

Theses and Dissertations

Thymidine kinase 1 (TK1) is a cancer biomarker which has diagnostic and prognostic potential in a variety of malignancies. TK1 is significantly elevated in the serum and tumor tissue of most malignancies. This increase in TK1 can be detected in the very early stages of malignancy, including in pre-malignant disease with an increased risk for progression. Several studies have demonstrated that elevated TK1 is found in serum months before any clinical symptoms of malignancy. It has also been demonstrated that TK1 is elevated months before clinical recurrence of malignancy. This work first sought to demonstrate the early nature of TK1 …

Resource Legacies And Priming Regulate Microbial Communities In Antarctica's Dry Valleys, Sabrina Deni Saurey

Theses and Dissertations

Multiple mechanisms control bacterial community structure but two in particular, the "legacy" of past environmental conditions, and the "priming" of bacteria to respond to seasonal or reoccurring fluctuations in resources, have the potential to determine both bacterial communities, as well as, temporal shifts in active bacterial taxa. To begin to evaluate the legacy effects of resources on microbial communities, we added four limiting resources annually (i.e., water only; C-mannitol + water; N-NH4NO3 + water; and C, N + water) and measured shifts in bacterial community composition after seven years in a cold desert ecosystem in the McMurdo Dry Valleys, Antarctica. …

Perception Of Maximum Stepping And Leaping Ability, Brian Michael Day

Theses and Dissertations

To successfully perform everyday behaviors, people must be able to perceive affordances.

Two general categories of affordances have been investigated: body-scaled affordances depend on geometric properties (e.g., arm length) and action-scaled affordances depend on dynamic properties (e.g., maximum running speed, body compressibility, etc.). The fact that these affordances depend on different kinds of relationships between animal and environment, suggests that body scaled affordances and action scaled affordances may be qualitatively different. We investigated this hypothesis by using a transfer of calibration paradigm. In particular, we investigated whether improvements in perception of maximum stepping distance (a body scaled affordance) transferred to …

Ethical Metafiction In Dickens's Christmas Hauntings, Mark Brian Sabey

Theses and Dissertations

Many critics have examined metanarrative aspects of Dickens's writing, and many have studied Dickens's ethics. None, however, has yet assessed the ways in which Dickens's directly interrogates the ethics of fiction. Surprisingly philosophical treatments of the ethics of fiction take place in A Christmas Carol and A House to Let, both of which turn the ghost story of the traditional winter's tale to metafictional purposes. No one has yet dealt with Dickens's own meta-commentary on the ethics of fiction with the degree of philosophical nuance it deserves. Writings about the ethics of Dickens's fiction (and of fiction generally) often involves …

The Effect Of Using The Ipad To Enhance Sight Word Acquisition Of Students With Autism, Jeffrey Emerson

Theses and Dissertations

The purposes of this study were to (a) investigate the effectiveness of the Apple iPad as an assistive technology device to support students with autism spectrum disorders in their acquisition of sight words and (b) examine the social validity of using the iPad in the classroom. The participants were two 2nd and two 3rd graders diagnosed with autism spectrum disorders. Baseline data was collected by evaluating student progress of sight word acquisition at the end of each week for three weeks. A multiple baseline across students with AB phases was used in this study. During Intervention, the iPad was integrated …

Poly(N-Isopropylacrylamide)-Based Scaffolds For Tissue Engineering Applications, Pamela Kubinski

Theses and Dissertations

The primary goal of this work is to investigate the potential of poly(Nisopropylacrylamide)- based scaffolds in tissue engineering applications, specifically spinal injury and nucleus pulposus replacement. Poly(N-isopropylacrylamide), denoted PNIPAAm, is a synthetic polymer with hydrophilic properties at room temperature, but above 32C the chains become hydrophobic and entangle to form physical crosslinks. This thermoresponsive property enables PNIPAAm to be implanted as a free-flowing solution at room temperature and collapse into a gel in physiological conditions. However, as a homopolymer, the hydrophobicity of PNIPAAm in vivo causes the hydrogel to expel water and exhibit inelastic properties that do not mimic those …

Negotiating The Double Mandate: Mapping Ethical Conflict Experienced By Practicing Educational Leaders, Jeffrey Mcgee

Theses and Dissertations

The qualitative approach used in this study captured and described ethical conflict experienced by a sample of practicing educational leaders. Narrative inquiry data were collected from 42 former and current doctoral students and additional data were captured through follow-up interviews with selected participants. The major findings of the study suggest that ethical conflict is inherent in the practice of educational leadership. Such conflict is most often experienced in relation to colleagues when the ethics of justice and care collide. Leaders’ ability to mitigate conflict that is often the result of institutional and external factors is promoted by varied background and …

Kosova War Museum And Memorial, Ermal Buçinca

Theses and Dissertations

No abstract provided.