Digital Commons Network^™

Location Of Modulatory Β Subunits In Bk Potassium Channels, Guoxia Liu, Xiaowei Niu, Roland S. Wu, Neelesh Chudasama, Yongneng Yao, Xin Jin, Richard Weinberg, Sergey I. Zakharov, Howard Motoike, Steven O. Marx, Arthur Karlin

Publications and Research

Large-conductance voltage- and calcium-activated potassium (BK) channels contain four pore-forming α subunits and four modulatory β subunits. From the extents of disulfide cross-linking in channels on the cell surface between cysteine (Cys) substituted for residues in the first turns in the membrane of the S0 transmembrane (TM) helix, unique to BK α, and of the voltage-sensing domain TM helices S1–S4, we infer that S0 is next to S3 and S4, but not to S1 and S2. Furthermore, of the two β1 TM helices, TM2 is next to S0, and TM1 is next to TM2. Coexpression of α with two substituted …

Impact Of Resilience Enhancing Programs On Youth Surviving The Beslan School Siege, Stefan Vetter, Igor Dulaev, Mario Mueller, Robert R. Henley, William T. Gallo, Zalina Kanukova

Publications and Research

The objective of this study was to evaluate a resilience-enhancing program for youth (mean age = 13.32 years) from Beslan, North Ossetia, in the Russian Federation. The program, offered in the summer of 2006, combined recreation, sport, and psychosocial rehabilitation activities for 94 participants, 46 of who were taken hostage in the 2004 school tragedy and experienced those events first hand. Self-reported resilience, as measured by the CD-RISC, was compared within subjects at the study baseline and at two follow-up assessments: immediately after the program and 6 months later. We also compared changes in resilience levels across groups that differed …

Excitability Changes In The Sciatic Nerve And Triceps Surae Muscle After Spinal Cord Injury In Mice, Zaghloul Ahmed, Robert Freedland, Andrzej Wieraszko

Publications and Research

Background From the onset to the chronic phase of spinal cord injury (SCI), peripheral axons and muscles are subjected to abnormal states of activity. This starts with very intense spasms during the first instant of SCI, through a no activity flaccidity phase, to a chronic hyperactivity phase. It remains unclear how the nature of this sequence may affect the peripheral axons and muscles. Methods We set out to investigate the changes in excitability of the sciatic nerve and to characterize the properties of muscle contractility after contusive injury of the mouse thoracic spinal cord. Results The following changes were observed …

Impact Of Insurance Status On Migraine Care In The United States, Andrew Wilper, Steffie Woolhandler, David U. Himmelstein, Rachel Nardin

Publications and Research

Objective
To determine whether insurance status is associated with differential outpatient treatment of migraine in the United States.

Methods
We analyzed 11 years of data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey (1997–2007), which survey patient visits to doctors’ offices, hospital outpatient departments, and emergency departments (EDs) in the United States. We used logistic regression to determine whether insurance status was associated with the prescription of standard migraine therapy, defined as 1) a triptan or dihydroergotamine and 2) a prophylactic agent.

Results
We identified 6,814 individual patient visits for migraine, representing 68.6 million …

Going No Place?: Foreground Nostalgia And Psychological Spaces In Wharton's The House Of Mirth, Sean Scanlan

Publications and Research

This essay argues that the power of Edith Wharton's The House of Mirth comes not from Lily Bart's function as a mere symptom of historical and economic pressures, but from the complex narrative and psychological process by which she negotiates a sequence of homes and their repeated collapse. Informing this process is nostalgia, a feeling that frames Lily Bart's step-by-step fall from riches to rags. Reading Lily via cognitive and family systems approaches suggests that Lily's rootlessness is predicated on a subtle transformation from her reliance upon simple “background” (aesthetic and monetary) nostalgia to a more complex and overwhelming “foreground” …

Laetoli Footprints Preserve Earliest Direct Evidence Of Human-Like Bipedal Biomechanics, David A. Raichlen, Adam D. Gordon, William E. H. Harcourt-Smith, Adam D. Foster, Wm. Randall Haas

Publications and Research

Background Debates over the evolution of hominin bipedalism, a defining human characteristic, revolve around whether early bipeds walked more like humans, with energetically efficient extended hind limbs, or more like apes with flexed hind limbs. The 3.6 million year old hominin footprints at Laetoli, Tanzania represent the earliest direct evidence of hominin bipedalism. Determining the kinematics of Laetoli hominins will allow us to understand whether selection acted to decrease energy costs of bipedalism by 3.6 Ma. Methodology/Principal Findings Using an experimental design, we show that the Laetoli hominins walked with weight transfer most similar to the economical extended limb bipedalism …

Tredd—A Database For Tandem Repeats Over The Edit Distance, Dina Sokol, Firat Atagun

Publications and Research

A ‘tandem repeat’ in DNA is a sequence of two or more contiguous, approximate copies of a pattern of nucleotides. Tandem repeats are common in the genomes of both eukaryotic and prokaryotic organisms. They are significant markers for human identity testing, disease diagnosis, sequence homology and population studies. In this article, we describe a new database, TRedD, which contains the tandem repeats found in the human genome. The database is publicly available online, and the software for locating the repeats is also freely available. The definition of tandem repeats used by TRedD is a new and innovative definition based upon …

Functional Dissociation Of The Frontoinsular And Anterior Cingulate Cortices In Empathy For Pain, Xiaosi Gu, Xun Liu, Kevin G. Guise, Thomas P. Naidich, Patrick R. Hof, Jin Fan

Publications and Research

The frontoinsular cortex (FI) and the anterior cingulate cortex (ACC) are thought to be involved in empathy for others' pain. However, the functional roles of FI and ACC in empathetic responses have not yet been clearly dissociated in previous studies. In this study, participants viewed color photographs depicting human body parts in painful or nonpainful situations and performed either pain judgment (painful/nonpainful) or laterality judgment (left/right) of the body parts. We found that activation of FI, rather than ACC, showed significant increase for painful compared with nonpainful images, regardless of the task requirement. Our data suggest a clear functional dissociation …

Campaigns To Change Health Damaging Corporate Practices, Nicholas Freudenberg

Publications and Research

When corporations claim the same citizenship rights as human citizens, they exercise an undue influence on health policy and democratic processes. Surprisingly, the same basic repertoire of tactics has been found to be employed by corporations to effect this influence, regardless of the specific industry at work. In this book, authors from around the world reveal the range of tactics used across the corporate world that ultimately favor the bottom line over the greater good.

The Bottom Line or Public Health deconstructs some of the most ubiquitous tactics at play, including public relations, political influence, legal maneuvering, and financial power, …

Information Literacy And Social Power, Jonathan Cope

Publications and Research

An examination of information literacy literature using the perspective of social power research.

"Can't Anyone Be A Teacher Anyway?": Student Perceptions Of Academic Librarians As Teachers, Mark Aaron Polger, Karen Okamoto

Publications and Research

The study explores student perceptions of the academic librarian as teachers. A questionnaire was distributed to 500 students at two City University of New York colleges. Convenience and snowball sampling were employed to reach as many respondents as possible. Questionnaires were administered following a library instruction class and in the campus cafeteria. Contrary to results from previous studies, many respondents consider librarians to be teachers.

The Career Progression Of Women In State Government Agencies, Maria J. D'Agostino, Helisse Levine

Publications and Research

Purpose – The purpose of this paper is to empirically examine the impact of the utilization of organizational practices on the career progression of women to executive positions in state-level government organizations in the USA.

Design/methodology/approach – The design included an online survey instrument sent to a purposive sample of 600 female administrative agency executives in 50 states. A standard multilinear regression model tests the predictive power of three composite explanatory utilization variables on the dependent variable, career progression of women to upper level management. The composite predictor variables are: utilization of work/family practices; utilization of diversity practices; and utilization …

An Integrated Intervention To Reduce Intimate Partner Violence In Pregnancy: A Randomized Trial, Michele Kiely, Ayman El-Mohandes, M. Nabil El-Khorazaty, Marie G. Gantz

Publications and Research

OBJECTIVE: We estimated the efficacy of a psycho-behavioral intervention in reducing intimate partner violence (IPV) recurrence during pregnancy and postpartum, and in improving birth outcomes in African-American women

METHODS: We conducted a randomized controlled trial in which 1,044 women were recruited. Individually-tailored counseling sessions were adapted from evidence-based interventions for IPV and other risks. Logistic regression was used to model IPV victimization recurrence, to predict minor, severe, physical and sexual IPV.

RESULTS: Women randomized to the intervention were less likely to have recurrent episodes of IPV victimization (OR=0.48, 95%CI=0.29-0.80). Women with minor IPV were significantly less likely to experience further …

Re-Thinking Library Jargon: Maintaining Consistency And Using Plain Language, Mark Aaron Polger

Publications and Research

No abstract provided.

Identification And Quantitation Of 3,4-Methylenedioxy-N-Methylamphetamine (Mdma, Ecstasy) In Human Urine By 1h Nmr Spectroscopy. Application To Five Cases Of Intoxication, Jonathan Liu, John Decatur, Gloria Proni, Elise Champeil

Publications and Research

Identification of 3,4-methylenedioxy-N-methylamphetamine (MDMA, ecstasy) in five cases of intoxication using nuclear magnetic resonance (NMR) spectroscopy of human urine is reported. A new water suppression technique PURGE (Presaturation Utilizing Relaxation Gradients and Echoes) was used. A calibration curve was obtained using spiked samples. The method gave a linear response (correlation coefficient of 0.992) over the range 0.01–1 mg/mL. Subsequently, quantitation of the amount of MDMA present in the samples was performed. The benefit and reliability of NMR investigations of human urine for cases of intoxication with MDMA are discussed.

Analysis Of Large Scale Spatial Variability Of Soil Moisture Using A Geostatistical Method, Tarendra Lakhankar, Andrew S. Jones, Cynthia L. Combs, Manajit Sengupta, Thomas H. Vonder Haar, Reza Khanbilvardi

Publications and Research

Spatial and temporal soil moisture dynamics are critically needed to improve the parameterization for hydrological and meteorological modeling processes. This study evaluates the statistical spatial structure of large-scale observed and simulated estimates of soil moisture under pre- and post-precipitation event conditions. This large scale variability is a crucial in calibration and validation of large-scale satellite based data assimilation systems. Spatial analysis using geostatistical approaches was used to validate modeled soil moisture by the Agriculture Meteorological (AGRMET) model using in situ measurements of soil moisture from a state-wide environmental monitoring network (Oklahoma Mesonet). The results show that AGRMET data produces larger …

From Ideal To Practice And Back Again: Beginning Teachers Teaching For Social Justice, Ruchi Agarwal, Shira Epstein, Rachel Oppenheim, Celia Oyler, Debbie Sonu

Publications and Research

The five authors of this article designed a multicase study to follow recent graduates of an elementary preservice teacher education program into their beginning teaching placements and explore the ways in which they enacted social justice curricula. The authors highlight the stories of three beginning teachers, honoring the plurality of their conceptions of social justice teaching and the resiliency they exhibited in translating social justice ideals into viable pedagogy. They also discuss the struggles the teachers faced when enacting social justice curricula and the tenuous connection they perceived between their conceptions and their practices. The authors emphasize that such struggles …

Comparative Analysis On Applicability Of Satellite And Meteorological Data For Prediction Of Malaria In Endemic Area In Bangladesh, Atiqur Rahman, Leonid Roytman, Mitch Goldberg, Felix Kogan

Publications and Research

Relationships between yearly malaria incidence and (1) climate data from weather station and (2) satellite-based vegetation health (VH) indices were investigated for prediction of malaria vector activities in Bangladesh. Correlation analysis of percent of malaria cases with Advanced Very High Resolution Radiometer- (AVHRR-) based VH indices represented by the vegetation condition index (VCI—moisture condition) and the temperature condition index (TCI—estimates thermal condition) and with rainfall, relative humidity, and temperature from ground-based meteorological stations. Results show that climate data from weather stations are poorly correlated and are not applicable to estimate prevalence in Bangladesh. The study also has shown that AVHRR-based …

On The Feasibility Of A Timely Transition To A More Sustainable Energy Future, Micha Tomkiewicz

Publications and Research

The paper uses the framework of the IPAT equation, as applied to CO2 emission, to decompose the various driving forces in the global energy use. Data from recent history are superimposed on projections of SRES IPCC scenarios to determine if enough sustainable capacity can be built to prevent irreversible ecological deterioration. The conclusion from the analysis is that, in agreement with the IPCC 4th report, until about 2030 there are no large differences between a sustainable scenario and the one that resembles “business as usual”. The sharp divergence that follows stems from different estimates in population growth and in the …

The Undiscovered Country: Execution Competency & Comprehending Death, Jeffrey Kirchmeier

Publications and Research

No abstract provided.

Abortion, The Undue Burden Standard, And The Evisceration Of Women's Privacy, Caitlin Borgmann

Publications and Research

No abstract provided.

Vigilante Justice: Prosecutor Misconduct In Capital Cases, Jeffrey Kirchmeier

Publications and Research

No abstract provided.

Family Structure, Parent-Child Conversation Time And Substance Use Among Chinese Adolescents, Kwok-Kei Mak, Sai-Yin Ho, G Neil Thomas, C Mary Schooling, Sarah M. Mcghee, Tai-Hing Lam

Publications and Research

Background: The family plays a vital role in shaping adolescent behaviours. The present study investigated the associations between family structure and substance use among Hong Kong Chinese adolescents.

Methods: A total of 32,961 Form 1 to 5 (grade 7-12 in the US) Hong Kong students participated in the Youth Smoking Survey in 2003-4. An anonymous questionnaire was used to obtain information about family structure, daily duration of parent-child conversation, smoking, alcohol drinking and drug use. Logistic regression was used to calculate the adjusted odds ratios (OR) for each substance use by family structure.

Results: Adjusting for sex, age, type of …

Appellate Review Of Social Facts In Constitutional Rights Cases, Caitlin E. Borgmann

Publications and Research

There is great confusion among scholars and courts about whether and when appellate courts may, or must, defer to trial courts' findings of social fact in constitutional rights cases. The Supreme Court has never directly decided the question and indeed has addressed it only once, in passing. A common assumption, promoted by scholars and adopted as binding by some circuits, is that the deferential, "clearly erroneous" standard of Federal Rule of Civil Procedure 52(a)(6) does not apply to social facts. This Article challenges that assumption. There is nothing in the text of the rule that supports this conclusion. Moreover, except …

Poverty, Guardianship, And The Vulnerable Elderly: Human Narrative And Statistical Patterns In A Snapshop Of Adult Guardianship Cases In New York City, Joseph Rosenberg

Publications and Research

No abstract provided.

What The 2007 Tac Market Design Game Tells Us About Effective Auction Mechanisms, Jinzhong Niu, Kai Cai, Simon Parsons, Peter Mcburney, Enrico Gerding

Publications and Research

This paper analyzes the entrants to the 2007 TAC Market Design Game. We present a classification of the entries to the competition, and use this classification to compare these entries. The paper also attempts to relate market dynamics to the auction rules adopted by these entries and their adaptive strategies via a set of post-tournament experiments. Based on this analysis, the paper speculates about the design of effective auction mechanisms, both in the setting of this competition and in the more general case.

Sex Education And Rape, Michelle Anderson

Publications and Research

No abstract provided.

Medical Conscience And The Policing Of Parenthood, Richard Storrow

Publications and Research

No abstract provided.

When Your Attorney Is Your Enemy: Preliminary Thoughts On Ensuring Effective Representation For Queer Youth, Sarah Valentine

Publications and Research

No abstract provided.

Deplete Locally, Impact Globally: Environmental History Of Shore-Whaling In Barbados, W.I, Aldemaro Romero Jr., Joel E. Creswell

Publications and Research

No abstract provided.