Digital Commons Network^™

W.E.B. Dubois For The Twenty‐First Century: On Being A Scholar‐Activist In The Digital Era, Jessie Daniels

Publications and Research

W.E.B. Du Bois began his work as a scholar-activist at the dawn of the twentieth century, and this paper argues that his example has much to teach contemporary scholar-activists in the twenty-first century. In order to publish The Crisis, the magazine of the activist organization he co-founded, DuBois purchased a printing press. This meant he could own the means of his own knowledge production and foretold both the promise of what it means to be a scholar-activist in the twenty-first century and the limitations built into the current systems of knowledge production. Du Bois was also prophetic when he …

Prostaglandin D2/J2 Signaling Pathway In A Rat Model Of Neuroinflammation Displaying Progressive Parkinsonian-Like Pathology: Potential Novel Therapeutic Targets, Chuhyon Corwin, Anastasia Nikolopoulou, Allen L. Pan, Mariela Nunez-Santos, Shankar Vallabhajosula, Peter A. Serrano, John Babich, Maria E. Figueiredo-Pereira

Publications and Research

Background: Prostaglandins are products of the cyclooxygenase pathway, which is implicated in Parkinson’s disease (PD). Limited knowledge is available on mechanisms by which prostaglandins contribute to PD neurodegeneration. To address this gap, we focused on the prostaglandin PGD2/J2 signaling pathway, because PGD2 is the most abundant prostaglandin in the brain, and the one that increases the most under pathological conditions. Moreover, PGJ2 is spontaneously derived from PGD2.

Methods: In this study, we determined in rats the impact of unilateral nigral PGJ2-microinfusions on COX-2, lipocalin-type PGD2 synthase (L-PGDS), PGD2/J2 receptor 2 (DP2), and 15 hydroxyprostaglandin dehydrogenase (15-PGDH). Nigral dopaminergic (DA) and …

The Role Of Proton Transport In Gating Current In A Voltage Gated Ion Channel, As Shown By Quantum Calculations, Alisher M. Kariev, Michael E. Green

Publications and Research

Over two-thirds of a century ago, Hodgkin and Huxley proposed the existence of voltage gated ion channels (VGIC) to carry Na⁺ and K⁺ ions across the cell membrane to create the nerve impulse, in response to depolarization of the membrane. The channels have multiple physiological roles, and play a central role in a wide variety of diseases when they malfunction. The first channel structure was found by MacKinnon and coworkers in 1998. Subsequently the structure of a number of VGIC was determined in the open (ion conducting) state. This type of channel consists of four voltage sensing domains …

Oxytocin And Cancer: An Emerging Link, Ben Lerman, Trisheena Harricharran, Olorunseun O. Ogunwobi

Publications and Research

The neuropeptide hormone oxytocin, which is released from the posterior pituitary gland, is involved in a number of physiological processes. Understanding of its effects is gradually increasing due to new research in this area. While mostly recognized as a reproductive system hormone, oxytocin also regulates other organ systems such as the brain and cardiovascular system. Recently, research has focused on unraveling its involvement in cancer, and emerging evidence suggests a potential role for oxytocin as a cancer biomarker. This review summarizes observations linking oxytocin and cancer, with a special emphasis on prostate cancer, where it may promote cell proliferation. Research …

Luciferin Production And Luciferase Transcription In The Bioluminescent Copepod Metridia Lucens, Michael Tessler, Jean P. Gaffney, Jason M. Crawford, Eric Trautman, Nehaben A. Gujarati, Philip Alatalo, Vincent A. Pierbone, David F. Gruber

Publications and Research

Bioluminescent copepods are often the most abundant marine zooplankton and play critical roles in oceanic food webs. Metridia copepods exhibit particularly bright bioluminescence, and the molecular basis of their light production has just recently begun to be explored. Here we add to this body of work by transcriptomically profiling Metridia lucens, a common species found in temperate, northern, and southern latitudes. In this previously molecularly-uncharacterized species, we find the typical luciferase paralog gene set found in Metridia. More surprisingly, we recover noteworthy putative luciferase sequences that had not been described from Metridia species, indicating that bioluminescence produced by these copepods …

Dobi Studies, Teaches The Marvels Of Genetics, Aldemaro Romero Jr.

Publications and Research

“When I was in third grade, a parent of one of the other students brought a number of cats to the library on a Saturday and talked about how there are all these different hereditary patterns that contribute to their coat colors and appearance, like spots, stripes, and white paws. I was just hooked because I loved cats, and I said this is what I want to do.”

That’s how Dr. Krista Dobi explains why she became a geneticist. A native of North Brunswick, New Jersey, Dobi received a bachelor of arts from Princeton University and a doctorate in genetics …

Different Ommochrome Pigment Mixtures Enable Sexually Dimorphic Batesian Mimicry In Disjunct Populations Of The Common Palmfly Butterfly, Elymnias Hypermnestra, Silvio Panettieri, Erisa Gjinaj, George John, David J. Lohman

Publications and Research

With varied, brightly patterned wings, butterflies have been the focus of much work on the evolution and development of phenotypic novelty. However, the chemical structures of wing pigments from few butterfly species have been identified. We characterized the orange wing pigments of female Elymnias hypermnestra butterflies (Lepidoptera: Nymphalidae: Satyrinae) from two Southeast Asian populations. This species is a sexually dimorphic Batesian mimic of several model species. Females are polymorphic: in some populations, females are dark, resemble conspecific males, and mimic Euploea spp. In other populations, females differ from males and mimic orange Danaus spp. Using LC-MS/MS, we identified nine ommochrome …

Testing A Web-Based Interactive Comic Tool To Decrease Obesity Risk Among Minority Preadolescents: Protocol For A Pilot Randomized Control Trial, May May Leung, Katrina F. Mateo, Sandra Verdaguer, Katarzyna Wyka

Publications and Research

Background: Childhood obesity is a public health crisis, particularly in low-income, minority populations in the United States. Innovative and technology-enhanced interventions may be an engaging approach to reach at-risk youth and their parents to improve dietary behaviors and feeding practices. However, such tools are limited, especially ones that are theory-based; co-developed with user-centered approaches; tailored to low-income, minority preadolescents; and include parent-focused content.

Objective: The objectives of this study include assessing the feasibility and acceptability and exploring the potential impact of the Intervention INC (Interactive Nutrition Comics for urban, minority preadolescents) Web-based tool, which is focused on decreasing childhood obesity …

Vaccination Recommendations For Oral Health Professionals, Susan H. Davide, Christine Macarelli, Anty Lam

Publications and Research

Dental teams should familiarize themselves with vaccination recommendations to reduce the risk of infectious diseases and better educate patients about the importance of immunizations

A Severe Case Of Neutropenia Secondary To Clopidogrel, Harrynauth Persaud, William B. Chung

Publications and Research

An 83-year-old male patient presented with complaints of generalized body aches, fever, rhinorrhea, and worsening dyspnea for the past 5 days. Four weeks ago, he was started on clopidogrel after he underwent stent placement to his left leg. Current admission laboratory findings revealed a white blood cell (WBC) count of 1180, with no neutrophils corresponding to an absolute neutrophil count of zero. After an extensive negative infectious workup, clopidogrel was determined to be the offending agent. This medication was discontinued and the patient was placed on a leukocyte growth factor with significant improvement in his WBC and neutrophil counts. On …

Maternal Experiences Of Intimate Partner Violence And C-Reactive Protein Levels In Young Children In Tanzania, Natalie Slopen, Jing Zhang, Samuel S. Urlacher, Gretchen De Silva, Mona Mittal

Publications and Research

Intimate partner violence (IPV) is a critical public health issue that impacts women and children across the globe.Prior studies have documented that maternal experiences of IPV are associated with adverse psychological and physical health outcomes in children; however, research on the underlying physiological pathways linking IPV to these conditions is limited. Drawing on data from the 2010 Tanzania Demographic and Health Survey, we examined the relationship between maternal report of IPV in the past 12 months and inflammation among children ages 6 months to 5 years. Our study included 503 children who were randomly selected to provide a blood sample …

Disequilibrium, Adaptation, And The Norse Settlement Of Greenland, Rowan Jackson, Jette Arneborg, Andrew Dugmore, Christian Madsen, Tom Mcgovern, Konrad Smiarowski, Richard Streeter

Publications and Research

There is increasing evidence to suggest that arctic cultures and ecosystems have followed non-linear responses to climate change. Norse Scandinavian farmers introduced agriculture to sub-arctic Greenland in the late tenth century, creating synanthropic landscapes and utilising seasonally abundant marine and terrestrial resources. Using a niche-construction framework and data from recent survey work, studies of diet, and regional-scale climate proxies we examine the potential mismatch between this imported agricultural niche and the constraints of the environment from the tenth to the fifteenth centuries. We argue that landscape modification conformed the Norse to a Scandinavian style of agriculture throughout settlement, structuring and …

Observed Differences Between Near-Surface Air And Skin Temperatures Using Satellite And Ground-Based Data, Satya Prakash, Farjana Shati, Hamidreza Norouzi, Reginald Blake

Publications and Research

Accurate estimates of long-term land surface temperature (T_s) and near-surface air temperature (T_a) at finer spatio-temporal resolutions are crucial for surface energy budget studies, for environmental applications, for land surface model data assimilation, and for climate change assessment and its associated impacts. The Atmospheric Infrared Sounder (AIRS) and Moderate Resolution Imaging Spectroradiometer (MODIS) sensors onboard the Aqua satellite provide a unique opportunity to estimate both temperatures twice daily at the global scale. In this study, differences between T_a and T_s were assessed locally over regions of North America from 2009 to 2013 …

Rapid, Field-Deployable Method For Collecting And Preserving Plant Metabolome For Biochemical And Functional Characterization, Sarah A. Skubel, Vyacheslav Dushenkov, Brittany L. Graf, Qingwei Niu, Alexander Poulev, Hetalben Kalariya, Llewellyn C. Foxcroft, Ilya Raskin

Publications and Research

Study of plant metabolome is a growing field of science that catalogs vast biochemical and functional diversity of phytochemicals. However, collecting and storing samples of plant metabolome, sharing these samples across the scientific community and making them compatible with bioactivity assays presents significant challenges to the advancement of metabolome research. We have developed a RApid Metabolome Extraction and Storage (RAMES) technology that allows efficient, highly compact, field-deployable collection and storage of libraries of plant metabolome. RAMES technology combines rapid extraction with immobilization of extracts on glass microfiber filter discs. Two grams of plant tissue extracted in ethanol, using a specially …

Preparation And Characterization Of Chemically-Modified Biomaterials And Their Application As Adsorbents Of Penicillin G, Jesie Silva, Lizebel Morante, Tesfamichael Demeke, Jacqueline Baah-Twum, Abel E. Navarro

Publications and Research

The prevalence of antibiotics in water creates microbial resistance and has a negative impact on the ecosystem. Biomaterials such as spent tea leaves are rich in functional groups and are suitable for chemical modification for diverse applications. This research proposes the use of spent tea leaves of chamomile (CM), green tea (GT), and peppermint (PM) as structural scaffolds for the incorporation of carboxyl, sulfonyl, and thiol groups to improve the adsorption of Penicillin G (Pe). Adsorbents characterization reported a higher number of acidic functional groups, mainly in thiolated products. Scanning electron microscopy (SEM) analysis showed changes on the surfaces of …

Genetic Determinants Of Telomere Length In African American Youth, Andrew M. Zeiger, Marquitta J. White, Celeste Eng, Sam S. Oh, Jonathan Witonsky, Pagé C. Goddard, Maria G. Contreras, Jennifer R. Elhawary, Donglei Hu, Angel C. Y. Mak, Eunice Y. Lee, Kevin L. Keys, Lesly-Anne Samedy, Oona Risse Adams, Joaquín Magaña, Scott Huntsman, Sandra Salazar, Adam Davis, Kelley Meade, Emerita Brigino-Buenaventura, Michael A. Lenoir, Harold J. Farber, Kirsten Bibbins-Domingo, Luisa N. Borrell, Esteban G. Burchard

Publications and Research

Telomere length (TL) is associated with numerous disease states and is affected by genetic and environmental factors. However, TL has been mostly studied in adult populations of European or Asian ancestry. These studies have identified 34 TL-associated genetic variants recently used as genetic proxies for TL. The generalizability of these associations to pediatric populations and racially diverse populations, specifically of African ancestry, remains unclear. Furthermore, six novel variants associated with TL in a population of European children have been identified but not validated. We measured TL from whole blood samples of 492 healthy African American youth (children and adolescents between …

The Diverse Magneto-Optical Selection Rules In Bilayer Black Phosphorus, Jhao-Ying Wu, Szu-Chao Chen, Thi-Nga Do, Wu-Pei Su, Godfrey Gumbs, Ming-Fa Lin

Publications and Research

The magneto-optical properties of bilayer phosphorene is investigated by the generalized tight-binding model and the gradient approximation. The vertical inter-Landau-level transitions, being sensitive to the polarization directions, are mainly determined by the spatial symmetries of sub-envelope functions on the distinct sublattices. The anisotropic excitations strongly depend on the electric and magnetic fields. A uniform perpendicular electric field could greatly diversify the selection rule, frequency, intensity, number and form of symmetric absorption peaks. Specifically, the unusual magneto-optical properties appear beyond the critical field as a result of two subgroups of Landau levels with the main and side modes. The rich and …

Optimizing Spacer Length For Positioning Functional Groups In Bio-Waste, Revathi Iyengar, Maria Faure-Betancourt, Saleh Talukdar, Jinting Ye, Abel E. Navarro

Publications and Research

The goal of this study was to determine the optimal chain length needed for tethering functional groups on bio-wastes. The purpose of modifying the surface of bio-waste is to improve their affinity for phenols. To this end, four different aminated green tea leaves, with the amine group located at the end of 6, 8, 10, and 12 carbons were synthesized. Green approaches to functionalization lead to fewer reactive sites. Optimizing spacer length is one way to ameliorate this. The aminated tea leaves were prepared by a tosylation reaction followed by displacement with a diamine used in excess. The tea leaves …

Idrissa Ouedraogo, The Maestro Of Burkina Cinema, Boukary Sawadogo

Publications and Research

No abstract provided.

Sex And The Single Feminist Science Fiction Scholar, Marleen S. Barr

Publications and Research

In the AAUP magazine ACADEME, feminist science fiction scholar Marleen S. Barr discusses her past in light of #MeToo.

Knowledge Management Paradigms, Philosophical Assumptions: An Outlook On Future Research, Isabel D.W. Rechberg

Publications and Research

This study informs knowledge management (KM) research assessing the philosophical assumptions and paradigms that have formed around the discipline. Reviewing positivism, critical realism, interpretivism or constructivism, and pragmatism the researcher suggests to draw on constructivism to inform KM theory. Moreover it is suggested that a mixed methods approach is the most suitable to engage in research on KM so that a flexibility can be maintained that will allow to detect what KM is and how knowledge can be managed.

The Impact Of Perineuronal Net Digestion Using Chondroitinase Abc On The Intrinsic Physiology Of Cortical Neurons, Philip Chu, Reena Abraham, Kumarie Budhu, Usma Khan, Natalie De Marco Garcia, Joshua C. Brumberg

Publications and Research

Perineuronal nets (PNNs) are a form of aggregate Extracellular Matrix (ECM) in the brain. Recent evidence suggests that the postnatal deposition of PNNs may play an active role in regulating neuroplasticity and, potentially, neurological disorders. Observations of high levels of PNNs expression around somas, proximal dendrites, and axon initial segments of a subtype of neurons have also led to proposals that PNNs may modulate the intrinsic properties of the neurons they ensheathe. While high levels of PNNs are postnatally expressed throughout the neocortex, it is still unclear how they impact the neuronal physiology of the many classes and subtypes of …

The Merchants At The Casino: Sephardic Elites And Leisure Time In Eighteenth-Century Livorno, Francesca Bregoli

Publications and Research

In 1712,a casino was established in the Jewish neighborhood of the Mediterranean port of Livorno. This venue, which stayed open until 1720, appears unique, as no similar Jewish institutions have been described in comparable communities. This explores the significance of the casino for the relationship of Livornese Jewry with Tuscan culture and the state by investigating internal documents from the Livornese Jewish community (nazione ebrea) in light of analogous Tuscan institutions. By considering an episode in the relatively little studied history of early modern Jewish leisure, we gain insight into values and aspirations of members of one of …

Jerome Lefkowitz: A Pragmatic Intellect And Major Figure In Taylor Law Historytaylor Law History, William A. Herbert

Publications and Research

This article examines the professional career of Jerome Lefkowitz, a central figure in the history of the Taylor Law, New York's public sector collective bargaining statute. Mr. Lefkowitz helped draft the Taylor Law, and served as the first Deputy Chairperson of the New York State Public Employment Relations Board (PERB) from 1967 until 1986, and the agency's fifth Chairperson from 2007 until 2015. PERB is the state agency responsible for administering the provisions of the Taylor Law. Between his two tenures at PERB, Mr. Lefkowitz was Deputy Counsel for the Civil Service Employees Association, Local 1000, AFL-CIO. The article examines …

Crafting A Research Question: Differentiated Teaching For Instruction With Primary Sources Across Diverse Learning Levels, Jen Hoyer, Kaitlin Holt, Julia Pelaez

Publications and Research

This case study illustrates methods for drawing on primary sources to instruct students on how to generate and refine research questions (Guidelines for Primary Source Literacy, learning objective 1C) and to recognize that research questions may change (Guidelines for Primary Source Literacy, learning objective 1D). The authors are educators with the Brooklyn Connections program, the school outreach arm of Brooklyn Public Library’s archive and rare book division. Given the diversity of the students served by this program, this case study focuses on adapting a lesson to three examples of lesson implementation, one each in elementary, middle, and high school, varyingly …

Place-Based Learning Across The Disciplines: A Living Laboratory Approach To Pedagogy, Karen Goodlad, Anne E. Leonard

Publications and Research

Faculty participants in a fellowship designed to engage students at an urban commuter college of technology in their general education curriculum evaluated and redesigned their courses to include place-based learning (PBL) using the Living Laboratory model of pedagogy. Focused on faculty perception of the relationship between PBL and its influence on general education, the study illustrates how faculty from across disciplines apply PBL techniques to revitalize general education learning outcomes. Findings include the influence of the fellowship on the design of PBL activities and perceived levels of student engagement, especially when compared to more traditional classroom instruction.

The Politics Of Apolitical Culture. The Cia And The Congress Of Cultural Freedom, Despina Lalaki

Publications and Research

No abstract provided.

Nano And Microsensors For Mammalian Cell Studies, Ioana Voiculescu, Masaya Toda, Naoki Inomata, Takahito Ono, Fang Li

Publications and Research

This review presents several sensors with dimensions at the nano- and micro-scale used for biological applications. Two types of cantilever beams employed as highly sensitive temperature sensors with biological applications will be presented. One type of cantilever beam is fabricated from composite materials and is operated in the deflection mode. In order to achieve the high sensitivity required for detection of heat generated by a single mammalian cell, the cantilever beam temperature sensor presented in this review was microprocessed with a length at the microscale and a thickness in the nanoscale dimension. The second type of cantilever beam presented in …

El Valor De Los Verbos Introductores De Las Citas En Los Textos Académicos De Posgrado Escritos En Español Peninsular Y En Inglés, David Sánchez-Jiménez

Publications and Research

Esta investigación tiene como objetivo identificar los diferentes valores que adquieren los verbos introductores de las citas en el contexto lingüístico en el que se circunscriben y estudiar su potencial evaluativo y persuasivo en el uso de estrategias interpersonales. En el estudio de corpus que se presenta se analizó la práctica de la citación en el apartado de la Conclusión en textos escritos por 10 estudiantes de máster y 10 estudiantes de doctorado españoles en la disciplina de la Lingüística Aplicada. Para entender el comportamiento de este fenómeno y sus implicaciones pragmáticas en el texto se utilizó la metodología del …

An Impact Evaluation Of Two Rounds Of Mass Drug Administration On The Prevalence Of Active Trachoma: A Clustered Cross Sectional Survey, Asrat G. Amnie

Publications and Research

Introduction We investigated the impact of two round of mass drug administration on trachoma prevalence in Plateau and Nasarawa States of Nigeria. The mass drug administration was conducted as a component of the SAFE Strategy, a combination of interventions recommended for the global elimination of blinding trachoma.

Methods The study consisted of a two-stage cross-sectional clustered sample survey in which 3990 people from 793 households were screened for clinical signs of trachoma.

Results Of the total 3990 people examined, 1530 were children, of which 808 (53%) were boys and 704 (47%) were girls. The impact of intervention as measured by …