Digital Commons Network^™

Structural And Functional Features On Quantitative Chest Computed Tomography In The Korean Asian Versus The White American Healthy Non-Smokers, Mario Castro, Et Al.

Open Access Publications

No abstract provided.

Insulin-Independent Reversal Of Type-1 Diabetes Following Transplantation Of Adult Brown Adipose Tissue Supplemented With Igf-1, Subhadra C. Gunawardana, David W. Piston

Open Access Publications

No abstract provided.

Complete Deconvolution Of Cellular Mixtures Based On Linearity Of Transcriptional Signatures, Konstantin Zaitsev, Monika Bambouskova, Amanda Swain, Maxim N. Artyomov

Open Access Publications

No abstract provided.

Regulated Phosphosignaling Associated With Breast Cancer Subtypes And Druggability, Kuan-Lin Huang, Yige Wu, Tina Primeau, Joshua F. Mcmichael, Adam D. Scott, Song Cao, Michael C. Wendl, Kimberly J. Johnson, Jason Held, Sherri Davies, R. Reid Townsend, Feng Chen, David Fenyö, Shunqiang Li, Tao Liu, Li Ding, Et Al.

Open Access Publications

No abstract provided.

Identifcation Of Small Molecule Enzyme Inhibitors As Broad-Spectrum Anthelmintics, Rahul Tyagi, Mostafa A. Elfawal, Scott A. Wildman, Jon Helander, Christina A. Bulman, Judy Sakanari, Bruce A. Rosa, Paul J. Brindley, James W. Janetka, Raffi V. Aroian, Makedonka Mitreva

Open Access Publications

No abstract provided.

Report From A Multidisciplinary Meeting On Anxiety As A Non-Motor Manifestation Of Parkinson’S Disease, Gregory M. Pontone, Eric J. Lenze, Et Al.

Open Access Publications

No abstract provided.

A Regulatory Variant Of Chrm3 Is Associated With Cannabis-Induced Hallucinations In European Americans, Zhongshan Cheng, Chureerat Phokaew, Yi-Ling Chou, Dongbing Lai, Jacquelyn L. Meyers, Arpana Agrawal, Lindsay A. Farrer, Henry R. Kranzler, Joel Gelernter

Open Access Publications

No abstract provided.

Vertical Transmission In Caenorhabditis Nematodes Of Rna Molecules Encoding A Viral Rna-Dependent Rna Polymerase, Aurélien Richaud, Lise Frézal, Stephen Tahan, Hongbing Jiang, Joshua A. Blatter, Guoyan Zhao, Taniya Kaur, David Wang, Marie-Anne Félix

Open Access Publications

No abstract provided.

Mechanisms Underlying Bone Loss Associated With Gut Inflammation, Ke Ke, Manoj Arra, Yousef Abu-Amer

Open Access Publications

Patients with gastrointestinal diseases frequently suffer from skeletal abnormality, characterized by reduced bone mineral density, increased fracture risk, and/or joint inflammation. This pathological process is characterized by altered immune cell activity and elevated inflammatory cytokines in the bone marrow microenvironment due to disrupted gut immune response. Gastrointestinal disease is recognized as an immune malfunction driven by multiple factors, including cytokines and signaling molecules. However, the mechanism by which intestinal inflammation magnified by gut-residing actors stimulates bone loss remains to be elucidated. In this article, we discuss the main risk factors potentially contributing to intestinal disease-associated bone loss, and summarize current …

Allogeneic Transplantation In Elderly Patients ≥65 Years With Non-Hodgkin Lymphoma: A Time-Trend Analysis, Nirav N. Shah, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

Quantification Of White Matter Cellularity And Damage In Preclinical And Early Symptomatic Alzheimer's Disease, Qing Wang, Yong Wang, Jingxia Liu, Courtney L. Sutphen, Carlos Cruchaga, Tyler Blazey, Brian A. Gordon, Yi Su, Charlie Chen, Joshua S. Shimony, Beau M. Ances, Nigel J. Cairns, Anne M. Fagan, John C. Morris, Tammie L.S. Benzinger

Open Access Publications

No abstract provided.

Integrated Analysis Of Environmental And Genetic Influences On Cord Blood Dna Methylation In New-Borns, John P. Rice, Andrew C. Heath, Pamela A. F. Madden, Et Al

Open Access Publications

No abstract provided.

The Role Of Membrane Excitability In Pancreatic Β-Cell Glucotoxicity, Zeenat A. Shyr, Zhiyu Wang, Nathaniel W. York, Colin G. Nichols, Maria S. Remedi

Open Access Publications

No abstract provided.

Protocol For The Effectiveness Of An Anesthesiology Control Tower System In Improving Perioperative Quality Metrics And Clinical Outcomes: The Tectonics Randomized, Pragmatic Trial, Christopher R King, Joanna Abraham, Thomas G Kannampallil, Bradley A Fritz, Arbi Ben Abdallah, Yixin Chen, Bernadette Henrichs, Mary Politi, Brian A Torres, Angela Mickle, Thaddeus P Budelier, Sherry Mckinnon, Stephen Gregory, Sachin Kheterpal, Troy Wildes, Michael S Avidan, Tectonics Research Group

Open Access Publications

No abstract provided.

Mission Critical Partnership For Infection Prevention Success, Karen Hoffmann, Hilary M Babcock

Open Access Publications

No abstract provided.

Clinical Events After Deferral Of Lad Revascularization Following Physiological Coronary Assessment, Sayan Sen, Jasvindar Singh, Et Al

Open Access Publications

No abstract provided.

First International Descriptive And Interventional Survey For Cholesterol And Non-Cholesterol Sterol Determination By Gas- And Liquid-Chromatography-Urgent Need For Harmonisation Of Analytical Methods, Dieter Lütjohann, Richard E. Ostlund, Et Al

Open Access Publications

No abstract provided.

Proteomic And Phosphoproteomic Analysis Reveals That Neurokinin-1 Receptor (Nk1r) Blockade With Aprepitant In Human Keratinocytes Activates A Distinct Subdomain Of Egfr Signaling: Implications For The Anti-Pruritic Activity Of Nk1r Antagonists, Shawn G Kwatra, Emily Boozalis, Amy H Huang, Cory Nanni, Raveena Khanna, Kyle A Williams, Yevgeniy R Semenov, Callie M Roberts, Robert F Burns, Madison Krischak, Madan M Kwatra

Open Access Publications

No abstract provided.

Developing Priorities To Achieve Health Equity Through Diabetes Translation Research: A Concept Mapping Study, Allison Phad, Shelly Johnston, Rachel G Tabak, Stephanie Mazzucca, Debra Haire-Joshu

Open Access Publications

Introduction: The goal of diabetes translation research is to advance research into practice and ensure equitable benefit from scientific evidence. This study uses concept mapping to inform and refine future directions of diabetes translation research with the goal of achieving health equity in diabetes prevention and control.

Research design and methods: This study used concept mapping and input from a national network of diabetes researchers and public health practitioners. Concept mapping is a mixed-method, participant-based process. First, participants generated statements by responding to a focus prompt ("

Results: Ten clusters were identified containing between 6 and 12 statements from 95 …

Mechanisms Of Reactivation Of Latent Tuberculosis Infection Due To Siv Coinfection, Allison N Bucşan, Ayan Chatterjee, Dhiraj K Singh, Taylor W Foreman, Tae-Hyung Lee, Breanna Threeton, Melanie G Kirkpatrick, Mushtaq Ahmed, Nadia Golden, Xavier Alvarez, James A Hoxie, Smriti Mehra, Jyothi Rengarajan, Shabaana A Khader, Deepak Kaushal

Open Access Publications

HIV is a major driver of tuberculosis (TB) reactivation. Depletion of CD4+ T cells is assumed to be the basis behind TB reactivation in individuals with latent tuberculosis infection (LTBI) coinfected with HIV. Nonhuman primates (NHPs) coinfected with a mutant simian immunodeficiency virus (SIVΔGY) that does not cause depletion of tissue CD4+ T cells during infection failed to reactivate TB. To investigate the contribution of CD4+ T cell depletion relative to other mechanisms of SIV-induced reactivation of LTBI, we used CD4R1 antibody to deplete CD4+ T cells in animals with LTBI without lentiviral infection. The mere depletion of CD4+ T …

Membrane Potential Determined By Flow Cytometry Predicts Fertilizing Ability Of Human Sperm, Lis C Puga Molina, Stephanie Gunderson, Joan Riley, Pascal Lybaert, Aluet Borrego-Alvarez, Emily S Jungheim, Celia M Santi

Open Access Publications

Infertility affects 10 to 15% of couples worldwide, with a male factor contributing up to 50% of these cases. The primary tool for diagnosing male infertility is traditional semen analysis, which reveals sperm concentration, morphology, and motility. However, 25% of infertile men are diagnosed as normozoospermic, meaning that, in many cases, normal-appearing sperm fail to fertilize an egg. Thus, new information regarding the mechanisms by which sperm acquire fertilizing ability is needed to develop a clinically feasible test that can predict sperm function failure. An important feature of sperm fertilization capability in many species is plasma membrane hyperpolarization (membrane potential …

Neuroinflammation And White Matter Alterations In Obesity Assessed By Diffusion Basis Spectrum Imaging, Amjad Samara, Tatianna Murphy, Jeremy Strain, Jerrel Rutlin, Peng Sun, Olga Neyman, Nitya Sreevalsan, Joshua S Shimony, Beau M Ances, Sheng-Kwei Song, Tamara Hershey, Sarah A Eisenstein

Open Access Publications

Human obesity is associated with low-grade chronic systemic inflammation, alterations in brain structure and function, and cognitive impairment. Rodent models of obesity show that high-calorie diets cause brain inflammation (neuroinflammation) in multiple regions, including the hippocampus, and impairments in hippocampal-dependent memory tasks. To determine if similar effects exist in humans with obesity, we applied Diffusion Basis Spectrum Imaging (DBSI) to evaluate neuroinflammation and axonal integrity. We examined diffusion-weighted magnetic resonance imaging (MRI) data in two independent cohorts of obese and non-obese individuals (Cohort 1: 25 obese/21 non-obese; Cohort 2: 18 obese/41 non-obese). We applied Tract-based Spatial Statistics (TBSS) to allow …

Foxm1 Drives Proximal Tubule Proliferation During Repair From Acute Ischemic Kidney Injury, Monica Chang-Panesso, Farid F Kadyrov, Matthew Lalli, Haojia Wu, Shiyo Ikeda, Eirini Kefaloyianni, Mai M Abdelmageed, Andreas Herrlich, Akio Kobayashi, Benjamin D Humphreys

Open Access Publications

The proximal tubule has a remarkable capacity for repair after acute injury, but the cellular lineage and molecular mechanisms underlying this repair response are incompletely understood. Here, we developed a Kim1-GFPCreERt2 knockin mouse line (Kim1-GCE) in order to perform genetic lineage tracing of dedifferentiated cells while measuring the cellular transcriptome of proximal tubule during repair. Acutely injured genetically labeled clones coexpressed KIM1, VIMENTIN, SOX9, and KI67, indicating a dedifferentiated and proliferative state. Clonal analysis revealed clonal expansion of Kim1+ cells, indicating that acutely injured, dedifferentiated proximal tubule cells, rather than fixed tubular progenitor cells, account for repair. Translational profiling during …

Confronting The Opioid Crisis: Practical Pain Management And Strategies: Aoa 2018 Critical Issues Symposium, Hassan R Mir, Anna N Miller, William T Obremskey, A Alex Jahangir, Joseph R Hsu

Open Access Publications

The United States is in the midst of an opioid crisis. Clinicians have been part of the problem because of overprescribing of narcotics for perioperative pain management. Clinicians need to understand the pathophysiology and science of addiction to improve perioperative management of pain for their patients. Multiple modalities for pain management exist that decrease the use of narcotics. Physical strategies, cognitive strategies, and multimodal medication can all provide improved pain relief and decrease the use of narcotics. National medical societies are developing clinical practice guidelines for pain management that incorporate multimodal strategies and multimodal medication. Changes to policy that improve …

The Interplay Between Tissue Niche And Macrophage Cellular Metabolism In Obesity, Sabine Daemen, Joel D Schilling

Open Access Publications

Obesity is associated with the development of metabolic diseases such as type 2 diabetes and non-alcoholic fatty liver disease. The presence of chronic, low-grade inflammation appears to be an important mechanistic link between excess nutrients and clinical disease. The onset of these metabolic disorders coincides with changes in the number and phenotype of macrophages in peripheral organs, particularly in the liver and adipose tissue. Macrophage accumulation in these tissues has been implicated in tissue inflammation and fibrosis, contributing to metabolic disease progression. Recently, the concept has emerged that changes in macrophage metabolism affects their functional phenotype, possibly triggered by distinct …

Washu Epigenome Browser Update 2019, Daofeng Li, Silas Hsu, Deepak Purushotham, Renee L. Sears, Ting Wang

Open Access Publications

No abstract provided.

Three Discipline Collaborative Radiation Therapy (3dcrt) Special Debate: Equipment Development Is Stifling Innovation In Radiation Oncology, Leonard Kim, Stephanie Markovina, Samantha J Van Nest, Subarna Eisaman, Lakshmi Santanam, Julie M Sullivan, Michael Dominello, Michael C Joiner, Jay Burmeister

Open Access Publications

No abstract provided.

Restoring Public Trust In Scientific Research By Reducing Conflicts Of Interest, Arthur M Feldman, Douglas L Mann

Open Access Publications

No abstract provided.

Ureteropelvic Junction Obstruction Caused By Metastatic Cholangiocarcinoma, Nicholas A Pickersgill, Alec J Wright, Robert S Figenshau

Open Access Publications

We describe the rare case of a 61-year-old female with right ureteropelvic junction (UPJ) obstruction caused by metastatic cholangiocarcinoma. Her past medical history was notable for cholangiocarcinoma treated with neoadjuvant chemoradiation and two orthotopic liver transplants six years earlier. Urology was consulted when she presented with flank pain and urinary tract infection. Diagnostic workup demonstrated right UPJ obstruction. She was managed acutely with percutaneous nephrostomy. She subsequently underwent robotic pyeloplasty and intrinsic obstruction of the UPJ was discovered. Histological examination revealed adenocarcinoma, consistent with systemic recurrence of the patient's known cholangiocarcinoma.

Edematous Severe Acute Malnutrition Is Characterized By Hypomethylation Of Dna, Katharina V. Schulze, Mark J. Manary, Indi Trehan, Et Al.

Open Access Publications

No abstract provided.