Digital Commons Network^™

Veliparib With First-Line Chemotherapy And As Maintenance Therapy In Ovarian Cancer, Robert L. Coleman, Andrea R. Hagemann, Et Al.

Open Access Publications

No abstract provided.

Predictors Of Radiographic Osteoarthritis 2 To 3 Years After Anterior Cruciate Ligament Reconstruction: Data From The Moon On-Site Nested Cohort, Morgan H. Jones, Robert H. Brophy, Moon Knee Group, Et Al

Open Access Publications

No abstract provided.

Multiplatform Urinary Metabolomics Profiling To Discriminate Cachectic From Non-Cachectic Colorectal Cancer Patients: Pilot Results From The Colocare Study, Jennifer Ose, Adetunji T Toriola, Et Al

Open Access Publications

Cachexia is a multifactorial syndrome that is characterized by loss of skeletal muscle mass in cancer patients. The biological pathways involved remain poorly characterized. Here, we compare urinary metabolic profiles in newly diagnosed colorectal cancer patients (stage I-IV) from the ColoCare Study in Heidelberg, Germany. Patients were classified as cachectic (

Protocol For The Electroencephalography Guidance Of Anesthesia To Alleviate Geriatric Syndromes (Engages-Canada) Study: A Pragmatic, Randomized Clinical Trial [Version 1; Peer Review: 2 Approved], Alain Deschamps, Jordan Oberhaus, Angela Mickle, Arbi Ben Abdallah, Michael S Avidan, Et Al

Open Access Publications

No abstract provided.

Clinical Variables And Genetic Risk Factors Associated With The Acute Outcome Of Ischemic Stroke: A Systematic Review, Nuria P. Torres-Aguila, Laura Ibañez, Laura Heitsch, Carlos Cruchaga, Jin-Moo Lee, Et Al.

Open Access Publications

No abstract provided.

Clinical Trials In Multiple Sclerosis: Potential Future Trial Designs, Navid Manouchehri, Yinan Zhang, Amber Salter, Rehana Z Hussain, Hans-Peter Hartung, Bernhard Hemmer, Ralf Linker, Benjamin M Segal, Gary Cutter, Olaf Stüve

Open Access Publications

Clinical trials of new treatments in multiple sclerosis (MS) currently require large sample sizes and long durations in order to yield reliable results. The differential responses of an already heterogeneous population of MS patients to individual disease-modifying therapies (DMTs) will further complicate future trials. MS trials with smaller samples and faster outcomes are conceivable through the substitution of current clinical and MRI outcomes with objectively measureable genomic and proteomic biomarkers. Currently, biomarkers that could be utilized for diagnosis and monitoring of MS disease activity are in the early validation phase. The power of single biomarkers or multiple correlated biomarkers to …

Segregated Neural Explants Exhibit Co-Oriented, Asymmetric, Neurite Outgrowth, David B Pettigrew, Curtis B Dobson, Lori G Isaacson, Eric C Leuthardt, Heather N Lilley, Georgette L Suidan, Keith A Crutcher

Open Access Publications

Explants of embryonic chick sympathetic and sensory ganglia were found to exhibit asymmetric radial outgrowth of neurites under standard culture conditions with or without exogenous Nerve Growth Factor [NGF]. Opposing sides of an explant exhibited: a) differences in neurite length and, b) differences in neurite morphology. Strikingly, this asymmetry exhibited co-orientation among segregated, neighboring explants. The underlying mechanism(s) of the asymmetry and its co-orientation are not known but appear to depend on cell clustering because dissociated sympathetic neurons do not exhibit co-orientation whereas re-aggregated clusters of cells do. This emergent behavior may be similar to the community effect described in …

Palatine Tonsillar Metastasis Of Lung Adenocarcinoma: An Unusual Immunohistochemical Phenotype And A Potential Diagnostic Pitfall, Ying Tian, Yunan Han, Jiang Du, Yao Zhang, Nan Liu, Xin Du, Bo Li

Open Access Publications

Metastasis rarely occurs to the palatine tonsils. Herein, we present an exceedingly rare case of palatine tonsillar metastasis from poorly differentiated lung adenocarcinoma with anaplastic lymphoma kinase (ALK) mutation in a 51-year-old woman. The patient manifested clinically as pharyngalgia without obvious respiratory symptoms, with swelling tonsil histomorphologically resembling lymphoma and partially expressing the markers of epithelial and squamous cell carcinoma (CK5/6, P63, and P40). Due to the non-specific immunohistochemical expression, it is easily misdiagnosed as a primary poorly differentiated squamous cell carcinoma of the tonsil. This case highlights the importance of a comprehensive assessment of suspicious tonsillar lesions, that may …

Contribution And Interaction Of Shiga Toxin Genes To Escherichia Coli O157:H7 Virulence, Gillian A M Tarr, Taryn Stokowski, Smriti Shringi, Phillip I Tarr, Stephen B Freedman, Hanna N Oltean, Peter M Rabinowitz, Linda Chui

Open Access Publications

No abstract provided.

Study Of Environmental Enteropathy And Malnutrition (Seem) In Pakistan: Protocols For Biopsy Based Biomarker Discovery And Validation, Najeeha T. Iqbal, Ta-Chiang Liu, Michael J. Barratt, Vanderlene L. Kung, Jeffrey I. Gordon, Et Al

Open Access Publications

No abstract provided.

Low Dose Chloroquine Decreases Insulin Resistance In Human Metabolic Syndrome But Does Not Reduce Carotid Intima-Media Thickness, Janet B Mcgill, Mariko Johnson, Stacy Hurst, William T Cade, Kevin E Yarasheski, Richard E Ostlund, Kenneth B Schechtman, Babak Razani, Michael B Kastan, Donald A Mcclain, Lisa De Las Fuentes, Victor G Davila-Roman, Daniel S Ory, Samuel A Wickline, Clay F Semenkovich

Open Access Publications

Background: Metabolic syndrome, an obesity-related condition associated with insulin resistance and low-grade inflammation, leads to diabetes, cardiovascular diseases, cancer, osteoarthritis, and other disorders. Optimal therapy is unknown. The antimalarial drug chloroquine activates the kinase ataxia telangiectasia mutated (ATM), improves metabolic syndrome and reduces atherosclerosis in mice. To translate this observation to humans, we conducted two clinical trials of chloroquine in people with the metabolic syndrome.

Methods: Eligibility included adults with at least 3 criteria of metabolic syndrome but who did not have diabetes. Subjects were studied in the setting of a single academic health center. The specific hypothesis: chloroquine improves …

Mir-892b Inhibits Hypertrophy By Targeting Klf10 In The Chondrogenesis Of Mesenchymal Stem Cells, Jong Min Lee, Ji-Yn Ko, Hye Young Kim, Jeong-Won Park, Farshid Guilak, Gun-Il Im

Open Access Publications

No abstract provided.

Trem1/3 Deficiency Impairs Tissue Repair After Acute Kidney Injury And Mitochondrial Metabolic Flexibility In Tubular Epithelial Cells, Alessandra Tammaro, Angelique M.L Scantlebery, Elena Rampanelli, Cristiana Borrelli, Nike Claessen, Loes M. Butter, Alessandra Soriani, Marco Colonna, Jaklien C. Leemans, Mark C. Dessing, Sandrine Florquin

Open Access Publications

No abstract provided.

Hospital Volume And Outcomes For Acute Pulmonary Embolism: Multinational Population Based Cohort Study, David Jimenez, Behnood Bikdeli, Andres Quezada, Alfonso Muriel, Jose Luis Lobo, Javier De Miguel-Diez, Luis Jara-Palomares, Pedro Ruiz-Artacho, Roger D. Yusen, Manuel Monreal, Riete Investigators

Open Access Publications

No abstract provided.

Early Increase Of Csf Strem2 In Alzheimer's Disease Is Associated With Tau Related-Neurodegeneration But Not With Amyloid-Β Pathology, Marc Suarez-Calvet, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Et Al

Open Access Publications

No abstract provided.

Interleukin-12 And -23 Blockade Mitigates Elastase-Induced Abdominal Aortic Aneurysm, Huimin Yan, Ying Hu, Antonina Akk, Karen Ye, John Bacon, Christine T.N. Pham

Open Access Publications

No abstract provided.

Achieving Tight Control Of A Photoactivatable Cre Recombinase Gene Switch: New Design Strategies And Functional Characterization In Mammalian Cells And Rodent, Kyle Meador, Christina L. Wysoczynski, Aaron J. Norris, Jason Aoto, Michael R. Bruchas, Chandra L. Tucker

Open Access Publications

No abstract provided.

Adiposity, Hepatic Triglyceride, And Carotid Intima Media Thickness During Behavioral Weight Loss Treatment In Antipsychotic-Treated Youth: A Randomized Pilot Study, Ginger E. Nicol, Rachel Kolko, Eric J. Lenze, Michael D. Yingling, J. Philip Miller, Amanda R. Ricchio, Julia A. Schweiger, Robert L. Findling, Denise Wilfley, John W. Newcomer

Open Access Publications

No abstract provided.

A Qualitative Study Identifying Barriers And Facilitators Of Physical Activity In Rural Communities, Amanda S. Gilbert, Dixie D. Duncan, Alan M. Beck, Amy A. Eyler, Ross C. Brownson

Open Access Publications

No abstract provided.

Effect Of Native And Acetylated Dietary Resistant Starches On Intestinal Fermentative Capacity Of Normal And Stunted Children In Southern India, Ramadass Balamurugan, Srinivasan Pugazhendhi, Gowri M Balachander, Tamilselvan Dharmalingam, Elissa K Mortimer, Geetha L Gopalsamy, Richard J Woodman, Rosie Meng, David H Alpers, Mark Manary, Henry J Binder, Ian L Brown, Graeme P Young, Balakrishnan S Ramakrishna

Open Access Publications

The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted ('healthy') children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. …

Potential Impact Of Interventions To Enhance Retention In Care During Real-World Hiv Pre-Exposure Prophylaxis Implementation, Philip A. Chan, William C. Goedel, Amy S. Nunn, Genoviva Sowemimo-Coker, Omar Galárraga, Mattia Prosperi, Rupa Patel, Leandro Mena, Madeline C. Montgomery, Brandon D.L. Marshall

Open Access Publications

No abstract provided.

Long-Term Treatment With Eteplirsen In Nonambulatory Patients With Duchenne Muscular Dystrophy, Anne M. Connolly, Et Al.

Open Access Publications

No abstract provided.

18f-Fdg Pet/Ct Radiomic Analysis With Machine Learning For Identifying Bone Marrow Involvement In The Patients With Suspected Relapsed Acute Leukemia, Hebei Li, Chongrui Xu, Bowen Xin, Chaojie Zheng, Yunyun Zhao, Keji Hao, Qian Wang, Richard L. Wahl, Xiuying Wang, Yun Zhou

Open Access Publications

No abstract provided.

Untangling The Evolutionary Roots Of Lung Cancer, Siddhartha Devarakonda, Ramaswamy Govindan

Open Access Publications

No abstract provided.

Increased Mtdna Abundance And Improved Function In Human Barth Syndrome Patient Fibroblasts Following Aav-Taz Gene Delivery, Silveli Suzuki-Hatano, Mughil Sriramvenugopal, Manash Ramanathan, Meghan Soustek, Barry J. Byrne, W. T. Cade, Peter B. Kang, Christina A. Pacak

Open Access Publications

No abstract provided.

Meniscus-Derived Matrix Scafolds Promote The Integrative Repair Of Meniscal Defects, Jacob C. Ruprecht, Taylor D. Waanders, Christopher R. Rowland, James F. Nishimuta, Katherine A. Glass, Jennifer Stencel, Louis E. Defrate, Farshid Guilak, J. Brice Weinberg, Amy L. Mcnulty

Open Access Publications

No abstract provided.

Relationship Between Device Acceptance And Patient-Reported Outcomes In Left Ventricular Assist Device (Lvad) Recipients, Crispino Tosto, Luigi Adamo, Heidi Craddock, Maria Di Blasi, Rosario Girgenti, Francesco Clemenza, Robert M. Carney, Gregory Ewald

Open Access Publications

No abstract provided.

Provider-Level Variation In Smoking Cessation Assistance Provided In The Cardiology Clinics: Insights From The Ncdr Pinnacle Registry, Mayank Sardana, Yuanyuan Tang, Jared W. Magnani, Ira S. Ockene, Jeroan J. Allison, Suzanne V. Arnold, Phillip G. Jones, Thomas M. Maddox, Salim S. Virani, David D. Mcmanus

Open Access Publications

No abstract provided.

Genotypic And Phenotypic Characterization Of Antimicrobial Resistance In Neisseria Gonorrhoeae: A Cross-Sectional Study Of Isolates Recovered From Routine Urine Cultures In A High-Incidence Setting, Adam L. Bailey, Robert F. Potter, Meghan A. Wallace, Caitlin Johnson, Gautam Dantas, Carey-Ann D. Burnham

Open Access Publications

No abstract provided.

Cemented Versus Cementless Total Knee Arthroplasty Of The Same Modern Design: A Prospective, Randomized Trial, Denis Nam, Charles M. Lawrie, Rondek Salih, Cindy R. Nahhas, Robert L. Barrack, Ryan M. Nunley

Open Access Publications

No abstract provided.