Digital Commons Network^™

Dna Double-Strand Breaks Induce H2ax Phosphorylation Domains In A Contact-Dependent Manner, Patrick L. Collins, Caitlin Purman, Sofia I. Porter, Vincent Nganga, Ankita Saini, Katharina E. Hayer, Greer L. Gurewitz, Barry P. Sleckman, Jeffrey J. Bednarski, Craig H. Bassing, Eugene M. Oltz

Open Access Publications

No abstract provided.

Bone Marrow Adipose Tissue Is A Unique Adipose Subtype With Distinct Roles In Glucose Homeostasis, Karla J. Suchacki, Erica L. Scheller, Et Al.

Open Access Publications

No abstract provided.

Mitigating Disruptions, And Scalability Of Radiation Oncology Physics Work During The Covid-19 Pandemic, Arash Darafsheh, Hossein Lavvafi, Reza Taleei, Rao Khan

Open Access Publications

PURPOSE: The COVID-19 pandemic has led to disorder in work and livelihood of a majority of the modern world. In this work, we review its major impacts on procedures and workflow of clinical physics tasks, and suggest alternate pathways to avoid major disruption or discontinuity of physics tasks in the context of small, medium, and large radiation oncology clinics. We also evaluate scalability of medical physics under the stress of "social distancing".

METHODS: Three models of facilities characterized by the number of clinical physicists, daily patient throughput, and equipment were identified for this purpose. For identical objectives of continuity of …

Immunomodulatory Roles Of Polysaccharide Capsules In The Intestine, Samantha A Hsieh, Paul M Allen

Open Access Publications

The interplay between the immune system and the microbiota in the human intestine dictates states of health vs. disease. Polysaccharide capsules are critical elements of bacteria that protect bacteria against environmental and host factors, including the host immune system. This review summarizes the mechanisms by which polysaccharide capsules from commensal and pathogenic bacteria in the gut microbiota modulate the innate and adaptive immune systems in the intestine. A deeper understanding of the roles of polysaccharide capsules in microbiota-immune interactions will provide a basis to harness their therapeutic potential to advance human health.

The Price Of The Ticket: Health Costs Of Upward Mobility Among African Americans, Darrell Hudson, Tina Sacks, Katie Irani, Antonia Asher

Open Access Publications

There is a growing literature that has documented diminishing health returns on upward social mobility among Black Americans. Due to historical policies and practices, upward social mobility is often an arduous, isolating process for Black Americans, especially as they navigate predominately white educational and workplace settings. This paper advances the literature in several meaningful and innovative ways. The goal of this paper is to provide a qualitative account of the health costs of upward social mobility and describe how these costs could diminish health returns despite greater levels of socioeconomic resources. Focus groups and surveys were the data collection methods …

Modeling Biological And Genetic Diversity In Upper Tract Urothelial Carcinoma With Patient Derived Xenografts, Kwanghee Kim, James J. Hsieh, Et Al.

Open Access Publications

No abstract provided.

The Role Of Eye Tracking Technology In Assessing Older Driver Safety, David B Carr, Prateek Grover

Open Access Publications

A growing body of literature is focused on the use of eye tracking (ET) technology to understand the association between objective visual parameters and higher order brain processes such as cognition. One of the settings where this principle has found practical utility is in the area of driving safety.

METHODS: We reviewed the literature to identify the changes in ET parameters with older adults and neurodegenerative disease.

RESULTS: This narrative review provides a brief overview of oculomotor system anatomy and physiology, defines common eye movements and tracking variables that are typically studied, explains the most common methods of eye tracking …

Comparison Of Differential Accessibility Analysis Strategies For Atac-Seq Data, Paul Gontarz, Shuhua Fu, Xiaoyun Xing, Shaopeng Liu, Benpeng Miao, Viktoriia Bazylianska, Akhil Sharma, Pamela Madden, Kitra Cates, Andrew Yoo, Anna Moszczynska, Ting Wang, Bo Zhang

Open Access Publications

No abstract provided.

Motor Unit Discharge Variability Is Increased In Mild-To-Moderate Parkinson's Disease, Jessica M Wilson, Christopher K Thompson, Laura Miller Mcpherson, Cindy Zadikoff, C J Heckman, Colum D Mackinnon

Open Access Publications

Individuals with Parkinson's disease (PD) demonstrate deficits in muscle activation such as decreased amplitude and inappropriate bursting. There is evidence that some of these disturbances are more pronounced in extensor vs. flexor muscles. Surface EMG has been used widely to quantify muscle activation deficits in PD, but analysis of discharge of the underlying motor units may provide greater insight and be more sensitive to changes early in the disease. Of the few studies that have examined motor unit discharge in PD, the majority were conducted in the first dorsal interosseous, and no studies have measured motor units from extensor and …

Trends In Diagnosis Related Groups For Inpatient Admissions And Associated Changes In Payment From 2012 To 2016, Ty J. Gluckman, Kateri J. Spinelli, Mansen Wang, Amir Yazdani, Gary Grunkemeier, Steven M. Bradley, Jason H. Wasfy, Abhinav Goyal, Andrew Oseran, Karen E. Joynt Maddox

Open Access Publications

Importance: Hospitals are reimbursed based on Diagnosis Related Groups (DRGs), which are defined, in part, by patients having 1 or more complications or comorbidities within a given DRG family. Hospitals have made substantial investment in efforts to document these complications and comorbidities.

Objective: To examine temporal trends in DRGs with a major complication or comorbidity, compare these findings with 2 alternative measures of disease severity, and estimate associated changes in payment.

Design, Setting, and Participants: This retrospective cohort study used data from the all-payer National Inpatient Sample for admissions assigned to 1 of the top 20 reimbursed DRG families at …

Californians Linking Action With Science For Prevention Of Breast Cancer (Clasp-Bc)-Phase 2, Jon F Kerner, Marion H E Kavanaugh-Lynch, Christopher Politis, Lourdes Baezconde-Garbanati, Aviva Prager, Ross C Brownson

Open Access Publications

Californians Linking Action with Science for Prevention of Breast Cancer (CLASP-BC) is part of California Breast Cancer Research Program's (CBCRP) Initiative strategic priority to disseminate and implement high-impact, population-based primary prevention interventions. CLASP-BC is informed by six years of funded program dissemination and implementation (D&I) research and evaluation conducted by the Canadian Partnership Against Cancer (CPAC) through its Coalitions Linking Action and Science for Prevention (CLASP). In its second phase, CLASP-BC will fund multi-sector, multi-jurisdictional initiatives that integrate the lessons learned from science with the lessons learned from practice and policy to reduce the risk of developing breast cancer and …

Pragmatic Application Of The Re-Aim Framework To Evaluate The Implementation Of Tobacco Cessation Programs Within Nci-Designated Cancer Centers, Heather D'Angelo, Alex T Ramsey, Li-Shiun Chen, Et Al

Open Access Publications

Tobacco cessation after cancer diagnosis leads to better patient outcomes. However, tobacco treatment services are frequently unavailable in cancer care settings, and multilevel implementation challenges can impede uptake of new programs. The National Cancer Institute (NCI) dedicated Cancer Moonshot funding through the Cancer Center Cessation Initiative (C3I) for NCI-Designated Cancer Centers to implement or enhance the implementation of tobacco treatment services. We examined a pragmatic application of the RE-AIM framework (reach, effectiveness, adoption, implementation, and maintenance) to evaluate tobacco treatment programs implemented within Cancer Centers funded through C3I. Using three C3I-funded Centers as examples, we describe how each RE-AIM construct …

Quality Of Life With Second Or Third Line Nab-Paclitaxel-Based Regimens In Advanced Non-Small-Cell Lung Cancer, Santiago Ponce Aix, Ramaswamy Govindan, Daniel Morgensztern, Et Al

Open Access Publications

No abstract provided.

Safety And Tolerability Of Srx246, A Vasopressin 1a Antagonist, In Irritable Huntington's Disease Patients—A Randomized Phase 2 Clinical Trial, Michael J Brownstein, Joel S Perlmutter, Elaine Most, Et Al

Open Access Publications

SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in an experimental medicine fMRI study and demonstrated excellent safety in Phase 1 multiple-ascending dose clinical trials. The present study was a 3-arm, multicenter, randomized, placebo-controlled, double-blind, 12-week, dose escalation study of SRX246 in early symptomatic Huntington's disease (HD) patients with irritability. Our goal was to determine whether SRX246 was safe and well tolerated in these HD patients given its potential use for the treatment of problematic …

Single-Cell Transcriptomic Analysis Identifies The Conversion Of Zebrafish Etv2-Deficient Vascular Progenitors Into Skeletal Muscle, Brendan Chestnut, Satish Casie Chetty, Andrew L. Koenig, Saulius Sumanas

Open Access Publications

No abstract provided.

Full-Range Space-Division Multiplexing Optical Coherence Tomography Angiography, Yongyang Huang, Jason Jerwick, Guoyan Liu, Chao Zhou

Open Access Publications

In this study, we demonstrated a full-range space-division multiplexing optical coherence tomography (FR-SDM-OCT) system. Utilizing the galvanometer-based phase modulation full-range technique, the total imaging range of FR-SDM-OCT can be extended to >20 mm in tissue, with a digitizer sampling rate of 500 MS/s and a laser sweeping rate of 100 kHz. Complex conjugate terms were suppressed in FR-SDM-OCT images with a measured rejection ratio of up to ∼46 dB at ∼1.4 mm depth and ∼30 dB at ∼19.4 mm depth. The feasibility of FR-SDM-OCT was validated by imaging Scotch tapes and human fingernails. Furthermore, we demonstrated the feasibility of FR-SDM-OCT …

Astrocyte Deletion Of Α2-Na/K Atpase Triggers Episodic Motor Paralysis In Mice Via A Metabolic Pathway, Sarah A. Smith, Xiaoying Chen, Lindsey M. Brier, Jonathan R. Bumstead, Nicholas R. Rensing, Alison E. Ringel, Haewon Shin, Anna Oldenborg, Jan R. Crowley, Annie R. Bice, Krikor Dikranian, Joseph E. Ippolito, Marcia C. Haigis, Thomas Papouin, Guoyan Zhao, Michael Wong, Joseph P. Culver, Azad Bonni

Open Access Publications

No abstract provided.

Harnessing Real-World Data To Inform Decision-Making: Multiple Sclerosis Partners Advancing Technology And Health Solutions (Ms Paths), Ellen M Mowry, Tammie L S Benzinger, Robert T Naismith, Et Al

Open Access Publications

No abstract provided.

Impact Of Cytogenetic Abnormalities On Outcomes Of Adult Philadelphia-Negative Acute Lymphoblastic Leukemia After Allogeneic Hematopoietic Stem Cell Transplantation: A Study By The Acute Leukemia Working Committee Of The Center For International Blood And Marrow Transplant Research, Aleksandr Lazaryan, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

Client Processing Is Altered By Novel Myopathy-Causing Mutations In The Hsp40 J Domain, Melanie Y. Pullen, Conrad C. Weihl, Heather L. True

Open Access Publications

The misfolding and aggregation of proteins is often implicated in the development and progression of degenerative diseases. Heat shock proteins (HSPs), such as the ubiquitously expressed Type II Hsp40 molecular chaperone, DNAJB6, assist in protein folding and disaggregation. Historically, mutations within the DNAJB6 G/F domain have been associated with Limb-Girdle Muscular Dystrophy type 1D, now referred to as LGMDD1, a dominantly inherited degenerative disease. Recently, novel mutations within the J domain of DNAJB6 have been reported in patients with LGMDD1. Since novel myopathy-causing mutations in the Hsp40 J domain have yet to be characterized and both the function of DNAJB6 …

Digital Translucence: Adapting Telemedicine Delivery Post-Covid-19, Thomas Kannampallil, Jun Ma

Open Access Publications

No abstract provided.

A Mobile App Directory Of Occupational Therapists Who Provide Home Modifications: Development And Preliminary Usability Evaluation, An Thi Nguyen, Emily Kling Somerville, Sandra Martina Espín-Tello, Marian Keglovits, Susan Lynn Stark

Open Access Publications

BACKGROUND: Home modifications provided by occupational therapists (OTs) are effective in improving daily activity performance and reducing fall risk among community-dwelling older adults. However, the prevalence of home modification is low. One reason is the lack of a centralized database of OTs who provide home modifications.

OBJECTIVE: This study aimed to develop and test the usability of a mobile app directory of OTs who provide home modifications in the United States.

METHODS: In phase 1, a prototype was developed by identifying OTs who provide home modifications through keyword Web searches. Referral information was confirmed by phone or email. In phase …

Inhibition Of Pikfyve Kinase Prevents Infection By Zaire Ebolavirus And Sars-Cov-2, Yuan-Lin Kang, Yi-Ying Chou, Paul W. Rothlauf, Zhuoming Liu, Timothy K. Soh, David Cureton, James Brett Case, Rita E. Chen, Michael S. Diamond, Sean P.J. Whelan, Tom Kirchhausen

Open Access Publications

No abstract provided.

Human Ferroportin Mediates Proton-Coupled Active Transport Of Iron, Shuang Li, Yihu Yang, Weikai Li

Open Access Publications

No abstract provided.

Going Beyond Integration: The Emerging Role Of Hiv-1 Integrase In Virion Morphogenesis, Jennifer L Elliott, Sebla B Kutluay

Open Access Publications

The HIV-1 integrase enzyme (IN) plays a critical role in the viral life cycle by integrating the reverse-transcribed viral DNA into the host chromosome. This function of IN has been well studied, and the knowledge gained has informed the design of small molecule inhibitors that now form key components of antiretroviral therapy regimens. Recent discoveries unveiled that IN has an under-studied yet equally vital second function in human immunodeficiency virus type 1 (HIV-1) replication. This involves IN binding to the viral RNA genome in virions, which is necessary for proper virion maturation and morphogenesis. Inhibition of IN binding to the …

Ldha-Mediated Ros Generation In Chondrocytes Is A Potential Therapeutic Target For Osteoarthritis, Manoj Arra, Gaurav Swarnkar, Ke Ke, Jesse E. Otero, Jun Ying, Xin Duan, Takashi Maruyama, Muhammad Farooq Rai, Regis J. O'Keefe, Gabriel Mbalaviele, Jie Shen, Yousef Abu-Amer

Open Access Publications

No abstract provided.

Midkine Activation Of Cd8+ T Cells Establishes A Neuron–Immune–Cancer Axis Responsible For Low-Grade Glioma Growth, Xiaofan Guo, Yuan Pan, Min Xiong, Shilpa Sanapala, Corina Anastasaki, Olivia Cobb, Sonika Dahiya, David H. Gutmann

Open Access Publications

No abstract provided.

Serum Urate Lowering With Allopurinol And Kidney Function In Type 1 Diabetes, Alessandro Doria, Janet B. Mcgill, Et Al.

Open Access Publications

No abstract provided.

Abatacept Is Effective As Gvhd Prophylaxis In Unrelated Donor Stem Cell Transplantation For Children With Severe Sickle Cell Disease, Alexander Ngwube, Niketa Shah, Kamar Godder, David Jacobsohn, Monica L. Hulbert, Shalini Shenoy

Open Access Publications

No abstract provided.

Exercise Training Results In Lower Amyloid Plaque Load And Greater Cognitive Function In An Intensity Dependent Manner In The Tg2576 Mouse Model Of Alzheimer's Disease, Riya Thomas, Scott D Zimmerman, Kayla M Yuede, John R Cirrito, Leon M Tai, Benjamin F Timson, Carla M Yuede

Open Access Publications

Three months of exercise training (ET) decreases soluble Aβ