Digital Commons Network^™

The Cinema Of Control: On Diabetic Excess And Illness In Film, Kevin L. Ferguson

Publications and Research

While not rare, films that do represent diabetes must work around the disease’s banal invisibility,and images of diabetics in film are thus especially susceptible to metaphor and exaggeration.This essay is the first to outline a diabetic filmography, discussing medical and cinematic strategies for visualizing the disease as well as how the illness informs family plots and heroic characters in horror films. Doing so, it participates in a larger discussion of the manner in which film images of ill or disabled groups sustain notions of “normalcy” by both representing and denying otherness.

Electronic Document Delivery: A Survey Of The Landscape And Horizon, Nathan Hosburgh, Karen Okamoto

Publications and Research

The authors examine, based on a survey of users, the electronic document delivery methods currently in place as well as changes in the recent past and future developments. Interlibrary loan and document delivery staff were surveyed from institutions across the United States in order to ascertain what document delivery mechanisms are currently in place, how they are being used, and why. Findings from this study should lead to an increased awareness of electronic delivery options in libraries across the country and elucidate the dynamics involved at individual sites. This, in turn, will assist librarians in making decisions, based not only …

Pharmacological Characterization Of Gabaa Receptors In Taurine-Fed Mice, William J. L’Amoreaux, Alexandra Marsillo, Abdeslem El Idrissi

Publications and Research

Background Taurine is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. Chronic supplementation of taurine in drinking water to mice increases brain excitability mainly through alterations in the inhibitory GABAergic system. These changes include elevated expression level of glutamic acid decarboxylase (GAD) and increased levels of GABA. Additionally we reported that GABAA receptors were down regulated with chronic administration of taurine. Here, we investigated pharmacologically the functional significance of decreased / or change in subunit composition of the GABAA receptors by determining the threshold for picrotoxin-induced seizures. Picrotoxin, an antagonist of GABAA …

Taurine Regulates Insulin Release From Pancreatic Beta Cell Lines, William J. L’Amoreaux, Christina Cuttitta, Allison Santora, Jonathan F. Blaize, Janto Tachjadi, Abdeslem El Idrissi

Publications and Research

Background Pancreatic β-cells release insulin via an electrogenic response triggered by an increase in plasma glucose concentrations. The critical plasma glucose concentration has been determined to be ~3 mM, at which time both insulin and GABA are released from pancreatic β-cells. Taurine, a β-sulfonic acid, may be transported into cells to balance osmotic pressure. The taurine transporter (TauT) has been described in pancreatic tissue, but the function of taurine in insulin release has not been established. Uptake of taurine by pancreatic β-cells may alter membrane potential and have an effect on ion currents. If taurine uptake does alter β-cell current, …

Taurine Regulation Of Short Term Synaptic Plasticity In Fragile X Mice, Abdeslem El Idrissi, Lorenz S. Neuwirth, William L’Amoreaux

Publications and Research

Background Fragile X Syndrome is the most common known genetic cause of autism. The Fmr1-KO mouse, lacks the fragile X mental retardation protein (FMRP), and is used as a model of the syndrome. The core behavioral deficits of autism may be conceptualized either as excessive adherence to patterns as seen in repetitive actions and aberrant language, or as insensitivity to subtle but socially important changes in patterns. The hippocampus receives information from the entorhinal cortex and plays a crucial role in the processing of patterned information. To gain more insight into the physiological function of FMRP and the neuronal mechanisms …

Neuro-Endocrine Basis For Altered Plasma Glucose Homeostasis In The Fragile X Mouse, Abdeslem El Idrissi, Xin Yan, Francoise Sidime, William L’Amoreaux

Publications and Research

Background The fragile X mouse model shows an increase in seizure susceptibility, indicating an involvement of the GABAergic system via an alteration in cellular excitability. In the brain, we have previously described a reduction in GABAA receptor expression as a likely basis for this susceptibility. In the brains of fragile X mice, this reduction in receptor expression culminates with a concomitant increase in the expression of glutamic acid decarboxylase (GAD), the enzyme responsible for GABA synthesis. Further, voltage-sensitive calcium channel expression is reduced in the pancreas of the fragile X mouse. Since there are considerable similarities in the GABAergic system …

Scattering Amplitudes From Unitarity-Based Reduction Algorithm At The Integrand-Level, P. Mastrolia, Giovanni Ossola, T. Reiter, F. Tramontano

Publications and Research

Samurai is a tool for the automated numerical evaluation of one-loop corrections to any scattering amplitudes within the dimensional-regularization scheme. It is based on the decomposition of the integrand according to the OPP-approach, extended to accommodate an implementation of the generalized d-dimensional unitarity-cuts technique, and uses a polynomial interpolation exploiting the Discrete Fourier Transform. samurai can process integrands written either as numerator of Feynman diagrams or as product of tree-level amplitudes. We discuss some applications, among which the 6- and 8-photon scattering in QED, and the 6-quark scattering in QCD. samurai has been implemented as a Fortran90 library, publicly available, …

Ageing, The Urban-Rural Gap And Disability Trends: 19 Years Of Experience In China - 1987 To 2006, Xiaoxia Peng, Shige Song, Sheena Sullivan, Jingjun Qiu, Wei Wang

Publications and Research

Background: As the age of a population increases, so too does the rate of disability. In addition, disability is likely to be more common in rural compared with urban areas. The present study aimed to examine the influence of rapid population changes in terms of age and rural/urban residence on the prevalence of disability.

Methods: Data from the 1987 and 2006 China Sampling Surveys on Disability were used to estimate the impacts of rapid ageing and the widening urban-rural gap on the prevalence of disability. Stratum specific rates of disability were estimated by 5-year age-group and type of residence. The …

Delayed Onset Of A Daytime Nap Facilitates Retention Of Declarative Memory, Sara E. Alger, Hiuyan Lau, William Fishbein

Publications and Research

Background Learning followed by a period of sleep, even as little as a nap, promotes memory consolidation. It is now generally recognized that sleep facilitates the stabilization of information acquired prior to sleep. However, the temporal nature of the effect of sleep on retention of declarative memory is yet to be understood. We examined the impact of a delayed nap onset on the recognition of neutral pictorial stimuli with an added spatial component. Methodology/Principal Findings Participants completed an initial study session involving 150 neutral pictures of people, places, and objects. Immediately following the picture presentation, participants were asked to make …

Weighing In: A Critical Analysis Of New York City’S Calorie Labeling Law, Josephine Barnett

Publications and Research

The ‘obesity’ epidemic has The health of New York City Residents has been a significant concern of public health officials with the rates of obesity and diabetes ranking eighth of all cities nationally. The New York City (NYC) Board of Health laid the foundation and influenced the legislative efforts of means to address the ‘obesity-diabetes’ epidemic for public health officials consider this to be one of the major health concerns among Americans and particularly NYC residents. The major initiatives implemented by NYC official include: (1) a ban on trans-fat (2) a city registry of those with diabetes, and (3) menu-labeling. …

Identification And Structural Characterization Of Fyve Domain-Containing Proteins Of Arabidopsis Thaliana, Ewa Wywial, Shaneen M. Singh

Publications and Research

Background FYVE domains have emerged as membrane-targeting domains highly specific for phosphatidylinositol 3-phosphate (PtdIns(3)P). They are predominantly found in proteins involved in various trafficking pathways. Although FYVE domains may function as individual modules, dimers or in partnership with other proteins, structurally, all FYVE domains share a fold comprising two small characteristic double-stranded β-sheets, and a C-terminal α-helix, which houses eight conserved Zn2+ ion-binding cysteines. To date, the structural, biochemical, and biophysical mechanisms for subcellular targeting of FYVE domains for proteins from various model organisms have been worked out but plant FYVE domains remain noticeably under-investigated.

Results We carried out an …

Drug Offenders’ Perceptions Of Motivation: The Role Of Motivation In Rehabilitation And Reintegration, Lior Gideon

Publications and Research

This article presents a qualitative analysis of participants’ perceptions of the importance of motivation in the detoxification and rehabilitation process. As part of an outcome evaluation of recovering drug addicts who participated in a prison-based therapeutic community, 39 participants (a nonrandomized subsample) are interviewed regarding their rehabilitation and reintegration experiences. Although many studies show that participation in prison-based drug treatment programs reduces the likelihood of recidivism, clients in this study suggest that other factors might be equally important, and in particular clients’ own motivation to change their lives. This study raises some questions about the true ability of drug treatment …

Differential Toxicity Of Dna Adducts Of Mitomycin C, Jill Bargonetti, Elise Champeil, Maria Tomasz

Publications and Research

The clinically used antitumor agent mitomycin C (MC) alkylates DNA upon reductive activation, forming six covalent DNA adducts in this process. This review focuses on differential biological effects of individual adducts in various mammalian cell cultures, observed in the authors' laboratories. Evidence is reviewed that various adducts are capable of inducing different cell death pathways in cancer cells.This evidence is derived from a parallel study of MC and its derivatives 2,7-diaminomitosene (2,7-DAM) which is the main metabolite of MC and forms two mono-adducts with DNA, and decarbamoyl mitomycin C (DMC), which alkylates and cross-links DNA, predominantly with a chirality opposite …

Case Fatality Rates Based On Population Estimates Of Influenza-Like Illness Due To Novel H1n1 Influenza: New York City, May–June 2009, James L. Hadler, Kevin Konty, Katharine H. Mcveigh, Anne Fine, Donna Eisenhower, Bonnie Kerker, Lorna Thorpe

Publications and Research

Background The public health response to pandemic influenza is contingent on the pandemic strain's severity. In late April 2009, a potentially pandemic novel H1N1 influenza strain (nH1N1) was recognized. New York City (NYC) experienced an intensive initial outbreak that peaked in late May, providing the need and opportunity to rapidly quantify the severity of nH1N1. Methods and Findings Telephone surveys using rapid polling methods of approximately 1,000 households each were conducted May 20–27 and June 15–19, 2009. Respondents were asked about the occurrence of influenza-like illness (ILI, fever with either cough or sore throat) for each household member from May …

Meditation And Mental Freedom: A Buddhist Theory Of Free Will, Rick Repetti

Publications and Research

I argue that central Buddhist tenets and meditation methodology support a view of free will similar to Harry Frankfurt’s optimistic view and contrary to Galen Strawson’s pessimistic view. For Frankfurt, free will involves a relationship between actions, volitions, and “metavolitions” (volitions about volitions): simplifying greatly, volitional actions are free if the agent approves of them. For Buddhists, mental freedom involves a relationship between mental states and “metamental” states (mental attitudes toward mental states): simplifying greatly, one has mental freedom if one is able to control one’s mental states, and to the extent one has mental freedom when choosing, one has …

Effect Of Teammates On Changes In Physical Activity In A Statewide Campaign, Tricia M. Leahey, Melissa M. Crane, Angela Marinilli Pinto, Brad A. Weinberg, Rajiv Kumar, Rena R. Wing

Publications and Research

Objective—Most Americans do not meet physical activity recommendations. Statewide campaigns can effectively increase activity levels. Reported herein are physical activity outcomes from Shape Up Rhode Island (SURI) 2007, a statewide campaign to increase steps through team-based competition. Given the importance of social networks in behavior change, this paper focused on the effects of team and team characteristics on activity outcomes. Method—For 16-weeks, 5333 adults comprising 652 teams wore pedometers and reported their steps online. Results—Participants’ daily steps increased from 7029(3915) at baseline to 9393(5976) at SURI end (p<.001). There was a significant intraclass correlation for step change among team members (ICC=.09); thus, an individual’s change in steps was influenced by what team they were on. Moreover, baseline team characteristics predicted individual step change; being on a more active team was associated with greater increases in activity for individual members (p<.001), whereas being on a team with a broad range of steps was associated with smaller changes in activity for individual members (p=.02). Conclusion—These findings are the first to suggest that team members influence individual activity outcomes in team-based statewide campaigns. Future research should explore ways to use social network factors to enhance team-based physical activity programs.

The Inadvertent Alliance Of Anthony Comstock And Margaret Sanger: Abortion, Freedom, And Class In Modern America, Karen Weingarten

Publications and Research

This article investigates how moral-reformer Anthony Comstock, who helped outlaw the practice of birth control and to have abortion criminalized, and Margaret Sanger, founder of Planned Parenthood and birth-control activist, advanced their causes through the discourse of freedom and self-control. While Comstock’s and Sanger’s works are often seen in opposition, this article questions that positioning by pointing out how they both lobbied against accessible abortion using similar tactics. Finally, this article demonstrates how Comstock and Sanger, through different means, worked to present abortion as a depraved practice that would lead to the demise of American society. Presenting Comstock and Sanger …

Videos In The Kitchen: The Lesbian Herstory Archives As A Moving-Herstorical-Image, Shawn(Ta) D. Smith

Publications and Research

No abstract provided.

Consistency And Precision Of Cancer Reporting In A Multiwave National Panel Survey, Anna Zajacova, Jennifer Beam Dowd, Robert F. Schoeni, Robert B. Wallace

Publications and Research

Background Many epidemiological studies rely on self-reported information, the accuracy of which is critical for unbiased estimates of population health. Previously, accuracy has been analyzed by comparing self-reports to other sources, such as cancer registries. Cancer is believed to be a well-reported condition. This paper uses novel panel data to test the consistency of cancer reports for respondents with repeated self-reports. Methods Data come from 978 adults who reported having been diagnosed with cancer in at least one of four waves of the Panel Study of Income Dynamics, 1999-2005. Consistency of cancer occurrence reports and precision of timing of onset …

Neural Substrates Of Reliability-Weighted Visual-Tactile Multisensory Integration, Michael S. Beauchamp, Siavash Pasalar, Tony Ro

Publications and Research

As sensory systems deteriorate in aging or disease, the brain must relearn the appropriate weights to assign each modality during multisensory integration. Using blood-oxygen level dependent functional magnetic resonance imaging of human subjects, we tested a model for the neural mechanisms of sensory weighting, termed “weighted connections.” This model holds that the connection weights between early and late areas vary depending on the reliability of the modality, independent of the level of early sensory cortex activity. When subjects detected viewed and felt touches to the hand, a network of brain areas was active, including visual areas in lateral occipital cortex, …

Optimizing Radiology Peer Review: A Mathematical Model For Selecting Future Cases Based On Prior Errors, Yun Robert Sheu, Elie Feder, Igor Balsim, Victor F. Levin, Andrew G. Bleicher, Barton F. Branstetter Iv

Publications and Research

Introduction: Peer review is an essential process for physicians because it facilitates improved quality of patient care and continuing physician learning and improvement. However, peer review often is not well received by radiologists, who note that it is time intensive, subjective, and lacks demonstrable impact on patient care. Current advances in peer review include the RADPEER system with its standardization of discrepancies and incorporation of the peer review process into the PACS itself. Our purpose was to build on RADPEER and similar systems by using a mathematical model to optimally select the types of cases to be reviewed, for each …

A History And One Or Two Things I’Ve Learned, Irvin Sam Schonfeld

Publications and Research

No abstract provided.

Interactive Kinds, Muhammad Ali Khalidi

Publications and Research

This paper examines the phenomenon of 'interactive kinds' first identified by Ian Hacking. An interactive kind is one that is created or significantly modified once a concept of it has been formulated and acted upon in certain ways. Interactive kinds may also 'loop back' to influence our concepts and classifications. According to Hacking, interactive kinds are found exclusively in the human domain. After providing a general account of interactive kinds and outlining their philosophical significance, I argue that they are not confined to the human realm, but that they can also occur elsewhere. Hence, I conclude by arguing that interactive …

A Genealogical Review Of The Worldview Framework In African-Centered Psychology, Karanja Keita Carroll

Publications and Research

Of all the subject/content areas within Africana Studies, African-centered (African/Africana/Black) psychology has been instrumental in advancing culturally-specific theory and research. Central to the field of African-centered psychology is the usage of worldview as the conceptual and philosophical framework. This essay provides a genealogical review of the worldview framework as discussed within African-centered psychology. A focus is on understanding the developmental history and usage of worldview as it relates to producing culturally-specific theory and research consistent with the aims and goals of African-centered psychology and Africana Studies.

Marketing And Communications Librarians: An Exploration Of Roles And Responsibilities, Mark Aaron Polger, Karen Okamoto

Publications and Research

No abstract provided.

Estimated Birth Weight And Adult Cardiovascular Risk Factors In A Developing Southern Chinese Population: A Cross Sectional Study, C. Mary Schooling, C. Q. Jiang, T. H. Lam, B. J. Cowling, S. L. Yeung, W. S. Zhang, K. K. Cheng, G. M. Leung

Publications and Research

Background: Birth weight is negatively associated with cardiovascular diseases and diabetes, but the associations are less well-established in developing populations where birth weight is often unavailable. We studied the association of birth weight and cardiovascular risk, using birth rank as an instrumental variable, in Southern China.

Methods: We used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 & 3 (2005-8) to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older …

Measuring Social Capital As An Outcome Of Service Learning, Maria J. D'Agostino

Publications and Research

Service-learning has been put forth as one of the proposed solutions to increasing social capital. However, service-learning research has not significantly addressed the impact of service learning on social capital. Unlike most previous studies, this research used quantitative analysis to measure the effect of university service-learning programs on social capital by examining the question: What impact do service-learning programs have on social capital post-graduation? This study showed that service learning addresses the civic engagement problem by providing evidence suggesting that service learning predicts social capital post-graduation.

Comparing The Validity Of Five Participation Instruments In Persons With Spinal Conditions, Vanessa K. Noonan, Jacek A. Kopec, Luc Noreau, Joel Singer, Louise C. Mâsse, Hongbin Zhang, Marcel F. Dvorak

Publications and Research

Objective: To evaluate and compare the construct validity of 5 participation instruments developed using the International Classification of Functioning, Disability and Health (ICF). Methods: A total of 545 subjects diagnosed and treated for a spinal condition at an acute hospital were followed-up and consented to complete a questionnaire. Subjects completed 5 participation instruments (Impact on Participation and Autonomy (IPA), Keele Assessment of Participation (KAP), Participation Measure-Post Acute Care (PM-PAC), Participation Objective Participation Subjective (POPS), World Health Organization Disability Assessment Schedule II (WHODAS II)). In addition, each subject completed a health status instrument and a quality of life instrument. The dimensionality, …

Interactions Of Host Proteins With The Murine Leukemia Virus Integrase, Barbara Studamire, Stephen P. Goff

Publications and Research

Retroviral infections cause a variety of cancers in animals and a number of diverse diseases in humans such as leukemia and acquired immune deficiency syndrome. Productive and efficient proviral integration is critical for retroviral function and is the key step in establishing a stable and productive infection, as well as the mechanism by which host genes are activated in leukemogenesis. Host factors are widely anticipated to be involved in all stages of the retroviral life cycle, and the identification of integrase interacting factors has the potential to increase our understanding of mechanisms by which the incoming virus might appropriate cellular …

Sensitivity Analysis Of B-Factor In Microwave Emission Model For Soil Moisture Retrieval: A Case Study For Smap Mission, Dugwon Seo, Tarendra Lakhankar, Reza Khanbilvardi

Publications and Research

Sensitivity analysis is critically needed to better understand the microwave emission model for soil moisture retrieval using passive microwave remote sensing data. The vegetation b-factor along with vegetation water content and surface characteristics has significant impact in model prediction. This study evaluates the sensitivity of the b-factor, which is function of vegetation type. The analysis is carried out using Passive and Active L and S-band airborne sensor (PALS) and measured field soil moisture from Southern Great Plains experiment (SGP99). The results show that the relative sensitivity of the b-factor is 86% in wet soil condition and 88% in high vegetated …