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The Role Of The Methyl Dna Binding Domain Protein 2 (Mbd2) In Breast Cancer, Omar Mian Jan 2010

The Role Of The Methyl Dna Binding Domain Protein 2 (Mbd2) In Breast Cancer, Omar Mian

Theses and Dissertations

Methyl-CpG Binding Proteins (MCBPs) are thought to function as the interpreters of epigenetic information encoded in cytosine methylation. Their ability to translate DNA methylation into local transcriptional repression has sparked interest in the role of Methyl-Binding Domain Proteins (MBDs) in cancer, where repatterning of CpG methylation is common. In this dissertation I summarize and discuss observations made in the Ginder Lab linking MCBPs to the progression of neoplastic disease. It is clear from our work that the Methyl Binding Domain Protein 2 (MBD2) is necessary for the persistent repression of critical tumor suppressor genes in breast cancer. We show that …

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Dendritic Spine Density Varies Between Unisensory And Multisensory Cortical Regions, Moazzum Bajwa Jan 2010

Dendritic Spine Density Varies Between Unisensory And Multisensory Cortical Regions, Moazzum Bajwa

Theses and Dissertations

In the brain, the dendritic spine is a point of information exchange that extends the neuronal surface on which synapses occur, as well as facilitates and stabilizes those contacts. Furthermore, dendritic spines dynamically change in shape and number in response to a variety of factors. Dendritic spine numbers are reduced in mental retardation, enhanced during development, sensory enrichment or physical exercise, or fluctuate during the reproductive cycle. Thus, for a given neuron type, it might be expected that dendritic spine number might achieve a dynamic optimum. Indeed, many studies of spine density of pyramidal neurons in sensory cortex indicate that …

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Ipla2Β, Alternative Splicing And Apoptosis Of Pancreatic Islets, Bhargavi Emani Jan 2010

Ipla2Β, Alternative Splicing And Apoptosis Of Pancreatic Islets, Bhargavi Emani

Theses and Dissertations

Ceramides are bioactive lipids that can promote splicing of apoptosis-related genes, including caspase 9 and BCL-x. A recent study demonstrated that expression of neutral sphingomyelinase (NSMase), an enzyme that hydrolyzes sphingomyelins to generate ceramide, is regulated by Group VIA phospholipase A2 (iPLA2β)-dependent mechanism during β-cell apoptosis. This prompted us to hypothesize that iPLA2 is upstream of ceramide generation in the process regulating splicing of apoptotic genes. To test this, Jurkat T cells were treated with the selective inhibitor of iPLA2β, bromoenol lactone (BEL), RNA was isolated and converted to cDNA, and caspase 9 and BCL-x mRNA viii species were amplified …

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Influence Of Retinal States On The Development And Maintenance Of Retinofugal Projections, Duncan Morhardt Jan 2010

Influence Of Retinal States On The Development And Maintenance Of Retinofugal Projections, Duncan Morhardt

Theses and Dissertations

Vision provides a critical interface with the physical world. This work examines visual development and vision loss in mice to glean the influence of the retinal state on visual connections. I first assessed the impact of retinal activity on the eye-specific segregation of retinal afferents in the lateral geniculate nucleus (LGN) of young Gβ5 -/- mice. Gβ5 is the fifth member of the β subfamily of heterotrimeric G proteins. Gβ5 binds and stabilizes the R7 family of regulators of G-protein signaling (RGS), which accelerate Gi/o GTP hydrolysis. Gβ5 -/- mice, which lack R7RGS activity, have malformed synapses in the outer …

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Novel Cinnamic Acid-Based Dehydropolymers For Emphysema: In Vitro And In Vivo Assessment Of Their Activities, Bhawana Saluja Jan 2010

Novel Cinnamic Acid-Based Dehydropolymers For Emphysema: In Vitro And In Vivo Assessment Of Their Activities, Bhawana Saluja

Theses and Dissertations

Pulmonary emphysema is a serious worldwide illness, causing progressive and irreversible alveolar wall loss and difficulty in breathing. It is caused mostly by cigarette smoking. However, its unresolved complex and multiple pathogenic mechanisms have left this disease without effective pharmacotherapy. This project hypothesized that cinnamic acid-based dehydropolymers (DHPs), originally discovered as novel anti-coagulants, protect against emphysema through their potent triple inhibitory actions against oxidative stress, inflammation and elastase, some of the pathogenic mechanisms associated with this disease. Three in vitro inhibitory activity assays for oxidative stress, lung inflammation and neutrophil elastase (NE) were developed and used to identify the most …

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The Role Of Synaptically Evoked Plateau Potentials In Retinogeniculate Development, Emily Dilger Jan 2010

The Role Of Synaptically Evoked Plateau Potentials In Retinogeniculate Development, Emily Dilger

Theses and Dissertations

We study the activity-dependent refinement of sensory systems by using the mouse retinogeniculate system as a model. Spontaneous retinal waves lead to robust excitatory post-synaptic activity in developing relay cells in the dorsal lateral geniculate nucleus (dLGN) of the thalamus and are reportedly needed to help guide the segregation of retinal inputs into eye-specific domains as well as for the pruning of extraneous retinal inputs onto single dLGN relay cells. The composition of retinally evoked post-synaptic activity activated by these retinal waves in dLGN is largely unknown, but based on our in vitro recordings, such activity seems well suited to …

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Patient Ventilator Dyssynchrony: Types, Frequency And Patterns In Critically Ill Adults, Karen Mellott Jan 2010

Patient Ventilator Dyssynchrony: Types, Frequency And Patterns In Critically Ill Adults, Karen Mellott

Theses and Dissertations

Patient ventilator dyssynchrony (PVD) occurs frequently, but little is known about the types, frequency and patterns of PVD for longer than 30 minutes. Deeper levels of sedation are associated with PVD. Evaluation of ventilator graphics and the ability to identify PVD should assist clinicians to optimize patient ventilator interactions and promote earlier interventions. The purpose of this study was to identify the different types, frequency and patterns of PVD in critically ill adults and determine the effect of sedation level on PVD. Thirty medical and surgical ICU adult patients were enrolled; 27 were used for analysis. Pressure/time and flow/ time …

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Altered Interactions, Kristen Rego Jan 2010

Altered Interactions, Kristen Rego

Theses and Dissertations

Surrounding materials, signage, and detritus on the daily path offer plenty to look at, if not too much. The eye seeks comfort in its passive vision by ignoring its peripheries. Identification of my personal vision reveals itself through the manipulation of ignored material. I consider hand-made vs. machine made, singular vs. the multiple particularly in plastics, packaging and other utilitarian objects. Industrial processes influence my one-person operation. Understanding the way objects are made allows for an opportunity to connect with them. I’m already surrounded by them, the least I can do is get to know them better.

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Dreamfall: The Fleeting-Ness Of Memory, Hon Chen Jan 2010

Dreamfall: The Fleeting-Ness Of Memory, Hon Chen

Theses and Dissertations

My work seeks to simulate the impermanence of memory, through the creation of structures and images that translate the mind’s formless but living past into physical material and sensation. The need to search for the missing six years of my childhood memories in Thailand has been the driving force behind the works, along with the lingering emotions of emptiness and unfulfillment. I create multimedia installations with materials, such as plaster, pvc panels, acrylic, polycrylic and dura-lar, to structurally realize a subject as intangible and elusive as memory. Issues of duality, identity, impermanence and memory are underlying themes for my thesis …

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Journeys Into The Unknown: A Series Of Science Architecture Tasks And Events, Space-Bound Explorations And Far-Travels, Discoveries And Misses (Near And Far), Imaginative Space-Gazing And Related Investigations, Observations, Orbits, And Other Repetitious Monitoring Tasks, Leah Beeferman Jan 2010

Journeys Into The Unknown: A Series Of Science Architecture Tasks And Events, Space-Bound Explorations And Far-Travels, Discoveries And Misses (Near And Far), Imaginative Space-Gazing And Related Investigations, Observations, Orbits, And Other Repetitious Monitoring Tasks, Leah Beeferman

Theses and Dissertations

This thesis expansively and inclusively puts forth the imaginings, research, processes and experiences behind my two thesis exhibitions, "Journeys into the unknown: a series of science architecture tasks and events, space-bound explorations and far-travels, discoveries and misses (near and far), imaginative space-gazing and related investigations, observations, orbits, and other repetitious monitoring tasks" and "Timed travel: asystematic accounts of regular and geometrical timekeeping, orbital flight, repetitive rotations and other journeys into actual time and slow space." It begins with an abstract interpretation of the dial: a tool not limited to scientific measurement but, instead, a gauge of an object’s overall position …

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The Everyday In America, Janet Bruhn Jan 2010

The Everyday In America, Janet Bruhn

Theses and Dissertations

Abstract: My vanilla, Grade A, white bread, run-of-the-mill, middle-of-the-road, threadbare, well-worn, moth-eaten, potato sack, butterscotch, grass stained America: Mundane American life is an existence clinging to the ordinary, where a quilt of mass- mediated preferences and ingrained traditions define many people, specifically from north to south and east to west. Yet, the tastes and dialects of people within the mundane are complex. Ideological preferences are rooted in immigrant history and political persuasion. Various modes of realism have been used by American painters such as The Ash Can School, Regionalists of the 1930’s, and Pop Art. The notion of the real …

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The Adventures Of A Young Artist, And The Promise Of The Digital Culture In Art, Jonathan Marshall Jan 2010

The Adventures Of A Young Artist, And The Promise Of The Digital Culture In Art, Jonathan Marshall

Theses and Dissertations

An analysis and explanation of my reasons for working in video, painting and drawing, and sculpture, considering the technological developments of the past decade; the possibility to use the internet as a distribution tool for works of art, and to shift the decision-making balance of the art-world; the ways that this approach is a democratic format for output in the arts and within communities of artists; an explanation of my studio practice while a graduate student at Virginia Commonwealth University.

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Studies On Inositol Polyphosphates And Their Role In Programmed Cell Death, Rakhee Agarwal Dec 2009

Studies On Inositol Polyphosphates And Their Role In Programmed Cell Death, Rakhee Agarwal

Theses and Dissertations

The agents that induce apoptosis in cancerous cells are considered as potential candidates for cancer therapy. Inositol polyphosphates, the naturally occurring compounds, regulate diverse cellular processes including induction of apoptosis in certain cancerous cells and hence can be considered as potential anticancer agents. The aim of this research dissertation was to establish firmly the role of inositol polyphosphates in induction of apoptosis by examining their mechanism of action. The overall hypothesis was that alterations in intracellular levels of inositol polyphosphates would bring about apoptotic changes. The hypothesis was tested by changing endogenous inositol polyphosphates by way of chemical treatments known …

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Influence Of Soil Water Repellency On Post-Fire Revegetation Success And Management Techniques To Improve Establishment Of Desired Species, Matthew D. Madsen Dec 2009

Influence Of Soil Water Repellency On Post-Fire Revegetation Success And Management Techniques To Improve Establishment Of Desired Species, Matthew D. Madsen

Theses and Dissertations

The influence of soil water repellency (WR) on vegetation recovery after a fire is poorly understood. This dissertation presents strategies to broaden opportunities for enhanced post-fire rangeland restoration and monitoring of burned piñon and juniper (P-J) woodlands by: 1) mapping the extent and severity of critical and subcritical WR, 2) determining the influence of WR on soil ecohydrologic properties and revegetation success, and 3) evaluating the suitability of a wetting agent composed of alkylpolyglycoside-ethylene oxide/propylene oxide block copolymers as a post-fire restoration tool for ameliorating the effects of soil WR and increasing seedling establishment. Results indicate that:

• Post-fire patterns …

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Inferring Dispersal Of Aquatic Invertebrates From Genetic Variation: A Comparative Study Of An Amphipod (Talitridae Hyalella Azteca) And Mayfly (Baetidae Callibaetis Americanus) In Great Basin Springs, Heather Lynn Stutz Dec 2009

Inferring Dispersal Of Aquatic Invertebrates From Genetic Variation: A Comparative Study Of An Amphipod (Talitridae Hyalella Azteca) And Mayfly (Baetidae Callibaetis Americanus) In Great Basin Springs, Heather Lynn Stutz

Theses and Dissertations

Whether active or passive, dispersal accompanied by gene flow shapes the population genetics and evolutionary divergence of species. Indirect methods which use genetic markers have the ability to assess effective dispersal—that which resulted in gene flow. My objective was to see if an aquatic insect and an obligate aquatic invertebrate show similar phylogeographic patterns and genetic uniqueness. Hyalella azteca and Callibaetis americanus were collected from 4-5 springs in each of six basins in the Great Basin of western North America. No dispersal or genetic studies of C. americanus have been conducted to date. However, several studies focusing on mtDNA diversity …

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Acoustic Mediation Of Vocalized Emotion Identification: Do Decoders Identify Emotions Idiographically Or Nomothetically?, Michael Kenneth Lauritzen Dec 2009

Acoustic Mediation Of Vocalized Emotion Identification: Do Decoders Identify Emotions Idiographically Or Nomothetically?, Michael Kenneth Lauritzen

Theses and Dissertations

Most research investigating vocal expressions of emotion has focused on one or more of three questions: whether there exist unique acoustic profiles of individual encoded emotions, whether the nature of emotion expression is universal across cultures, and how accurately decoders can identify expressed emotions. This dissertation begins to answer a fourth question, whether there exist unique patterns in the types of acoustic properties persons focus on to identify vocalized emotions. Three hypotheses were tested: first, whether acoustic patterns are interpreted idiographically or nomothetically as reflected in a comparison of individual vs. group lens model identification ratios; second, whether there exists …

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Comparison Of Single-Use And Multiple-Use Electrodes For Sensory, Motor Threshold Amplitudes And Force Production, Lucia Maloy Dec 2009

Comparison Of Single-Use And Multiple-Use Electrodes For Sensory, Motor Threshold Amplitudes And Force Production, Lucia Maloy

Theses and Dissertations

Context: Electrodes play an important role in interfacing tissue with electrical stimulation devices. Manufacturers recommend that adhesive metallic mesh cloth electrodes be used no more than 10 times before they are discarded, however, clinically the electrodes are often used up to 30 times. Another concern is sanitation. When electrodes are used on different patients, there is a chance for cross-contamination and bacterial growth on the electrode. Objective: To compare amplitudes of perceived sensation, motor twitch and force produced at specific amplitudes using single-use electrodes that run no risk of cross-contamination, and multiple-use electrodes. Design: Mixed model ANOVA with the subject …

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Decision-Based Data Fusion Of Complementary Features For The Early Diagnosis Of Alzheimer's Disease, Metin Ahiskali Dec 2009

Decision-Based Data Fusion Of Complementary Features For The Early Diagnosis Of Alzheimer's Disease, Metin Ahiskali

Theses and Dissertations

As the average life expectancy increases, particularly in developing countries, the prevalence of Alzheimer's disease (AD), which is the most common form of dementia worldwide, has increased dramatically. As there is no cure to stop or reverse the effects of AD, the early diagnosis and detection is of utmost concern. Recent pharmacological advances have shown the ability to slow the progression of AD; however, the efficacy of these treatments is dependent on the ability to detect the disease at the earliest stage possible. Many patients are limited to small community clinics, by geographic and/or financial constraints. Making diagnosis possible at …

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Modeling Of The Biomass Power Generation And Techno-Economic Analysis, Shireesha Methuku Dec 2009

Modeling Of The Biomass Power Generation And Techno-Economic Analysis, Shireesha Methuku

Theses and Dissertations

Biomass is one of the renewable energy sources being used widely for power generation. This research work includes developing a comprehensive model for a biomass based power generation system as well as analyzing the technical, economical, and environmental impacts. The research objectives include modeling of the system, stability studies, and sensitivity analysis using MATLAB/Simulink. A mathematical model for the gas turbine has been developed and successfully interconnected with the distribution network. Transient stability of the power system has been carried out for four bus and six bus test case systems. Maximum rotor speed deviation, oscillation duration, rotor angle, and mechanical …

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Osteogenic Regulatory Mechanisms Activated By Pressure In Aortic Heart Valve, Carol Andrea Pregonero Gamez Dec 2009

Osteogenic Regulatory Mechanisms Activated By Pressure In Aortic Heart Valve, Carol Andrea Pregonero Gamez

Theses and Dissertations

Calcific aortic valve disease (CAVD) is the most common cause of aortic valve failure and replacement in the elderly population, affecting 25% of the population over 65 years of age. Current pharmacological approaches for preventing the onset and progression of calcific aortic valve disease have not shown consistent benefits in clinical studies. Differentiation of valvular interstitial cells (VICs) into osteoblast–like cells is an integral step in the calcification process. Although clinical evidence suggests hypertension as a potential candidate contributing to the development of CAVD, the underlying molecular mechanisms that cause de-differentiation remain unclear. The present study investigates the role of …

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Implantable Antennas For Wireless Data Telemetry: Design, Simulation, And Measurement Techniques, Tutku Karacolak Dec 2009

Implantable Antennas For Wireless Data Telemetry: Design, Simulation, And Measurement Techniques, Tutku Karacolak

Theses and Dissertations

Recent advances in electrical engineering have let the realization of small size electrical systems for in-body applications. Today’s hybrid implantable systems combine radio frequency and biosensor technologies. The biosensors are intended for wireless medical monitoring of the physiological parameters such as glucose, pressure, temperature etc. Enabling wireless communication with these biosensors is vital to allow continuous monitoring of the patients over a distance via radio frequency (RF) technology. Because the implantable antennas provide communication between the implanted device and the external environment, their efficient design is vital for overall system reliability. However, antenna design for implantable RF systems is a …

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Analysis Of Electromagnetic And Seismic Geophysical Methods For Investigating Shallow Sub-Surface Hydrogeology, Eric M. Parks Dec 2009

Analysis Of Electromagnetic And Seismic Geophysical Methods For Investigating Shallow Sub-Surface Hydrogeology, Eric M. Parks

Theses and Dissertations

An integrated electromagnetic (EM) and seismic geophysical study was performed to evaluate non-invasive approaches to estimate depth to shallow groundwater in arid environments with elevated soil salinity where the installation of piezometers would be impractical or prohibited. Both methods were tested in two study areas (semi-arid and arid respectively), one in Palmyra, Utah, USA near the shore of Utah Lake where groundwater is shallow and unconfined in relatively homogeneous lacustrine sediments. The other area is Carson Slough, Nevada, USA near Ash Meadows National Wildlife Refuge in Amargosa Valley. The area is underlain by valley fill, with generally variable shallow depths …

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The Ecological Importance Of Extrinsic And Intrinsic Drivers Of Animal Movement, Josh Earl Rasmussen Dec 2009

The Ecological Importance Of Extrinsic And Intrinsic Drivers Of Animal Movement, Josh Earl Rasmussen

Theses and Dissertations

The movement of individuals is foundational to many ecological processes. For example, the movement of an organism from one place to another alters population density at both sites and has potential for affecting the genetic dynamics within the new population. Individual movement events may be in synchrony with overall trends in populations, e.g. spawning migrations, or may be atypical (asynchronous). This latter movement type can affect population and metapopulation dynamics, depending on its prevalence within a population. Nevertheless, given the complexity of interactions, the causative factors of movement are understood vaguely, much less for aquatic organisms. Drivers of movement are …

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Analysis Of Regulatory T Cell Activation Markers In Feline Immunodeficiency Virus (Fiv)-Infected And Control Placenta Samples From Early And Late Term Pregnancy, Nikki Nikkia Lockett Dec 2009

Analysis Of Regulatory T Cell Activation Markers In Feline Immunodeficiency Virus (Fiv)-Infected And Control Placenta Samples From Early And Late Term Pregnancy, Nikki Nikkia Lockett

Theses and Dissertations

Mother-to-child transmission of HIV is the leading cause of pediatric AIDS; however, mechanisms by which HIV compromises pregnancy are not understood. CD4+CD25+ T-regulatory (Treg) cells play a role in pregnancy maintenance. RNA from early and late gestation placentas and fetuses from FIV-infected and control cats were probed for expression of FIV gag and Treg markers CD25, FOXP3, and CTLA4, using real time reverse-transcriptase (RT)-PCR. High rates of vertical transmission and reproductive failure were detected in early and late pregnancy. In control animals, both FOXP3 and CTLA4 expression decreased with gestational stage, indicating a natural decline in Tregs. Expression of FOXP3 …

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The Effectiveness Of Distance Education For Computer Application Software Instruction Versus The Cost Of Development And Implementation, Martha Anne Brock Dec 2009

The Effectiveness Of Distance Education For Computer Application Software Instruction Versus The Cost Of Development And Implementation, Martha Anne Brock

Theses and Dissertations

The primary purpose of this study was to determine if various types of distance education formats would be suitable for conducting a training course for a computer application. The study sought to determine if a face-toace format, interactive video format, minimally interactive online format or highly interactive and multimedia rich online format produced similar results in student performance in a training course for a computer application. The secondary purpose of this study was to determine if the increased cost of development of a highly interactive and multimedia rich online format was justified based on observed differences in student achievement in …

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The Role Of Cattle And Gulf Coast Ticks (Amblyomma Maculatum) In The Epidemiology Of Rickettsia Parkeri Infection, Kristine T. Edwards Dec 2009

The Role Of Cattle And Gulf Coast Ticks (Amblyomma Maculatum) In The Epidemiology Of Rickettsia Parkeri Infection, Kristine T. Edwards

Theses and Dissertations

I hypothesized cattle and Gulf Coast ticks (GCT), Amblyomma maculatum, may be involved in epidemiology of Rickettsia parkeri infection. I demonstrated transient rickettsemia by polymerase chain reaction (PCR) for the 17 kilodalton (kDa) gene in 33% (2/6) of calves experimentally exposed to R. parkeri either by direct inoculation or by placement of R. parkeri-infected GCT on calves’ ears. Calves (4/4) receiving GCT developed lesions at attachment sites consistent with a pathologic condition known as “gotch” ear whether or not GCT were infected with R. parkeri, suggesting the condition is related to GCT attachment and not to rickettsial infection. In calves …

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Rapid Identification Of Aspergillus Spp. Using A Pcr Based Melting Curve Method And Characterization Of A Novel Chitinase In Insect Resistant Maize Lines, Biing-Ru Wu Dec 2009

Rapid Identification Of Aspergillus Spp. Using A Pcr Based Melting Curve Method And Characterization Of A Novel Chitinase In Insect Resistant Maize Lines, Biing-Ru Wu

Theses and Dissertations

Identification of fungal isolates is critical in studying Aspergillus flavus ecology and for developing methods to reduce aflatoxin contamination. In our efforts to track biocontrol applications of the atoxigenic A. flavus K49 (NRRL 30797), we have developed a rapid and accurate classification system for A. flavus based on PCR product melting temperatures (Tm). Using 18 primers and a total of 59 Aspergilli strains, including all 49 representatives of the Georgian peanut Vegetative Compatibility Groups (VCGs), a decision tree Tm flowchart was generated. The decision tree can classify all 59 strains using only 9 of the SSR primers and an average …

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Nutrient Management In On-Site Wastewater Treatment, Ayanangshu Dey Dec 2009

Nutrient Management In On-Site Wastewater Treatment, Ayanangshu Dey

Theses and Dissertations

Groundwater and surface water contamination has been linked in the past to inadequate or failing on-site wastewater treatment and disposal systems. The on-site wastewater systems installed in coastal areas have more potential for inflicting this kind of environmental damage. This work studied the regulatory compliance and environmental protection of the four types of on-site wastewater disposal systems found on the Mississippi Gulf Coast; i.e., vegetative rock filter, subsurface drip irrigation, sand mound, and sprinkler systems, by statistical techniques. Compliance was also evaluated for groundwater samples collected from monitoring wells installed at four corners of a disposal field. This work eventually …

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Optimization Of The Production Of The Lantibiotics Mutacin 1140 In Modified M9 Media, Neeti Dahal Dec 2009

Optimization Of The Production Of The Lantibiotics Mutacin 1140 In Modified M9 Media, Neeti Dahal

Theses and Dissertations

Mutacin 1140, a class 1 bacteriocin, is produced by Streptococcus mutans and belongs to the type A lantibiotic family. Experiments were done to optimize production of mutacin 1140 in minimal media enabling a more cost efficient downstream purification method. The development of a small volume fermentation method enabled a rapid screen of several variables in a standard shaking incubator. This method provided a fast approach for determining components that promote mutacin 1140 production in minimal media broth. Lactose was determined to be the optimal carbon source for mutacin 1140 production. High concentrations of CaCl2 (0.3% w/v) and MgSO4 (0.77% w/v) …

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Pathogen Entrance And Development Of Disease During Infection Of The American Channel Catfish Ictalurus Punctatus By The Enterobacterium Edwardsiella Ictaluri, Simon Menanteau-Ledouble Dec 2009

Pathogen Entrance And Development Of Disease During Infection Of The American Channel Catfish Ictalurus Punctatus By The Enterobacterium Edwardsiella Ictaluri, Simon Menanteau-Ledouble

Theses and Dissertations

Since being first reported in the late 1980ies, the Enterobacterium Edwardsiella ictaluri has rose in prevalence to become one of the two most damaging pathogens affecting the channel catfish industry. Despite this significance of the pathogen, understanding of the development of the disease, especially its route of entry into the host and the earlier stages of the infection, is still incomplete. A series of challenges were conducted using bioluminescent E. ictaluri either by infecting fish through immersion or topical application of the bacteria directly on the intact or abraded epithelium. This showed that abraded fish developed septicemia and died faster …

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