Digital Commons Network^™

Rev-Erbs And Glia—Implications For Neurodegenerative Diseases, Percy Griffin, Julie M. Dimitry, Erik S. Musiek

Open Access Publications

No abstract provided.

A Phase Ii Clinical Study Of 13-Deoxy, 5-Iminodoxorubicin (Gpx-150) With Metastatic And Unresectable Soft Tissue Sarcoma, Brian A. Van Tine, Mark Agulnik, Richard D. Olson, Gerald M. Walsh, Arthur Klausner, Nicole E. Frank, Todd T. Talley, Mohammed M. Milhem

Open Access Publications

No abstract provided.

Emerging Therapeutics For The Treatment Of Light Chain And Transthyretin Amyloidosis, Kathleen W. Zhang, Keith E. Stockerl-Goldstein, Daniel J. Lenihan

Open Access Publications

No abstract provided.

Smoking Status And Subsequent Gastric Cancer Risk In Men Compared With Women: A Meta-Analysis Of Prospective Observational Studies, Wen-Ya Li, Yunan Han, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yong-Xi Song, Hao Xu, Song-Cheng Yin, Xing-Yu Liu, Zhi-Feng Miao

Open Access Publications

No abstract provided.

Importance Of The Conserved Carboxyl-Terminal Cnot1 Binding Domain To Tristetraprolin Activity In Vivo, Wi S. Lai, Deborah J. Stumpo, Melissa L. Wells, Artion Gruzdev, Stephanie N. Hicks, Cindo O. Nicholson, Zhengfeng Yang, Roberta Faccio, Michael W. Webster, Lori A. Passmore, Perry J. Blackshear

Open Access Publications

No abstract provided.

Phages And Human Health: More Than Idle Hitchhikers, Dylan Lawrence, Megan T. Baldridge, Scott A. Handley

Open Access Publications

No abstract provided.

Lncrna Malat1 Gene Polymorphisms In Coronary Artery Disease: A Case-Control Study In A Chinese Population, Weina Hu, Hanxi Ding, An Ouyang, Xiaohong Zhang, Qian Xu, Yunan Han, Xueying Zhang, Yuanzhe Jin

Open Access Publications

No abstract provided.

The Spectrum Of Bladder Health: The Relationship Between Lower Urinary Tract Symptoms And Interference With Activities, Siobhan Sutcliffe, Tamara Bavendam, Charles Cain, Neill Epperson, Colleen M. Fitzgerald, Sheila Gahagan, Alayne D. Markland, David A. Shoham, Ariana L. Smith, Mary K. Townsend, Kyle Rudser, Prevention Of Lower Urinary Tract Symptoms Research Consortium

Open Access Publications

No abstract provided.

Temperament And Character Profiles Of Medical Students Associated With Tolerance Of Ambiguity And Perfectionism, Janni Leung, C Robert Cloninger, Barry A Hong, Kevin M Cloninger, Diann S Eley

Open Access Publications

Background: Certain personal attributes, such as perfectionism and tolerance of ambiguity, have been identified as influential in high achieving students. Medical students have been identified as high achievers and perfectionistic, and as such may be challenged by ambiguity. Medical students undertake a long and challenging degree. Personality has been shown to influence the well-being and coping and may equip some students to better cope with challenges. This paper examines the association between temperament and character personality profiles with measures of tolerance of ambiguity and with both adaptive and maladaptive constructs of perfectionism.

Methods: A self-report questionnaire collected data on a …

A Synthesis Strategy For Tetracyclic Terpenoids Leads To Agonists Of Erβ, Wan Shin Kim, Zachary A. Shalit, Sidney M. Nguyen, Emmalie Schoepke, Alan Eastman, Thomas P. Burris, Arti B. Gaur, Glenn C. Micalizio

Open Access Publications

No abstract provided.

Photoreceptors In A Mouse Model Of Leigh Syndrome Are Capable Of Normal Light-Evoked Signaling, Sidney M. Gospe Iii, Amanda M. Travis, Alexander V. Kolesnikov, Mikael Klingeborn, Luyu Wang, Vladimir J. Kefalov, Vadim Y. Arshavsky

Open Access Publications

No abstract provided.

Molluscum Contagiosum Virus Mc80 Sabotages Mhc-I Antigen Presentation By Targeting Tapasin For Er-Associated Degradation, Ian B. Harvey, Xiaoli Wang, Daved H. Fremont

Open Access Publications

No abstract provided.

Use Of The Who Access, Watch, And Reserve Classification To Define Patterns Of Hospital Antibiotic Use (Aware): An Analysis Of Paediatric Survey Data From 56 Countries, Yingfen Hsia, Brian R. Lee, Ann Versporten, Yonghong Yang, Julia Bielicki, Charlotte Jackson, Jason Newland, Herman Goossens, Nicola Magrini, Mike Sharland

Open Access Publications

No abstract provided.

Tgf-Β Signaling Plays An Essential Role In The Lineage Specification Of Mesenchymal Stem/Progenitor Cells In Fetal Bone Marrow, Grazia Abou-Ezzi, Teerawit Supakorndej, Jingzhu Zhang, Bryan Anthony, Joseph Krambs, Hamza Celik, Darja Karpova, Clarissa S. Craft, Daniel C. Link

Open Access Publications

No abstract provided.

Activation Of Tel1atm Kinase Requires Rad50 Atpase And Long Nucleosome-Free Dna But No Dna Ends, Sarem Hailemariam, Sandeep Kumar, Peter M. Burgers

Open Access Publications

No abstract provided.

The Impact Of Surgeon Volume And Training Status On Implant Alignment In Total Knee Arthroplasty, Gregory S Kazarian, Charles M Lawrie, Toby N Barrack, Matthew J Donaldson, Gary M Miller, Fares S Haddad, Robert L Barrack

Open Access Publications

BACKGROUND: Implant malalignment may predispose patients to prosthetic failure following total knee arthroplasty (TKA). A more thorough understanding of the surgeon-specific factors that contribute to implant malalignment following TKA may uncover actionable strategies for improving implant survival. The purpose of this study was to determine the impact of surgeon volume and training status on malalignment.

METHODS: In this retrospective multicenter study, we performed a radiographic analysis of 1,570 primary TKAs performed at 4 private academic and state-funded centers in the U.S. and U.K. Surgeons were categorized as high-volume (≥50 TKAs/year) or low-volume (<50 TKAs/year), and as a trainee (fellow/resident under the supervision of an attending surgeon) or a non-trainee (attending surgeon). On the basis of these designations, 3 groups were defined: high-volume non-trainee, low-volume non-trainee, and trainee. The postoperative medial distal femoral angle (DFA), medial proximal tibial angle (PTA), and posterior tibial slope angle (PSA) were radiographically measured. Outlier measurements were defined as follows: DFA, outside of 5° ± 3° of valgus; PTA, >±3° deviation from the neutral axis; and …

Dietary Pattern And Risk Of Multiple Myeloma In Two Large Prospective Us Cohort Studies, Dong Hoon Lee, Teresa T. Fung, Fred K. Tabung, Graham A. Colditz, Irene M. Ghobrial, Bernard A. Rosner, Edward L. Giovannucci, Brenda M. Birmann

Open Access Publications

No abstract provided.

Comparison Of The Clinical Characteristics Of Hospital-Acquired And Non-Hospital-Acquired Acinetobacter Calcoaceticus-Baumannii Complex In A Large Midwest Us Health Care System, Juan J. Calix, Jason P. Burnham, Mario F. Feldman

Open Access Publications

No abstract provided.

Mouse Model Recapitulates The Phenotypic Heterogeneity Of Human Adult T-Cell Leukemia/Lymphoma In Bone, Nicole A. Kohart, Said M. Elshafae, Wachirapan Supsahvad, Aylin Alasonyalilar-Demirer, Amanda R. Panfil, Jingyu Xiang, Wessel P. Dirksen, Deborah J. Veis, Patrick L. Green, Katherine N. Weilbaecher, Thomas J. Rosol

Open Access Publications

No abstract provided.

The Complex Genetics And Biology Of Human Temperament: A Review Of Traditional Concepts In Relation To New Molecular Findings, C. Robert Cloninger, Kevin M. Cloninger, Igor Zwir, Lisa Keltikangas-Järvinen

Open Access Publications

No abstract provided.

Amigo2 Scales Dendrite Arbors In The Retina, Florentina Soto, Nai-Wen Tien, Anurag Goel, Lei Zhao, Philip A. Ruzycki, Daniel Kerschensteiner

Open Access Publications

No abstract provided.

The Peptide Hormone Adropin Regulates Signal Transduction Pathways Controlling Hepatic Glucose Metabolism In A Mouse Model Of Diet-Induced Obesity, Su Gao, Sarbani Ghoshal, Liyan Zhang, Joseph R. Stevens, Kyle S. Mccommis, Brian N. Finck, Gary D. Lopaschuk, Andrew A. Butler

Open Access Publications

No abstract provided.

Implementation Of The Uterine Fibroids Option Grid Patient Decision Aids Across Five Organizational Settings: A Randomized Stepped-Wedge Study Protocol, Peter Scalia, Mary C. Politi, Tessa Madden, Et Al

Open Access Publications

No abstract provided.

Microglia Drive Apoe-Dependent Neurodegeneration In A Tauopathy Mouse Model, Yang Shi, Melissa Manis, Justin Long, Kairuo Wang, Patrick M. Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M. Holtzman

Open Access Publications

No abstract provided.

Sedentary Behaviors, Tv Viewing Time, And Risk Of Young-Onset Colorectal Cancer, Long H. Nguyen, Po-Hong Liu, Xiaobin Zheng, Nana Keum, Xiaoyu Zong, Xiao Li, Kana Wu, Charles S. Fuchs, Shuji Ogino, Kimmie Ng, Walter C. Willett, Andrew T. Chan, Edward L. Giovannucci, Yin Cao

Open Access Publications

No abstract provided.

Synthesis And Characterization Of Diazirine Alkyne Probes For The Study Of Intracellular Cholesterol Trafficking, Mckenna Feltes, Samantha Moores, Sarah E. Gale, Kathiresan Krishnan, Laurel Mydock-Mcgrane, Douglas F. Covey, Daniel S. Ory, Jean E. Schaffer

Open Access Publications

No abstract provided.

Detection Of Tar Dna-Binding Protein 43 (Tdp-43) Oligomers As Initial Intermediate Species During Aggregate Formation, Rachel L. French, Zachary R. Grese, Himani Aligireddy, Dhruva D. Dhavale, Ashley N. Reeb, Niraja Kedia, Paul T. Kotzbauer, Jan Bieschke, Yuna M. Ayala

Open Access Publications

No abstract provided.

The Structure Of Acinetobacter-Secreted Protease Cpaa Complexed With Its Chaperone Cpab Reveals A Novel Mode Of A T2ss Chaperone–Substrate Interaction, Darya V. Urusova, Rachel L. Kinsella, Nichole D. Salinas, M. Florencia Haurat, Mario F. Feldman, Niraj H. Tolia

Open Access Publications

No abstract provided.

Hepatic Monoacylglycerol Acyltransferase 1 Is Induced By Prolonged Food Deprivation To Modulate The Hepatic Fasting Response, Andrew J. Lutkewitte, Kyle S. Mccommis, George G. Schweitzer, Kari T. Chambers, Mark J. Graham, Lingjue Wang, Gary J. Patti, Angela M. Hall, Brian N. Finck

Open Access Publications

No abstract provided.

Heterogeneity Diffusion Imaging Of Gliomas: Initial Experience And Validation, Qing Wang, Gloria J. Guzmán Pérez-Carrillo, Maria Rosana Ponisio, Pamela Lamontagne, Sonika Dahiya, Daniel S. Marcus, Mikhail Milchenko, Joshua Shimony, Jingxia Liu, Gengsheng Chen, Amber Salter, Parinaz Massoumzadeh, Michelle M. Miller-Thomas, Keith M. Rich, Jonathan Mcconathy, Tammie L. S. Benzinger, Yong Wang

Open Access Publications

OBJECTIVES: Primary brain tumors are composed of tumor cells, neural/glial tissues, edema, and vasculature tissue. Conventional MRI has a limited ability to evaluate heterogeneous tumor pathologies. We developed a novel diffusion MRI-based method-Heterogeneity Diffusion Imaging (HDI)-to simultaneously detect and characterize multiple tumor pathologies and capillary blood perfusion using a single diffusion MRI scan.

METHODS: Seven adult patients with primary brain tumors underwent standard-of-care MRI protocols and HDI protocol before planned surgical resection and/or stereotactic biopsy. Twelve tumor sampling sites were identified using a neuronavigational system and recorded for imaging data quantification. Metrics from both protocols were compared between World Health …