Digital Commons Network^™

Rituximab/Bendamustine And Rituximab/Cytarabine Induction Therapy For Transplant-Eligible Mantle Cell Lymphoma, Reid W. Merryman, Natasha Edwin, Amanda Cashen, Nancy L. Bartlett, Neha Mehta-Shah, Armin Ghobadi, Brad Kahl, Et Al.

Open Access Publications

No abstract provided.

Human Brain Functional Network Organization Is Disrupted After Whole-Brain Radiation Therapy, Timothy J. Mitchell, Benjamin A. Seitzman, Nicholas Ballard, Steven E. Petersen, Joshua S. Shimony, Eric C. Leuthardt

Open Access Publications

No abstract provided.

Sensitivity Analysis Of Monte Carlo Model Of A Gantry-Mounted Passively Scattered Proton System, Milad Baradaran-Ghahfarokhi, Francisco Reynoso, Michael T Prusator, Baozhou Sun, Tianyu Zhao

Open Access Publications

PURPOSE: This study aimed to present guidance on the correlation between treatment nozzle and proton source parameters, and dose distribution of a passive double scattering compact proton therapy unit, known as Mevion S250.

METHODS: All 24 beam options were modeled using the MCNPX MC code. The calculated physical dose for pristine peak, profiles, and spread out Bragg peak (SOBP) were benchmarked with the measured data. Track-averaged LET (LET

RESULTS: For the physical dose distribution, the MCNPX MC model matched measurements data for all the options to within 2 mm and 2% criterion. The Mevion S250 was found to have a …

Impact Of Gender And Caregiving Responsibilities On Academic Success In Hematology, Allison A. King, Sara K. Vesely, Emily Vettese, Sadie Cook, Adam Cuker, Wendy Stock, Morgan Homer, Josel Fritz, Lilian Sung

Open Access Publications

No abstract provided.

Investigating The Effect Of Thyroid Nodule Location On The Risk Of Thyroid Cancer, Sina Jasim, Thomas J. Baranski, Sharlene A. Teefey, William D. Middleton

Open Access Publications

No abstract provided.

Family Encouragement Of Healthy Eating Predicts Child Dietary Intake And Weight Loss In Family-Based Behavioral Weight-Loss Treatment, Sophia A. Rotman, Lauren A. Fowler, Mary Katherine Ray, Richard I. Stein, Jacqueline F. Hayes, Rachel P. Kolko, Katherine N. Balantekin, Alexis Engel, Brian E. Saelens, R. Robinson Welch, Michael G. Perri, Leonard H. Epstein, Denise E. Wilfley

Open Access Publications

No abstract provided.

Deciphering The Factors That Influence Participation In Studies Requiring Serial Lumbar Punctures, Gregory S Day, Tracy Rappai, Sushila Sathyan, John C Morris

Open Access Publications

Introduction: Cerebrospinal fluid biomarkers increasingly inform the causes of dementia and may provide objective markers of disease progression. There is a need to decipher participant and procedural factors that promote participation in studies incorporating longitudinal biomarker measures.

Methods: Participant and procedural factors associated with participation in longitudinal biomarker studies were determined in individuals enrolled in studies of memory and aging at the Knight Alzheimer Disease Research Center (Saint Louis, MO, USA).

Results: Complications were encountered following 331 of 1484 lumbar punctures (22.3%; LPs), affecting 280 of 929 participants (30.1%); in >95% complications were minor. Three hundred fifteen of 679 eligible …

Strong Concordance Between Rna Structural And Single Nucleotide Variants Identified Via Next Generation Sequencing Techniques In Primary Pediatric Leukemia And Patient-Derived Xenograft Samples, Sonali P. Barwe, Anilkumar Gopalakrisnapillai, Nitin Mahajan, Todd E. Druley, E. Anders Kolb, Erin L. Crowgey

Open Access Publications

No abstract provided.

Wikidata As A Knowledge Graph For The Life Sciences, Andra Waagmeester, Malachi Griffith, Obi L. Griffith, Et Al.

Open Access Publications

No abstract provided.

Diabetes Minimally Mediated The Association Between Pm2.5 Air Pollution And Kidney Outcomes, Benjamin Bowe, Yan Xie, Yan Yan, Hong Xian, Ziyad Al-Aly

Open Access Publications

No abstract provided.

Activating Immunity To Fight A Foe — A New Path, Richard S. Hotchkiss, Steven M. Opal

Open Access Publications

No abstract provided.

The Cartilage Matrisome In Adolescent Idiopathic Scoliosis, Carol A. Wise, Diane Sepich, Aki Ushiki, Anas M. Khanshour, Yared H. Kidane, Nadja Makki, Christina A. Gurnett, Ryan S. Gray, Jonathan J. Rios, Nadav Ahituv, Lila Solnica-Krezel

Open Access Publications

No abstract provided.

Refined National Institutes Of Health Response Algorithm For Chronic Graft-Versus-Host Disease In Joints And Fascia, Yoshihiro Inamoto, Stephanie J. Lee, Lynn E. Onstad, Mary E.D. Flowers, Betty K. Hamilton, Madan H. Jagasia, Paul J. Martin, Steven Z. Pavletic, Joseph A. Pidala, Iskra Pusic, Georgia B. Vogelsang, Daniel Wolff, Paul A. Carpenter

Open Access Publications

No abstract provided.

Monitoring The Itinerary Of Lysosomal Cholesterol In Niemann-Pick Type C1-Deficient Cells After Cyclodextrin Treatment, Mckenna Feltes, Sarah E. Gale, Samantha Moores, Daniel S. Ory, Jean E. Schaffer

Open Access Publications

No abstract provided.

Incidence And Prediction Of Intraoperative And Postoperative Cardiac Arrest Requiring Cardiopulmonary Resuscitation And 30-Day Mortality In Non-Cardiac Surgical Patients, Heiko A. Kaiser, Nahel N. Saied, Andreas S. Kokoefer, Lina Saffour, Jonathan K. Zoller, Mohammad A. Helwani

Open Access Publications

BACKGROUND: The incidence, prediction and mortality outcomes of intraoperative and postoperative cardiac arrest requiring cardiopulmonary resuscitation (CPR) in surgical patients are under investigated and have not been studied concurrently in a single study.

METHODS: A retrospective cohort study was conducted using the American College of Surgeons National Surgical Quality Improvement Program data between 2008 and 2012. Firth's penalized logistic regression was used to study the incidence and identify risk factors for intra- and postoperative CPR and 30-day mortality. simplified prediction model was constructed and internally validated to predict the studied outcomes.

RESULTS: Among about 1.86 million non-cardiac operations, the incidence …

Redox Systems Biology: Harnessing The Sentinels Of The Cysteine Redoxome, Jason M. Held

Open Access Publications

No abstract provided.

Ancestry Specific Associations Of Fto Gene Variant And Metabolic Syndrome: A Longitudinal Aric Study, Dale S. Hardy, Jane T. Garvin, Tesfaye B. Mersha, Susan B. Racette

Open Access Publications

No abstract provided.

Insulin Resistance Drives Hepatic De Novo Lipogenesis In Nonalcoholic Fatty Liver Disease, Gordon I Smith, Mahalakshmi Shankaran, Mihoko Yoshino, George G Schweitzer, Maria Chondronikola, Joseph W Beals, Adewole L Okunade, Bruce W Patterson, Edna Nyangau, Tyler Field, Claude B Sirlin, Saswata Talukdar, Marc K Hellerstein, Samuel Klein

Open Access Publications

BACKGROUNDAn increase in intrahepatic triglyceride (IHTG) is the hallmark feature of nonalcoholic fatty liver disease (NAFLD) and is decreased by weight loss. Hepatic de novo lipogenesis (DNL) contributes to steatosis in individuals with NAFLD. The physiological factors that stimulate hepatic DNL and the effect of weight loss on hepatic DNL are not clear.METHODSHepatic DNL, 24-hour integrated plasma insulin and glucose concentrations, and both liver and whole-body insulin sensitivity were determined in individuals who were lean (n = 14), obese with normal IHTG content (n = 26), or obese with NAFLD (n = 27). Hepatic DNL was assessed using the deuterated …

Inducible Expression Of Wnt7b Promotes Bone Formation In Aged Mice And Enhances Fracture Healing, Deye Song, Guangxu He, Fangfang Song, Zhepeng Wang, Xiaochen Liu, Lele Liao, Jiangdong Ni, Matthew J. Silva, Fanxin Long

Open Access Publications

No abstract provided.

Movement Pattern Training Compared With Standard Strengthening And Flexibility Among Patients With Hip-Related Groin Pain: Results Of A Pilot Multicentre Randomised Clinical Trial, Marcie Harris-Hayes, Karen Steger-May, Allyn M. Bove, Stefanie N. Foster, Michael J. Mueller, John C. Clohisy, G. Kelley Fitzgerald

Open Access Publications

No abstract provided.

Dietary Glycaemic Index, Glycaemic Load And Head And Neck Cancer Risk: A Pooled Analysis In An International Consortium, Chun-Pin Chang, Jose P Zevallos, Et Al

Open Access Publications

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (OR

Mouse Genetics Identifies Unique And Overlapping Functions Of Fibroblast Growth Factor Receptors In Keratinocytes, Michael Meyer, Maya Ben-Yehuda Greenwald, Theresa Rauschendorfer, Catharina Sänger, Marko Jukic, Haruka Iizuka, Fumimasa Kubo, Lin Chen, David M Ornitz, Sabine Werner

Open Access Publications

Fibroblast growth factors (FGFs) are key regulators of tissue development, homeostasis and repair, and abnormal FGF signalling is associated with various human diseases. In human and murine epidermis, FGF receptor 3 (FGFR3) activation causes benign skin tumours, but the consequences of FGFR3 deficiency in this tissue have not been determined. Here, we show that FGFR3 in keratinocytes is dispensable for mouse skin development, homeostasis and wound repair. However, the defect in the epidermal barrier and the resulting inflammatory skin disease that develops in mice lacking FGFR1 and FGFR2 in keratinocytes were further aggravated upon additional loss of FGFR3. This caused …

Heavy Metals Contaminating The Environment Of A Progressive Supranuclear Palsy Cluster Induce Tau Accumulation And Cell Death In Cultured Neurons, Carolina Alquezar, Jessica B. Felix, Elizabeth Mccandlish, Brian T. Buckley, Dominique Caparros-Lefebvre, Celeste M. Karch, Lawrence I. Golbe, Aimee W. Kao

Open Access Publications

No abstract provided.

Medulloblastoma Has A Global Impact On Health Related Quality Of Life: Findings From An International Cohort, Cynthia B De Medeiros, Josh Rubin, Et Al

Open Access Publications

BACKGROUND: Understanding the global impact of medulloblastoma on health related quality of life (HRQL) is critical to characterizing the broad impact of this disease and realizing the benefits of modern treatments. We evaluated HRQL in an international cohort of pediatric medulloblastoma patients.

METHODS: Seventy-six patients were selected from 10 sites across North America, Europe, and Asia, who participated in the Medulloblastoma Advanced Genomics International Consortium (MAGIC). The Health Utilities Index (HUI) was administered to patients and/or parents at each site. Responses were used to determine overall HRQL and attributes (ie specific subdomains). The impact of various demographic and medical variables …

A Meta-Analysis Of Genome-Wide Association Studies Of Multiple Myeloma Among Men And Women Of African Ancestry, Zhaohui Du, Graham A. Colditz, Mark A. Fiala, Ravi Vij, Et Al.

Open Access Publications

No abstract provided.

Uncovering Tumour Heterogeneity Through Pkr And Nc886 Analysis In Metastatic Colon Cancer Patients Treated With 5-Fu-Based Chemotherapy, María Belén Ortega-García, Igor Zwir, Et Al

Open Access Publications

Colorectal cancer treatment has advanced over the past decade. The drug 5-fluorouracil is still used with a wide percentage of patients who do not respond. Therefore, a challenge is the identification of predictive biomarkers. The protein kinase R (PKR also called EIF2AK2) and its regulator, the non-coding pre-mir-nc886, have multiple effects on cells in response to numerous types of stress, including chemotherapy. In this work, we performed an ambispective study with 197 metastatic colon cancer patients with unresectable metastases to determine the relative expression levels of both nc886 and PKR by qPCR, as well as the location of PKR by …

Polycystin 2 Is Increased In Disease To Protect Against Stress-Induced Cell Death, Allison L. Brill, Tom T. Fischer, Jennifer M. Walters, Arnaud Marlier, Lorenzo R. Sewanan, Parker C. Wilson, Eric K. Johnson, Gilbert Moeckel, Lloyd G. Cantley, Stuart G. Campbell, Jeanne M. Nerbonne, Hee Jung Chung, Marie E. Robert, Barbara E. Ehrlich

Open Access Publications

No abstract provided.

Frequency And Clinical Significance Of Localized Adverse Events Following Mass Drug Administration For Lymphatic Filariasis In An Endemic Area In South India, Vijesh Sreedhar Kuttiatt, Roopali K Somani, Subramanian Swaminathan, Kaliannagounder Krishnamoorthy, Gary J Weil, Jambulingam Purushothaman

Open Access Publications

Fear of adverse events (AEs) negatively affects compliance to mass drug administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic AEs are believed to occur because of killing of microfilariae, whereas localized soft tissue reactions might be due to the death of adult worms following therapy. Most AEs are mild and self-limited. However, localized AEs are sometimes more significant and of concern to participants. Here, we describe localized AEs that were noted during a large community study that evaluated the safety of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) for the treatment of LF in India. We have also discussed …

A Novel Histological Index For Evaluation Of Environmental Enteric Dysfunction Identifies Geographic-Specific Features Of Enteropathy Among Children With Suboptimal Growth, Ta-Chiang Liu, Kelley Vanbuskirk, Lori R. Holtz, I. Malick Ndao, Michael H. Isaacs, John D. Pfeifer, Phillip I. Tarr, Et Al.

Open Access Publications

BACKGROUND: A major limitation to understanding the etiopathogenesis of environmental enteric dysfunction (EED) is the lack of a comprehensive, reproducible histologic framework for characterizing the small bowel lesions. We hypothesized that the development of such a system will identify unique histology features for EED, and that some features might correlate with clinical severity.

METHODS: Duodenal endoscopic biopsies from two cohorts where EED is prevalent (Pakistan, Zambia) and North American children with and without gluten sensitive enteropathy (GSE) were processed for routine hematoxylin & eosin (H&E) staining, and scanned to produce whole slide images (WSIs) which we shared among study pathologists …

A Wnt-Mediated Transformation Of The Bone Marrow Stromal Cell Identity Orchestrates Skeletal Regeneration, Yuki Matsushita, Mizuki Nagata, Kenneth M. Kozloff, Joshua D. Welch, Koji Mizuhashi, Nicha Tokavanich, Shawn A. Hallett, Daniel C. Link, Takashi Nagasawa, Wanida Ono, Noriaki Ono

Open Access Publications

No abstract provided.