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Beyond Neurons: Impact Of Cannabidiol On Glial Cells In Ischemic Stroke, Victória Linden De Rezende, Khiany Mathias, Cinara Ludvig Gonçalves, Rafael Mariano De Bitencourt, Tatiana Barichello, Fabricia Petronilho

Faculty, Staff and Student Publications

Ischemic stroke triggers a complex cascade of events involving inflammation, oxidative stress, and glial cell dysfunction, all of which contribute to neuronal damage and impaired recovery. Glial cells (e.g., astrocytes, microglia, and oligodendrocytes) play key roles in neuroinflammatory responses, making them attractive targets for therapeutic modulation. Cannabidiol, a non-psychoactive phytocannabinoid from Cannabis sativa, exhibits anti-inflammatory, antioxidant, and neuroprotective properties. Preclinical evidence indicates that cannabidiol attenuates glial reactivity, reduces pro-inflammatory signaling, mitigates oxidative stress, and preserves blood-brain and intestinal barrier integrity in stroke models. Moreover, cannabidiol modulates key molecular pathways (e.g., nuclear factor-κB, tumor necrosis factor, and calcium-related signaling), contributing to …

Structures Of Invertebrate Pezo-1 Isoforms With A Compact Architecture And A Dispensable Pore-Distal N-Terminal Blade, Briar Bell, Angela M Jaramillo-Granada, Daniel J Orlin, Wei-Hsiang Weng, Haosheng Wen, Marcos Sotomayor, Alexander T Chesler, Matthew L Baker, Julio F Cordero-Morales, Valeria Vásquez

Faculty, Staff and Student Publications

PIEZO channels are mechanosensitive ion channels conserved from plants to humans, yet structures exist for only a few mammalian orthologs. We define the structural and functional diversity of Caenorhabditis elegans PEZO-1, a single gene with extensive alternative splicing, by determining cryo-electron microscopy structures of three representative isoforms: G (full length), K (lacking the pore-distal N-terminal blade), and L (missing most of the blade). PEZO-1G displays mechanically evoked currents yet adopts a compact, semi-flattened conformation that significantly differs from the mammalian domes. The blades exhibit a three-step slope architecture stabilized by inter-blade latching among transmembrane helical units, yielding a circular, steering-wheel-like …

Structures Of Trpv1 Bound By Hyperthermia-Inducing Analgesics, Yu-Hao Gao, Yi-Zhe Huang, Zhao-Xing Li, Xiao-Ying Chen, Chang-Yan Shao, Han-Wen Li, Bin Liu, Fán Yang, Mei-Rong Chen, Mei-Ling Lu, Michael X Zhu, Fan Yang, Yi-Bei Xiao, Ye Yu

Faculty, Staff and Student Publications

TRPV1, a member of the transient receptor potential vanilloid subfamily, mediates nociception and thermoregulation. TRPV1-targeting analgesics frequently induce hyperthermia, underscoring the need for structural insights to guide the development of safer compounds. Here, we determined the structures of rat TRPV1 bound to the clinical candidate analgesics AMG517, AMG9810, and SB366791. AMG517 and AMG9810 are deeply situated within the S3-S4 interface of the vanilloid pocket, where they interact with residues from the S3-S6 helices, as well as the S4-S5 linker. These interactions induce local deformations in the TRP-box and lower S6 helix, accompanied by a modest rotation of the S1-S4 bundle, …

Payload Diversification Overcomes Resistance And Guides Sequential Antibody-Drug Conjugate Therapy In Breast Cancer, Dileep Reddy Rampa, Minji Seo, Nanae Ogata, Zhaoxuan Yang, Nithya Sridhar, Fujii Takeo, Chalothorn Wannaphut, Jennifer A Maynard, Kyoji Tsuchikama, George W Sledge, Naoto T Ueno, Jangsoon Lee

Faculty, Staff and Student Publications

Purpose: Antibody-drug conjugates (ADCs) have transformed the treatment of breast cancer. FDA-approved ADCs such as trastuzumab deruxtecan (T-DXd), sacituzumab govitecan (SG), and datopotamab deruxtecan (Dato-DXd) have demonstrated clinical benefit; however, drug resistance will almost inevitably emerge in the metastatic setting, and there is no established strategy for selecting subsequent ADCs after disease progression to the first exposure to the ADC. This study aimed to define mechanisms of acquired resistance and evaluate rational sequencing approaches.

Experimental design: We generated breast cancer cell lines resistant to T-DXd (TDXd-R) and SG (SG-R). We assessed antigen expression, internalization, and resistance pathways, including efflux transporter …

Common Octopus (Octopus Vulgaris) Blooms Off The Southwest Of The Uk: History, Trends, Causes And Consequences.: Report On Work Package 1: History, Causes And Consequences Of Octopus Blooms, Bryce Stewart, Simon Thomas, Tim J. Smyth, Molly K. James, Emma Sullivan, Alice Hall, Tully Osmond, Emma Sheehan

School of Biological and Marine Sciences

Common octopus (Octopus vulgaris) are normally uncommon in UK waters, with a mainly south-westerly distribution linked to the species’ preference for warmer conditions. However, a major population bloom occurred off southwest UK in 2025, comparable to rare historical blooms recorded in 1899–1900, 1932–33 and 1950–51. The species’ rapid growth, high fecundity and short lifespan make its populations highly responsive to environmental conditions. Evidence from fisheries landings, scientific surveys and citizen science confirmed the bloom, with commercial fisheries landings of common octopus in 2025 being almost 65 times higher than recent annual averages. The 2025 bloom and all previous blooms were …

A Bovine Cell Line Resistant To Japanese Encephalitis Virus Entry But Permissive To Post-Entry Replication, Sang-Im Yun, Young-Min Lee

Animal, Dairy, and Veterinary Science Faculty Publications

Japanese encephalitis virus (JEV) is a mosquito-borne zoonotic orthoflavivirus that poses a significant global health threat. It causes severe neuroinflammatory disease in humans and reproductive failure in swine. Because of the broad host range and cell tropism of JEV, identifying animal cell lines resistant to infection has been a persistent challenge. In this study, we demonstrate that Madin–Darby bovine kidney (MDBK) cells are resistant to JEV infection yet remain fully permissive to viral replication when transfected with viral genomic RNA. Using immunoblotting, immunofluorescence, and flow cytometry, we show that MDBK cells, unlike the highly susceptible baby hamster kidney (BHK-21) cells …

Seizure Presentation Of A Grade Ii Astrocytoma In A Patient With Ollier's Disease: A Case Report And Brief Review, Marissa Vail, Hunter Slosser, Robert Steele, Brian Curtis, Daniel Henry

Student Publications

Ollier's disease (enchondromatosis) is a dysplasia of cartilage characterized by multiple enchondromas. Current evidence supports a measurable prevalence of concurrent gliomas in patients with Ollier's disease. In patients with Ollier's disease, isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) mutations were shown to be a predisposing factor to the development of astrocytomas in conjunction with subsequent mutations in adenosine triphosphate (ATP)-dependent helicase ATRX (ATRX) and tumor protein p53 (TP53). We present the case report of a 21-year-old man with an adolescent diagnosis of Ollier's disease who developed a grade II astrocytoma in early adulthood. The patient presented to the …

Mechanical Performance Evaluation Of Natural Composites Recycled Hemp Rice Bag Reinforced With And Without Silicon Carbide Particles, Gaber A. Elawadi, A. S. Fayed

Mansoura Engineering Journal

Significant progress has been made in the development of natural fiber-reinforced composite materials, owing to their potential to enhance mechanical properties while offering a greener and more sustainable alternative to traditional materials. These materials combine superior ecological benefits with enhanced mechanical performance. This study examines how recycled hemp fiber bags, including recycled hemp fibers obtained from rice hemp fiber bags, affect the mechanical characteristics of unreinforced and reinforced composites. Four composite systems were fabricated and tested: (1) HFR (randomly chipped recycled hemp fiber bags–epoxy composite), (2) HFB (continuous recycled hemp fiber bag–epoxy composite), (3) HFR SiC (randomly chipped recycled hemp …

A Constructive-Engaging Analysis Of Descarrtes (European) And Oyeshile (African) On Personhood, Olanrewaju Shitta-Bey

Comparative Philosophy

An examination of the nature of the human person provides a crucial foundation for understanding human life and identity. Conceptions of personhood have far-reaching implications beyond philosophy, influencing politics, ethics, religion, and epistemology. Beliefs about what constitutes a person shapes theories of rights, responsibility, and justice; moral views on duty and accountability; religious understandings of the soul and the afterlife; and epistemological reflections on the sources and limits of knowledge. Inquiry into human nature is therefore not merely abstract, but central to understanding social organization and individual conduct. This paper examines two influential accounts of human nature drawn from distinct …

Father Knows Best? Not Here: Metaphors Of Kinship And Kingship In Haudenosaunee, Aristotelian, And Confucian Political Thought, Ian Kalman

Comparative Philosophy

The notion that the organization of large-scale social structures are rooted in domestic ones has a longstanding history in both Chinese and Greek classical political philosophy. Aristotle and Confucius independently reasoned that a good family, one with a strong father, mapped onto a good state, one with a strong king - though they differed on the details. While there is a strong literature juxtaposing these two titans, less attention has been paid to how their ideas compare with other philosophical traditions. This article provides an anthropological intervention to the comparative study of Confucius and Aristotle – while both autonomously argued …

The Coherence Of Navayāna Pragmatism: Ambedkar And The Pragmatist Reconstruction Of Buddhist Philosophy, Danish Hamid

Comparative Philosophy

This paper examines the philosophical coherence of B.R. Ambedkar’s reconstruction of his (Navayāna) Buddhism in relation to John Dewey’s pragmatism. Building on Scott Stroud’s reading of Ambedkar as a Deweyan Pragmatist (2017, 2023), it argues that Dewey’s evolutionary naturalism, his conception of growth, and pragmatic redefinition of concepts provide Ambedkar with the methodological tools for a naturalistic and socially reconstructive reinterpretation of Buddhist doctrines such as anicca (impermanence), dhamma (Buddha’s teaching), nirvāṇa (enlightenment), karuna (compassion), etc. Ambedkar transforms impermanence from a metaphysics of flux into an ethics of progressive growth, and recasts dhamma as a social morality grounded in fraternity …

Profile: John Mcphee, Michael Pearson

Creative Nonfiction Magazine

No abstract provided.

Pilgrims, Philip Garrison

Creative Nonfiction Magazine

No abstract provided.

How Tununak Came To Me, Carolyn Kremers

Creative Nonfiction Magazine

No abstract provided.

Bush Taxi Commandos, Peter Chilson

Creative Nonfiction Magazine

No abstract provided.

Divining Domination: Steve Bannon As A Political Mystagogue, Tony Allen Feldmann

Fast Capitalism

Right-wing commentators (on tv, radio, newspapers, documentaries, or the internet) are often considered a source of misinformation and radicalization in American politics. Understanding the role of such commentators in the political sphere has taken on new significance since the election of Trump, who regularly takes talking points as well as political advice from prominent figures in right-wing media. The purpose of these political "shock jocks" also extends beyond mere political commentary: They offer their audience a framework for understanding the world. This framework contains certain reified perceptions of society and history. Durkheim and those working in his tradition have long …

Hamlet's Father: Hauntology And The Roots Of The Modern Self, Lukas Szrot

Fast Capitalism

In his 1949 work Hamlet's Ghost, Richard Flatter wrote of the ghost of Hamlet's father that the play ultimately belongs to him, to the ghost.   Modernity, like the play, belongs to its ghosts, to its dead fathers haunting their wayward sons, the metaphysical specters it imperfectly endeavors to exorcise. Critical theory has often focused on the possibility, and the contours, of a utopia populated by liberatory spirit and liberated persons. Less well explored, however, are the implications for tradition, religion, and the transmission of culture at a metaphorical echelon—those ostensibly "pre-modern" ideas which the broader project of Enlightenment liberalism never …

Shakespeare's Plays Of Deranged Authority: The King's Three Bodies, Daniel Krier

Fast Capitalism

Shakespeare's plays are situated upon the threshold of two worlds: a declining traditional order torn apart by political rivalry and ascendant early-modern capitalism. The history plays dramatize infighting among warring factions of privileged aristocrats as well as revolutionary forces propelled by the rising commons and the politics of commodity. Legitimate authority is rarely secure among the kings perched upon Shakespearean thrones. In Shakespeare's Henriad and King John, crowns are contested from the moment they are placed upon royal heads, inspiring Kantorwicz's political theology: the corporeal body of short-lived kings is distinct from the sovereign's sublime body that reigns without cease. …

The Master's Race: Phallic Whiteness In "The Young Savages", Graham Cassano

Fast Capitalism

This essay examines two parallel, historically contemporaneous, depictions of the Freudian master-slave dialectic. John Frankenheimer's first film, The Young Savages (1961), reconstructs Hank Bell's (Burt Lancaster) repressed transformation from Italian racial other into a white ethnic. In doing so, the film approaches the possibility that race itself may be a kind of social construction. To get at this notion, the film explores the meaning of race in an overtly psychoanalytic language. In fact, The Young Savages echoes the argument of Jacques Lacan's nearly contemporaneous essay, "The subversion of the subject and the dialectic of desire in the Freudian unconscious." Lacan's …

Ignoring Goethe's Faust: A Critical-Theoretical Perspective On American Ideology, Harry F. Dahms

Fast Capitalism

The neglect of Goethe, his work in general, and Faust in particular, in English-speaking countries, is notorious. While Shakespeare's plays have been prominent and widely performed in German-speaking countries, the same is not true for Goethe in the English-speaking world. Focusing non-exclusively on Faust, and cutting a link to Thomas Mann's Doctor Faustus, I will endeavor to delineate problematic aspects of American ideology, and what it would take, within U.S. sociology, to be cognizant of the latter.   Georg Lukacs wrote about Goethe and Faust, and so did Theodor W. Adorno and Leo Loewenthal, highlighting its importance to critical theory. The …

Have A Heart For The Holocene: The Politics Of Ark Activism, Collaborative Conservation, And Sponsored Survival At Museums, Timothy W. Luke

Fast Capitalism

No abstract provided.

The Tragedy Of The Commonplace: Clichés In The Age Of Copyright, Jakob Norberg

Fast Capitalism

No abstract provided.

Writing Circuit Histories, Sascha Engel

Fast Capitalism

No abstract provided.

Review Of "World War Zoos: Humans And Other Animals In The Deadliest Conflict Of The Modern Age" By John M. Kinder, Matthew Barrett

Canadian Military History

Review of World War Zoos: Humans and Other Animals in the Deadliest Conflict of the Modern Age by John M. Kinder

Photocrosslinkable Morin-Loaded Gelatin-G-Gma Composite Hydrogel For Accelerating Burn Wound Healing: In Vitro And In Vivo Assessments, Samar A. Salim

Nanotechnology Research Centre

The impaired skin regeneration, scarring, and delayed healing make the management of burn injuries a challenging task. We designed a photopolymerized hydrogel of gelatin-grafted with glycidyl methacrylate (GMA) for burn management applications. Hydrogel was incorporated with Morin, a plant flavonoid that was originally isolated from the Moraceae family, with known anti-antioxidant and antifibrotic activities. The physicochemical characterization of the resultant hydrogel, including its gelation time and swelling properties, was conducted. The characterization results indicated that the hydrogel development was successful, exhibiting well-established porosity, as evidenced by the SEM images. In vivo evaluation demonstrated improved tissue regeneration characterized by enhanced collagen …

Exploring Opportunities With Global Citizenship Education: Practice, Frameworks, And Curriculum Renewal, Miguel Heilbron

Consensus

No abstract provided.

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Zonation-Dependent Distribution Of Microplastic Occurrence In Patella Caerulea From Mersin Coast, Türkiye, Ezgi̇ Deği̇rmenci̇, Nuray Çi̇ftçi̇, Sedat Gündoğdu, Deni̇z Ayas

Turkish Journal of Zoology

Increasing plastic pollution has become a critical environmental issue, leading to  challenges in management. Specifically, microplastics (MPs) are of particular concern  because they can persist in aquatic ecosystems and adversely affect marine  organisms. The objective of this study was to assess the occurrence of MPs  in the soft tissues of Patella caerulea (Linnaeus, 1758) collected from the Mersin  Viranşehir coastal area. As no specimens were found in the supralittoral zone, the  decision was taken to conduct sampling only in the mediolittoral and infralittoral  zones. The total sampling area was 24 m2 divided into three 4-m2 plots in each zone.  A …

Blinking Without Eyelids: First Video-Documented Evidence Of A Blink-Like Reflex In Ophisops Elegans (Reptilia: Lacertidae), Turan Meri̇ç Çelebi̇, Yusuf Çeli̇kaği, Tuana Kinay, Arda Cem Kuyucu, Muammer Kurnaz, Mehmet Kürşat Şahi̇n

Turkish Journal of Zoology

Eyelids play a crucial role in protecting the eyes of vertebrates; however, certain  reptile species, such as Ophisops elegans, completely lack movable eyelids. In this  study, we present the first video-documented evidence of a blink-like reflex in O.  elegans, captured through endoscopic field observations and corroborated by laboratory video analysis. The observed movement consisted of a brief convex  deformation of the ocular surface, lasting approximately 0.3 s and resembling a blink  despite the presence of a fixed transparent brille. This behavior was observed once in  the field and twice under controlled laboratory conditions. We propose that O.  elegans may employ …

Growth Patterns And The Shift From Predominantly Female To Balanced Sex Ratios In Carassius Gibelio (Bloch, 1782): A Comparative Study Of Lotic And Lentic Populations In  Serbia, Tamara Mitić, Jelena Čanak Atlagić, Ana Marić, Jelena Stanković Ristić, Nikola Marinković, Momir Paunović, Predrag Simonović

Turkish Journal of Zoology

Since its introduction into Serbian watercourses, the invasive Carassius gibelio (Bloch, 1782) (Prussian carp) has spread rapidly. This paper provides an up-to-date overview of the sex ratio, age structure, and growth parameters in Serbian  populations of this fish and describes how growth varies in two contrasting  ecosystems: lotic and lentic. A total of 133 individuals were sampled. The individuals  from lentic habitats were longer on average, with no significant differences in average  weight or age between the two ecosystem types. There was a difference in  the sex ratio between the ecosystems, as indicated by a higher proportion of males in …