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Full-Text Articles in Entire DC Network
Improving Mycobacterium Bovis Bacillus Calmette-Guèrin As A Vaccine Delivery Vector For Viral Antigens By Incorporation Of Glycolipid Activators Of Nkt Cells, Manjunatha M. Venkataswamy, Tony W. Ng, Shalu S. Kharkwal, Leandro J. Carreño, Alison J. Johnson, Shajo Kunnath-Velayudhan, Zheng Liu, Robert Bittman, Peter J. Jervis, Liam R. Cox, Gurdyal S. Besra, Xiangshu Wen, Weiming Yuan, Moriya Tsuji, Xiangming Li, David D. Ho, John Chan, Sunhee Lee, Richard Frothingham, Barton F. Haynes
Improving Mycobacterium Bovis Bacillus Calmette-Guèrin As A Vaccine Delivery Vector For Viral Antigens By Incorporation Of Glycolipid Activators Of Nkt Cells, Manjunatha M. Venkataswamy, Tony W. Ng, Shalu S. Kharkwal, Leandro J. Carreño, Alison J. Johnson, Shajo Kunnath-Velayudhan, Zheng Liu, Robert Bittman, Peter J. Jervis, Liam R. Cox, Gurdyal S. Besra, Xiangshu Wen, Weiming Yuan, Moriya Tsuji, Xiangming Li, David D. Ho, John Chan, Sunhee Lee, Richard Frothingham, Barton F. Haynes
Publications and Research
Recombinant Mycobacterium bovis bacillus Calmette-Guèrin (rBCG) has been explored as a vector for vaccines against HIV because of its ability to induce long lasting humoral and cell mediated immune responses. To maximize the potential for rBCG vaccines to induce effective immunity against HIV, various strategies are being employed to improve its ability to prime CD8+ T cells, which play an important role in the control of HIV infections. In this study we adopted a previously described approach of incorporating glycolipids that activate CD1d-restricted natural killer T (NKT) cells to enhance priming of CD8+ T cells by rBCG strains expressing an …
Angiopoietin-1, Angiopoietin-2 And Bicarbonate As Diagnostic Biomarkers In Children With Severe Sepsis, Kun Wang, Vineet Bhandari, John S. Giuliano, Corey S. O′Hern, Mark D. Shattuck, Michael Kirby
Angiopoietin-1, Angiopoietin-2 And Bicarbonate As Diagnostic Biomarkers In Children With Severe Sepsis, Kun Wang, Vineet Bhandari, John S. Giuliano, Corey S. O′Hern, Mark D. Shattuck, Michael Kirby
Publications and Research
Severe pediatric sepsis continues to be associated with high mortality rates in children. Thus, an important area of biomedical research is to identify biomarkers that can classify sepsis severity and outcomes. The complex and heterogeneous nature of sepsis makes the prospect of the classification of sepsis severity using a single biomarker less likely. Instead, we employ machine learning techniques to validate the use of a multiple biomarkers scoring system to determine the severity of sepsis in critically ill children. The study was based on clinical data and plasma samples provided by a tertiary care center's Pediatric Intensive Care Unit (PICU) …
Hemispheric Asymmetry In New Neurons In Adulthood Is Associated With Vocal Learning And Auditory Memory, Shuk C. Tsoi, Utsav V. Aiya, Kobi D. Wasner, Mimi L. Phan, Carolyn L. Pytte, David S. Vicario
Hemispheric Asymmetry In New Neurons In Adulthood Is Associated With Vocal Learning And Auditory Memory, Shuk C. Tsoi, Utsav V. Aiya, Kobi D. Wasner, Mimi L. Phan, Carolyn L. Pytte, David S. Vicario
Publications and Research
Many brain regions exhibit lateral differences in structure and function, and also incorporate new neurons in adulthood, thought to function in learning and in the formation of new memories. However, the contribution of new neurons to hemispheric differences in processing is unknown. The present study combines cellular, behavioral, and physiological methods to address whether 1) new neuron incorporation differs between the brain hemispheres, and 2) the degree to which hemispheric lateralization of new neurons correlates with behavioral and physiological measures of learning and memory. The songbird provides a model system for assessing the contribution of new neurons to hemispheric specialization …
Dynamically-Expressed Prion-Like Proteins Form A Cuticle In The Pharynx Of Caenorhabditis Elegans, Julia B. George-Raizen, Keith R. Shockley, Nicholas F. Trojanowski, Annesia L. Lamb, David M. Raizen
Dynamically-Expressed Prion-Like Proteins Form A Cuticle In The Pharynx Of Caenorhabditis Elegans, Julia B. George-Raizen, Keith R. Shockley, Nicholas F. Trojanowski, Annesia L. Lamb, David M. Raizen
Publications and Research
In molting animals, a cuticular extracellular matrix forms the first barrier to infection and other environmental insults. In the nematode Caenorhabditis elegans there are two types of cuticle: a wellstudied collagenous cuticle lines the body, and a poorly-understood chitinous cuticle lines the pharynx. In the posterior end of the pharynx is the grinder, a tooth-like cuticular specialization that crushes food prior to transport to the intestine for digestion. We here show that the grinder increases in size only during the molt. To gain molecular insight into the structure of the grinder and pharyngeal cuticle, we performed a microarray analysis to …
Quantification Of Transient Increase Of The Blood–Brain Barrier Permeability To Macromolecules By Optimized Focused Ultrasound Combined With Microbubbles, Lingyan Shi, Paolo Palacio-Mancheno, Joseph Badami, Da Wi Shin, Min Zeng, Luis Cardoso, Raymond Tu, Bingmei M. Fu
Quantification Of Transient Increase Of The Blood–Brain Barrier Permeability To Macromolecules By Optimized Focused Ultrasound Combined With Microbubbles, Lingyan Shi, Paolo Palacio-Mancheno, Joseph Badami, Da Wi Shin, Min Zeng, Luis Cardoso, Raymond Tu, Bingmei M. Fu
Publications and Research
Radioimmunotherapy using a radiolabeled monoclonal antibody that targets tumor cells has been shown to be efficient for the treatment of many malignant cancers, with reduced side effects. However, the blood–brain barrier (BBB) inhibits the transport of intravenous antibodies to tumors in the brain. Recent studies have demonstrated that focused ultrasound (FUS) combined with microbubbles (MBs) is a promising method to transiently disrupt the BBB for the drug delivery to the central nervous system. To find the optimal FUS and MBs that can induce reversible increase in the BBB permeability, we employed minimally invasive multiphoton microscopy to quantify the BBB permeability …
Nesting Behaviour Influences Species-Specific Gas Exchange Across Avian Eggshells, Steven J. Portugal, Golo Maurer, Gavin H. Thomas, Mark E. Hauber, Tomáš Grim, Phillip Cassey
Nesting Behaviour Influences Species-Specific Gas Exchange Across Avian Eggshells, Steven J. Portugal, Golo Maurer, Gavin H. Thomas, Mark E. Hauber, Tomáš Grim, Phillip Cassey
Publications and Research
Carefully controlled gas exchange across the eggshell is essential for the development of the avian embryo. Water vapour conductance (GH2O) across the shell, typically measured as mass loss during incubation, has been demonstrated to optimally ensure the healthy development of the embryo while avoiding desiccation. Accordingly, eggs exposed to sub-optimal gas exchange have reduced hatching success. We tested the association between eggshell GH2O and putative life-history correlates of adult birds, ecological nest parameters and physical characteristics of the egg itself to investigate how variation in GH2O has evolved to maintain optimal water loss across a diverse set of nest environments. …
Detecting Concerted Demographic Response Across Community Assemblages Using Hierarchical Approximate Bayesian Computation, Yvonne L. Chan, David Schanzenbach, Michael J. Hickerson
Detecting Concerted Demographic Response Across Community Assemblages Using Hierarchical Approximate Bayesian Computation, Yvonne L. Chan, David Schanzenbach, Michael J. Hickerson
Publications and Research
Methods that integrate population-level sampling from multiple taxa into a single community-level analysis are an essential addition to the comparative phylogeographic toolkit. Detecting how species within communities have demographically tracked each other in space and time is important for understanding the effects of future climate and landscape changes and the resulting acceleration of extinctions, biological invasions, and potential surges in adaptive evolution. Here, we present a statistical framework for such an analysis based on hierarchical approximate Bayesian computation (hABC) with the goal of detecting concerted demographic histories across an ecological assemblage. Our method combines population genetic data sets from multiple …
Translational Regulation Of The Doubletime/Ckiδ/Ε Kinase By Lark Contributes To Circadian Period Modulation, Yanmei Huang, Gerard P. Mcneil, F. Rob Jackson
Translational Regulation Of The Doubletime/Ckiδ/Ε Kinase By Lark Contributes To Circadian Period Modulation, Yanmei Huang, Gerard P. Mcneil, F. Rob Jackson
Publications and Research
The Drosophila homolog of Casein Kinase I δ/ε, DOUBLETIME (DBT), is required for Wnt, Hedgehog, Fat and Hippo signaling as well as circadian clock function. Extensive studies have established a critical role of DBT in circadian period determination. However, how DBT expression is regulated remains largely unexplored. In this study, we show that translation of dbt transcripts are directly regulated by a rhythmic RNA-binding protein (RBP) called LARK (known as RBM4 in mammals). LARK promotes translation of specific alternative dbt transcripts in clock cells, in particular the dbt-RC transcript. Translation of dbt-RC exhibits circadian changes under free-running conditions, indicative of …
Acid-Base Properties Of The Adsorption Of Synthetic Dyes From Solutions, Rada-Mayya Kostadinova, Gabriela Sikorska, Michelle Naidoo, Abel E. Navarro
Acid-Base Properties Of The Adsorption Of Synthetic Dyes From Solutions, Rada-Mayya Kostadinova, Gabriela Sikorska, Michelle Naidoo, Abel E. Navarro
Publications and Research
The presence of synthetic dyes is often underestimated in environmental protection. However, it has been demonstrated the impact of colored compounds in ecology and human health. Green tea (GT) and peppermint (PM) tea bag wastes were used as potential adsorbents of dyes from aqueous solutions to evaluate the effect of pH on the adsorption. Basic yellow 57, basic blue 99 and crystal violet were chosen as model dyes due to their widespread use in the industry. Dye solutions at different pH values were placed in contact with the adsorbents in batch experiments at room temperature. Results indicate that crystal violet …
Dog Movie Stars And Dog Breed Popularity: A Case Study In Media Influence On Choice, Stefano Ghirlanda, Alberto Acerbi, Harold Herzog
Dog Movie Stars And Dog Breed Popularity: A Case Study In Media Influence On Choice, Stefano Ghirlanda, Alberto Acerbi, Harold Herzog
Publications and Research
Fashions and fads are important phenomena that influence many individual choices. They are ubiquitous in human societies, and have recently been used as a source of data to test models of cultural dynamics. Although a few statistical regularities have been observed in fashion cycles, their empirical characterization is still incomplete. Here we consider the impact of mass media on popular culture, showing that the release of movies featuring dogs is often associated with an increase in the popularity of featured breeds, for up to 10 years after movie release. We also find that a movie's impact on breed popularity correlates …
Assessment Of The Effect Of Sphingosine Kinase Inhibitors On Apoptosis,Unfolded Protein Response And Autophagy Of T-Cell Acute Lymphoblastic Leukemia Cells; Indications For Novel Therapeutics, Cecilia Evangelisti, Camilla Evangelisti, Gabriella Teti, Francesca Chiarini, Mirella Falconi, Fraia Melchionda, Andrea Pession, Alice Bertaina, Franco Locatelli, James A. Mccubrey, Dong Jae Beak, Robert Bittman, Susan Pyne, Nigel J. Pyne, Alberto M. Martelli
Assessment Of The Effect Of Sphingosine Kinase Inhibitors On Apoptosis,Unfolded Protein Response And Autophagy Of T-Cell Acute Lymphoblastic Leukemia Cells; Indications For Novel Therapeutics, Cecilia Evangelisti, Camilla Evangelisti, Gabriella Teti, Francesca Chiarini, Mirella Falconi, Fraia Melchionda, Andrea Pession, Alice Bertaina, Franco Locatelli, James A. Mccubrey, Dong Jae Beak, Robert Bittman, Susan Pyne, Nigel J. Pyne, Alberto M. Martelli
Publications and Research
Sphingosine 1-phosphate (S1P) is a bioactive lipid that is formed by the phosphorylation of sphingosine and catalysed by sphingosine kinase 1 (SK1) or sphingosine kinase 2 (SK2). Sphingosine kinases play a fundamental role in many signaling pathways associated with cancer, suggesting that proteins belonging to this signaling network represent potential therapeutic targets. Over the last years, many improvements have been made in the treatment of T-cell acute lymphoblastic leukemia (T-ALL); however, novel and less toxic therapies are still needed, especially for relapsing and chemo-resistant patients. Here, we analyzed the therapeutic potential of SKi and ROMe, a sphingosine kinase 1 and …
Use Of Caenorhabditis Elegans As A Model To Study Alzheimer’S Disease And Other Neurodegenerative Diseases, Adanna G. Alexander, Vanessa Marfil, Chris Li
Use Of Caenorhabditis Elegans As A Model To Study Alzheimer’S Disease And Other Neurodegenerative Diseases, Adanna G. Alexander, Vanessa Marfil, Chris Li
Publications and Research
Advances in research and technology has increased our quality of life, allowed us to combat diseases, and achieve increased longevity. Unfortunately, increased longevity is accompanied by a rise in the incidences of age-related diseases such as Alzheimer’s disease (AD). AD is the sixth leading cause of death, and one of the leading causes of dementia amongst the aged population in the USA. It is a progressive neurodegenerative disorder, characterized by the prevalence of extracellular Aβ plaques and intracellular neurofibrillary tangles, derived from the proteolysis of the amyloid precursor protein (APP) and the hyperphosphorylation of microtubule-associated protein tau, respectively. Despite years …
Histone Methyltransferase Mmset/Nsd2 Alters Ezh2 Binding And Reprograms The Myeloma Epigenome Through Global And Focal Changes In H3k36 And H3k27 Methylation, Relja Popovic, Eva Martinez-Garcia, Eugenia G. Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y. Shah, Yupeng Zheng, Christine M. Will, Eliza C. Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A. Calogero, William L. Kath, Neil L. Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D. Licht
Histone Methyltransferase Mmset/Nsd2 Alters Ezh2 Binding And Reprograms The Myeloma Epigenome Through Global And Focal Changes In H3k36 And H3k27 Methylation, Relja Popovic, Eva Martinez-Garcia, Eugenia G. Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y. Shah, Yupeng Zheng, Christine M. Will, Eliza C. Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A. Calogero, William L. Kath, Neil L. Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D. Licht
Publications and Research
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and its overexpression causes a global increase in H3K36me2, redistributing this mark in a broad, elevated level across the genome. Here, we demonstrate that an increased level of MMSET also induces a global reduction of lysine 27 trimethylation on histone H3 (H3K27me3). Despite the net decrease in H3K27 methylation, specific genomic loci exhibit enhanced recruitment of the EZH2 histone methyltransferase and become hypermethylated on …
Long-Term Cre-Mediated Retrograde Tagging Of Neurons Using A Novel Recombinant Pseudorabies Virus, Hysell V. Oviedo, Hassasna K. Oyibo, Petr Znamenskiy, Lynn W. Enquist, Anthony M. Zador
Long-Term Cre-Mediated Retrograde Tagging Of Neurons Using A Novel Recombinant Pseudorabies Virus, Hysell V. Oviedo, Hassasna K. Oyibo, Petr Znamenskiy, Lynn W. Enquist, Anthony M. Zador
Publications and Research
Brain regions contain diverse populations of neurons that project to different long-range targets. The study of these subpopulations in circuit function and behavior requires a toolkit to characterize and manipulate their activity in vivo. We have developed a novel set of reagents based on Pseudorabies Virus (PRV) for efficient and long-term genetic tagging of neurons based on their projection targets. By deleting IE180, the master transcriptional regulator in the PRV genome, we have produced a mutant virus capable of infection and transgene expression in neurons but unable to replicate in or spread from those neurons. IE180-null mutants showed no cytotoxicity, …
Statistical Signs Of Social Influence On Suicides, Hygor Piaget M. Melo, André A. Moreira, Élcio Batista, Hernán A. Makse, José S. Andrade
Statistical Signs Of Social Influence On Suicides, Hygor Piaget M. Melo, André A. Moreira, Élcio Batista, Hernán A. Makse, José S. Andrade
Publications and Research
By treating the suicide as a social fact, Durkheim envisaged that suicide rates should be determined by the connections between people and society. Under the same framework, he considered that crime is bound up with the fundamental conditions of all social life. The social effect on the occurrence of homicides has been previously substantiated, and confirmed here, in terms of a superlinear scaling relation: by doubling the population of a Brazilian city results in an average increment of 135% in the number of homicides, rather than the expected isometric increase of 100%, as found, for example, for the mortality due …
The Longitudinal Effect Of Drug Use On Productivity Status Of Nonmetropolitan African American Young Adults, María Isabel Roldós
The Longitudinal Effect Of Drug Use On Productivity Status Of Nonmetropolitan African American Young Adults, María Isabel Roldós
Publications and Research
The purpose of this study was to investigate the longitudinal effect of marijuana and heavy alcohol use on the productivity status of nonmetropolitan African American young adults. This analysis was based on secondary data from the Family and Community Health Study. For alcohol, the study evaluated the effects on productivity status for individuals with heavy alcohol use trajectories from adolescence into young adulthood while marijuana effects were evaluated during the period when adolescents are more likely to have initiated usage (14-16 years of age). Productivity status was measured when study participants were between 18 and 21 years, for both alcohol …
Student Reading Practices In Print And Electronic Media, Nancy M. Foasberg
Student Reading Practices In Print And Electronic Media, Nancy M. Foasberg
Publications and Research
This paper reports a diary-based qualitative study on college students’ reading habits with regard to print and electronic media. Students used a form to record information about their reading practices for twelve days, including length of reading event, location, format used, and the purpose of reading. Students tended to use print for academic and long-form reading and to engage with it more deeply. Although electronic resources were sometimes used for academic purposes, students often used them for shorter and nonacademic reading. Students found electronic media convenient, but most of them did not wish to switch to electronic media for their …
Info-Graphic Of The Hall Of Fame For Great Americans, Julia Pollack
Info-Graphic Of The Hall Of Fame For Great Americans, Julia Pollack
Publications and Research
What do we know about the Hall of Fame for Great Americans? This graphic is intended to show some comparative information about the Hall of Fame inductees. One of the most frequent questions raised about the Hall of Fame is about who was allowed to be inducted? There is extensive documentation about the voting process involved in the Hall of Fame. There were national calls for Hall of Fame candidates, and the a body of Hall of Fame delegates voted on who of these candidates should be chosen. Much attention was paid to making sure the delegates represented all the …
Enzymatic Oxidation Of Cholesterol: Properties And Functional Effects Of Cholestenone In Cell Membranes, Maarit Neuvonen, Moutusi Manna, Sini Mokkila, Matti Javanainen, Tomasz Rog, Zheng Liu, Robert Bittman, Ilpo Vattulainen, Elina Ikonen
Enzymatic Oxidation Of Cholesterol: Properties And Functional Effects Of Cholestenone In Cell Membranes, Maarit Neuvonen, Moutusi Manna, Sini Mokkila, Matti Javanainen, Tomasz Rog, Zheng Liu, Robert Bittman, Ilpo Vattulainen, Elina Ikonen
Publications and Research
Bacterial cholesterol oxidase is commonly used as an experimental tool to reduce cellular cholesterol content. That the treatment also generates the poorly degradable metabolite 4-cholesten-3-one (cholestenone) has received less attention. Here, we investigated the membrane partitioning of cholestenone using simulations and cell biological experiments and assessed the functional effects of cholestenone in human cells. Atomistic simulations predicted that cholestenone reduces membrane order, undergoes faster flip-flop and desorbs more readily from membranes than cholesterol. In primary human fibroblasts, cholestenone was released from membranes to physiological extracellular acceptors more avidly than cholesterol, but without acceptors it remained in cells over a day. …
Elevated Carbon Dioxide And Ozone Alter Productivity And Ecosystem Carbon Content In Northern Temperate Forests, Alan F. Talhelm, Kurt S. Pregitzer, Mark E. Kubiske, Donald R. Zak, Courtney E. Campany, Andrew J. Burton, Richard E. Dickson, George R. Hendrey, J G. Isebrands, Keith F. Lewin, John Nagy, David F. Karnosky
Elevated Carbon Dioxide And Ozone Alter Productivity And Ecosystem Carbon Content In Northern Temperate Forests, Alan F. Talhelm, Kurt S. Pregitzer, Mark E. Kubiske, Donald R. Zak, Courtney E. Campany, Andrew J. Burton, Richard E. Dickson, George R. Hendrey, J G. Isebrands, Keith F. Lewin, John Nagy, David F. Karnosky
Publications and Research
Three young northern temperate forest communities in the north-central United States were exposed to factorial combinations of elevated carbon dioxide (CO2) and tropospheric ozone (O3) for 11 years. Here, we report results from an extensive sampling of plant biomass and soil conducted at the conclusion of the experiment that enabled us to estimate ecosystem carbon (C) content and cumulative net primary productivity (NPP). Elevated CO2 enhanced ecosystem C content by 11%, whereas elevated O3 decreased ecosystem C content by 9%. There was little variation in treatment effects on C content across communities and no meaningful interactions between CO2 and O3. …
Genetic Markers For Sex Identification In Forensic Dna Analysis, Erin Butler, Richard Li
Genetic Markers For Sex Identification In Forensic Dna Analysis, Erin Butler, Richard Li
Publications and Research
The ability to determine the sex of an individual based on DNA evidence can be crucial in instances such as identification of victims of mass disaster, missing persons investigations, and sexual assault cases. The Y chromosome marker amelogenin is currently in widespread use for determination of chromosomal sex of an unknown DNA donor and differentiating the relative contributions of male and female DNA in a mixed forensic sample. However, many cases of the failure of the amelogenin marker to correctly determine the sex of DNA donors have been reported, causing the usefulness of the amelogenin marker in forensics to be …
Peak Electric Load Relief In Northern Manhattan: An Exploratory Data Analysis, Hildegaard D. Link, José Pillich, Yehuda L. Klein
Peak Electric Load Relief In Northern Manhattan: An Exploratory Data Analysis, Hildegaard D. Link, José Pillich, Yehuda L. Klein
Publications and Research
The aphorism “Think globally, act locally,” attributed to René Dubos, reflects the vision that the solution to global environmental problems must begin with efforts within our communities. PlaNYC 2030, the New York City sustainability plan, is the starting point for this study. Results include (a) a case study based on the City College of New York (CCNY) energy audit, in which we model the impacts of green roofs on campus energy demand and (b) a case study of energy use at the neighborhood scale. We find that reducing the urban heat island effect can reduce building cooling requirements, peak electricity …
The Debt Penalty: Exposing The Financial Barriers To Offender Reintegration, Douglas N. Evans
The Debt Penalty: Exposing The Financial Barriers To Offender Reintegration, Douglas N. Evans
Publications and Research
Financial debt associated with legal system involvement is a pressing issue that affects the criminal justice system, offenders, and taxpayers. Mere contact with the criminal justice system often results in fees and fines that increase with progression through the system. Criminal justice fines and fees punish offenders and are designed to generate revenue for legal systems operating on limited budgets. However, fines and fees often fail to accomplish this second goal because many offenders are too poor to pay them. If they do not pay their financial obligations, they may be subject to late fees and interest requirements, all of …
Facile Synthesis Of 1-Alkoxy-1h-Benzo- And 7-Azabenzotriazoles From Peptide Coupling Agents, Mechanistic Studies, And Synthetic Applications, Mahesh K. Lakshman, Manish K. Singh, Mukesh Kumar, Raghu Ram Chamala, Vijayender R. Yedulla, Domenick Wagner, Evan Leung, Lijia Yang, Asha Matin, Sadia Ahmad
Facile Synthesis Of 1-Alkoxy-1h-Benzo- And 7-Azabenzotriazoles From Peptide Coupling Agents, Mechanistic Studies, And Synthetic Applications, Mahesh K. Lakshman, Manish K. Singh, Mukesh Kumar, Raghu Ram Chamala, Vijayender R. Yedulla, Domenick Wagner, Evan Leung, Lijia Yang, Asha Matin, Sadia Ahmad
Publications and Research
(1H-Benzo[d][1,2,3]triazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP), 1H-benzo[d][1,2,3]triazol-1-yl 4-methylbenzenesulfonate (Bt-OTs), and 3H-[1,2,3]triazolo[4,5-b]pyridine-3-yl 4-methylbenzenesulfonate (At-OTs) are classically utilized in peptide synthesis for amide-bond formation. However, a previously undescribed reaction of these compounds with alcohols in the presence of a base, leads to 1-alkoxy-1H-benzo- (Bt-OR) and 7-azabenzotriazoles (At-OR). Although BOP undergoes reactions with alcohols to furnish 1-alkoxy-1H-benzotriazoles, Bt-OTs proved to be superior. Both, primary and secondary alcohols undergo reaction under generally mild reaction conditions. Correspondingly, 1-alkoxy-1H-7-azabenzotriazoles were synthesized from At-OTs. Mechanistically, there are three pathways by which these peptide-coupling agents can react with alcohols. From 31P{1H}, [18O]-labeling, and other chemical experiments, phosphonium and tosylate derivatives of …
Systems Biology Of Cancer: A Challenging Expedition For Clinical And Quantitative Biologists, Ilya Korsunsky, Kathleen Mcgovern, Tom Lagatta, Loes Olde Loohuis, Terri Grosso-Applewhite, Nancy Griffeth, Bud Mishra
Systems Biology Of Cancer: A Challenging Expedition For Clinical And Quantitative Biologists, Ilya Korsunsky, Kathleen Mcgovern, Tom Lagatta, Loes Olde Loohuis, Terri Grosso-Applewhite, Nancy Griffeth, Bud Mishra
Publications and Research
A systems-biology approach to complex disease (such as cancer) is now complementing traditional experience-based approaches, which have typically been invasive and expensive. The rapid progress in biomedical knowledge is enabling the targeting of disease with therapies that are precise, proactive, preventive, and personalized. In this paper, we summarize and classify models of systems biology and model checking tools, which have been used to great success in computational biology and related fields. We demonstrate how these models and tools have been used to study some of the twelve biochemical pathways implicated in but not unique to pancreatic cancer, and conclude that …
Inferring The Provenance Of An Alien Species With Dna Barcodes: The Neotropical Butterfly Dryas Iulia In Thailand, Noah A. Burg, Ashman Pradhan, Rebecca M. Gonzalez, Emely Z. Morban, Erica W. Zhen, Watana Sakchoowong, David J. Lohman
Inferring The Provenance Of An Alien Species With Dna Barcodes: The Neotropical Butterfly Dryas Iulia In Thailand, Noah A. Burg, Ashman Pradhan, Rebecca M. Gonzalez, Emely Z. Morban, Erica W. Zhen, Watana Sakchoowong, David J. Lohman
Publications and Research
The Neotropical butterfly Dryas iulia has been collected from several locations in Thailand and Malaysia since 2007, and has been observed breeding in the wild, using introduced Passiflora foetida as a larval host plant. The butterfly is bred by a butterfly house in Phuket, Thailand, for release at weddings and Buddhist ceremonies, and we hypothesized that this butterfly house was the source of wild, Thai individuals. We compared wing patterns and COI barcodes from two, wild Thai populations with individuals obtained from this butterfly house. All Thai individuals resemble the subspecies D. iulia modesta, and barcodes from wild and captive …
Nucleolar Integrity Is Required For The Maintenance Of Long-Term Synaptic Plasticity, Kim D. Allen, Andrei V. Gourov, Christopher Harte, Peng Gao, Clarice, Darlene Sylvain, Joshua M. Splett, William C. Oxberry, Paula S. Van De Nes, Matthew J. Troy-Regier, Jason Wolk, Juan M. Alarcon, A. Iván Hernández
Nucleolar Integrity Is Required For The Maintenance Of Long-Term Synaptic Plasticity, Kim D. Allen, Andrei V. Gourov, Christopher Harte, Peng Gao, Clarice, Darlene Sylvain, Joshua M. Splett, William C. Oxberry, Paula S. Van De Nes, Matthew J. Troy-Regier, Jason Wolk, Juan M. Alarcon, A. Iván Hernández
Publications and Research
Long-term memory (LTM) formation requires new protein synthesis and new gene expression. Based on our work in Aplysia, we hypothesized that the rRNA genes, stimulation-dependent targets of the enzyme Poly(ADP-ribose) polymerase-1 (PARP-1), are primary effectors of the activity-dependent changes in synaptic function that maintain synaptic plasticity and memory. Using electrophysiology, immunohistochemistry, pharmacology and molecular biology techniques, we show here, for the first time, that the maintenance of forskolin-induced late-phase long-term potentiation (L-LTP) in mouse hippocampal slices requires nucleolar integrity and the expression of new rRNAs. The activity-dependent upregulation of rRNA, as well as L-LTP expression, are poly(ADP-ribosyl)ation (PAR) dependent and …
Carbon Partitioning In Green Algae (Chlorophyta) And The Enolase Enzyme, Jürgen E. W. Polle, Peter Neofotis, Andy Huang, William Chang, Kiran Sury, Eliza M. Wiech
Carbon Partitioning In Green Algae (Chlorophyta) And The Enolase Enzyme, Jürgen E. W. Polle, Peter Neofotis, Andy Huang, William Chang, Kiran Sury, Eliza M. Wiech
Publications and Research
The exact mechanisms underlying the distribution of fixed carbon within photoautotrophic cells, also referred to as carbon partitioning, and the subcellular localization of many enzymes involved in carbon metabolism are still unknown. In contrast to the majority of investigated green algae, higher plants have multiple isoforms of the glycolytic enolase enzyme, which are differentially regulated in higher plants. Here we report on the number of gene copies coding for the enolase in several genomes of species spanning the major classes of green algae. Our genomic analysis of several green algae revealed the presence of only one gene coding for a …
Revisiting The Feminine Mystique, Cynthia Fuchs Epstein
Revisiting The Feminine Mystique, Cynthia Fuchs Epstein
Publications and Research
No abstract provided.
Review: Zinc’S Functional Significance In The Vertebrate Retina, Harris Ripps, Richard L. Chappell
Review: Zinc’S Functional Significance In The Vertebrate Retina, Harris Ripps, Richard L. Chappell
Publications and Research
This review covers a broad range of topics related to the actions of zinc on the cells of the vertebrate retina. Much of this review relies on studies in which zinc was applied exogenously, and therefore the results, albeit highly suggestive, lack physiologic significance. This view stems from the fact that the concentrations of zinc used in these studies may not be encountered under the normal circumstances of life. This caveat is due to the lack of a zinc-specific probe with which to measure the concentrations of Zn2+ that may be released from neurons or act upon them. However, a …