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Extracellular Matrix Based Substrates For Propagation Of Human Pluripotent Stem Cells, Sheena Abraham
Extracellular Matrix Based Substrates For Propagation Of Human Pluripotent Stem Cells, Sheena Abraham
Theses and Dissertations
In human pluripotent stem cell (hPSC) research and applications, the need for a culture system devoid of non-human components is crucial. Such a system should exhibit characteristics observed in conventional culture systems that have used mouse embryonic fibroblast feeders for hPSC self renewal without the requirement of excessive supplementation with growth factors. To achieve this, we focused on the identification and characterization of extracellular matrix (ECM) substrates for hPSC propagation. ECM substrates derived from mouse and human fibroblasts were assessed for their ability to support self-renewal of hPSCs. Characterization of hPSCs on ECM-based substrates demonstrated maintenance of pluripotent characteristics based …
Recapitulating Osteoblastogenesis With Electrospun Fibrinogen Nanofibers And Adipose Stem Cells And Electrospinning Adipose Tissue-Derived Basement Membrane, Michael Francis
Theses and Dissertations
To repair, replace, or regenerate damaged or diseased tissue has been a long-standing, albeit elusive, goal in medical research. Here, we characterize patient-derivable mesenchymal stem cell types, termed adipose-derived stem cells (ASCs). These cells, which can be derived from liposuction fat and lipoaspirate saline, are sources for patient-derivable extracellular matrix (ECM), fibrinogen (Fg) and adipose tissue extracellular matrix, and may prove useful for synthesizing new bone tissue analogues in vitro. Traditionally and rapidly isolated ASCs were thoroughly characterized as multipotent, having osteogenic, adipogenic, and chondrogenic differentiation potential, and they exhibited comparable proliferative lifespans. These ASCs also shared an indistinguishable immunophenotype …
Instructional Television Programs In Egypt: A Case Study Of The Primary Stage Programs, Mahitab Khalil
Instructional Television Programs In Egypt: A Case Study Of The Primary Stage Programs, Mahitab Khalil
Theses and Dissertations
This study focuses on media for development; using television as a mass medium to serve education in Egypt. The study in hand is a case study concerned with the instructional television programs for the primary stage students in Egypt. The researcher focused on three pillars that are: education, media and more importantly, students and their parents. The study is guided by a learning system: Rich Environment for Active Learning. This system is based on the constructive theory that deals with learning as a life long experience. The learning process, thus, has to be joyful and engaging so that it makes …
Graph-Based Global Illumination, Brian C. Ricks
Graph-Based Global Illumination, Brian C. Ricks
Theses and Dissertations
The slow render times of global illumination algorithms make them impractical in most commercial and academic settings. We propose a novel framework for calculating the computational complexity of global illumination algorithms and show that no other recent improvements have reduced this complexity. We further show that many algorithms use a tree as their rendering paradigm. We propose a new rendering algorithm, pipe casting, which calculates light paths using a graph instead of a tree. Pipe casting significantly reduces both computational complexity and actual render time of rendering. Using an L2 pixel-wise error comparison, on average our algorithm can render a …
Virtual Reality In Art Education, Sohhyoun Yoon
Virtual Reality In Art Education, Sohhyoun Yoon
Theses and Dissertations
This thesis project presents possible uses of Virtual Reality for art education. To understand VR, this thesis reviews the history of using technology in educational environments and explores the concepts, definitions, and characteristics of VR in general. Then, it shows diverse purposes of VR for education and art educational environments. For an art class, the units present the use of Teen Second Life, which is a free on-line virtual world. The units demonstrate how art educators may use Teen Second life for high school art classes to build students’ understandings of their identities by creating their avatars, clothing, objects and …
The Effects Of Pet Ownership On Physical Well-Being In Older Adults, Tami Pohnert
The Effects Of Pet Ownership On Physical Well-Being In Older Adults, Tami Pohnert
Theses and Dissertations
A large percentage of Americans own pets which may impact their health. This study examines pet ownership’s effect on well being in older adults looking at race/ethnicity. A sample of 6,565 older adults (>60) was selected from the Third National Health and Nutrition Survey. Pet owners comprised 28.3% of the sample. The theories of symbolic interaction and social integration were used to examine pet ownership’s effect on physical components of well-being. The descriptive results showed statistically significant differences in age, education, income, and marital status between pet owners and non-pet owners. Pet owners were younger, more educate, higher income …
The Actor's Process : From Page To Stage, Julia N. Porter
The Actor's Process : From Page To Stage, Julia N. Porter
Theses and Dissertations
No abstract provided.
Terra Australis Incognita During The Age Of Exploration: A Window Into The Changing European World View, Adam Aaron Marshall
Terra Australis Incognita During The Age Of Exploration: A Window Into The Changing European World View, Adam Aaron Marshall
Theses and Dissertations
For nearly two millennia some Europeans believed that a vast, wealthy, and peopled continent, Terra Australis Incognita, lay in the southern ocean, and acted as a stabilizing counterweight to the northern landmasses. The presence of this frontier, if only imaginary, represented geographical opportunity, and served as a psychological safety valve. Until discoverers possessed the ability to accurately chart the southern seas, the existence of the theoretical continent went unchallenged. Two voyagers serve as bookends in this search during the Age of Exploration: Pedro Ferdinand de Quirós (1565-1615), and Captain James Cook (1728-1779). Beyond their actual voyages, these men serve as …
The Role Of The Ca2+-Dependent Protein Kinase, Camk-Ii, In Heart And Kidney Development In The Zebrafish, Danio Rerio, Sarah Rothschild
The Role Of The Ca2+-Dependent Protein Kinase, Camk-Ii, In Heart And Kidney Development In The Zebrafish, Danio Rerio, Sarah Rothschild
Theses and Dissertations
Ca2+/calmodulin-dependent protein kinase type II (CaMK-II) is a multifunctional serine/threonine kinase that is ubiquitously expressed throughout the lifespan of metazoans. Mammals encode four genes (α, β, γ, δ) that generate over forty splice-variants. CaMK-II is important in a myriad of functions, including ion channel regulation, cell-cycle progression, and long term potentiation. In adults, alterations in activation of CaMK-II induce cardiac arrhythmias and heart failure. Developmental roles for CaMK-II are not as well understood since mouse knockouts are embryonic lethal. Therefore the identification of other vertebrate CaMK-II genes will add to our understanding of development. Zebrafish encode seven catalytically active CaMK-II …
Role Of Oxidative Reactive Species And Antioxidants In Metabolism And Transport Of Therapeutic Drugs, Svetlana Verenich
Role Of Oxidative Reactive Species And Antioxidants In Metabolism And Transport Of Therapeutic Drugs, Svetlana Verenich
Theses and Dissertations
Oxidative stress (OS) is a frequent complication of various disease conditions such as Alzheimer’s and Parkinson’s disease, atherosclerosis, preeclampsia, rheumatoid arthritis, diabetes including gestational diabetes, etc. OS is defined as an imbalance between the production of reactive species and the ability of an organism to detoxify the reactive intermediates and repair the damage. As a result of OS, the excess of reactive species such as oxygen superoxide (O2-), hydroxyl radical (OH), peroxynitrite (ONOO−), 4-hydroxynonenal (4HNE), etc., have a tendency to react with nearby proteins/nucleic acids/lipids changing their functionality or inactivating them completely. The organism has many ways to protect itself …
Autotaxin: A Regulator Of Oligodendrocyte Differentiation, Larra Yuelling
Autotaxin: A Regulator Of Oligodendrocyte Differentiation, Larra Yuelling
Theses and Dissertations
In order for oligodendrocyte progenitor cells (OPCs) to differentiate into fully mature, myelinating oligodendrocytes, they must be specified at the correct times and undergo coordinated changes in both gene expression and morphology. As oligodendrocytes differentiate, they transition from a bipolar morphology into a morphology characterized by a complex network of multiple processes, which will eventually generate membranous structures necessary for myelination of axonal segments. As changes are observed in cellular morphology, oligodendrocytes also undergo changes in their gene expression profile and express genes necessary for both early and later stages of development such as olig1 and myelin basic protein (mbp), …
Hyperbranched Polymer Membranes For Gas And Liquid Separation, Irfan I. Shaikh
Hyperbranched Polymer Membranes For Gas And Liquid Separation, Irfan I. Shaikh
Theses and Dissertations
No abstract provided.
Phylogeny Of The Tiger Moth Genus Phoenicoprocta Druce (Noctuidae: Arctiinae: Euchromiina) For Use In Examining The Evolution Of Courtship Systems, Janna Lee Mabey
Phylogeny Of The Tiger Moth Genus Phoenicoprocta Druce (Noctuidae: Arctiinae: Euchromiina) For Use In Examining The Evolution Of Courtship Systems, Janna Lee Mabey
Theses and Dissertations
No abstract provided.
A Comparative Examination Of Embryonic Cardiovascular Regulation In The Cananda Goose (Branta Canadensis) And Domestic Goose (Anser Anser Domesticus), Justin C. Swart
A Comparative Examination Of Embryonic Cardiovascular Regulation In The Cananda Goose (Branta Canadensis) And Domestic Goose (Anser Anser Domesticus), Justin C. Swart
Theses and Dissertations
No abstract provided.
The Weight Of Something There, Luke Geiver
The Weight Of Something There, Luke Geiver
Theses and Dissertations
No abstract provided.
Landscape Utilization Of Four Anuran Species In Northeastern North Dakota, Kyna M. Hogg
Landscape Utilization Of Four Anuran Species In Northeastern North Dakota, Kyna M. Hogg
Theses and Dissertations
No abstract provided.
Historically Informed Performance Practice Of The Baroque Era, Amanda Beard
Historically Informed Performance Practice Of The Baroque Era, Amanda Beard
Theses and Dissertations
In recent years, much debate has ensued regarding the level of consideration that should be given to the historical context of musical compositions that were written and performed during the Baroque era, which extends from 1600 to 1750 CE. The question arises as to how closely we should strive to emulate the performance conditions that would have been present during the Baroque era. Robert Donington, an English musicologist and author of two definitive texts on Baroque performance practice, suggests in his Performer's Guide to Baroque Music that we can meet the expectations of the Baroque composers to a greater degree …
Klebsiella Pneumoniae Induces Dna Damage In Lung Cells And The Potential Role Of Dna Repair Pathways In Klebsiella Pneumonia, Huang Huang
Theses and Dissertations
No abstract provided.
Assessment Of Education For Sustainable Development In Universities In Costa Rica: Implications For Latin America And The Caribbean, Jairo H. Garcia
Assessment Of Education For Sustainable Development In Universities In Costa Rica: Implications For Latin America And The Caribbean, Jairo H. Garcia
Theses and Dissertations
Higher Education is a key factor for social change influencing future decision-makers in business, education, politics and science. As such, sustainable development requires creating awareness amongst these decision-makers of their responsibilities and opportunities in this area. Higher education for sustainable development is championed in developed countries, but in developing countries it is just beginning to become an element of interest for the international community. The purpose of this study was to perform an assessment of the extent to which universities in Costa Rica are including education for sustainable development in their programs and curriculum, research and scholarship, faculty and staff …
Indian Psychology: The Connection Between Mind, Body, And The Universe, Sandeep Atwal
Indian Psychology: The Connection Between Mind, Body, And The Universe, Sandeep Atwal
Theses and Dissertations
The purpose of this study was to devise a mode of treatment that would be helpful when clinically working with the East Indian community. A theoretical orientation of Indian psychology was describes using the principles found in various Hindu scriptures. The scriptures show that an unbalance and a disconnection from the true self causes psychological problems and as the individual comes in contact with the true self the psychological problems are eliminated. Different theories for understanding the human psyche are used to describe this process: the triguna theory, the kosha theory, Ayurveda, and Patanjali's Yoga. These different theories work together …
Positive Psychology And The Jewish Holiday Calendar: A Resource Manual For Small Groups, Tami Krichiver
Positive Psychology And The Jewish Holiday Calendar: A Resource Manual For Small Groups, Tami Krichiver
Theses and Dissertations
Research indicates the Jewish community could benefit from additional resources aimed at supporting the psychospiritual needs of community members. While clergy and mental health professionals often collaborate to address these needs, there is no model that utilizes psychologists in a non-clinical setting for the purpose of integrating common positive psychology and spiritual concepts. The literature reveals many commonalities between positive psychology strengths and Jewish holiday themes. The purpose of this study was to develop a resource manual for psychologists and rabbis. The primary aims of the manual were to (a) utilize positive psychology to enhance psychospiritual development within the Jewish …
And Her Increase And Selected Stories, Catherine Hart
And Her Increase And Selected Stories, Catherine Hart
Theses and Dissertations
A recently freed slave strives for her independence and renegotiates her relationship with the white father of her children in the aftermath of the Civil War. Foreclosed homeowners find a literally explosive artifact. Co-workers cope with layoffs and a suicide. A fugitive witch struggles against a fantasy theocracy. A revolutionary tries to save an innocent man and her conscience. A doctor chooses to resist an oppressive regime in a dystopian future. The historical novel And Her Increase and these widely varying stories coalesce around themes of freedom and oppression, choice and desire.
Prediction Of Human Systemic, Biologically Relevant Pharmacokinetic (Pk) Properties Based On Quantitative Structure Pharmacokinetic Relationships (Qspkr) And Interspecies Pharmacokinetic Allometric Scaling (Pk-As), Prajakta Badri
Theses and Dissertations
This research developed validated QSPKR and PK-AS models for predicting human systemic PK properties of three, preselected, pharmacological classes of drugs, namely opioids, β-adrenergic receptor ligands (β-ARL) and β-lactam antibiotics (β-LAs) using pertinent human and animal systemic PK properties (fu,, CLtot, Vdss, fe) and their biologically relevant unbound counterparts from the published literature, followed by an assessment of the effect of different molecular descriptors on these PK properties and on the PK-AS slopes for CLtot and Vdss from two species (rat and dog). Lipophilicity (log (D)7.4) and molecular weight (MW) were found to be the most statistically significant and biologically …
In-Vitro Metabolism And Protein Binding Of 5-Hmf, A Potential Antisickling Agent, Taghrid Obied
In-Vitro Metabolism And Protein Binding Of 5-Hmf, A Potential Antisickling Agent, Taghrid Obied
Theses and Dissertations
Purpose. 5-HMF is a potential antisickling agent forming a Schiff-adduct with hemoglobin (Hb). In-vitro studies were designed to identify the metabolic pathways of 5-HMF in human hepatic cytosol, to assess inter-species differences in its hepatic metabolism, and to predict in-vivo PK properties. Moreover, metabolism of 5-HMF in human RBCs was investigated. Finally, in-vitro studies were done to characterize 5-HMF binding kinetics with human Hb and albumin (HSA). Methods. NAD+ reduction was monitored at 340 nm in human hepatic cytosol for 5-HMF (26 mM) and prototypical ADH and ALDH substrates in the presence or absence of their inhibitors. Furthermore, concentration-dependency studies …
Agronomic Performance Of Five Varieties Of Forage Grasses Inroduced In Carmen Pampa, Province Of Nor Yungas, La Paz, Joel Eliseo Bautista Vargas
Agronomic Performance Of Five Varieties Of Forage Grasses Inroduced In Carmen Pampa, Province Of Nor Yungas, La Paz, Joel Eliseo Bautista Vargas
Theses and Dissertations
This study was done with the objective of evaluating the agronomic performance of five varieties of forage grasses introduced to the community of Carmen Pampa in the province of Nor Yungas, La Paz from 2005-2006. The average temperature during the study was 11.93ºC and the average precipitation was 801.75 mm. The trial was done with a design of randomized blocks having five species and six repetitions. The species studied were: Panicum virgatum, Sorghastrum nutans, Andropogon gerardii, Tripsacum dactyloides, and Eragrostis curvula. Variables evaluated were: plant height (cm), coverage (%), number of plants, bunches of florets, and dry matter yield (kg/ha). …
Geographic Distribution Of Natural And Anthropogenic Noise In Selected Grand Forks Parks, Erin A. Pederson
Geographic Distribution Of Natural And Anthropogenic Noise In Selected Grand Forks Parks, Erin A. Pederson
Theses and Dissertations
No abstract provided.
Evaluation Of A Novel Therapeutic Agent For The Treatment Of West Nile Virus, Sherae Lynette Hunter
Evaluation Of A Novel Therapeutic Agent For The Treatment Of West Nile Virus, Sherae Lynette Hunter
Theses and Dissertations
No abstract provided.
Renshaw Interneuron Loss In A Mouse Model Of Amyotrophic Lateral Sclerosis, Sarmad I. Al-Marsoummi
Renshaw Interneuron Loss In A Mouse Model Of Amyotrophic Lateral Sclerosis, Sarmad I. Al-Marsoummi
Theses and Dissertations
No abstract provided.
The Frequency Of Typically Developing Children Acknowledging Semantic Absurdities In Spoken Language, Aynsley K. Allen
The Frequency Of Typically Developing Children Acknowledging Semantic Absurdities In Spoken Language, Aynsley K. Allen
Theses and Dissertations
No abstract provided.
Study Of Decarboxylation And Alkylation Of Catalytically Cracked Soybean Oil, Malhar A. Khambete
Study Of Decarboxylation And Alkylation Of Catalytically Cracked Soybean Oil, Malhar A. Khambete
Theses and Dissertations
No abstract provided.