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Botanicals As Prospective Agents Against Sars-Cov-2 Virus, Vyacheslav Dushenkov, Anna Dushenkov
Botanicals As Prospective Agents Against Sars-Cov-2 Virus, Vyacheslav Dushenkov, Anna Dushenkov
Publications and Research
The COVID-19 high morbidity and mortality resulted in a worldwide healthcare emergency that triggered accelerated and amplified efforts in the relevant areas of health sciences research and practice. Purpose: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus. Methods: This narrative review examined the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus based on the references limited to the English language and published up to February 2022 and retrieved from common academic search engines using multiple keywords and their combinations. The scientific names of plant species were confirmed using World Flora Online …
Combinatorial Optimization With Photonics-Inspired Clock Models, Mostafa Honari-Latifpour, Matthew S. Mills, Mohammad-Ali Miri
Combinatorial Optimization With Photonics-Inspired Clock Models, Mostafa Honari-Latifpour, Matthew S. Mills, Mohammad-Ali Miri
Publications and Research
NP-hard combinatorial optimization problems are in general hard problems that their computational complexity grows faster than polynomial scaling with the size of the problem. Thus, over the years there has been a great interest in developing unconventional methods and algorithms for solving such problems. Here, inspired by the nonlinear optical process of q-photon down-conversion, in which a photon is converted into q degenerate lower energy photons, we introduce a nonlinear dynamical model that builds on coupled single-variable phase oscillators and allows for efficiently approximating the ground state of the classical q-state planar Potts Hamiltonian. This reduces the exhaustive search in …
Prenatal Exposure To A Natural Disaster And Early Development Of Psychiatric Disorders During The Preschool Years: Stress In Pregnancy Study, Yoko Nomura, Jeffrey H. Newcorn, Christine Ginalis, Catherine Heitz, Jeenia Zaki, Farzana Khan, Mardia Nasrin, Kathryn Sie, Donato Deingeniis, Yasmin L. Hurd
Prenatal Exposure To A Natural Disaster And Early Development Of Psychiatric Disorders During The Preschool Years: Stress In Pregnancy Study, Yoko Nomura, Jeffrey H. Newcorn, Christine Ginalis, Catherine Heitz, Jeenia Zaki, Farzana Khan, Mardia Nasrin, Kathryn Sie, Donato Deingeniis, Yasmin L. Hurd
Publications and Research
Background: Growing evidence shows an association between in utero exposure to natural disasters and child behavioral problems, but we still know little about the development of specific psychopathology in preschool-aged children. Methods: Preschool children (n = 163, mean age = 3.19, 85.5% racial and ethnic minorities) and their parents (n = 151) were evaluated annually at ages 2–5 to assess the emergence of psychopathology using the Preschool Age Psychopathological Assessment (PAPA), a parent-report structured diagnostic interview developed for preschool-age children. Sixty-six (40.5%) children were exposed to Sandy Storm (SS) in utero and 97 (59.5%) were not. Survival analysis evaluated patterns …
Meat May Never Die, Carlo Alvaro
Meat May Never Die, Carlo Alvaro
Publications and Research
The goal of ethical veganism is a vegan world or, at least, a significantly vegan world. However, despite the hard work done by vegan activists, global meat consumption has been increasing. Vegan advocates have focused on ethics but have ignored the importance of tradition and identity. And the advent of veggie meat alternatives has promoted food that emulates animal products thereby perpetuating the meat paradigm. I suggest that, in order to make significant changes toward ending animal exploitation, ethical vegans give more attention to tradition and identity. Furthermore, I propose that raw veganism is the most ethical diet and can …
A Framework For Near-Real Time Monitoring Of Diversity Patterns Based On Indirect Remote Sensing, With An Application In The Brazilian Atlantic Rainforest, Andrea Paz, Thiago S. Silva, Ana C. Carnaval
A Framework For Near-Real Time Monitoring Of Diversity Patterns Based On Indirect Remote Sensing, With An Application In The Brazilian Atlantic Rainforest, Andrea Paz, Thiago S. Silva, Ana C. Carnaval
Publications and Research
Monitoring biodiversity change is key to effective conservation policy. While it is difficult to establish in situ biodiversity monitoring programs at broad geographical scales, remote sensing advances allow for near-real time Earth observations that may help with this goal. We combine periodical and freely available remote sensing information describing temperature and precipitation with curated biological information from several groups of animals and plants in the Brazilian Atlantic rainforest to design an indirect remote sensing framework that monitors potential loss and gain of biodiversity in near-real time. Using data from biological collections and information from repeated field inventories, we demonstrate that …
Beyond The Covid-19 Pandemic: The Importance Of Social Determinants Of Health In Educating Healthcare Leaders, Tashuna Albritton, Miguel Muñoz-Laboy, Umadevi Yokeeswaran, Marlene Camacho-Rivera
Beyond The Covid-19 Pandemic: The Importance Of Social Determinants Of Health In Educating Healthcare Leaders, Tashuna Albritton, Miguel Muñoz-Laboy, Umadevi Yokeeswaran, Marlene Camacho-Rivera
Publications and Research
As scholars of color and educators in the health professions, we are compelled to advocate for the inclusion of the study of health disparities and social determinants of health (SDOH) throughout higher education to understand, analyze, and effectively respond to healthcare access disparities, including COVID-19 disparities, in Black and Latinx communities across the United States. In addition to our identities and lived experiences, healthcare access disparities and their root causes are woven throughout the courses that we teach in the departments of social medicine, social work, and social and behavioral sciences.
Humidity Reduces Rapid And Distant Airborne Dispersal Of Viable Viral Particles In Classroom Settings, Antun Skanata, Fabrizio Spagnolo, Molly Metz, Davida S. Smyth, John J. Dennehy
Humidity Reduces Rapid And Distant Airborne Dispersal Of Viable Viral Particles In Classroom Settings, Antun Skanata, Fabrizio Spagnolo, Molly Metz, Davida S. Smyth, John J. Dennehy
Publications and Research
The transmission of airborne pathogens is considered to be the main route through which a number of known and emerging respiratory diseases infect their hosts. While physical distancing and mask wearing may help mitigate short-range transmission, the extent of long-range transmission in closed spaces where a pathogen remains suspended in the air remains unknown. We have developed a method to detect viable virus particles by using an aerosolized bacteriophage Phi6 in combination with its host Pseudomonas phaseolicola, which when seeded on agar plates acts as a virus detector that can be placed at a range of distances away from an …
Tracking Cryptic Sars-Cov-2 Lineages Detected In Nyc Wastewater, Davida S. Smyth, Monica Trujillo, Devon A. Gregory, Kristen Cheung, Anna Gao, Maddie Graham, Yue Guan, Caitlyn Guldenpfennig, Irene Hoxie, Sherin Kannoly, Nanami Kubota, Terri D. Lyddon, Michelle Markman, Clayton Rushford, Kaung Myat San, Geena Sompanya, Fabrizio Spagnolo, Reinier Suarez, Emma Teixeiro, Mark Daniels, Marc C. Johnson, John J. Dennehy
Tracking Cryptic Sars-Cov-2 Lineages Detected In Nyc Wastewater, Davida S. Smyth, Monica Trujillo, Devon A. Gregory, Kristen Cheung, Anna Gao, Maddie Graham, Yue Guan, Caitlyn Guldenpfennig, Irene Hoxie, Sherin Kannoly, Nanami Kubota, Terri D. Lyddon, Michelle Markman, Clayton Rushford, Kaung Myat San, Geena Sompanya, Fabrizio Spagnolo, Reinier Suarez, Emma Teixeiro, Mark Daniels, Marc C. Johnson, John J. Dennehy
Publications and Research
Tracking SARS-CoV-2 genetic diversity is strongly indicated because diversifying selection may lead to the emergence of novel variants resistant to naturally acquired or vaccine-induced immunity. To monitor New York City (NYC) for the presence of novel variants, we deep sequence most of the receptor binding domain coding sequence of the S protein of SARS-CoV-2 isolated from the New York City wastewater. Here we report detecting increasing frequencies of novel cryptic SARS-CoV-2 lineages not recognized in GISAID’s EpiCoV database. These lineages contain mutations that had been rarely observed in clinical samples, including Q493K, Q498Y, E484A, and T572N and share many mutations …
Probing The Production Of Intracellular Vesicles Containing Reactive Oxygen And Nitrogen Species By Electrochemical Resistive-Pulse Sensing, Rui Jia
Publications and Research
No abstract provided.
Rainbow Research: Challenges And Recommendations For Sexual Orientation And Gender Identity And Expression (Sogie) Survey Design, Seth J. Meyer, Nicole M. Elias
Rainbow Research: Challenges And Recommendations For Sexual Orientation And Gender Identity And Expression (Sogie) Survey Design, Seth J. Meyer, Nicole M. Elias
Publications and Research
A growing number of people around the world identify, in some way, as Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ+); yet, these voices are noticeably absent from nonprofit research. To address issues of equity and the historic marginalization of LGBTQ+ people both societally and in the nonprofit sector, this manuscript seeks to answer the following questions: Why is it important to include sexual orientation and gender identity and expression (SOGIE) survey questions in nonprofit surveys? What are best practices for including SOGIE survey questions in nonprofit research? We present LGBTQ+ inclusive research strategies and suggested questions for inclusive SOGIE survey …
Making The Case For Addressing Second-Generation Gender Bias In Public Administration, Helisse Levine, Maria J. D’Agostino, Meghna Sabharwal
Making The Case For Addressing Second-Generation Gender Bias In Public Administration, Helisse Levine, Maria J. D’Agostino, Meghna Sabharwal
Publications and Research
No abstract provided.
Promoting Stem Learning Through A Multidisciplinary Sencer Framework At A Minority-Serving Institution, Diana Samaroo, Sandie Han, Liana Tsenova, Urmi Ghosh-Dastidar
Promoting Stem Learning Through A Multidisciplinary Sencer Framework At A Minority-Serving Institution, Diana Samaroo, Sandie Han, Liana Tsenova, Urmi Ghosh-Dastidar
Publications and Research
The Prospect Park Biodiversity Project was a SENCER collaboration project between the Departments of Biological Sciences, Chemistry, and Mathematics at the New York City College of Technology. The goal of this project was to enhance students' participation and learning in STEM disciplines through a civically engaged framework. The project utilized the eco-complexity of Prospect Park Lake in Brooklyn, New York for an interdisciplinary study on the water quality. The project, which involved ten students and four faculty mentors, integrated microbiology, chemistry, and mathematics perspectives using active-learning pedagogies, including hands-on exploration and collaborative learning.
Long Covid And Medical Gaslighting: Dismissal, Delayed Diagnosis, And Deferred Treatment, Larry Au, Cristian Capotescu, Gil Eyal, Gabrielle Finestone
Long Covid And Medical Gaslighting: Dismissal, Delayed Diagnosis, And Deferred Treatment, Larry Au, Cristian Capotescu, Gil Eyal, Gabrielle Finestone
Publications and Research
While we know a lot more about Long Covid today, patients who were infected with Covid-19 early on in the pandemic and developed Long Covid had to contend with medical professionals who lacked awareness of the potential for extended complications from Covid-19. Long Covid patients have responded by labeling their contentious interactions with medical professionals, organizations, and the broader medical system as “gaslighting.” We argue that the charge of medical gaslighting can be understood as a form of ontological politics. Not only do patients demand that their version of reality be recognized, but they also blame the experts who hold …
Addressing Gender-Based Violence Using Evidence-Based Practices During Covid-19: The Case Of Puerto Rico, Ayorkor Gaba, Roseanne Flores, María Rebecca Ward, Bailey Pridgen
Addressing Gender-Based Violence Using Evidence-Based Practices During Covid-19: The Case Of Puerto Rico, Ayorkor Gaba, Roseanne Flores, María Rebecca Ward, Bailey Pridgen
Publications and Research
As gender-based violence (GBV) surged during the COVID-19 pandemic, the 65th session of the Commission on the Status of Women (CSW65) called for member states, civil, and other stakeholders to consider the specific needs of women and girls in COVID-19 response and recovery efforts. Psychology provides scientific knowledge to help answer this call. Despite existing global guidance and psychological research to mitigate GBV, COVID-19 presents new challenges for consideration. This article summarizes existing GBV guidance/research and COVID-19 considerations, uses an illustrative case study to describe Puerto Rico’s application of GBV guidance/research during COVID-19, and provides preliminary policy and practice recommendations.
High-Resolution Cryo-Electron Microscopy Structure Of Photosystem Ii From The Mesophilic Cyanobacterium, Synechocystis Sp. Pcc 6803, Christopher J. Gisriel, Jimin Wang, Jinchan Liu, David A. Flesher, Krystle M. Reiss, Hao-Li Huang, Ke R. Yang, William H. Armstrong, M. R. Gunner, Victor S. Batista, Richard J. Debus, Gary W. Brudvig
High-Resolution Cryo-Electron Microscopy Structure Of Photosystem Ii From The Mesophilic Cyanobacterium, Synechocystis Sp. Pcc 6803, Christopher J. Gisriel, Jimin Wang, Jinchan Liu, David A. Flesher, Krystle M. Reiss, Hao-Li Huang, Ke R. Yang, William H. Armstrong, M. R. Gunner, Victor S. Batista, Richard J. Debus, Gary W. Brudvig
Publications and Research
Photosystem II (PSII) enables global-scale, light-driven water oxidation. Genetic manipulation of PSII from the mesophilic cyanobacterium Synechocystis sp. PCC 6803 has provided insights into the mechanism of water oxidation; however, the lack of a highresolution structure of oxygen-evolving PSII from this organism has limited the interpretation of biophysical data to models based on structures of thermophilic cyanobacterial PSII. Here, we report the cryo-electron microscopy structure of PSII from Synechocystis sp. PCC 6803 at 1.93-Å resolution. A number of differences are observed relative to thermophilic PSII structures, including the following: the extrinsic subunit PsbQ is maintained, the C terminus of the …
Cryptococcus Neoformans Melanization Incorporates Multiple Catecholamines To Produce Polytypic Melanin, Rosanna P. Baker, Christine Chrissian, Ruth E. Stark, Arturo Casadevall
Cryptococcus Neoformans Melanization Incorporates Multiple Catecholamines To Produce Polytypic Melanin, Rosanna P. Baker, Christine Chrissian, Ruth E. Stark, Arturo Casadevall
Publications and Research
Melanin is a major virulence factor in pathogenic fungi that enhances the ability of fungal cells to resist immune clearance. Cryptococcus neoformans is an important human pathogenic fungus that synthesizes melanin from exogenous tissue catecholamine precursors during infection, but the type of melanin made in cryptococcal meningoencephalitis is unknown. We analyzed the efficacy of various catecholamines found in brain tissue in supporting melanization using animal brain tissue and synthetic catecholamine mixtures reflecting brain tissue proportions. Solid-state NMR spectra of the melanin pigment produced from such mixtures yielded more melanin than expected if only the preferred constituent dopamine had been incorporated, …
Relationships Between Dress And Gender Identity: Lgbtqia+, Alyssa Dana Adomaitis, Diana Saiki, Kim K. P. Johnson, Rafi Sahanoor, Arsha Attique
Relationships Between Dress And Gender Identity: Lgbtqia+, Alyssa Dana Adomaitis, Diana Saiki, Kim K. P. Johnson, Rafi Sahanoor, Arsha Attique
Publications and Research
No abstract provided.
College Majors And Unemployment Rates, Anna M. Gellerman, Harshita Ahuja
College Majors And Unemployment Rates, Anna M. Gellerman, Harshita Ahuja
Publications and Research
College undergraduates often face the question of whether their major and related job force have high unemployment rates. The perceived high unemployment rates of certain majors due to circulating misinformation presents a need for comprehensive research on college majors and their associated unemployment rate. This paper dives into a ten year trend of unemployment rates by college major, and state to state variabilities of majors and their rates.
Elevated Growth And Biomass Along Temperate Forest Edges, Luca L. Morreale, Jonathan R. Thompson, Xiaojing Tang, Andrew B. Reinmann, Lucy R. Hutyra
Elevated Growth And Biomass Along Temperate Forest Edges, Luca L. Morreale, Jonathan R. Thompson, Xiaojing Tang, Andrew B. Reinmann, Lucy R. Hutyra
Publications and Research
Fragmentation transforms the environment along forest edges. The prevailing narrative, driven by research in tropical systems, suggests that edge environments increase tree mortality and structural degradation resulting in net decreases in ecosystem productivity. We show that, in contrast to tropical systems, temperate forest edges exhibit increased forest growth and biomass with no change in total mortality relative to the forest interior. We analyze > 48,000 forest inventory plots across the north-eastern US using a quasi- experimental matching design. At forest edges adjacent to anthropogenic land covers, we report increases of 36.3% and 24.1% in forest growth and biomass, respectively. Inclusion of …
Closely Related Gull Species Show Contrasting Foraging Strategies In An Urban Environment, K. A. Lato, D. J. Madigan, R. R. Veit, L. H. Thorne
Closely Related Gull Species Show Contrasting Foraging Strategies In An Urban Environment, K. A. Lato, D. J. Madigan, R. R. Veit, L. H. Thorne
Publications and Research
The expansion of urban landscapes has both negative and positive effects on wildlife. Understanding how different species respond to urbanization is key to assessing how urban landscapes influence regional wildlife behavior and ecosystem structure. Gulls are often described as strong urban adapters, but few studies have explored species-specific differences in habitat use. Here, we use GPS tracking in conjunction with stable isotope analysis (SIA) to quantify the habitat use and trophic ecology of great black-backed gulls (Larus marinus) and herring gulls (L. argentatus) in an urbanized area. Non-Metric Multidimensional Scaling (NMDS) of foraging locations revealed significant differences in the habitat …
Inflammation, Fracture And Bone Repair: A Meta Analysis And Experiments In Model Fruit Matrix With Contrast Enhanced Ct, Guito Charles, Maleeha Sheikh
Inflammation, Fracture And Bone Repair: A Meta Analysis And Experiments In Model Fruit Matrix With Contrast Enhanced Ct, Guito Charles, Maleeha Sheikh
Publications and Research
The purpose of this research is to perform a meta-analysis on inflammation, fracture and bone repair mechanisms in the presence of surgical implants as practiced by tissue engineering and materials science today. Inflammation is the human body's natural response to an injury that activates the immune system and sends out inflammatory cells. The result is usually pain, swelling, bruising or redness. Inflammation also affects our body and often difficult to detect by routine diagnostic imaging. An X-ray exam, often followed by CT, can map the nature and extent of the fracture and help guide surgery for internal fixation of orthopedic …
Neutron Activation Analysis Of Heavy Elements In The Environment, Le Van La, Vishwas Joshi
Neutron Activation Analysis Of Heavy Elements In The Environment, Le Van La, Vishwas Joshi
Publications and Research
The main focus of the research is: application of neutron activation analysis (NAA) to determine concentration and distribution of heavy metals in environmental samples. Due to human activity and industrialization, heavy metal pollutants have been accumulating in the environment. The heavy metal elements (such as: mercury (Hg), cadmium (Cd), arsenic (As), chromium (Cr), thallium (Tl), and lead (Pb)) tend to be toxic and their presence in the environment is problematic for plant, animal, and human health. The Neutron activation analysis (NAA) is one of nuclear techniques that has many useful applications such as bio-monitoring, biological analysis, environmental research and materials …
Expanding The Conceptualization Of Support In Low-Wage Carework: The Case Of Home Care Aides And Client Death, Emma K. Tsui, Marita Lamonica, Maryam Hyder, Paul Landsbergis, Jennifer Zelnick, Sherry Baron
Expanding The Conceptualization Of Support In Low-Wage Carework: The Case Of Home Care Aides And Client Death, Emma K. Tsui, Marita Lamonica, Maryam Hyder, Paul Landsbergis, Jennifer Zelnick, Sherry Baron
Publications and Research
Home care aides are a rapidly growing, non-standard workforce who face numerous health risks and stressors on the job. While research shows that aides receive limited support from their agency employers, few studies have explored the wider range of support that aides use when navigating work stress and considered the implications of these arrangements. To investigate this question, we conducted 47 in-depth interviews with 29 home care aides in New York City, focused specifically on aides’ use of support after client death. Theories of work stress, the social ecological framework, and feminist theories of care informed our research. Our analysis …
Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie
Exploration Of Dark Chemical Genomics Space Via Portal Learning: Applied To Targeting The Undruggable Genome And Covid-19 Anti-Infective Polypharmacology, Tian Cai, Li Xie, Muge Chen, Yang Liu, Di He, Shuo Zhang, Cameron Mura, Philip Boume, Lei Xie
Publications and Research
Advances in biomedicine are largely fueled by exploring uncharted territories of human biology. Machine learning can both enable and accelerate discovery, but faces a fundamental hurdle when applied to unseen data with distributions that differ from previously observed ones—a common dilemma in scientific inquiry. We have developed a new deep learning framework, called Portal Learning , to explore dark chemical and biological space. Three key, novel components of our approach include: (i) end-to-end, step-wise transfer learning, in recognition of biology’s sequence-structure-function paradigm, (ii) out-of-cluster meta-learning, and (iii) stress model selection. Portal Learning provides a practical solution to the out-of-distribution (OOD) …
Genome-Scale Data Reveal Deep Lineage Divergence And A Complex Demographic History In The Texas Horned Lizard (Phrynosoma Cornutum) Throughout The Southwestern And Central Us, Nicholas Finger, Keaka Farleigh, Jason T. Bracken, Adam D. Leaché, Olivier François, Ziheng Yang, Tomas Flouri, Tristan Charran, Tereza Jezkova, Dean A. Williams, Christopher Blair
Genome-Scale Data Reveal Deep Lineage Divergence And A Complex Demographic History In The Texas Horned Lizard (Phrynosoma Cornutum) Throughout The Southwestern And Central Us, Nicholas Finger, Keaka Farleigh, Jason T. Bracken, Adam D. Leaché, Olivier François, Ziheng Yang, Tomas Flouri, Tristan Charran, Tereza Jezkova, Dean A. Williams, Christopher Blair
Publications and Research
The southwestern and central US serve as an ideal region to test alternative hypotheses regarding biotic diversification. Genomic data can now be combined with sophisticated computational models to quantify the impacts of paleoclimate change, geographic features, and habitat heterogeneity on spatial patterns of genetic diversity. In this study we combine thousands of genotyping-by-sequencing (GBS) loci with mtDNA sequences (ND1) from the Texas Horned Lizard (Phrynosoma cornutum) to quantify relative support for different catalysts of diversification. Phylogenetic and clustering analyses of the GBS data indicate support for at least three primary populations. The spatial distribution of populations appears concordant …
Phylogenomics Of Alligator Lizards Elucidate Diversification Patterns Across The Mexican Transition Zone And Support The Recognition Of A New Genus, Christopher Blair, Robert W. Bryson Jr, Uri O. García-Vázquez, Adrián Nieto-Montes De Oca, David Lazcano, John E. Mccormack, John Klicka
Phylogenomics Of Alligator Lizards Elucidate Diversification Patterns Across The Mexican Transition Zone And Support The Recognition Of A New Genus, Christopher Blair, Robert W. Bryson Jr, Uri O. García-Vázquez, Adrián Nieto-Montes De Oca, David Lazcano, John E. Mccormack, John Klicka
Publications and Research
Genomic data continue to advance our understanding of species limits and biogeographic patterns. However, there is still no consensus regarding appropriate methods of phylogenomic analysis that make the best use of these heterogeneous data sets. In this study, we used thousands of ultraconserved element (UCE) loci from alligator lizards in the genus Gerrhonotus to compare and contrast species trees inferred using multiple contemporary methods and provide a time frame for biological diversification across the Mexican Transition Zone (MTZ). Concatenated maximum likelihood (ML) and Bayesian analyses provided highly congruent results, with differences limited to poorly supported nodes. Similar topologies were inferred …
The Aesthetic Legacy Of Evolution: The History Of The Arts As A Window Into Human Nature, Aaron Kozbelt
The Aesthetic Legacy Of Evolution: The History Of The Arts As A Window Into Human Nature, Aaron Kozbelt
Publications and Research
No abstract provided.
A Full-Factorial Randomized Controlled Trial Of Adjunct Couples Hiv Testing And Counseling Components Addressing Drug Use And Communication Skills Among Sexual Minority Male Couples, Tyrel J. Starks, Kory D. Kyre, Christine B. Cowles, Juan Castiblanco, Catherine Washington, Jayelin N. Parker, Erin M. Kahle, Rob Stephenson
A Full-Factorial Randomized Controlled Trial Of Adjunct Couples Hiv Testing And Counseling Components Addressing Drug Use And Communication Skills Among Sexual Minority Male Couples, Tyrel J. Starks, Kory D. Kyre, Christine B. Cowles, Juan Castiblanco, Catherine Washington, Jayelin N. Parker, Erin M. Kahle, Rob Stephenson
Publications and Research
Background: The past decade has seen increasing attention directed to the development of HIV prevention interventions for male couples, driven by epidemiological data indicating that main or primary – rather than causal – partnerships account for a substantial number of HIV infections in this population. Couples HIV testing and counseling (CHTC) has emerged as a standard of care in the US. This protocol describes a study that aims to evaluate the efficacy of two adjunct components to CHTC – communication training (CT) videos and a substance use module (SUM) – to reduce drug use and sexual HIV transmission risk …
Competition And Geography Underlie Speciation And Morphological Evolution In Indo-Australasian Monitor Lizards, Carlos J. Pavón-Vázquez, Ian G. Brennan, Alexander Skeels, J. Scott Keogh
Competition And Geography Underlie Speciation And Morphological Evolution In Indo-Australasian Monitor Lizards, Carlos J. Pavón-Vázquez, Ian G. Brennan, Alexander Skeels, J. Scott Keogh
Publications and Research
How biotic and abiotic factors act together to shape biological diversity is a major question in evolutionary biology. The recent availability of large datasets and development of new methodological approaches provide new tools to evaluate the predicted effects of ecological interactions and geography on lineage diversification and phenotypic evolution. Here, we use a near complete phylogenomic-scale phylogeny and a comprehensive morphological dataset comprising more than a thousand specimens to assess the role of biotic and abiotic processes in the diversification of monitor lizards (Varanidae). This charismatic group of lizards shows striking variation in species richness among its clades and multiple …
Oligomerization Of Mutant P53 R273h Is Not Required For Gain-Of-Function Chromatin Associated Activities, George K. Annor, Nour Elshabassy, Devon Lundine, Don-Gerard Conde, Gu Xiao, Viola Ellison, Jill Bargonetti
Oligomerization Of Mutant P53 R273h Is Not Required For Gain-Of-Function Chromatin Associated Activities, George K. Annor, Nour Elshabassy, Devon Lundine, Don-Gerard Conde, Gu Xiao, Viola Ellison, Jill Bargonetti
Publications and Research
The TP53 gene is often mutated in cancer, with missense mutations found in the central DNA binding domain, and less often in the C-terminal oligomerization domain (OD). These types of mutations are found in patients with the rare inherited cancer predisposition disorder called Li-Fraumeni syndrome. We previously found that mutant p53 (mtp53) R273H associates with replicating DNA and promotes the chromatin association of replication-associated proteins mini-chromosome maintenance 2 (MCM2), and poly ADP-ribose polymerase 1(PARP1). Herein, we created dual mutants in order to test if the oligomerization state of mtp53 R273H played a role in chromatin binding oncogenic gain-of-function (GOF) activities. …