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Perspectives On Natural Philosophy, Stanley N. Salthe

Publications and Research

This paper presents a viewpoint on natural philosophy focusing on the organization of substance, as well as its changes as invited by the Second Law of thermodynamics. Modes of change are pointed to as definitive of levels of organization; these include physical, chemical, and biological modes of change. Conceptual uses of the subsumptive hierarchy format are employed throughout this paper. Developmental change in dissipative structures is examined in some detail, generating an argument for the use of final causality in studies of natural systems. Considerations of ‘internalism’ in science are presented along the way.

Leveraging Pet To Image Folate Receptor Α Therapy Of An Antibody-Drug Conjugate, Christian Brand, Ahmad Sadique, Jacob L. Houghton, Kishore Gangagari, Jose F. Ponte, Jason S. Lewis, Naga Vara Kishore Pillarsetty, Joseph A. Konner, Thomas Reiner

Publications and Research

Background: The folate receptor α (FRα)-targeting antibody-drug conjugate (ADC), IMGN853, shows great antitumor activity against FRα-expressing tumors in vivo, but patient selection and consequently therapy outcome are based on immunohistochemistry. The aim of this study is to develop an antibody-derived immuno-PET imaging agent strategy for targeting FRα in ovarian cancer as a predictor of treatment success. Methods: We developed [89Zr]Zr-DFO-M9346A, a humanized antibody-based radiotracer targeting tumorassociated FRα in the preclinical setting. [89Zr]Zr-DFO-M9346A’s binding ability was tested in an in vitro uptake assay using cell lines with varying FRα expression levels. The diagnostic potential of [89Zr]Zr-M9346A was evaluated in KB and …

Empowering With Prep (E-Prep), A Peer-Led Social Media–Based Intervention To Facilitate Hiv Preexposure Prophylaxis Adoption Among Young Black And Latinx Gay And Bisexual Men: Protocol For A Cluster Randomized Controlled Trial, Viraj V. Patel, Zoë Ginsburg, Sarit A. Golub, Keith J. Horvath, Nataly Rios, Kenneth H. Mayer, Ryunh S. Kim, Julia H. Arnsten

Publications and Research

Background: Young black and Latinx, gay, bisexual, and other men who have sex with men (YBLGBM, aged 18-29 years) have among the highest rates of new HIV infections in the United States and are not consistently reached by existing prevention interventions. Preexposure prophylaxis (PrEP), an oral antiretroviral regimen taken daily by HIV-uninfected individuals to prevent HIV acquisition, is highly efficacious in reducing HIV acquisition and could help stop the HIV epidemic in YBLGBM. Use of social media (eg, Facebook, Twitter, online dating sites) is ubiquitous among young people, providing an efficient avenue to engage YBLGBM to facilitate PrEP adoption.

Objective: …

Generating The Pipeline: Addressing Bias In Recruiting And Hiring, Aldemaro Romero Jr.

Publications and Research

In past articles of this column we have reported data that show that women in general find more barriers than their male counterparts in getting into academic careers. Further, female college professors earn on average 10 percent less in salaries than their male colleagues.

If you are a woman in academia and aspire to an administrative job in order to substantially improve your earnings and make them more in par with the males around you, you should think twice.

Let’S Never Forget: Extinction Is Forever, Aldemaro Romero Jr.

Publications and Research

For many, the conservation of nature is seen as an essential component of human wellbeing. Its value is oftentimes referred to in relation to the four “Es”: economic, environmental, esthetic and ethical values.

From an economic viewpoint, we know that the entire pharmaceutical industry is built upon known natural substances we find in plants and animals, as are the varieties of many domesticated animals we use for food. On the environmental front, we know how essential it is for human health to have an abundant availability of clean water and air.

Esthetically speaking, natural areas represent one of the major …

“My Sexuality…It Creates A Stress”: Hiv-Related Communication Among Bisexual Black And Latino Men, New York City, Kirk D. Henny, Kathryn Drumhiller, Madeline Y. Sutton, Jose Nanín

Publications and Research

Men who have sex with men and women (including bisexual men) comprise 35% of all men who have sex with men (MSM) in the U.S. It is estimated that 121,800 men who have been bisexually active within the past year are living with HIV in the U.S. Communication about HIV may result in risk-reduction behaviors. However, little is known about the nature or context for HIV prevention communication among bisexual men, particularly for blacks and Hispanic/Latinos who are disproportionately at greater HIV risk. Therefore, we explored patterns and contexts of HIV-related communications occurring within personal social networks among bisexual black …

Master Integrals For Double Real Radiation Emission In Heavy-To-Light Quark Decay, Roberto Bonciani, Alessandro Broggio, Leandro Cieri, Andrea Ferroglia

Publications and Research

We evaluate analytically the master integrals for double real radiation emission in the b→uW∗" role="presentation" style="box-sizing: inherit; display: inline-block; line-height: normal; word-spacing: normal; overflow-wrap: normal; text-wrap: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;">��→����∗ decay, where b and u are a massive and massless quark, respectively, while W∗" role="presentation" style="box-sizing: inherit; display: inline-block; line-height: normal; word-spacing: normal; overflow-wrap: normal; text-wrap: nowrap; float: none; direction: ltr; max-width: none; max-height: none; min-width: 0px; min-height: 0px; border: 0px; padding: 0px; margin: 0px; position: relative;">��∗ is an off-shell charged …

The Price Of A Vote: Diseconomy In Proportional Elections, Hygor Piaget M. Melo, Saulo D. S. Reis, Andre ́ A. Moreira, Hernan Makse, Jose ́ S. Andrade Jr.

Publications and Research

The increasing cost of electoral campaigns raises the need for effective campaign planning and a precise understanding of the return of such investment. Interestingly, despite the strong impact of elections on our daily lives, how this investment is translated into votes is still unknown. By performing data analysis and modeling, we show that top candidates spend more money per vote than the less successful and poorer candidates, a relation that discloses a diseconomy of scale. We demonstrate that such electoral diseconomy arises from the competition between candidates due to inefficient campaign expenditure. Our approach succeeds in two important tests. First, …

Graphic Representations Of Grammatical Gender In Spanish Language Anarchist Publications, Mariel Mercedes Acosta Matos

Publications and Research

This paper offers a descriptive analysis of the suffixes -@, -x, -e and other orthographic innovations as transgressions to the genderedness of Spanish language. First I discuss the grammatical rules of expressing gender in Spanish and a summary of the ongoing debates concerning linguistic sexism and androcentrism in Spanish language. Then I present some examples of the gender neutral suffixes drawn from articles found in 3 “Do It Yourself” journals published online by three anarchist collectives in Latin America.

Losing Protection From Predatory Colleges, Aldemaro Romero Jr.

Publications and Research

Two weeks ago, Education Secretary Betsy DeVos made an announcement that can have serious implications for students registering for classes at for-profit institutions of higher education in particular, and colleges and universities in general.

In a written statement posted on the Department of Education’s website, DeVoss announced plans to eliminate the so-called gainful employment rule created during the Obama administration in 2011. That rule was aimed at holding for-profit and career college programs accountable for graduating students with poor job prospects and overwhelming debt. The rule penalized programs if their graduates had student loan payments that exceeded a specific percentage …

A Call For Second-Generation Cryptocurrency Valuation Metrics, Edward Lehner, Louis Carter, John Ziegler

Publications and Research

This article builds on the body of work that has depicted cryptocurrency as a model for science and higher education funding. To that end, this work examines the degree to which one or more cryptocurrencies would need to be adopted and achieve a network effect prior to implementation of such a funding model. Empirical data from three different cryptocurrencies were examined. The current work deploys generalized autoregressive conditional heteroskedasticity (GARCH) to analyze stochastic volatility. This work contends that the examined coins are likely overdistributed and too volatile, thereby limiting the wealth generation possibilities for funding science or higher education. Additionally, …

Supermarket Retailers’ Perspectives On Healthy Food Retail Strategies: In-Depth Interviews, Olivia Martinez, Noemi Rodriguez, Allison Mercurio, Marie Bragg, Brian Elbel

Publications and Research

Background

Excess calorie consumption and poor diet are major contributors to the obesity epidemic. Food retailers, in particular at supermarkets, are key shapers of the food environment which influences consumers’ diets. This study seeks to understand the decision-making processes of supermarket retailers—including motivators for and barriers to promoting more healthy products—and to catalogue elements of the complex relationships between customers, suppliers, and, supermarket retailers.

Methods

We recruited 20 supermarket retailers from a convenience sample of full service supermarkets and national supermarket chain headquarters serving low- and high-income consumers in urban and non-urban areas of New York. Individuals responsible for making …

Burning Man’S Mathematical Underbelly, Seth S. Cottrell

Publications and Research

A math degree can take you to a lot of places, both physically and figuratively, and if you play your cards right, you too can argue counterfactual definiteness with a shaman. First in 2008, and several times since, a fellow math PhD and I traveled to the Burning Man art festival to sit in the desert and talk with the locals about whatever they happened to be curious about.

Translating Research As An Approach To Enhance Science Engagement, Michelle T. Juarez, Chloe M. Kenet

Publications and Research

The impact of research depends on the effective communication of discoveries. Scientific writing is the primary tool for the dissemination of research, and is an important skill that biomedical trainees have to develop. Despite its importance, scientific writing is not part of the mainstream curriculum. One strategy used to teach scientific writing is holding a journal club style discussion of primary research literature that the students are asked to read. However, this activity can result in a passive learning experience and limit the development of trainees’ scientific writing skills. In order to improve trainees’ written communication skills, we tested an …

Records Of A School At Sea, Annie E. Tummino

Publications and Research

This presentation is largely about strategies for dealing with archival legacy description. Not just in terms of data migration or updating standards, but what to do when you inherit a large scale collection that was organized using a methodology that no longer works in a 21st century context. How do you move forward, and how do you document your interventions and decisions? This is what happened to me at SUNY Maritime with the college’s institutional records.

Kinetic Effects In 2d And 3d Quantum Dots: Comparison Between High And Low Electron Correlation Regimes, Marlina Slamet, Viraht Sahni

Publications and Research

Kinetic related ground state properties of a two-electron 2D quantum dot in a magnetic field and a 3D quantum dot (Hooke's atom) are compared in the Wigner high (HEC) and low (LEC) electron correlation regimes. The HEC regime corresponds to low densities sufficient for the creation of a Wigner molecule. The LEC regime densities are similar to those of natural atoms and molecules. The results are determined employing exact closed-form analytical solutions of the Schrödinger-Pauli and Schrödinger equations, respectively. The properties studied are the local and nonlocal quantal sources of the density and the single particle density matrix; the kinetic …

Tributyltin Inhibits Neural Induction Of Human Induced Pluripotent Stem Cells, Shigeru Yamada, Yusuke Kubo, Daiju Yamazaki, Yuko Sekino, Yoko Nomura, Sachiko Yoshida, Yusunari Kanda

Publications and Research

Tributyltin (TBT), one of the organotin compounds, is a well-known environmental pollutant. In our recent study, we reported that TBT induces mitochondrial dysfunction, in human-induced pluripotent stem cells (iPSCs) through the degradation of mitofusin1 (Mfn1), which is a mitochondrial fusion factor. However, the effect of TBT toxicity on the developmental process of iPSCs was not clear. The present study examined the effect of TBT on the differentiation of iPSCs into the ectodermal, mesodermal, and endodermal germ layers. We found that exposure to nanomolar concentration of TBT (50 nM) selectively inhibited the induction of iPSCs into the ectoderm, which is the …

Adviser Nomination Spurs Questions, Aldemaro Romero Jr.

Publications and Research

After a 19-month delay, the Trump Administration has nominated someone to be the director of the Office of Science and Technology Policy, or as is more colloquially known, the science adviser to the president.

Congress established the White House Office of Science and Technology Policy (OSTP) in 1976. President Gerald Ford, a Republican, signed the act creating the agency into law. That took place after President Nixon disbanded the then-called “President Advisory Committee” in 1973.

The mandate for the agency is to provide the president and others within the Executive Office of the President with advice on the scientific, engineering, …

Quasi-Experimental Comparison Design For Evaluating The Mayor’S Action Plan For Neighborhood Safety. Map Evaluation Update Number 1., Sheyla A. Delgado, Wogod Alawlaqi, Richard A. Espinobarros, Laila Alsabahi, Anjelica Camacho, Jeffrey A. Butts

Publications and Research

This is the first of six updates presenting interim findings from the evaluation of the NYC Mayor’s Action Plan for Neighborhood Safety (MAP). As part of an evaluation of the New York City Mayor’s Action Plan for Neighborhood Safety (MAP), the John Jay College Research and Evaluation Center created methods to assemble various outcome measures about participating NYCHA MAP developments. The team also utilized statistical procedures to select a matched comparison group of NYCHA housing developments not participating in MAP. Differences in outcomes between the 17 MAP and 17 non-MAP housing developments will serve as the statistical basis for estimating …

Immobilization Nematodes For Live Imaging Using An Agarose Pad Produced With A Vinyl Record, Katherine A. Rivera Gomez, Mara Schvarzstein

Publications and Research

Numerous microfluidic systems have been developed and used for live imaging of Caenorhabditis nematodes (Allen et al., 2008; Zhang et al., 2008; Krajniak and Lu, 2010; Krajniak et al., 2013; Cornaglia et al., 2015). These systems can be costly, complex to set up, or require high-maintenance between uses. In addition, microfluidic rigs can be thick, preventing live imaging of worms from strains expressing low fluorescence fusion proteins. In the absence of elaborate microfluidic rigs, most live imaging protocols utilize flat agarose pads along with anesthetics and/or microbeads to immobilize the nematodes (Kim et al., 2013). Since this method does not …

The Transcriptome Of The Bermuda Fireworm Odontosyllis Enopla (Annelida: Syllidae): A Unique Luciferase Gene Family And Putative Epitoky-Related Genes, Mercer R. Brugler, M. Teresa Aguado, Michael Tessler, Mark Siddall

Publications and Research

The Bermuda fireworm Odontosyllis enopla exhibits an extremely tight circalunar circadian behavior that results in an impressive bioluminescent mating swarm, thought to be due to a conventional luciferase-mediated oxidation of a light-emitting luciferin. In addition, the four eyes become hypertrophied and heavily pigmented, and the nephridial system is modified to store and release gametes and associated secretions. In an effort to elucidate transcripts related to bioluminescence, circadian or circalunar periodicity, as well as epitoky-related changes of the eyes and nephridial system, we examined the transcriptomic profile of three female O. enopladuring a bioluminescent swarm in Ferry Reach, Bermuda. …

Disparities In Pulmonary Fibrosis Care In The United States: An Analysis From The Nationwide Inpatient Sample, Adam W. Gaffney, Steffie Woolhander, David Himmelstein, Danny Mccormick

Publications and Research

Background: Idiopathic pulmonary fibrosis is a disease with high morbidity and mortality. Care for these patients, including lung transplantation, may provide significant benefits, but is resource-intensive and expensive. Disadvantaged patients with IPF may hence be at risk for receiving inferior care.

Methods: We analyzed data from the Nationwide Inpatient Sample, a database consisting of all hospitalizations from a 20% sample of US hospitals. We identified adults hospitalized with IPF between 1998 and 2011 using ICD-9 codes. We assessed the effect of insurance coverage and socioeconomic status (SES) on lung transplantation, a treatment that may improve survival. We also examined the …

Supply Chain Organizational Learning, Exploration, Exploitation, And Firm Performance: A Creation-Dispersion Perspective, Divesh Ojha, Elisabeth Struckell, Chandan Acharya, Pankaj C. Patel

Publications and Research

We introduce and empirically test the creation-dispersion model of supply chain organizational learning to align learning orientations in a supply chain context. Our paper seeks to advance the knowledge on supply chain organizational learning by showing that four distinct supply chain learning orientations (team, learning, memory, and systems), previously studied only as a collective, can be parsed strategically. We parse these four learning orientations into creation capacity (team and learning orientations) and dispersion capacity (memory and system orientations). The creation and dispersion capacity can enhance exploration (long-term) and exploitation (short-term) practices respectively in supply chain organizations. We used a survey …

A Hands-On Robotics Concentration Curricula In Engineering Technology Programs, Andy S. Zhang, Angran Xiao, Yu Wang, Farrukh Zia, Muhammad Ummy

Publications and Research

This paper discusses the creation of a robotic concentration with four courses to meet the industry demands for qualified graduates in product design and services. Advances in computer technology and electronics have created a new field called mechatronics. Nowadays almost all high tech products are mechatronics in nature. Products such as automotive subsystems (such as anti-lock braking systems and automatic steering systems), medical devices, environmental monitoring systems, service and surgical robots are all mechatronic products. The robotic concentration focus on one of the most popular and visible area of mechatronics: robotics. The creation of the four courses: Embedded Systems Fundamentals, …

Rankings Can Be Bad For Colleges’ Health, Aldemaro Romero Jr.

Publications and Research

In previous columns I have reported how a number of external factors, such as funding, demographics, politics and the like have been hurting higher education. In many other cases – overblown athletic programs, misguided marketing, and plain bad leadership – the injuries have been self-inflicted. To these cases we can now add the race for the rankings.

I have argued in this column in the past that rankings like the ones by U.S. News & World Reportand its copycats make little sense. To begin with, many of the things they claim to measure, such as athletics, facilities, and “reputation,” …

Jewish Germany: An Enduring Presence From The Fourth To The Twenty-First Century, John A. Drobnicki

Publications and Research

Review of the book Jewish Germany: An enduring presence from the fourth to the twenty-first century.

“Our Lab Is The Community”: Defining Essential Supporting Infrastructure In Engagement Research, Donald E. Nease Jr., Dee Burton, Sarah L. Cutrona, Lauren Edmundson, Alex H. Krist, Michael Barton Laws, Montelle Tamez

Publications and Research

Introduction: Effective patient engagement is central to patient-centered outcomes research. A well-designed infrastructure supports and facilitates patient engagement, enabling study development and implementation. We sought to understand infrastructure needs from recipients of Patient-Centered Outcomes Research Institute (PCORI) pilot grant awards. Methods: We surveyed recipients of PCORI pilot project awards on self-perceived strengths in engagement infrastructure through PCORI’s Ways of Engaging-Engagement Activity Tool survey, and interviewed leaders of 8 projects who volunteered as exemplars. Descriptive statistics summarized the survey findings. We conducted a thematic analysis of the interview transcripts. Results: Of the 50 surveyed pilots, 22 answered the engagement infrastructure questions …

Shipboard Design And Fabrication Of Custom 3d-Printed Soft Robotic Manipulators For The Investigation Of Delicate Deep-Sea Organisms, Daniel M. Vogt, Kaitlyn P. Becker, Brennan T. Phillips, Moritz A. Graule, Randi D. Rotjan, Timothy M. Shank, Erik E. Cordes, Robert J. Wood, David F. Gruber

Publications and Research

Soft robotics is an emerging technology that has shown considerable promise in deep-sea marine biological applications. It is particularly useful in facilitating delicate interactions with fragile marine organisms. This study describes the shipboard design, 3D printing and integration of custom soft robotic manipulators for investigating and interacting with deep-sea organisms. Soft robotics manipulators were tested down to 2224m via a Remotely-Operated Vehicle (ROV) in the Phoenix Islands Protected Area (PIPA) and facilitated the study of a diverse suite of soft-bodied and fragile marine life. Instantaneous feedback from the ROV pilots and biologists allowed for rapid re-design, such as adding ªfingernailsº, …

African Trypanosomes Evade Immune Clearance By Oglycosylation Of The Vsg Surface Coat, Jason Pinger, Dragana Nešić, Liaqat Ali, Francisco Aresta-Branco, Mirjana Lilic, Shanin Chowdhury, Hee-Sook Kim, Joseph Verdi, Jayne Raper, Michael A. J. Ferguson, F. Nina Papavasiliou, C. Erec Stebbins

Publications and Research

The African trypanosome, Trypanosoma brucei spp., is a paradigm for antigenic variation, the orchestrated alteration of cell surface molecules to evade host immunity. The parasite elicits robust antibody-mediated immune responses to its Variant Surface Glycoprotein (VSG) coat, but evades immune clearance by repeatedly accessing a large genetic VSG repertoire and “switching” to antigenically distinct VSGs. This persistent immune evasion has been ascribed exclusively to amino acid variance on the VSG surface presented by a conserved underlying protein architecture. We establish here that this model does not account for the scope of VSG structural and biochemical diversity. The 1.4Å resolution crystal …

Losing Its Way: The Landmarks Preservation Commission In Eclipse, Jeffrey A. Kroessler

Publications and Research

New York City’s Landmarks Preservation Commission has an admirable history of protecting the city's historic character. Increasingly in recent years, the commission has backed away from proactively designated sites of historical, architectural, or cultural significance as city landmarks. At the same time, the commission has shown greater deference to the owner of a property when deciding whether to designate, and to the wishes of the owners of designated properties in matters of regulation, notwithstanding that owner consent is nowhere in the landmarks law. At the same time, the commission has introduced new definitions, such as “period of significance,” contributing/non-contributing, and …