Digital Commons Network^™

A Philosophy Of Permanence: The Indians' Legacy For The West, David Getches

Publications

Article published in the July, 1990 issue of the Journal of the West.

The Community Leader's Letters, Vol. 1, No. 3, 1990 Fall, Author Unknown

Publications

Quarterly publication on news and views for South Carolina's grassroots leaders.

The Community Leader's Letters, Vol. 1, No. 4, 1990 Winter, Author Unknown

Publications

Quarterly publication on news and views for South Carolina's grassroots leaders.

Dendritic Cells Stimulate Primary Human Cytolytic Lymphocyte Responses In The Absence Of Cd4+ Helper T Cells, James W. Young, Ralph M. Steinman

Publications

[No abstract available]

The Effect Of Immunosuppressive Agents On The Induction Of Nuclear Factors That Bind To Sites On The Interleukin 2 Promoter, Angela Granelli-Piperno, Patricia Nolan, Kayo Inaba, Ralph M. Steinman

Publications

Cyclosporin A (CSA), FK506, and glucocorticosteroids all inhibit the production of lymphokines by decreasing lymphokine gene expression. Previous experiments have defined six different sites that may contribute to the transcriptional control of the interleukin 2 (IL2) promoter, and for each, active nuclear binding factors are induced upon mitogenic stimulation. While dexamethasone markedly blocks the increase in IL2 mRNA in stimulated human blood T cells, we found that the drug does not block the appearance of factors that bind to the transcriptional control sites termed AP-1, AP-3, NF-kB, OCT1, B site, and NF-AT. In contrast, both CSA and FK506 have similar …

Meeting The Enemy, Robert F. Nagel

Publications

No abstract provided.

Book Review, Richard B. Collins

Publications

No abstract provided.

Court-Appointed Attorneys: Old Problems And New Solutions, H. Patrick Furman

Publications

No abstract provided.

Looking In Our Backyards, Georgia Briscoe

Publications

No abstract provided.

Book Review, William T. Pizzi

Publications

No abstract provided.

Book Review, Mark J. Loewenstein

Publications

No abstract provided.

Advice, Consent, And Influence, Robert F. Nagel

Publications

No abstract provided.

Age Structure Of Refractory Interstellar Dust And Isotopic Consequences, Donald D. Clayton, Paul Scowen, Kurt Liffman

Publications

A sputtering and recycling Monte Carlo model, developed by Liffman and Clayton (1988) is used to calculate the distribution of existence times of the matter in interstellar dust composed of refractory metals. The mean age of each dust particle is defined not as the time it has existed but rather as the mass-weighted existence times of its parts at t = 6 Gyr of the modeled solar system formation. It is shown that Galactic evolution generates a mean correlation, applying to large numbers of particles binned according to size rather than according to individual particles, whose mean ages fluctuate statistically. …

Aerodynamic Forces On Flight Crew Helmets, Timothy A. Sestak, Richard M. Howard, Chester A. Heard

Publications

Wind tunnel tests were conducted to deter- mine the aerodynamic forces generated on aircrew flight helmets. Three helmets were tested: two used by aircrews flying ejection seat aircraft in the U.S. military, the Navy HGU-33/P and the Air Force HGU-53/P; and one prototype helmet of significantly different shape and volume. Axial and normal forces were measured through a range of pitch and yaw angles. It was found that large forces exist tending to promote helmet loss during ejection, and that simple modifications to the current helmet configurations can reduce those forces by as much as 40%. It is demonstrated that …

Impact Of An Interbasin Water Transfer On The Market Values Of Lakeshore Properties, 1989 August, Janardan Bikram Khatri-Chhetri, James C. Hite 1941-

Publications

No abstract provided.

Angular Clustering Properties Of Gamma-Ray Bursts And Quantitative Constraints On Their Distances, Dieter Hartmann, George R. Blumenthal

Publications

We derive upper limits on the angular correlation function W(θ) of γ-ray bursts and show that these limits substantially constrain the sources to be very nearby or very distant. Since quiescent counterparts of γ-ray bursts have not as yett been unambiguously identified in any wavelength band, the γ burst distance scale remains uncertain. Earlier work has shown that the angular distribution of γ-ray burts on the celestial sphere axies of clusters. To test whether or not γ-ray bursts are associated with objects at great distance, we compare their clustering propertis with theose of known extragalctic populations, such as galaxies or …

Transboundary Groundwaters: The Bellagio Draft Treaty, Robert D. Hayton, Albert E. Utton

Publications

Increasing populations and industrial and agricultural development worldwide are placing much greater demands on groundwater supplies. Many of these groundwater basins or aquifers underlie two or more countries and are, thus, international or transboundary. Withdrawals from one country can drain life-giving water from a neighboring country and, as a consequence, be the source of severe and protracted conflict. Unfortunately, international law and treaty practice are only at a beginning stage. With the goal of advancing international law and institutions on the matter, a multi-disciplinary group of specialists over an eight-year period have developed a draft international groundwater treaty.

The draft …

Stochastic Evolution Of Refractory Interstellar Dust During The Chemical Evolution Of A Two-Phase Interstellar Medium, Kurt Liffman, Donald D. Clayton

Publications

The evolution course of refractory interstellar dust during the chemical evolution of a two-phase interstellar medium (ISM) is studied using a simple model of the chemical evolution of ISM. It is assumed that, in this medium, the stars are born in molecular clouds, but new nucleosynthesis products and stellar return are entered into a complementary diffuse medium; the well-mixed matter of each interstellar phase is repeatedly cycled stochastically through the complementary phase and back. The dust is studied on a particle-by-particle bases as it is sputtered by shock waves in the diffuse medium, accretes an amorphous mantle of gaseous refractory …

Origin Of Heavy Xenon In Meteoritic Diamonds, Donald D. Clayton

Publications

The neutrino burst from the collapsed core in Type II supernovae liberates free neutrons by nu, nu-prime(n) reactions which drive isotopic abundances several mass steps heavier. The neutron fluence in the He shell, abetted by another burst 10 s later from alpha, n reactions, is about right for rendering Xe-136, the most abundant Xe isotope. The Xe isotopic composition is a good match to Xe-H, the unshielded neutron-rich Xe component abundant in carbonaceous meteorites. The He shell is implicated because it is the only C-rich shell in massive stars that can be expected to condense solid carbon thermally, a requirement …

Uaa Student Showcase Journal: Recognizing Excellence (Spring, 1989), N/A N/A

Publications

No abstract provided.

Ots 1809+314 And The Gamma-Ray Burst Gb 790325b, Dieter H. Hartmann, Richard W. Pogge, Kevin Hurley, Frederick J. Vrba, Mark C. Jennings

Publications

We present deep CCD images of the field containing the recurring Optical Transient Source (OTS) 1809+314 recently discovered on the archival plates of the Sonneberg Observatory. At the position of OTS 1809+314 we find no optical counterpart brighter tha V=24.0 24.5, rgunn = 22.0-22.5 and I = 22.0 22.5, and I = 22.0-22.5. In the zero proper motion limit our observations place severe constraints on possible quiescent counterparts. There is no compelling evidence to suggest an association between the historical optical transient source and the gamma-ray burst GB 790325b located ~ 5' to the east of OTS 1809+314.

Clonal Expansion Of Human T Lymphocytes Initiated By Dendritic Cells, Erik G. Langhoff, Ralph M. Steinman

Publications

The accessory cell requirements for cloning T cells in the presence of lectin and T cell growth factors were examined with cells from human peripheral blood. We found that dendritic cells were active and perhaps essential. Single CD4⁺ lymphocytes could be cloned with 80% efficiency, and CD8⁺ cells with 50-60% efficiency if 10³ syngeneic or allogeneic dendritic cells were added. Some T cell clones developed even with one dendritic cell. Monocytes or B lymphocytes from blood were at least 100-fold weaker in supporting clonal growth. These findings suggest a specialized feeder cell requirement, namely dendritic cells, for …

Macrophages Phagocytose Thymic Lymphocytes With Productively Rearranged T Cell Receptor Α And Β Genes, Kayo Inaba, Muneo M. Inaba, Tatsuo Kinashi

Publications

[No abstract available]

Interleukin 1 Production During Accessory Cell-Dependent Mitogenesis Of T Lymphocytes, Nina Bharwaj, Lisa L. Lau, Steven M. Friedman

Publications

We have studied the control and significance of IL-1 production in human leukocyte cultures during accessory cell-dependent, T lymphocyte mitogenesis using sensitive bioassays and immunolabeling techniques. In primary antigen-dependent systems like the MLR, IL-1 production was not detected in accessory cells (monocytes, dendritic cells) or T cells, suggesting that it is not an early product in these responses. However, monocytes could be induced to make IL-1 after interacting with sensitized antigen-specific T cells. Both alloreactive T cell clones or freshly prepared lymphoblasts induced IL-1 provided the monocytes carried the HLA-DR antigens to which the T cells were initially sensitized. Even …

An Antigen-Independent Contact Mechanism As An Early Step In T Cell-Proliferative Responses To Dendritic Cells, Kayo Inaba, Nikolaus Romani, Ralph M. Steinman

Publications

Dendritic cells bearing antigen efficiently aggregate and stimulate antigen-specific T cells. We describe an experimental model in which an initial, apparently antigen-independent binding step is followed by ligation of the TCR. The model is the polyclonal response to mAb to the CD3 portion of the TCR complex. Epidermal and thymic dendritic cells utilize low levels of Fc receptors to present the anti-CD3 mAb and induce mitogenesis. Within 3 h of coculture, most of the dendritic cells have formed clusters with the resting T lymphocytes, and these clusters are the site for subsequent DNA synthesis and cell growth. However, the binding …

Most Cd4+ T Cells From Human Immunodeficiency Virus-1 Infected Patients Can Undergo Prolonged Clonal Expansion, Erik G. Langhoff, Margaret J. Mcelrath, Harm J. Bos

Publications

We have addressed the capacity of HIV-1 infection to alter the growth of primary CD4⁺ T cells, but at the clonal level. Single T cells were expanded in the presence of PHA, IL-2, and small numbers of accessory dendritic cells. We report two new findings. First, T cells from seropositive individuals, even those with AIDS and markedly reduced CD4⁺ counts, exhibit a normal cloning efficiency, and proliferative capacity. This result is in contrast to two prior reports of a low cloning efficiency in CD4⁺ T cells from HIV-1-infected patients. Second, when we added high doses of exogenous …

Presentation Of Exogenous Protein Antigens By Dendritic Cells To T Cell Clones. Intact Protein Is Presented Best By Immature, Epidermal Langerhans Cells, Nikolaus Romani, Sumil Koide, Mary T. Crowley

Publications

The capacity of dendritic cells to present protein antigens has been studied with two MHC class II-restricted, myoglobin-specific, T cell clones. Spleen dendritic cells and cultured epidermal Langerhans cells (LC) presented native myoglobin weakly and often not at all. These same populations were powerful stimulators of allogeneic T cells in the primary MLR. Freshly isolated LC were in contrast very active in presenting proteins to T cell clones but were weak stimulators of the MLR. Both fresh and cultured LC could present specific peptide fragments of myoglobin to the clones. These results suggest that dendritic cells in nonlymphoid tissues like …

Aquatic Insects Of Lake Jocassee Catchment In North And South Carolina, With Descriptions Of Four New Species Of Caddisflies (Trichoptera), John C. Morse, Steven W. Hamilton, Kevin M. Hoffman

Publications

With the invitation and support of Duke Power Company, aquatic insects were collected in North and South Carolina streams above Lake Jocassee from April through October 1987. A variety of collecting equipment and techniques were used including all night light traps, 24-hour Malaise traps, qualitative examination of benthic materials, benthic nets, and aerial nets.

Distinct Features Of Dendritic Cells And Anti-Ig Activated B Cells As Stimulators Of The Primary Mixed Leukocyte Reaction, Joshua P. Metlay, Ellen Puré

Publications

Highly enriched populations of B lymphoblasts have been isolated after culture with anti-Ig-Sepharose and compared with dendritic cells as stimulators of CD4⁺ T cells in the murine MLR. The two populations clearly differed in phenotype; anti-Ig blasts were FcR⁺, B220⁺, 33D1^-, while dendritic cells were FcR^-, B220^-, 33D1⁺. However, as MLR stimulators, they shared many common features. Both cells (a) expressed comparable levels of class II MHC products; (b) independently stimulated the primary MLR and the production of several T derived lymphokines including IL-2 and IL-4; and …

A Small Number Of Anti-Cd3 Molecules On Dendritic Cells Stimulate Dna Synthesis In Mouse T Lymphocytes, Nikolaus Romani, Ellen Puré, Kayo Inaba

Publications

Resting T cells enter cell cycle when challenged with anti-CD3 mAb and accessory cells that bear required Fc receptor (FcR). Presentation of anti-CD3 is though to be a model for antigens presented by accessory cells to the TCR complex. We have obtained evidence that the number of anti-CD3 molecules that are associated with the accessory cell can be very small. We first noticed that thymic dendritic cells and cultured, but not freshly isolated, epidermal Langerhans cells (LC) were active accessory cells for responses to anti-CD3 mAb. DNA synthesis was abrogated by a mAb to the FcR but not by mAb …