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Long-Distance Retinoid Signaling In The Zebra Finch Brain, Tina C. Roeske, Constance Scharff, Christopher R. Olson, Arpik Nshdejan, Claudio V. Mello
Long-Distance Retinoid Signaling In The Zebra Finch Brain, Tina C. Roeske, Constance Scharff, Christopher R. Olson, Arpik Nshdejan, Claudio V. Mello
Publications and Research
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays an important role in the maturation of learned song. The distribution of the ATRA-synthesizing enzyme, zRalDH, and of ATRA receptors (RARs) have been described, but information on the distribution of other components of the retinoid signaling pathway is still lacking. To address this gap, we have determined the expression patterns of two obligatory RAR co-receptors, the retinoid X receptors (RXR) …
Tcr Triggering By Pmhc Ligands Tethered On Surfaces Via Poly(Ethylene Glycol) Depends On Polymer Length, Zhengyu Ma, David N. Lebard, Sharon M. Loverde, Kim A. Sharp, Michael L. Klein, Dennis E. Discher, Terri H. Finkel
Tcr Triggering By Pmhc Ligands Tethered On Surfaces Via Poly(Ethylene Glycol) Depends On Polymer Length, Zhengyu Ma, David N. Lebard, Sharon M. Loverde, Kim A. Sharp, Michael L. Klein, Dennis E. Discher, Terri H. Finkel
Publications and Research
Antigen recognition by T cells relies on the interaction between T cell receptor (TCR) and peptide-major histocompatibility complex (pMHC) at the interface between the T cell and the antigen presenting cell (APC). The pMHC-TCR interaction is two-dimensional (2D), in that both the ligand and receptor are membrane-anchored and their movement is limited to 2D diffusion. The 2D nature of the interaction is critical for the ability of pMHC ligands to trigger TCR. The exact properties of the 2D pMHC-TCR interaction that enable TCR triggering, however, are not fully understood. Here, we altered the 2D pMHC-TCR interaction by tethering pMHC ligands …
Minerals In The Foods Eaten By Mountain Gorillas (Gorilla Beringei), Emma C. Cancelliere, Nicole Deangelis, John Bosco Nkurunungi, David R. Raubenheimer, Jessica M. Rothman
Minerals In The Foods Eaten By Mountain Gorillas (Gorilla Beringei), Emma C. Cancelliere, Nicole Deangelis, John Bosco Nkurunungi, David R. Raubenheimer, Jessica M. Rothman
Publications and Research
Minerals are critical to an individual’s health and fitness, and yet little is known about mineral nutrition and requirements in free-ranging primates. We estimated the mineral content of foods consumed by mountain gorillas (Gorilla beringei beringei) in the Bwindi Impenetrable National Park, Uganda. Mountain gorillas acquire the majority of their minerals from herbaceous leaves, which constitute the bulk of their diet. However, less commonly eaten foods were sometimes found to be higher in specific minerals, suggesting their potential importance. A principal component analysis demonstrated little correlation among minerals in food items, which further suggests that mountain gorillas might increase dietary …
Rationale, Design, And Method Of The Diabetes & Women’S Health Study – A Study Of Long-Term Health Implications Of Glucose Intolerance In Pregnancy And Their Determinants, Cuilin Zhang, Frank B. Hu, Sjurdur F. Olsen, Allan Vaag, Robert Gore-Langton, Jorge E. Chavarro, Wei Bao, Edwina Yeung, Katherine Bowers, Louise Groth Grunnet, Seth Sherman, Michele Kiely, Marin Strøm, Susanne Hansen, Aiyi Liu, James Mills, Ruzong Fan
Rationale, Design, And Method Of The Diabetes & Women’S Health Study – A Study Of Long-Term Health Implications Of Glucose Intolerance In Pregnancy And Their Determinants, Cuilin Zhang, Frank B. Hu, Sjurdur F. Olsen, Allan Vaag, Robert Gore-Langton, Jorge E. Chavarro, Wei Bao, Edwina Yeung, Katherine Bowers, Louise Groth Grunnet, Seth Sherman, Michele Kiely, Marin Strøm, Susanne Hansen, Aiyi Liu, James Mills, Ruzong Fan
Publications and Research
Women who develop gestational diabetes mellitus or impaired glucose tolerance during pregnancy are at substantially increased risk for type 2 diabetes and comorbidities after pregnancy. Little is known about the role of genetic factors and their interactions with environmental factors in determining the transition from gestational diabetes mellitus to overt type 2 diabetes mellitus. These critical data gaps served as the impetus for this Diabetes & Women’s Health study with the overall goal of investigating genetic factors and their interactions with risk factors amenable to clinical or public health interventions in relation to the transition of gestational diabetes mellitus to …
Music Education, Aesthetics, And The Measure Of Academic Achievement, Karl Madden, David Orenstein, Alexei Oulanov, Yelena Novitskaya, Ida Bazan, Thomas Ostrowski, Min Hyung Ahn
Music Education, Aesthetics, And The Measure Of Academic Achievement, Karl Madden, David Orenstein, Alexei Oulanov, Yelena Novitskaya, Ida Bazan, Thomas Ostrowski, Min Hyung Ahn
Publications and Research
Grades and test scores are the traditional measurement of academic achievement. Quantitative improvements on standardized scores in Math/Science/Language are highly-coveted outcomes for meeting accreditation standards required for institutional program funding. Music and the Fine Arts, difficult to assess by traditional academic achievement measurement, and often devalued as so-called “luxury” subjects, struggle for necessary funding. Showing measureable collateral value to other academic subjects—such as math—in order to justify music program funding is dubious. To objectify the purpose of music education in terms of its influence on other subjects is to overlook aesthetic value. The scholarly literature recognizes an historical tendency to …
Raw Milk, Raw Power: States Of (Mis)Trust, Diana Mincyte
Raw Milk, Raw Power: States Of (Mis)Trust, Diana Mincyte
Publications and Research
In recent years, raw milk has emerged as one of the most contentious food commodities, considered a serious health risk by public health officials and a source of healing and nourishment by raw milk proponents. The purpose of this article is to explore the ways in which consumers construct and experience trust in food that is often procured in informal markets. Because the image of an overreaching, exploitative government features prominently in popular narratives surrounding raw milk consumption, this article is explicitly concerned with the role of the state in public food debates. Drawing on two complementary empirical cases of …
Introduction: Critical Perspectives On Food Sovereignty, Marc Edelman, Tony Weis, Amita Baviskar, Saturnino M. Borras Jr., Eric Holt-Giménez, Deniz Kandiyoti, Wendy Wolford
Introduction: Critical Perspectives On Food Sovereignty, Marc Edelman, Tony Weis, Amita Baviskar, Saturnino M. Borras Jr., Eric Holt-Giménez, Deniz Kandiyoti, Wendy Wolford
Publications and Research
Visions of food sovereignty have been extremely important in helping to galvanize broad-based and diverse movements around the need for radical changes in agro-food systems. Yet while food sovereignty has thrived as a ‘dynamic process’, until recently there has been insufficient attention to many thorny questions, such as its origins, its connection to other food justice movements, its relation to rights discourses, the roles of markets and states and the challenges of implementation. This essay contributes to food sovereignty praxis by pushing the process of critical self- reflection forward and considering its relation to critical agrarian studies – and vice …
The Health Advantage Of A Vegan Diet: Exploring The Gut Microbiota Connection, Marian Glick-Bauer, Ming-Chin Yeh
The Health Advantage Of A Vegan Diet: Exploring The Gut Microbiota Connection, Marian Glick-Bauer, Ming-Chin Yeh
Publications and Research
This review examines whether there is evidence that a strict vegan diet confers health advantages beyond that of a vegetarian diet or overall healthy eating. Few studies include vegan subjects as a distinct experimental group, yet when vegan diets are directly compared to vegetarian and omnivorous diets, a pattern of protective health benefits emerges. The relatively recent inclusion of vegan diets in studies of gut microbiota and health allows us the opportunity to assess whether the vegan gut microbiota is distinct, and whether the health advantages characteristic of a vegan diet may be partially explained by the associated microbiota profile. …
Gestural And Symbolic Development Among Apes And Humans: Support For A Multimodal Theory Of Language Evolution, Kristen Gillespie-Lynch, Patricia M. Greenfield, Heidi Lyn, Sue Savage-Rumbaugh
Gestural And Symbolic Development Among Apes And Humans: Support For A Multimodal Theory Of Language Evolution, Kristen Gillespie-Lynch, Patricia M. Greenfield, Heidi Lyn, Sue Savage-Rumbaugh
Publications and Research
What are the implications of similarities and differences in the gestural and symbolic development of apes and humans?This focused review uses as a starting point our recent study that provided evidence that gesture supported the symbolic development of a chimpanzee, a bonobo, and a human child reared in language-enriched environments at comparable stages of communicative development. These three species constitute a complete clade, species possessing a common immediate ancestor. Communicative behaviors observed among all species in a clade are likely to have been present in the common ancestor. Similarities in the form and function of many gestures produced by the …
Toward A Quantitative Theory Of Food Consumption Choices And Body Weight, Sebastien Buttet, Veronika Dolar
Toward A Quantitative Theory Of Food Consumption Choices And Body Weight, Sebastien Buttet, Veronika Dolar
Publications and Research
We propose a calibrated dynamic model of food consumption choices and body weight to study changes in daily caloric intake, weight, and the away-from-home share of calories consumed by adult men and women in the U.S. during the period between 1971 and 2006. Calibration reveals substantial preference heterogeneity between men and women. For example, utility losses stemming from weight gains are ten times greater for women compared to men. Counterfactual experiments show that changes in food prices and household income account for half of the increase in weight of adult men, but only a small fraction of women’s weight. We …
Differential Expressions Of The Alternatively Spliced Variant Mrnas Of The Μ Opioid Receptor Gene, Oprm1, In Brain Regions Of Four Inbred Mouse Strains, Jin Xu, Zhigang Lu, Mingming Xu, Grace C. Rossi, Benjamin Kest, Amanda R. Waxman, Gavril W. Pasternak, Ying-Xian Pan
Differential Expressions Of The Alternatively Spliced Variant Mrnas Of The Μ Opioid Receptor Gene, Oprm1, In Brain Regions Of Four Inbred Mouse Strains, Jin Xu, Zhigang Lu, Mingming Xu, Grace C. Rossi, Benjamin Kest, Amanda R. Waxman, Gavril W. Pasternak, Ying-Xian Pan
Publications and Research
The µ opioid receptor gene, OPRM1, undergoes extensive alternative pre-mRNA splicing in rodents and humans, with dozens of alternatively spliced variants of the OPRM1 gene. The present studies establish a SYBR green quantitative PCR (qPCR) assay to more accurately quantify mouse OPRM1 splice variant mRNAs. Using these qPCR assays, we examined the expression of OPRM1 splice variant mRNAs in selected brain regions of four inbred mouse strains displaying differences in µ opioid-induced tolerance and physical dependence: C56BL/6J, 129P3/J, SJL/J and SWR/J. The complete mRNA expression profiles of the OPRM1 splice variants reveal marked differences of the variant mRNA expression among …
Revisiting The Vanishing Refuge Model Of Diversification, Robert Damasceno, Maria L. Strangas, Ana C. Carnaval, Miguel T. Rodrigues, Craig Moritz
Revisiting The Vanishing Refuge Model Of Diversification, Robert Damasceno, Maria L. Strangas, Ana C. Carnaval, Miguel T. Rodrigues, Craig Moritz
Publications and Research
Much of the debate around speciation and historical biogeography has focused on the role of stabilizing selection on the physiological (abiotic) niche, emphasizing how isolation and vicariance, when associated with niche conservatism, may drive tropical speciation. Yet, recent re-emphasis on the ecological dimensions of speciation points to a more prominent role of divergent selection in driving genetic, phenotypic, and niche divergence. The vanishing refuge model (VRM), first described by Vanzolini and Williams (1981), describes a process of diversification through climate-driven habitat fragmentation and exposure to new environments, integrating both vicariance and divergent selection. This model suggests that dynamic climates and …
Between-Domain Relations Of Students' Academic Emotions And Their Judgments Of School Domain Similarity, Thomas Goetz, Ludwig Haag, Anastasiya A. Lipnevich, Melanie M. Keller, Anne C. Frenzel, Antonie P. M. Collier
Between-Domain Relations Of Students' Academic Emotions And Their Judgments Of School Domain Similarity, Thomas Goetz, Ludwig Haag, Anastasiya A. Lipnevich, Melanie M. Keller, Anne C. Frenzel, Antonie P. M. Collier
Publications and Research
With the aim to deepen our understanding of the between-domain relations of academic emotions, a series of three studies was conducted. We theorized that between-domain relations of trait (i.e., habitual) emotions reflected students' judgments of domain similarities, whereas between-domain relations of state (i.e., momentary) emotions did not. This supposition was based on the accessibility model of emotional self-report, according to which individuals' beliefs tend to strongly impact trait, but not state emotions. The aim of Study 1 (interviews; N = 40; 8th and 11th graders) was to gather salient characteristics of academic domains from students' perspective. In Study 2 ( …
Focal Cortical Thickness Correlates Of Exceptional Memory Training In Vedic Priests, Giridhar P. Kalamangalam, Timothy M. Ellmore
Focal Cortical Thickness Correlates Of Exceptional Memory Training In Vedic Priests, Giridhar P. Kalamangalam, Timothy M. Ellmore
Publications and Research
The capacity for semantic memory—the ability to acquire and store knowledge of the world—is highly developed in the human brain. In particular, semantic memory assimilated through an auditory route may be a uniquely human capacity. One method of obtaining neurobiological insight into memory mechanisms is through the study of experts. In this work, we study a group of Hindu Vedic priests, whose religious training requires the memorization of vast tracts of scriptural texts through an oral tradition, recalled spontaneously during a lifetime of subsequent spiritual practice. We demonstrate focal increases of cortical thickness in regions of the left prefrontal lobe …
Sculpting The Umls Refined Semantic Network, Zhe He, C. Paul Morrey, Yehoshua Perl, Gai Elhanan, Ling Chen, Yan Chen, James Geller
Sculpting The Umls Refined Semantic Network, Zhe He, C. Paul Morrey, Yehoshua Perl, Gai Elhanan, Ling Chen, Yan Chen, James Geller
Publications and Research
Background The Refined Semantic Network (RSN) for the UMLS was previously introduced to complement the UMLS Semantic Network (SN). The RSN partitions the UMLS Metathesaurus (META) into disjoint groups of concepts. Each such group is semantically uniform. However, the RSN was initially an order of magnitude larger than the SN, which is undesirable since to be useful, a semantic network should be compact. Most semantic types in the RSN represent combinations of semantic types in the UMLS SN. Such a “combination semantic type” is called Intersection Semantic Type (IST). Many ISTs are assigned to very few concepts. Moreover, when reviewing …
On The Origin And Future Of Poetry: Notes Towards An Investigation, Carlos Aguasaco
On The Origin And Future Of Poetry: Notes Towards An Investigation, Carlos Aguasaco
Publications and Research
An exploration on the historical and material conditions that allowed the emergence of metaphors and poetry alongside language. This article analyzes the historical relation between poetry and technology across history. It discusses the so-called ontological crisis of poetry and opens the conversation on its future.
Can Establishment Success Be Determined Through Demographic Parameters? A Case Study On Five Introduced Bird Species, Ana Sanz-Aguilar, José D. Anadón, Pim Edelaar, Martina Carrete, José Luis Tella
Can Establishment Success Be Determined Through Demographic Parameters? A Case Study On Five Introduced Bird Species, Ana Sanz-Aguilar, José D. Anadón, Pim Edelaar, Martina Carrete, José Luis Tella
Publications and Research
The dominant criterion to determine when an introduced species is established relies on the maintenance of a self-sustaining population in the area of introduction, i.e. on the viability of the population from a demographic perspective. There is however a paucity of demographic studies on introduced species, and establishment success is thus generally determined by expert opinion without undertaking population viability analyses (PVAs). By means of an intensive five year capture-recapture monitoring program (involving >12,000 marked individuals) we studied the demography of five introduced passerine bird species in southern Spain which are established and have undergone a fast expansion over the …
Octopus Tetricus (Mollusca: Cephalopoda) As An Ecosystem Engineer, David Scheel, Peter Godfrey-Smith, Matthew Lawrence
Octopus Tetricus (Mollusca: Cephalopoda) As An Ecosystem Engineer, David Scheel, Peter Godfrey-Smith, Matthew Lawrence
Publications and Research
The Sydney octopus (Octopus tetricus) occurs in unusual numbers on a shell bed of its prey remains that have accumulated as an extended midden where additional octopuses excavate dens. Here, O tetricus are ecosystem engineers, organisms that modulate availability of resources to other species and to their own species by causing physical state changes in materials. A community of invertebrate grazers and scavengers has developed on the shell bed. Fishes are attracted to the shell bed in numbers significantly greater than in nearby habitats. Large predators, including wobbegong sharks, were attracted to and fed on concentrations of fish, inhibiting the …
Induced Expression Of Nucleolin Phosphorylation-Deficient Mutant Confers Dominant-Negative Effect On Cell Proliferation, Shu Xiao, Elif Caglar, Priscilla Maldonado, Dibash Das, Zaineb Nadeem, Angela Chi, Benjamin Trinité, Xin Li, Anjana Saxena
Induced Expression Of Nucleolin Phosphorylation-Deficient Mutant Confers Dominant-Negative Effect On Cell Proliferation, Shu Xiao, Elif Caglar, Priscilla Maldonado, Dibash Das, Zaineb Nadeem, Angela Chi, Benjamin Trinité, Xin Li, Anjana Saxena
Publications and Research
Nucleolin (NCL) is a major nucleolar phosphoprotein that has pleiotropic effects on cell proliferation and is elevated in a variety of tumors. NCL is highly phosphorylated at the N-terminus by two major kinases: interphase casein kinase 2 (CK2) and mitotic cyclin-dependent kinase 1 (CDK1). Earlier we demonstrated that a NCL-mutant that is partly defective in undergoing phosphorylation by CK2 inhibits chromosomal replication through its interactions with Replication Protein A, mimicking the cellular response to DNA damage. We further delineated that the N-terminus of NCL associates with Hdm2, the most common E3 ubiquitin ligase of p53. We reported that NCL antagonizes …
Family Of Flp Peptides In Caenorhabditis Elegans And Related Nematodes, Chris Li, Kyuhyung Kim
Family Of Flp Peptides In Caenorhabditis Elegans And Related Nematodes, Chris Li, Kyuhyung Kim
Publications and Research
Neuropeptides regulate all aspects of behavior in multicellular organisms. Because of their ability to act at long distances, neuropeptides can exert their effects beyond the conventional synaptic connections, thereby adding an intricate layer of complexity to the activity of neural networks. In the nematode Caenorhabditis elegans, a large number of neuropeptide genes that are expressed throughout the nervous system have been identified.The actions of these peptides supplement the synaptic connections of the 302 neurons, allowing for fine tuning of neural networks and increasing the ways in which behaviors can be regulated. In this review, we focus on a large …
Breast Cancer Incidence And Mortality In A Transitioning Chinese Population: Current And Future Trends, O. L. Wong, Mary Schooling, Benjamin J. Cowling, Gabriel M. Leung
Breast Cancer Incidence And Mortality In A Transitioning Chinese Population: Current And Future Trends, O. L. Wong, Mary Schooling, Benjamin J. Cowling, Gabriel M. Leung
Publications and Research
Background Projections of future trends in cancer incidence and mortality are important for public health planning. Methods By using 1976–2010 data in Hong Kong, we fitted Poisson age-period-cohort models and made projections for future breast cancer incidence and mortality to 2025. Results Age-standardised breast cancer incidence (/mortality) is projected to increase (/decline) from 56.7 (/9.3) in 2011–2015 to 62.5 (/8.6) per 100 000 women in 2021–2025. Conclusions The incidence pattern may relate to Hong Kong’s socio-economic developmental history, while falling mortality trends are, most likely, due to improvements in survival from treatment advancement and improved health service delivery.
Effects Of Extreme Climate Events On Tea (Camellia Sinensis) Functional Quality Validate Indigenous Farmer Knowledge And Sensory Preferences In Tropical China, Selena Ahmed, John Richard Stepp, Colin M. Orians, Timothy S. Griffin, Corene Matyas, Albert Robbat, Sean Cash, Dayuan Xue, Chunlin Long, Uchenna Unachukwu, Sarabeth Buckley, Edward J. Kennelly
Effects Of Extreme Climate Events On Tea (Camellia Sinensis) Functional Quality Validate Indigenous Farmer Knowledge And Sensory Preferences In Tropical China, Selena Ahmed, John Richard Stepp, Colin M. Orians, Timothy S. Griffin, Corene Matyas, Albert Robbat, Sean Cash, Dayuan Xue, Chunlin Long, Uchenna Unachukwu, Sarabeth Buckley, Edward J. Kennelly
Publications and Research
Climate change is impacting agro-ecosystems, crops, and farmer livelihoods in communities worldwide. While it is well understood that more frequent and intense climate events in many areas are resulting in a decline in crop yields, the impact on crop quality is less acknowledged, yet it is critical for food systems that benefit both farmers and consumers through high-quality products. This study examines tea (Camellia sinensis; Theaceae), the world’s most widely consumed beverage after water, as a study system to measure effects of seasonal precipitation variability on crop functional quality and associated farmer knowledge, preferences, and livelihoods. Sampling was conducted in …
Do We Speak The Same Language? A Study Of Faculty Perceptions Of Information Literacy, Jonathan Cope, Jesús E. Sanabria
Do We Speak The Same Language? A Study Of Faculty Perceptions Of Information Literacy, Jonathan Cope, Jesús E. Sanabria
Publications and Research
The authors analyze twenty in-depth interviews with faculty members about how they perceive information literacy (IL) to examine two key factors: how disciplinary background influences conceptions of IL among faculty members in academic departments and how the instructors’ perception of information literacy differs from that of professionals in library and information science. The investigators analyzed these interviews by utilizing a phenomenological method. The faculty members were interviewed at a four-year college, the College of Staten Island, and at a community college, the Bronx Community College, both part of the City University of New York.
Dynamics Of Alpha Control: Preparatory Suppression Of Posterior Alpha Oscillations By Frontal Modulators Revealed With Combined Eeg And Event-Related Optical Signal, Kyle E. Mathewson, Diane M. Beck, Tony Ro, Edward L. Maclin, Kathy A. Low, Monica Fabiani, Gabriele Gratton
Dynamics Of Alpha Control: Preparatory Suppression Of Posterior Alpha Oscillations By Frontal Modulators Revealed With Combined Eeg And Event-Related Optical Signal, Kyle E. Mathewson, Diane M. Beck, Tony Ro, Edward L. Maclin, Kathy A. Low, Monica Fabiani, Gabriele Gratton
Publications and Research
We investigated the dynamics of brain processes facilitating conscious experience of external stimuli. Previously, we proposed that alpha (8–12 Hz) oscillations, which fluctuate with both sustained and directed attention, represent a pulsed inhibition of ongoing sensory brain activity. Here we tested the prediction that inhibitory alpha oscillations in visual cortex are modulated by top–down signals from frontoparietal attention networks. We measured modulations in phase-coherent alpha oscillations from superficial frontal, parietal, and occipital cortices using the event-related optical signal (EROS), a measure of neuronal activity affording high spatiotemporal resolution, along with concurrently recorded EEG, while participants performed a visual target detection …
In What Senses Are Free Spirits Free?, Christa Davis Acampora
In What Senses Are Free Spirits Free?, Christa Davis Acampora
Publications and Research
My broadest claim in this article is, unsurprisingly, that there are multiple senses of freedom associated with the freedom of the free spirit. These include both positive and negative senses – that is, when describing how free spirits are free, Nietzsche sometimes characterizes this as freedom to do something, and sometimes as freedom from certain kinds of constraints. In this article, I do not aim to provide an exhaustive catalogue of the different senses invoked in Nietzsche’s ‘free spirit’ texts. Instead, I wish to highlight some particular senses, including some that are less frequently discussed in the scholarly literature and …
Human Sexuality As A Critical Subfield In Social Work, Emily Mccave, Benjamin C. Shepard, Virginia Ramseyer Winter
Human Sexuality As A Critical Subfield In Social Work, Emily Mccave, Benjamin C. Shepard, Virginia Ramseyer Winter
Publications and Research
Human sexuality is of vital importance to social work practitioners, educators, and scholars. Yet historically, the profession’s leadership around it has waxed and waned, impacting practice. This article discusses the importance of human sexuality as a critical subfield within social work. It suggests that the mechanisms, namely textbooks, journals, and national conferences, for stimulating human sexuality social work scholarship are limited. The authors assert that the taboo of human sexuality limits the advancement of a cohesive professional discourse and contributes to the continued oppression of marginalized populations. Recommendations for providing better support for those who study, teach, and practice in …
Analysis Of Candidate Genes Has Proposed The Role Of Y Chromosome In Human Prostate Cancer, Pegah Khosravi, Javad Zahiri, Vahid H. Gazestani, Samira Mirkhalaf, Mohammad Akbarzadeh, Mehdi Sadeghi, Bahram Goliaei
Analysis Of Candidate Genes Has Proposed The Role Of Y Chromosome In Human Prostate Cancer, Pegah Khosravi, Javad Zahiri, Vahid H. Gazestani, Samira Mirkhalaf, Mohammad Akbarzadeh, Mehdi Sadeghi, Bahram Goliaei
Publications and Research
Background: Prostate cancer, a serious genetic disease, has known as the first widespread cancer in men, but the molecular changes required for the cancer progression has not fully understood. Availability of high-throughput gene expression data has led to the development of various computational methods, for identification of the critical genes, have involved in the cancer. Methods: In this paper, we have shown the construction of co-expression networks, which have been using Y-chromosome genes, provided an alternative strategy for detecting of new candidate, might involve in prostate cancer. In our approach, we have constructed independent co-expression networks from normal and cancerous …
High Local Diversity Of Trypanosoma In A Common Bat Species, And Implications For The Biogeography And Taxonomy Of The T. Cruzi Clade, Veronika M. Cottontail, Elisabeth K. V. Kalko, Iain Cottontail, Nele Wellinghausen, Marco Tschapka, Susan L. Perkins, C. Miguel Pinto
High Local Diversity Of Trypanosoma In A Common Bat Species, And Implications For The Biogeography And Taxonomy Of The T. Cruzi Clade, Veronika M. Cottontail, Elisabeth K. V. Kalko, Iain Cottontail, Nele Wellinghausen, Marco Tschapka, Susan L. Perkins, C. Miguel Pinto
Publications and Research
The Trypanosoma cruzi clade is a group of parasites that comprises T. cruzi sensu lato and its closest relatives. Although several species have been confirmed phylogenetically to belong to this clade, it is uncertain how many more species can be expected to belong into this group. Here, we present the results of a survey of trypanosome parasites of the bat Artibeus jamaicensis from the Panama´ Canal Zone, an important seed disperser. Using a genealogical species delimitation approach, the Poisson tree processes (PTP), we tentatively identified five species of trypanosomes – all belonging to the T. cruzi clade. A small monophyletic …
Carboxymethylcellulose Hydrogels Support Central Nervous System-Derived Tumor-Cell Chemotactic Migration: Comparison With Conventional Extracellular Matrix Macromolecules, Tanya Singh, Chandrasekhar Kothapalli, Devika Varma, Steven B. Nicoll, Maribel Vazquez
Carboxymethylcellulose Hydrogels Support Central Nervous System-Derived Tumor-Cell Chemotactic Migration: Comparison With Conventional Extracellular Matrix Macromolecules, Tanya Singh, Chandrasekhar Kothapalli, Devika Varma, Steven B. Nicoll, Maribel Vazquez
Publications and Research
The local microenvironment plays an important role in maintaining the dynamics of the extracellular matrix and the cell-extracellular matrix relationship. The extracellular matrix is a complex network of macromolecules with distinct mechanical and biochemical characteristics. Disruptions in extracellular matrix homeostasis are associated with the onset of cancer. The extracellular matrix becomes highly disorganized, and the cell-matrix relationship changes, resulting in altered cell-signaling processes and metastasis. Medulloblastoma is one of the most common malignant pediatric brain tumors in the United States. In order to gain a better understanding of the interplay between cell-extracellular matrix interactions and cell-migratory responses in tumors, eight …
Carbon Losses From Pyrolysed And Original Wood In A Forest Soil Under Natural And Increased N Deposition, B. Maestrini, S. Abiven, N. Singh, J. Bird, M. W. I. Schmidt
Carbon Losses From Pyrolysed And Original Wood In A Forest Soil Under Natural And Increased N Deposition, B. Maestrini, S. Abiven, N. Singh, J. Bird, M. W. I. Schmidt
Publications and Research
Pyrogenic organic matter (PyOM) plays an important role as a stable carbon (C) sink in the soils of terrestrial ecosystems. However, uncertainties remain about in situ turnover rates of fire-derived PyOM in soil, the main processes leading to PyOM-C and nitrogen (N) losses from the soil, and the role of N availability on PyOM cycling in soils. We measured PyOM and native soil organic carbon losses from the soil as carbon dioxide and dissolved organic carbon (DOC) using additions of highly 13C-labelled PyOM (2.03 atom %) and its precursor pinewood during 1 year in a temperate forest soil. The field …