Digital Commons Network^™

Glp-1 Drugs And The Emerging Mass Tort Crisis: Navigating Legal Risks And Regulatory Gaps, Angelina Ferrara

UMKC Law Review

No abstract provided.

Can We Refute A Role For Infections In Alzheimer's Disease Pathogenesis?, Zena K Chatila, Michael R Duggan, Esther Silberberg, Juan Fernandez, Lavinia A Auber, Elizabeth M Bradshaw, Nikki M. Schultek

PCOM Scholarly Works

While a growing body of literature suggests a role for infections in Alzheimer's disease (AD), microbial contributions to AD remains a contentious topic, in part due to challenges in reconciling the positive evidence with studies reporting null findings. Here, we examine the evidence that argues against a role for infections in AD, while offering mechanistic hypotheses that may account for both the negative and positive findings, including dysregulated host immunity and gene-environment interactions of AD-associated genes.

Improvements To Fisheries Compensation Processes And Valuation Methodologies In Western Australia, Department Of Primary Industries And Regional Development, Western Australia

Fisheries Published Reports

This report has been prepared by the Compensation Working Group (WG) to provide advice to the Minister for Fisheries on improving Western Australia’s (WA) fisheries compensation processes under two key legislative frameworks:

• Fisheries adjustment schemes, under the Fisheries Adjustment Scheme Act 1987
• (FAS Act), and 
• Statutory compensation under Fishing and Related Industries Compensation (Marine Reserves) Act 1997 (FRICMA).

This work has been undertaken as a precursor to the larger scale adjustment and compensation processes that will be required as part of the implementation of several marine parks throughout the Kimberley and South Coast of WA.

The Festival Of “Geristoba” (The Feast Of The Moon) In Shida Kartli, Associated With The Cult Of Saint George, Giorgi Sosiashvili Prof. Dr., Aleksandre Mgebrishvili Prof. Dr.

Occasional Papers on Religion in Eastern Europe

This study examines Geristoba, the Saint George feast historically celebrated around the Church of Saint George in Geri (Shida Kartli, Georgia) and its related sanctuary in Arbo. Drawing on the Chronicle of Geri (compiled by Deacon Iakob Lomouri), 19th–20th-century ethnographic accounts (S. Makalatia), historical notes (A. Garsevanishvili, Z. Chichinadze), and period press reports (Tsnobis Purtseli, Mtskemsi), the article reconstructs the site’s foundation traditions—attributed to King Pharsman and later royal patronage under Queen Tamar—alongside the ritual calendar and practices. It argues that Geristoba preserves a layered syncretism: Christian veneration of Saint George overlaid on earlier lunar cult symbolism, visible in the …

Fisheries Occasional Publication No. 150 - Response To 2024 External Review Of Integrated Stock Assessments For Key Wa Demersal Indicator Stocks, Rubie Evans-Powell, S. A. Hesp, Ainslie Denham, Emily A. Fisher, Rachel Marks, Fabian I. Trinnie, Brett Crisafulli

Fisheries Occasional Publications

In Western Australia (WA), stock assessments for key demersal species, including snapper and red emperor, have traditionally used bespoke integrated models developed in-house by the Department of Primary Industries and Regional Development (DPIRD). In line with other Australian jurisdictions, DPIRD is transitioning to Stock Synthesis (SS) as its primary platform for integrated stock assessments of WA finfish. To support this transition, DPIRD commissioned an independent expert review of recent integrated models applied to three demersal stocks. This publication responds to recommendations from Professor André Punt (University of Washington and CSIRO) in his 2024 review, which examined assessments for Pilbara red …

The Lawyer’S Swan Lake: Generative Ai, Legal Epistemology, And The Nondelegable Duty To Think, Angie Zinzilieta

The Business, Entrepreneurship & Tax Law Review

Generative artificial intelligence (“GAI”) has entered law wearing the costume of competence: fluent, confident, and fast. But legal practice is not a memory sport despite the bar exam. Lawyers are paid to create, test, and refine ideas (arguments, narratives, and theories of liability) inside an adversarial system that punishes error, rewards precision, and demands accountability. This article argues that the central risk of GAI in legal work is not merely “hallucinations” or confidentiality breaches; it is epistemic atrophy, an outsourcing of the intellectual labor by which lawyers understand where law comes from, how it changes, and why it applies. Using …

Carotenoid Profiles Of Momordica Cochinchinensis (Lour.) Spreng. Aril And Leaves As Potential Dietary Caroteniod Sources [Research Note], Francis A. Aguilar, Antonio C. Laurena, Nerrisa K. Torreta, Vida Faith R. Galvez, Evelyn B. Rodriguez, Lourdes B. Cardenas

The Philippine Agricultural Scientist

Momordica cochinchinensis (Lour.) Spreng. or sweet gourd is a perennial, dioecious vine known to possess remarkable carotenogenic capacity. To explore its potential as a dietary carotenoid source, this study evaluated the carotenoids of aril from ripe fruits and of leaves of an accession from Laoag, Ilocos Norte, Philippines, through open-column chromatography. Data reveal that the optimal fruit ripeness for aril carotenoid quantification, determined by fruit skin redness (CIELAB a* value), was achieved 6 to 7 wk after pollination, at which time the aril was found to contain lycopene at 1,260.64 ± 56.17 μg g⁻¹ fresh weight (FW) and β-carotene …

Characterization Of Syntaxin 18 In Peregrinus Maidis And In Vitro Dsrna Synthesis For Potential Rnai-Mediated Control Of Maize Mosaic Alphanucleorhabdovirus (Mmv) Transmission, Hannah Corinne T. Cantaros, Charlene Niebres, Ruth Alessandra Banasihan, Argel L. Arenas, Karen B. Alviar

The Philippine Agricultural Scientist

The plant virus known as Maize mosaic alphanucleorhabdovirus (MMV) is a persistent, propagative pathogen transmitted by the corn planthopper Peregrinus maidis Ashmead (Hemiptera: Delphacidae). It is the causal agent for a mosaic disease that can cause significant loss in corn yield. Currently, disease management is focused on controlling its insect vector population. The molecular mechanisms of virus transmission by the insect vector are not yet fully understood. Previously, P. maidis syntaxin 18 (PmSTX18) was identified as a receptor for MMV. PmSTX18 interacts with the viral glycoprotein and potentially facilitates MMV recognition and entry into the vector, enabling virus …

Improvement Of Forage Productivity By Intercropping Pakchong 1 And Napier Grass With Mungbean And Soybean In Los Baños, Laguna, Philippines, Paul Joshua C. Marquez, Eureka Teresa M. Ocampo, Menandro M. Loresco, Lourdes S. Edano Ma, Agapita J. Salces

The Philippine Agricultural Scientist

Forage demand is rising in the Philippines, and to sustainably boost agronomic performance, the beneficial impact of intercropping was investigated. This study characterized the performance of high-yielding forages, namely Napier grass (NG) and Pakchong 1 (PK), when intercropped with soybean (SB) and mungbean (MB) under rain-fed conditions in Los Banos, Laguna. The experiment was conducted in a repeated-measures RCBD replicated 3 times with grass species and cropping system as main factors, resulting in the following treatment combinations: Sole NG, Sole PK, NGSB, NGMB, PKSB, and PKMB. Grasses were ratooned, legumes were harvested, and legume seeds were re-sown every 45 to …

Characterization Of Syntaxin 18 In Peregrinus Maidis And In Vitro Dsrna Synthesis For Potential Rnai-Mediated Control Of Maize Mosaic Alphanucleorhabdovirus (Mmv) Transmission, Hannah Corinne T. Cantaros, Charlene Niebres, Ruth Alessandra Banasihan, Argel L. Arenas, Karen B. Alviar

The Philippine Agricultural Scientist

The plant virus known as Maize mosaic alphanucleorhabdovirus (MMV) is a persistent, propagative pathogen transmitted by the corn planthopper Peregrinus maidis Ashmead (Hemiptera: Delphacidae). It is the causal agent for a mosaic disease that can cause significant loss in corn yield. Currently, disease management is focused on controlling its insect vector population. The molecular mechanisms of virus transmission by the insect vector are not yet fully understood. Previously, P. maidis syntaxin 18 (PmSTX18) was identified as a receptor for MMV. PmSTX18 interacts with the viral glycoprotein and potentially facilitates MMV recognition and entry into the vector, enabling virus …

Beta-Casomorphin7 Detection In Milk From Dairy Species And Beta-Casein Protein Characterization In Cattle From Selected Provinces In The Philippines, Angelo M. Tapia, Maria Cynthia R. Oliveros, Queennie Hope D. Umipon, Hazel Marie E. Nicolas, Naoya Ogawa, Yasuyuki Kitaura

The Philippine Agricultural Scientist

This study was conducted to detect β-casomorphin7 (BCM7) in dairy animals and to characterize the β-casein (CSN2) genotype among dairy cattle breeds in the Philippines. A total of 59 dairy animals, composed of 35 cattle (12 Holstein Sahiwal [HS16 Jersey × Holstein Friesian [JHF], and 7 Siquijor Native Cattle [SNC]), 15 buffaloes (Bulgarian Murrah and Brazilian Murrah), and 9 goats (Saanen and Anglo-Nubian) were collected with milk samples. Milk protein was extracted and subjected to high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) analysis after stimulated gastrointestinal digestion. BCM7 was detected in cattle with an average concentration of 0.322 + 0.080, whereas …

Improvement Of Forage Productivity By Intercropping Pakchong 1 And Napier Grass With Mungbean And Soybean In Los Baños, Laguna, Philippines, Paul Joshua C. Marquez, Eureka Teresa M. Ocampo, Menandro M. Loresco, Ma Lourdes S. Edano, Agapita J. Salces

The Philippine Agricultural Scientist

Forage demand is rising in the Philippines, and to sustainably boost agronomic performance, the beneficial impact of intercropping was investigated. This study characterized the performance of high-yielding forages, namely Napier grass (NG) and Pakchong 1 (PK), when intercropped with soybean (SB) and mungbean (MB) under rain-fed conditions in Los Banos, Laguna. The experiment was conducted in a repeated-measures RCBD replicated 3 times with grass species and cropping system as main factors, resulting in the following treatment combinations: Sole NG, Sole PK, NGSB, NGMB, PKSB, and PKMB. Grasses were ratooned, legumes were harvested, and legume seeds were re-sown every 45 to …

Carotenoid Profiles Of Momordica Cochinchinensis (Lour.) Spreng. Aril And Leaves As Potential Dietary Caroteniod Sources [Research Note], Francis A. Aguilar, Antonio C. Laurena, Nerrisa K. Torreta, Vida Faith R. Galvez, Evelyn B. Rodriguez, Lourdes B. Cardenas

The Philippine Agricultural Scientist

Momordica cochinchinensis (Lour.) Spreng. or sweet gourd is a perennial, dioecious vine known to possess remarkable carotenogenic capacity. To explore its potential as a dietary carotenoid source, this study evaluated the carotenoids of aril from ripe fruits and of leaves of an accession from Laoag, Ilocos Norte, Philippines, through open-column chromatography. Data reveal that the optimal fruit ripeness for aril carotenoid quantification, determined by fruit skin redness (CIELAB a* value), was achieved 6 to 7 wk after pollination, at which time the aril was found to contain lycopene at 1,260.64 ± 56.17 μg g⁻¹ fresh weight (FW) and β-carotene …

Beta-Casomorphin7 Detection In Milk From Dairy Species And Beta-Casein Protein Characterization In Cattle From Selected Provinces In The Philippines, Angelo M. Tapia, Cynthia R. Oliveros Maria, Queennie Hope D. Umipon, Hazel Marie E. Nicolas, Naoya Ogawa, Yasuyuki Kitaura

The Philippine Agricultural Scientist

This study was conducted to detect β-casomorphin7 (BCM7) in dairy animals and to characterize the β-casein (CSN2) genotype among dairy cattle breeds in the Philippines. A total of 59 dairy animals, composed of 35 cattle (12 Holstein Sahiwal [HS16 Jersey × Holstein Friesian [JHF], and 7 Siquijor Native Cattle [SNC]), 15 buffaloes (Bulgarian Murrah and Brazilian Murrah), and 9 goats (Saanen and Anglo-Nubian) were collected with milk samples. Milk protein was extracted and subjected to high-performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) analysis after stimulated gastrointestinal digestion. BCM7 was detected in cattle with an average concentration of 0.322 + 0.080, whereas …

Text Messages To Improve Young Child Diets: Results From A Cluster-Randomized Controlled Trial In Kanchanpur, Nepal, Kenda Cunningham, Sidney Cech, Aman Sen Gupta, Pooja Pandey Rana, Debbie Humphries, Edward A. Frongillo Jr. Ph.D.

Faculty Publications

The objective of this study was to test whether adding a text message campaign about the importance of eating eggs and other nutrition-related behaviours to an on-going package of large-scale, diverse social and behaviour change interventions would improve four types of nutrition-related knowledge and behaviour outcomes: child diets (egg consumption as the primary outcome), maternal diets, maternal nutrition knowledge, and maternal participation in additional interventions. The cluster-randomized controlled trial involved a repeat cross-sectional design, recruiting families with children 12–23 months of age at baseline and endline in one plains district of Nepal. Throughout the 1000-day period, 51 text messages were …

Impact Of Suaahara, An At-Scale Multisectoral Nutrition Programme, On Health Workers’ Maternal And Child Health, And Nutrition Knowledge And Skills In Nepal, Deependra K. Thapa, Edward A. Frongillo Jr. Ph.D., Shalini Suresh, Ramesh P. Adhikari, Bhim Pun, Karuna L. Shakya, Raj Mandal, Subir K. Kole, Kenda Cunningham

Faculty Publications

Suaahara, an at-scale multisectoral nutrition programme in Nepal, aimed to advance knowledge and skills of frontline health workers to improve the quality of nutrition and health services at health facility and community levels. This study assessed the impact of Suaahara interventions on knowledge and skills of health facility workers and Female Community Health Volunteers (FCHVs). The study used a quasi-experimental design in which four Suaahara intervention districts were compared with pair-matched comparison districts. One health facility worker and three FCHVs from each survey cluster were included. Baseline survey consisted of 93 health facility workers (2015) and 118 FCHVs (2012), and …

Thirty Years, Give Or Take: Reflections On My Life In Banking, Joseph A. Smith Jr.

North Carolina Banking Institute

No abstract provided.

The Lindenwood Review, Issue 16 (2026), Full Issue

The Lindenwood Review: a journal of literary prose

No abstract provided.

A Right Without A Remedy: The Court’S Failure To Quantify The Agua Caliente’S Federal Reserved Water Rights, Lauren Block

Washington Law Review

The Agua Caliente Band of Cahuilla Indians has inhabited the Coachella Valley region since time immemorial. Through a series of 1870s executive orders, the United States government reserved land for the Tribe to establish a permanent home within the bounds of their ancestral homeland. Underlying this permanent home is the Coachella Valley aquifer, a groundwater source that has been in a continuous state of overdraft for decades. Against the backdrop of climate change, water scarcity, and other concerns, the Tribe sued Coachella Valley’s water management agencies in 2013, alleging the Tribe owned a portion of the water in the aquifer …

Cholecalciferol (Vitamin D3) Is An Agonist Of The Alzheimer's Disease-Associated Immune Receptor Trem2, Hunter B Dean, Ryan A Tuckey, Rory A Greer, Jessica A Greven, Shan-Zhong Yang, Daniel S Elston, Gunnar N Eastep, Yuwei Song, Thomas J Brett, Yuhua Song, Erik D Roberson

2020-Current year OA Pubs

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) is one of the strongest genetic risk factors for late-onset Alzheimer's disease (AD). Several TREM2 ligands are known, including charged lipids and AD-associated proteins like apolipoprotein E and amyloid-β, but the full range of endogenous ligands for TREM2 remains unknown. Here we combined virtual screening of the Human Metabolome Database with molecular dynamics simulations, binding free energy estimation, and biolayer interferometry to identify novel TREM2 ligands and map their binding sites. Cholecalciferol, the unmodified parent form of vitamin D3, emerged as a top candidate. Structural modeling indicated that cholecalciferol binds TREM2 at …

Astrocyte-Specific Deletion Of Lrrc8a Causes Neurological Dysfunction But Not Chronic White Matter Edema, Sven Kerst, Leoni Hoogterp, Marjolein Breur, Gemma M Van Rooijen-Van Leeuwen, Marianna Bugiani, Rajan Sah, Huibert D Mansvelder, Marjo S Van Der Knaap, Rogier Min

2020-Current year OA Pubs

Volume-regulated anion channels (VRACs) are central to cell volume homeostasis. They mediate swelling-induced efflux of chloride and organic osmolytes to drive regulatory volume decrease. In the brain, VRACs have been proposed to play a key role in astrocytic volume regulation. Genetic defects in astrocytic VRAC modulating proteins (MLC1, GlialCAM, Aquaporin-4, GPRC5B) cause the leukodystrophy Megalencephalic leukoencephalopathy with subcortical cysts (MLC), characterized by chronic white matter edema and myelin vacuolization. Disrupted VRAC activity in MLC-patient-derived lymphoblasts and primary astrocytes from MLC mice further supports a pathogenic link between defective VRAC activity and MLC. Here, we studied the physiological and pathological consequences …

In The Miery Swamp: Metacomet And Memory, Allison Rose, Marianne Holdzkom

The Kennesaw Journal of Undergraduate Research

Abstract for “In the Miery Swamp: Metacomet and Memory”, written by Allison Rose and sponsored by Dr. Marianne Holdzkom

Memorials have become omnipresent ties to our communal past. Plaques and dedications materialize in our town squares. Statues loom over our city parks. Monuments tower over our cemeteries. A large issue facing public historians today is the disconnect between the original intent of public memorials and the collective representation of diverse histories. “In the Miery Swamp: Metacomet and Memory” addresses how interactions with the public alter and transform four public memorials. Through a chronological and historical analysis of four monuments to …

Less Fisher More Doe: Non-Testimonial Mental Content And A New Rule For Unlocking Digital Devices, Jordan Wallace-Wolf

William & Mary Bill of Rights Journal

Roughly fifteen years ago, courts started to regularly confront a fact pattern that I refer to as the unlocking scenario. In this kind of case, the government seeks evidence on a criminal defendant’s digital device, but it cannot access it due to a sufficiently strong system of password protection or encryption. May the government compel the defendant to unlock the device, or would this compulsion make the defendant “a witness against himself”?

Courts gave different answers to this question right from the start, but their answers have started to diverge even more markedly in recent years, notwithstanding two formative papers …

Free Speech Trapped In Amber: The Rise Of The 'History And Tradition' Test, From Unregulated Guns To Highly Regulated Speech, Matthew D. Bunker, Emily Erickson

William & Mary Bill of Rights Journal

An insidious virus appears poised to invade First Amendment free speech doctrine. “History and tradition,” a deeply flawed variant of originalism, threatens to transform speech law from a rational enterprise, employing tiers of scrutiny to evaluate potential infringements on speech, to a random scavenger hunt through the distant past that could upend numerous vital First Amendment principles.

Traditionalism’s ascendence to the forefront of history-centric constitutional interpretation was heralded in three dramatic cases decided at the end of the U.S. Supreme Court’s October 2021 term. New York State Rifle & Pistol Ass’n v. Bruen elicited particular concern among First Amendment scholars, …

Signatures Of The Anthropocene: Population Genomic Structure Detected In Pennsylvania Coyotes, Craig A. Marshall, Julia Halo, Kyle Van Why, Yeraldi Loera, Stavi R. Tennenbaum, Casey Burton, Ariana Di Landro, Dominic Dominguez, Daniel Duncan, Madison Machado, Catalina Posada, Stephen J. Gaughran, Madison Lichak, Kristin Brzeski, Elizabeth Heppenheimer, Bridgett Vonholdt

Michigan Tech Publications

Coyotes (Canis latrans) expanded across eastern North America in the last century and are ecological generalists capable of thriving across diverse habitats. Broad genetic surveillance has reported little spatial genetic patterning for this highly dispersive species. Here, we explore the genome-wide signatures of spatial patterns found in a 10-year study of 1199 coyotes from northeastern United States, with a temporal analysis of Pennsylvania coyotes. Despite their broad dispersal capability, we detected subtle but significant population structure, with two genetic clusters that have a weak clinal transition zone. This partitioning aligned qualitatively with patterns of human population density and activity. We …

Physical And Occupational Therapist Evaluations For Fall Prevention In The Emergency Department: A Geriatric Ed Guidelines 2.0 Systematic Review, Lauren T Southerland, Pedro K Curiati, Richard D Shih, Alexander X Lo, Kristie Harper, Ian Tarnovsky, Alexis Brengartner, Luna Ragsdale, Neha Raukar, Suzanne Ryer, Katherine M Hunold, Fabrice Mowbray, Charles L Maddow, Christopher R Carpenter, Shan W Liu

Faculty, Staff and Student Publications

Background: Older adults are at high risk for severe injuries and death from falls. Physical therapist (PT) and occupational therapist (OT) evaluations have been introduced into Emergency Department (ED) care to assist with fall risk evaluation and fall prevention care. An evaluation of current evidence was undertaken to inform the Geriatric ED Guidelines 2.0.

Methods: Systematic review of physical and/or occupational therapy evaluation for fall prevention in the ED. The intervention was evaluation by a rehabilitation therapist (PT, OT, or both) for fall prevention, fall assessment, or mitigation of fall risk factors. Studies that did not perform the evaluation during …

Ƒ(Cell): Software For Reproducible Analysis Of Optoretinograms, Robert F. Cooper, Mina Gaffney, Brea D. Brennan, Niko Rios

Biomedical Engineering Faculty Research and Publications

Purpose: There has been a marked increase in use of a noninvasive functional imaging technique called optoretinography (ORG). As more groups use ORGs, it is crucial to have a consistent methodology, and understand what analysis parameters influence repeatability. In this work, we present an open-source software library called ƒ(Cell) designed to facilitate reproducible and repeatable analyses of ORG data.

Methods: We designed ƒ(Cell) as a Python software library that can co-register and analyze ORG datasets, while also enabling process auditing. To validate the software, we used our previously obtained normative optoretinography datasets as well as datasets from six …

Sidewalk Living, Michael C. Pollack

Articles

In City of Grants Pass v. Johnson, the Supreme Court held that the Eighth Amendment does not prohibit a city from enforcing a criminal ban on encampments on public property such as parks and sidewalks. But even if municipalities are now permitted to use tactics such as policing, encampment clearing, arrests, and imprisonment, these are not the right ways to address the problems of public homelessness.

Instead, homelessness must be understood as one of many conflicts over limited public space. At its best, vibrant sidewalk life enhances communities and local economies. But at its worst, every use of these finite …

Awakening To Languages: Preparing A Peaceful Multilingual World, Michel Candelier, Jean François De Pietro

Dimensions

Awakening to Languages (AtL) is a teaching approach that proposes multilingual activities and accompanies language teaching to foster the learners’ awareness of and openness to multilingualism, while increasing their reflexive metalinguistic abilities. In this article, we describe ATL as a component of Didactics of Plurilingualism (DP) and its main aims and characteristics which will be illustrated through multiple examples of activities and teaching materials. We further discuss the reported effects of AtL on learners, teachers, and parents, followed by current trends in integrating AtL in schools. We then turn to a comparison of core concepts of AtL and DP to …

Omni: A Modular Open-Source Framework For Interactive Multi-Omics Data Integration And Visualization., Grace Potter, Jacob A Beierle, Camron Bryant, Sadhna Phanse, Carl White, Andrew Emili, Indranil Paul

Faculty Research 2026

Omics Notebook Interactive (OmNI) is an R-based, open-source, and modular framework engineered for streamlined multi-omics data inte- gration and analysis across diverse data types, incorporating interactive visualizations at each processing step. OmNI performs differential expression analysis utilizing customizable linear models, accommodating various covariates and complex experimental designs. For cross- omic layer integration, OmNI employs a modified S-score statistic, ensuring sensitive detection of differential features. The framework also integrates network and metabolomics data, offering detailed insights into regulatory mechanisms through comprehensive enrichment analy- sis using multiple pathway databases. Outputs include interactive HTML reports, CSV/TSV files, and Cytoscape-compatible objects. OmNI is readily …